{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:53:59Z","timestamp":1775008439149,"version":"3.50.1"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0025623","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T05:40:24Z","timestamp":1317188424000},"page":"e25623","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":55,"title":["The Transcription Factor Ndt80 Does Not Contribute to Mrr1-, Tac1-, and Upc2-Mediated Fluconazole Resistance in Candida albicans"],"prefix":"10.1371","volume":"6","author":[{"given":"Christoph","family":"Sasse","sequence":"first","affiliation":[]},{"given":"Rebecca","family":"Schillig","sequence":"additional","affiliation":[]},{"given":"Franziska","family":"Dierolf","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Weyler","sequence":"additional","affiliation":[]},{"given":"Sabrina","family":"Schneider","sequence":"additional","affiliation":[]},{"given":"Selene","family":"Mogavero","sequence":"additional","affiliation":[]},{"given":"P. David","family":"Rogers","sequence":"additional","affiliation":[]},{"given":"Joachim","family":"Morschh\u00e4user","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2011,9,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0925-4439(02)00087-X","article-title":"The genetic basis of fluconazole resistance development in <italic>Candida albicans<\/italic>.","volume":"1587","author":"J Morschh\u00e4user","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1128\/AAC.49.5.1745-1752.2005","article-title":"<italic>Candida albicans<\/italic> zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes.","volume":"49","author":"S MacPherson","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1128\/EC.3.6.1391-1397.2004","article-title":"Role of <italic>Candida albicans<\/italic> transcription factor Upc2p in drug resistance and sterol metabolism.","volume":"3","author":"PM Silver","year":"2004","journal-title":"Eukaryot Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/EC.3.6.1639-1652.2004","article-title":"<italic>TAC1<\/italic>, transcriptional activator of <italic>CDR<\/italic> genes, is a new transcription factor involved in the regulation of <italic>Candida albicans<\/italic> ABC transporters <italic>CDR1<\/italic> and <italic>CDR2<\/italic>.","volume":"3","author":"AT Coste","year":"2004","journal-title":"Eukaryot Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1371\/journal.ppat.0030164","article-title":"The transcription factor Mrr1p controls expression of the <italic>MDR1<\/italic> efflux pump and mediates multidrug resistance in <italic>Candida albicans<\/italic>.","volume":"3","author":"J Morschh\u00e4user","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1128\/EC.00151-07","article-title":"Genotypic evolution of azole resistance mechanisms in sequential <italic>Candida albicans<\/italic> isolates.","volume":"6","author":"A Coste","year":"2007","journal-title":"Eukaryot Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1534\/genetics.105.054767","article-title":"A mutation in Tac1p, a transcription factor regulating <italic>CDR1<\/italic> and <italic>CDR2<\/italic>, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in <italic>Candida albicans<\/italic>.","volume":"172","author":"A Coste","year":"2006","journal-title":"Genetics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1128\/EC.00069-09","article-title":"Functional analysis of cis- and trans-acting elements of the <italic>Candida albicans CDR2<\/italic> promoter with a novel promoter reporter system.","volume":"8","author":"AT Coste","year":"2009","journal-title":"Eukaryot Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1365-2958.2008.06309.x","article-title":"Mutations in the multi-drug resistance regulator <italic>MRR1<\/italic>, followed by loss of heterozygosity, are the main cause of <italic>MDR1<\/italic> overexpression in fluconazole-resistant <italic>Candida albicans<\/italic> strains.","volume":"69","author":"N Dunkel","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1128\/EC.00103-08","article-title":"A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical <italic>Candida albicans<\/italic> isolate.","volume":"7","author":"N Dunkel","year":"2008","journal-title":"Eukaryot Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/AAC.01102-09","article-title":"An A643T mutation in the transcription factor Upc2p causes constitutive <italic>ERG11<\/italic> upregulation and increased fluconazole resistance in <italic>Candida albicans<\/italic>.","volume":"54","author":"CJ Heilmann","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1128\/AAC.00995-10","article-title":"An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of <italic>Candida albicans<\/italic>.","volume":"55","author":"SJ Hoot","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1128\/AAC.00740-08","article-title":"Gain-of-function mutations in the transcription factor <italic>MRR1<\/italic> are responsible for overexpression of the <italic>MDR1<\/italic> efflux pump in fluconazole-resistant <italic>Candida dubliniensis<\/italic> strains.","volume":"52","author":"S Schubert","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2958.2007.05931.x","article-title":"The zinc cluster transcription factor Tac1p regulates <italic>PDR16<\/italic> expression in <italic>Candida albicans<\/italic>.","volume":"66","author":"S Znaidi","year":"2007","journal-title":"Mol Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1128\/EC.00325-09","article-title":"Role of transcription factor CaNdt80p in cell separation, hyphal growth, and virulence in <italic>Candida albicans<\/italic>.","volume":"9","author":"A Sellam","year":"2010","journal-title":"Eukaryot Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1128\/EC.00074-09","article-title":"Role of Ndt80p in sterol metabolism regulation and azole resistance in <italic>Candida albicans<\/italic>.","volume":"8","author":"A Sellam","year":"2009","journal-title":"Eukaryot Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1128\/AAC.48.12.4505-4512.2004","article-title":"CaNdt80 