{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:30:12Z","timestamp":1773297012614,"version":"3.50.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T00:00:00Z","timestamp":1292803200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0015605","type":"journal-article","created":{"date-parts":[[2010,12,20]],"date-time":"2010-12-20T21:10:17Z","timestamp":1292879417000},"page":"e15605","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Non-Invasive In Vivo Imaging of Tumor-Associated CD133\/Prominin"],"prefix":"10.1371","volume":"5","author":[{"given":"Chizuko","family":"Tsurumi","sequence":"first","affiliation":[]},{"given":"Norbert","family":"Esser","sequence":"additional","affiliation":[]},{"given":"Elke","family":"Firat","sequence":"additional","affiliation":[]},{"given":"Simone","family":"Gaedicke","sequence":"additional","affiliation":[]},{"given":"Marie","family":"Follo","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Behe","sequence":"additional","affiliation":[]},{"given":"Ursula","family":"Els\u00e4sser-Beile","sequence":"additional","affiliation":[]},{"given":"Anca-Ligia","family":"Grosu","sequence":"additional","affiliation":[]},{"given":"Ralph","family":"Graeser","sequence":"additional","affiliation":[]},{"given":"Gabriele","family":"Niedermann","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2010,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrd2137","article-title":"Tumour-initiating cells: challenges and opportunities for anticancer drug discovery.","volume":"8","author":"BB Zhou","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.semradonc.2008.11.001","article-title":"Cancer stem cells in solid tumors: an overview.","volume":"19","author":"CA O'Brien","year":"2009","journal-title":"Semin Radiat Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1126\/science.1171837","article-title":"The increasing complexity of the cancer stem cell paradigm.","volume":"324","author":"JM Rosen","year":"2009","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2007.06.002","article-title":"Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.","volume":"1","author":"PC Hermann","year":"2007","journal-title":"Cell Stem Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.molonc.2010.06.002","article-title":"Pancreatic cancer stem cells - update and future perspectives.","volume":"4","author":"E Lonardo","year":"2010","journal-title":"Mol Oncol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/stem.318","article-title":"Radiation resistance of cancer stem cells: the 4 R's of radiobiology revisited.","volume":"28","author":"F Pajonk","year":"2010","journal-title":"Stem Cells"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.semradonc.2008.11.003","article-title":"Radiosensitivity of cancer-initiating cells and normal stem cells (or what the Heisenberg uncertainly principle has to do with biology).","volume":"19","author":"WA Woodward","year":"2009","journal-title":"Semin Radiat Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10555-008-9130-2","article-title":"Cancer stem cells: markers or biomarkers?","volume":"27","author":"WA Woodward","year":"2008","journal-title":"Cancer Metastasis Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1073\/pnas.94.23.12425","article-title":"Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells.","volume":"94","author":"A Weigmann","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1182\/blood.V90.12.5002","article-title":"AC133, a novel marker for human hematopoietic stem and progenitor cells.","volume":"90","author":"AH Yin","year":"1997","journal-title":"Blood"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1158\/0008-5472.CAN-09-1820","article-title":"The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation.","volume":"70","author":"K Kemper","year":"2010","journal-title":"Cancer Res"},{"key":"ref12","first-page":"5821","article-title":"Identification of a cancer stem cell in human brain tumors.","volume":"63","author":"SK Singh","year":"2003","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1517\/14728220903005616","article-title":"Targeting CD133 antigen in cancer.","volume":"13","author":"G Ferrandina","year":"2009","journal-title":"Expert Opin Ther Targets"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1158\/1078-0432.CCR-07-0932","article-title":"Stem cell marker CD133 affects clinical outcome in glioma patients.","volume":"14","author":"F Zeppernick","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e2090","DOI":"10.1371\/journal.pone.0002090","article-title":"Identification of CD133-positive radioresistant cells in atypical teratoid\/rhabdoid tumor.","volume":"3","author":"SH Chiou","year":"2008","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.","volume":"444","author":"S Bao","year":"2006","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1200\/JCO.2008.16.9573","article-title":"Invincible, but not invisible: imaging approaches toward in vivo detection of cancer stem cells.","volume":"26","author":"LS Hart","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1586\/14737159.8.4.387","article-title":"Targeting cancer stem cells with monoclonal antibodies: a new perspective in cancer therapy and diagnosis.","volume":"8","author":"OK Okamoto","year":"2008","journal-title":"Expert Rev Mol Diagn"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/sj.bjc.6604437","article-title":"CD133\/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers.","volume":"99","author":"LM