{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:34:35Z","timestamp":1778816075585,"version":"3.51.4"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2008,10,22]],"date-time":"2008-10-22T00:00:00Z","timestamp":1224633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0003474","type":"journal-article","created":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T20:01:45Z","timestamp":1224619305000},"page":"e3474","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":184,"title":["Transcriptional and Functional Profiling of Human Embryonic Stem Cell-Derived Cardiomyocytes"],"prefix":"10.1371","volume":"3","author":[{"given":"Feng","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitchener D.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Dong","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha","family":"Drukker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald A.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjiv S.","family":"Gambhir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irving L.","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2008,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev.med.46.1.455","article-title":"Left ventricular remodeling after acute myocardial infarction.","volume":"46","author":"MA Pfeffer","year":"1995","journal-title":"Annu Rev Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts.","volume":"282","author":"JA Thomson","year":"1998","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/74447","article-title":"Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro.","volume":"18","author":"BE Reubinoff","year":"2000","journal-title":"Nat Biotech"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI200112131","article-title":"Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.","volume":"108","author":"I Kehat","year":"2001","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/01.RES.0000035254.80718.91","article-title":"Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells.","volume":"91","author":"C Xu","year":"2002","journal-title":"Circ Res"},{"key":"ref6","first-page":"12","article-title":"Human embryonic stem cell transplantation to repair the infarcted myocardium.","volume":"12","author":"J Leor","year":"2007","journal-title":"Heart"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response.","volume":"98","author":"VG Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0092-8674(03)00392-1","article-title":"Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.","volume":"113","author":"I Chambers","year":"2003","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.cr.7310125","article-title":"Nanog and transcriptional networks in embryonic stem cell pluripotency.","volume":"17","author":"G Pan","year":"2007","journal-title":"Cell Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4161\/epi.2.1.4067","article-title":"Transcription factor networks in embryonic stem cells and testicular cancer and the definition of epigenetics.","volume":"2","author":"WA Schulz","year":"2007","journal-title":"Epigenetics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"33497","DOI":"10.1074\/jbc.M606975200","article-title":"Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3.","volume":"281","author":"M Hentschke","year":"2006","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1124\/mol.104.010231","article-title":"SRC family kinase activity is required for murine embryonic stem cell growth and differentiation.","volume":"68","author":"MA Meyn 3rd","year":"2005","journal-title":"Mol Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"33034","DOI":"10.1074\/jbc.M703245200","article-title":"Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage.","volume":"282","author":"H Masaki","year":"2007","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1006\/geno.1993.1505","article-title":"Hesx1, a homeobox gene expressed by murine embryonic stem cells, maps to mouse chromosome 14, bands A3-B.","volume":"18","author":"GC Webb","year":"1993","journal-title":"Genomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/01.RES.0000027530.58419.82","article-title":"Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade.","volume":"91","author":"DE Michele","year":"2002","journal-title":"Circ Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1093\/hmg\/ddl423","article-title":"Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes.","volume":"15","author":"JM Holaska","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/dbio.1997.8621","article-title":"Evidence for serum response factor-mediated regulatory networks governing SM22alpha transcription in smooth, skeletal, and cardiac muscle cells.","volume":"187","author":"L Li","year":"1997","journal-title":"Dev Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1046\/j.1469-7580.2003.00228.x","article-title":"Postnatal changes in caldesmon expression and localization in cardiac myocytes.","volume":"203","author":"GA McMartin","year":"2003","journal-title":"J Anat"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1432-1033.1991.tb15951.x","article-title":"The complete primary structure of the human alpha 1 (VIII) chain and assignment of its gene (COL8A1) to chromosome 3.","volume":"197","author":"Y Muragaki","year":"1991","journal-title":"Eur J Biochem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1056\/NEJMoa071906","article-title":"COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps.","volume":"357","author":"E Plaisier","year":"2007","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/ana.21213","article-title":"Molecular consequences of dominant Bethlem myopathy collagen VI mutations.","volume":"62","author":"NL Baker","year":"2007","journal-title":"Ann Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ydbio.2007.02.002","article-title":"Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development.","volume":"305","author":"J Lincoln","year":"2007","journal-title":"Dev Biol"},{"key":"ref23","article-title":"Features