is involved in drug resistance in <italic>Candida albicans<\/italic> by regulating <italic>CDR1<\/italic>.","volume":"48","author":"CG Chen","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2199-7-22","article-title":"Serum repressing efflux pump <italic>CDR1<\/italic> in <italic>Candida albicans<\/italic>.","volume":"7","author":"YL Yang","year":"2006","journal-title":"BMC Mol Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1128\/AAC.45.6.1660-1670.2001","article-title":"Genomic profiling of the response of <italic>Candida albicans<\/italic> to itraconazole treatment using a DNA microarray.","volume":"45","author":"MD De Backer","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s002940050385","article-title":"Identification of polymorphic mutant alleles of <italic>CaMDR1<\/italic>, a major facilitator of <italic>Candida albicans<\/italic> which confers multidrug resistance, and its in vitro transcriptional activation.","volume":"34","author":"V Gupta","year":"1998","journal-title":"Curr Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1128\/AAC.48.8.3064-3079.2004","article-title":"Comparison of gene expression profiles of <italic>Candida albicans<\/italic> azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters.","volume":"48","author":"M Karababa","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1128\/AAC.01343-10","article-title":"Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.","volume":"55","author":"S Schubert","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1046\/j.1365-2958.2002.02814.x","article-title":"A common drug-responsive element mediates the upregulation of the <italic>Candida albicans<\/italic> ABC transporters <italic>CDR1<\/italic> and <italic>CDR2<\/italic>, two genes involved in antifungal drug resistance.","volume":"43","author":"M de Micheli","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1099\/mic.0.29277-0","article-title":"Identification of promoter elements responsible for the regulation of <italic>MDR1<\/italic> from <italic>Candida albicans<\/italic>, a major facilitator transporter involved in azole resistance.","volume":"152","author":"B Rognon","year":"2006","journal-title":"Microbiology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1128\/AAC.00463-08","article-title":"ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant <italic>Candida albicans<\/italic> clinical isolates.","volume":"52","author":"AR Holmes","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1128\/AAC.00926-08","article-title":"Relative contributions of the <italic>Candida albicans<\/italic> ABC transporters Cdr1p and Cdr2p to clinical azole resistance.","volume":"53","author":"S Tsao","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1128\/EC.00070-08","article-title":"Genomewide location analysis of <italic>Candida albicans<\/italic> Upc2p, a regulator of sterol metabolism and azole drug resistance.","volume":"7","author":"S Znaidi","year":"2008","journal-title":"Eukaryot Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1128\/EC.00327-07","article-title":"Genome-wide expression and location analyses of the <italic>Candida albicans<\/italic> Tac1p regulon.","volume":"6","author":"TT Liu","year":"2007","journal-title":"Eukaryot Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1128\/CMR.00051-08","article-title":"Efflux-mediated antifungal drug resistance.","volume":"22","author":"RD Cannon","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/452541a","article-title":"Drug resistance: the fight against fungi.","volume":"452","author":"A Goffeau","year":"2008","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.gene.2004.06.021","article-title":"The <italic>SAT1<\/italic> flipper, an optimized tool for gene disruption in <italic>Candida albicans<\/italic>.","volume":"341","author":"O Reu\u00df","year":"2004","journal-title":"Gene"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1128\/IAI.70.2.921-927.2002","article-title":"Transcriptional regulators Cph1p and Efg1p mediate activation of the <italic>Candida albicans<\/italic> virulence gene <italic>SAP5<\/italic> during infection.","volume":"70","author":"P Staib","year":"2002","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1000089","DOI":"10.1371\/journal.ppat.1000089","article-title":"Environmental induction of white-opaque switching in <italic>Candida albicans<\/italic>.","volume":"4","author":"B Ram\u00edrez-Zavala","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s004380050665","article-title":"Expression of a chromosomally integrated, single-copy <italic>GFP<\/italic> gene in <italic>Candida albicans<\/italic>, and its use as a reporter of gene regulation.","volume":"257","author":"J Morschh\u00e4user","year":"1998","journal-title":"Mol Gen Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1128\/jb.179.7.2331-2338.1997","article-title":"Overexpression of a cloned IMP dehydrogenase gene of <italic>Candida albicans<\/italic> confers resistance to the specific inhibitor mycophenolic acid.","volume":"179","author":"GA K\u00f6hler","year":"1997","journal-title":"J Bacteriol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1128\/JCM.32.9.2092-2098.1994","article-title":"Emergence of fluconazole-resistant strains of <italic>Candida albicans<\/italic> in patients with recurrent oropharyngeal candidosis and human immunodeficiency virus infection.","volume":"32","author":"M Ruhnke","year":"1994","journal-title":"J Clin Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0025623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T04:24:12Z","timestamp":1593059052000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0025623"}},"subtitle":[],"editor":[{"given":"Julian","family":"Rutherford","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2011,9,27]]},"references-count":36,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,9,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0025623","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,27]]}}}