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Oakley","year":"2007","journal-title":"Infect Immun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1101\/gad.1214604","article-title":"SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?","volume":"18","author":"G Gill","year":"2004","journal-title":"Genes Dev"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1128\/MCB.24.10.4267-4274.2004","article-title":"Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae.","volume":"24","author":"L Haracska","year":"2004","journal-title":"Mol Cell Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nature00991","article-title":"RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.","volume":"419","author":"C Hoege","year":"2002","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.1038\/sj.onc.1203093","article-title":"Covalent modification of all members of human cullin family proteins by NEDD8.","volume":"18","author":"T Hori","year":"1999","journal-title":"Oncogene"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1301","article-title":"Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation.","volume":"7","author":"JT Wu","year":"2005","journal-title":"Nat Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1006\/bbrc.1993.2056","article-title":"Cloning of a cDNA which encodes a novel ubiquitin-like protein.","volume":"195","author":"S Kumar","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"7462","DOI":"10.1074\/jbc.275.11.7462","article-title":"A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes.","volume":"275","author":"K Furukawa","year":"2000","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/j.cub.2004.11.058","article-title":"Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast.","volume":"14","author":"CR Wilkinson","year":"2004","journal-title":"Curr Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0006-8993(03)03161-5","article-title":"Beacon\/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse.","volume":"984","author":"GC Brailoiu","year":"2003","journal-title":"Brain Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1128\/EC.2.5.930-936.2003","article-title":"Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p.","volume":"2","author":"AS Goehring","year":"2003","journal-title":"Eukaryot Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/26506","article-title":"A protein conjugation system essential for autophagy.","volume":"395","author":"N Mizushima","year":"1998","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"11384","DOI":"10.1074\/jbc.M512307200","article-title":"Endosome sorting and autophagy are essential for differentiation and virulence of Leishmania major.","volume":"281","author":"S Besteiro","year":"2006","journal-title":"J Biol Chem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/sj.onc.1207393","article-title":"Ubiquitin-like protein activation.","volume":"23","author":"DT Huang","year":"2004","journal-title":"Oncogene"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature01456","article-title":"Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.","volume":"422","author":"H Walden","year":"2003","journal-title":"Nature"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature04104","article-title":"A protein interaction network of the malaria parasite Plasmodium falciparum.","volume":"438","author":"DJ LaCount","year":"2005","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.1998.1998","article-title":"A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain.","volume":"282","author":"K Hofmann","year":"1998","journal-title":"J Mol Biol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"9846","DOI":"10.1074\/jbc.M007737200","article-title":"The C-terminal region of an Apg7p\/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation.","volume":"276","author":"M Komatsu","year":"2001","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/80384","article-title":"Basic Medical Research Award. 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Cell"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.270.29.17442","article-title":"A proteolytic pathway that recognizes ubiquitin as a degradation signal.","volume":"270","author":"ES Johnson","year":"1995","journal-title":"J Biol Chem"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-2443.1997.1020301.x","article-title":"The N-end rule pathway of protein degradation.","volume":"2","author":"A Varshavsky","year":"1997","journal-title":"Genes to Cells"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.bbrc.2006.01.013","article-title":"A synthetic defect in protein degradation caused by loss of Ufd4 and Rad23.","volume":"341","author":"D Ju","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0092-8674(00)80574-7","article-title":"A novel ubiquitination factor, E4, is involved in 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Ye","year":"2006","journal-title":"J Struct Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"D363","DOI":"10.1093\/nar\/gkj123","article-title":"OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups.","volume":"34","author":"F Chen","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1021\/bi051787e","article-title":"The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquitin ligases.","volume":"45","author":"CW Vander Kooi","year":"2006","journal-title":"Biochemistry"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"42370","DOI":"10.1074\/jbc.M105453200","article-title":"A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing.","volume":"276","author":"P Ajuh","year":"2001","journal-title":"J Biol