Smith","year":"2008","journal-title":"Br J Cancer"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature06489","article-title":"Identification of cells initiating human melanomas.","volume":"451","author":"T Schatton","year":"2008","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4161\/mabs.1.1.7347","article-title":"Antibodies targeting cancer stem cells: a new paradigm in immunotherapy?","volume":"1","author":"MP Deonarain","year":"2009","journal-title":"MAbs"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/jnci\/djn509","article-title":"In vivo imaging, tracking, and targeting of cancer stem cells.","volume":"101","author":"E Vlashi","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nbt1074","article-title":"Looking and listening to light: the evolution of whole-body photonic imaging.","volume":"23","author":"V Ntziachristos","year":"2005","journal-title":"Nat Biotechnol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1158\/0008-5472.CAN-05-0382","article-title":"Tomographic fluorescence mapping of tumor targets.","volume":"65","author":"X Montet","year":"2005","journal-title":"Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.282.5393.1497","article-title":"Requirement for p53 and p21 to sustain G2 arrest after DNA damage.","volume":"282","author":"F Bunz","year":"1998","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.bbrc.2009.06.068","article-title":"Viability and DNA damage responses of TPPII-deficient Myc- and Ras-transformed fibroblasts.","volume":"386","author":"C Tsurumi","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1158\/0008-5472.CAN-08-3116","article-title":"In vivo molecular imaging of cancer with a quenching near-infrared fluorescent probe using conjugates of monoclonal antibodies and indocyanine green.","volume":"69","author":"M Ogawa","year":"2009","journal-title":"Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1053\/j.gastro.2008.02.057","article-title":"Knockdown of RNA binding protein musashi-1 leads to tumor regression in vivo.","volume":"134","author":"SM Sureban","year":"2008","journal-title":"Gastroenterology"},{"key":"ref29","article-title":"Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT).","author":"S Kossodo","year":"2009","journal-title":"Mol Imaging Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/nbt1141","article-title":"Arming antibodies: prospects and challenges for immunoconjugates.","volume":"23","author":"AM Wu","year":"2005","journal-title":"Nat Biotechnol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1189\/jlb.1107762","article-title":"Macrophages define the invasive microenvironment in breast cancer.","volume":"84","author":"JW Pollard","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/pros.21176","article-title":"High-resolution animal PET imaging of prostate cancer xenografts with three different 64Cu-labeled antibodies against native cell-adherent PSMA.","volume":"70","author":"K Alt","year":"2010","journal-title":"Prostate"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1053\/j.semnuclmed.2009.12.005","article-title":"Antibody vectors for imaging.","volume":"40","author":"T Olafsen","year":"2010","journal-title":"Semin Nucl Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ejca.2007.01.017","article-title":"Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential.","volume":"43","author":"E Monzani","year":"2007","journal-title":"Eur J Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ccr.2009.12.049","article-title":"A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.","volume":"17","author":"R Chen","year":"2010","journal-title":"Cancer Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/09553000903419320","article-title":"Molecular radiobiology meets clinical radiation oncology.","volume":"86","author":"E Firat","year":"2010","journal-title":"Int J Radiat Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2283","article-title":"CD133: molecule of the moment.","volume":"214","author":"D Mizrak","year":"2008","journal-title":"J Pathol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1158\/0008-5472.CAN-07-0183","article-title":"CD133 is not present on neurogenic astrocytes in the adult subventricular zone, but on embryonic neural stem cells, ependymal cells, and glioblastoma cells.","volume":"67","author":"CV Pfenninger","year":"2007","journal-title":"Cancer Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/sj.bjc.6605610","article-title":"Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery.","volume":"102","author":"DD Fang","year":"2010","journal-title":"Br J Cancer"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1089\/scd.2008.0338","article-title":"CD133 as a marker for cancer stem cells: progresses and concerns.","volume":"18","author":"Y Wu","year":"2009","journal-title":"Stem Cells Dev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0015605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T21:41:38Z","timestamp":1592170898000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0015605"}},"subtitle":[],"editor":[{"given":"Xin Wei","family":"Wang","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2010,12,20]]},"references-count":40,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2010,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0015605","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,20]]}}}