of cardiomyocyte proliferation and its potential for cardiac regeneration.","author":"MJ van Amerongen","year":"2008","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/01.CIR.0000068356.38592.68","article-title":"Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells.","volume":"107","author":"C Mummery","year":"2003","journal-title":"Circulation"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/01.RES.0000080317.92718.99","article-title":"Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization.","volume":"93","author":"J-Q He","year":"2003","journal-title":"Circulation Research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/01.RES.0000039084.30342.9B","article-title":"High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction.","volume":"91","author":"I Kehat","year":"2002","journal-title":"Circulation Research"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature03649","article-title":"The initiation of liver development is dependent on Foxa transcription factors.","volume":"435","author":"CS Lee","year":"2005","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1161\/CIRCRESAHA.108.175505","article-title":"Human embryonic stem cell-derived cardiomyocytes and cardiac repair in rodents.","volume":"102","author":"LW van Laake","year":"2008","journal-title":"Circulation Research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature06894","article-title":"Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.","volume":"453","author":"L Yang","year":"2008","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nm0405-367","article-title":"Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.","volume":"11","author":"M Gnecchi","year":"2005","journal-title":"Nature Medicine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1096\/fj.05-5211com","article-title":"Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement.","volume":"20","author":"M Gnecchi","year":"2006","journal-title":"The FASEB Journal"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1073\/pnas.0610024104","article-title":"Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.","volume":"104","author":"M Mirotsou","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1634\/stemcells.2007-1033","article-title":"Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells.","volume":"26","author":"J Synnergren","year":"2008","journal-title":"Stem Cells"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1634\/stemcells.2006-0054","article-title":"Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes.","volume":"24","author":"A Beqqali","year":"2006","journal-title":"Stem Cells"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ydbio.2005.09.036","article-title":"Genome-wide expression dynamics during mouse embryonic development reveal similarities to Drosophila development.","volume":"288","author":"RA Wagner","year":"2005","journal-title":"Dev Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/jcp.21030","article-title":"Transcriptional activation by stimulating protein 1 and post-transcriptional repression by muscle-specific microRNAs of IKs-encoding genes and potential implications in regional heterogeneity of their expressions.","volume":"212","author":"X Luo","year":"2007","journal-title":"J Cell Physiol"},{"key":"ref37","first-page":"912","article-title":"Gene symbol: KCNQ1.","volume":"120","author":"L Crotti","year":"2007","journal-title":"Hum Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1161\/CIRCULATIONAHA.107.710780","article-title":"Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study.","volume":"116","author":"C Newton-Cheh","year":"2007","journal-title":"Circulation"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/hrt.2006.093161","article-title":"Human embryonic stem cell transplantation to repair the infarcted myocardium.","volume":"93","author":"J Leor","year":"2007","journal-title":"Heart"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0969-8051(99)00021-9","article-title":"Assays for noninvasive imaging of reporter gene expression.","volume":"26","author":"SS Gambhir","year":"1999","journal-title":"Nuclear Medicine and Biology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/nbt1327","article-title":"Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts.","volume":"25","author":"MA Laflamme","year":"2007","journal-title":"Nat Biotech"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/01.RES.0000196562.73231.7d","article-title":"Engineering myocardial tissue.","volume":"97","author":"T Eschenhagen","year":"2005","journal-title":"Circulation Research"},{"key":"ref43","first-page":"I150","article-title":"Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials.","volume":"112","author":"D Hou","year":"2005","journal-title":"Circulation"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.1128\/JVI.72.10.8150-8157.1998","article-title":"Development of a self-inactivating lentivirus vector.","volume":"72","author":"H Miyoshi","year":"1998","journal-title":"J Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nature02460","article-title":"Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium.","volume":"428","author":"LB Balsam","year":"2004","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1152\/physiolgenomics.00005.2003","article-title":"Use of echocardiography for the phenotypic assessment of genetically altered mice.","volume":"13","author":"KA Collins","year":"2003","journal-title":"Physiol Genomics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0003474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:26:56Z","timestamp":1589030816000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0003474"}},"subtitle":[],"editor":[{"given":"Marie","family":"Csete","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2008,10,22]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2008,10,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0003474","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,22]]}}}