Chem"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1261\/rna.2292106","article-title":"Functional links between the Prp19-associated complex, U4\/U6 biogenesis, and spliceosome recycling.","volume":"12","author":"CH Chen","year":"2006","journal-title":"Rna"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.1086602","article-title":"The Prp19p-associated complex in spliceosome activation.","volume":"302","author":"SP Chan","year":"2003","journal-title":"Science"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.bbrc.2007.01.097","article-title":"The Prp19\/Pso4 core complex undergoes ubiquitylation and structural alterations in response to DNA damage.","volume":"354","author":"X Lu","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0020-7519(02)00087-5","article-title":"Apoptosis in the malaria protozoan, Plasmodium berghei: a possible mechanism for limiting intensity of infection in the mosquito.","volume":"32","author":"EM Al-Olayan","year":"2002","journal-title":"Int J Parasitol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0035-9203(97)90039-0","article-title":"Apoptosis related to chloroquine sensitivity of the human malaria parasite Plasmodium falciparum.","volume":"91","author":"S Picot","year":"1997","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1017\/S0031182006000849","article-title":"Apoptosis-like death as a feature of malaria infection in mosquitoes.","volume":"132","author":"H Hurd","year":"2006","journal-title":"Parasitology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/PL00000838","article-title":"WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.","volume":"58","author":"D Li","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0968-0004(99)01384-5","article-title":"The WD repeat: a common architecture for diverse functions.","volume":"24","author":"TF Smith","year":"1999","journal-title":"Trends Biochem Sci"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S1357-2725(02)00394-1","article-title":"CHIP: a quality-control E3 ligase collaborating with molecular chaperones.","volume":"35","author":"S Murata","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.molcel.2005.09.023","article-title":"Chaperoned ubiquitylation\u2013crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.","volume":"20","author":"M Zhang","year":"2005","journal-title":"Mol Cell"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.semcdb.2005.02.010","article-title":"Regulation of the cell cycle by SCF-type ubiquitin ligases.","volume":"16","author":"KI Nakayama","year":"2005","journal-title":"Semin Cell Dev Biol"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"22828","DOI":"10.1074\/jbc.M210358200","article-title":"A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression.","volume":"278","author":"JJ Michel","year":"2003","journal-title":"J Biol Chem"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/00034989859357","article-title":"The Plasmodium cell-cycle: facts and questions.","volume":"92","author":"DE Arnot","year":"1998","journal-title":"Ann Trop Med Parasitol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-1-4615-4253-7_15","article-title":"The cell cycle in protozoan parasites.","volume":"4","author":"C Doerig","year":"2000","journal-title":"Prog Cell Cycle Res"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1017\/S0031182000075041","article-title":"Microtubular organization visualized by immunofluorescence microscopy during erythrocytic schizogony in Plasmodium falciparum and investigation of post-translational modifications of parasite tubulin.","volume":"106 ( Pt 3)","author":"M Read","year":"1993","journal-title":"Parasitology"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"24","DOI":"10.2307\/3578728","article-title":"Synergistic interactions between RAD5, RAD16 and RAD54, three partially homologous yeast DNA repair genes each in a different repair pathway.","volume":"139","author":"BJ Glassner","year":"1994","journal-title":"Radiat Res"},{"key":"ref95","article-title":"Saccharomyces cerevisiae Rad16 mediates ultraviolet-dependent histone H3 acetylation required for efficient global genome nucleotide-excision repair.","author":"Y Teng","year":"2007","journal-title":"EMBO Rep"},{"key":"ref96","article-title":"CWC24p, a novel Saccharomyces cerevisiae nuclear RING-finger protein, affects pre-snoRNA U3 splicing.","author":"MB Goldfeder","year":"2007","journal-title":"J Biol Chem"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cell.2005.01.036","article-title":"Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium faiciparum.","volume":"121","author":"MT Duraisingh","year":"2005","journal-title":"Cell"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cell.2005.01.037","article-title":"Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.","volume":"121","author":"LH Freitas-Junior","year":"2005","journal-title":"Cell"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1371\/journal.ppat.0030077","article-title":"Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii.","volume":"3","author":"M Gissot","year":"2007","journal-title":"Plos Pathogens"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1073\/pnas.95.11.5857","article-title":"SMART, a simple modular architecture research tool: Identification of signaling domains.","volume":"95","author":"J Schultz","year":"1998","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/cbic.200300781","article-title":"Coiled coil domains: stability, specificity, and biological implications.","volume":"5","author":"JM Mason","year":"2004","journal-title":"Chembiochem"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1046\/j.1365-2958.2002.03083.x","article-title":"Coiled-coil