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Effect of specimen anticoagulation on the measurement of circulating platelet-derived growth factors. Clin Chem. 2005 Dec;51(12): 2365\u20138.","volume":"51","author":"R Zimmermann","year":"2005","journal-title":"Clinical Chemistry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/bjc.1998.158","article-title":"Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology.","volume":"77","author":"RE Banks","year":"1998","journal-title":"British Journal of Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jim.2009.04.010","article-title":"EDTA plasma is unsuitable for in vivo determinations of platelet-derived angiogenic cytokines.","volume":"347","author":"R Zimmermann","year":"2009","journal-title":"Journal of Immunological Methods"},{"key":"ref29","first-page":"177","article-title":"Blair P, Flaumenhaft R. 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