proteins associated with type III secretion systems: a versatile domain revisited.","volume":"45","author":"RM Delahay","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1128\/JB.00459-07","article-title":"Integration of rotation and piston motions in coiled-coil signal transduction.","volume":"189","author":"R Gao","year":"2007","journal-title":"J Bacteriol"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"25631","DOI":"10.1074\/jbc.M703781200","article-title":"Conserved residue Lys574 in the cavity of HIV-1 Gp41 coiled-coil domain is critical for six-helix bundle stability and virus entry.","volume":"282","author":"Y He","year":"2007","journal-title":"J Biol Chem"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/jb\/mvj160","article-title":"A novel family of membrane-bound E3 ubiquitin ligases.","volume":"140","author":"M Ohmura-Hoshino","year":"2006","journal-title":"J Biochem"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S1357-2725(02)00392-8","article-title":"Deubiquitinating enzymes\u2013the importance of driving in reverse along the ubiquitin-proteasome pathway.","volume":"35","author":"SS Wing","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1093\/emboj\/20.18.5187","article-title":"A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.","volume":"20","author":"A Borodovsky","year":"2001","journal-title":"Embo J"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1126\/science.1075898","article-title":"Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.","volume":"298","author":"R Verma","year":"2002","journal-title":"Science"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/ncb983","article-title":"Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation.","volume":"5","author":"K Haglund","year":"2003","journal-title":"Nat Cell Biol"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.cellbio.19.110701.154617","article-title":"Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.","volume":"19","author":"L Hicke","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"37481","DOI":"10.1074\/jbc.M007251200","article-title":"A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V\/I)(D\/N)RXXKP.","volume":"275","author":"M Kato","year":"2000","journal-title":"J Biol Chem"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1091\/mbc.E05-06-0560","article-title":"Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes.","volume":"16","author":"E Mizuno","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"34167","DOI":"10.1074\/jbc.M706505200","article-title":"Ubiquitin-dependent proteolytic control of SUMO conjugates.","volume":"282","author":"K Uzunova","year":"2007","journal-title":"J Biol Chem"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1093\/hmg\/ddg344","article-title":"The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity.","volume":"12","author":"B Burnett","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1093\/hmg\/ddg297","article-title":"Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics.","volume":"12","author":"H Scheel","year":"2003","journal-title":"Hum Mol Genet"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/j.1462-5822.2007.00896.x","article-title":"Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution.","volume":"9","author":"EM Frickel","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/j.1365-2958.2006.05307.x","article-title":"Identification by functional proteomics of a deubiquitinating\/deNeddylating enzyme in Plasmodium falciparum.","volume":"61","author":"K Artavanis-Tsakonas","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"6123","DOI":"10.1128\/MCB.25.14.6123-6139.2005","article-title":"Ubp10\/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin.","volume":"25","author":"RG Gardner","year":"2005","journal-title":"Mol Cell Biol"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.molcel.2005.01.007","article-title":"Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.","volume":"17","author":"NC Emre","year":"2005","journal-title":"Mol Cell"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2958.2007.05753.x","article-title":"Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.","volume":"65","author":"P Hunt","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref121","article-title":"Plasmodium falciparum: Erythrocytic stages die by autophagic-like cell death under drug pressure.","author":"PR Totino","year":"2007","journal-title":"Exp Parasitol"},{"key":"ref122","article-title":"Marine actinomycetes: a new source of compounds against the human malaria parasite.","author":"J Prudhomme","journal-title":"PLoS One"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"D247","DOI":"10.1093\/nar\/gkj149","article-title":"Pfam: clans, web tools and services.","volume":"34","author":"RD Finn","year":"2006","journal-title":"Nucleic Acids Research"},{"key":"ref124","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511790492","article-title":"Biological sequence analysis: probabilistic models of proteins and nucleic acids: Cambridge University Press.","author":"R Durbin","year":"1998"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.","volume":"22","author":"JD Thompson","year":"1994","journal-title":"Nucleic Acids Research"},{"key":"ref126","article-title":"PHYLIP (Phylogeny Inference Package). 3.5c ed: Distributed by the author.","author":"J Felsenstein","year":"1993"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0.","volume":"24","author":"K Tamura","year":"2007","journal-title":"Molecular Biology and Evolution"}],"container-title":["PLoS 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