{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:34:14Z","timestamp":1771461254567,"version":"3.50.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T00:00:00Z","timestamp":1410220800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0105046","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T17:49:43Z","timestamp":1410284983000},"page":"e105046","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":81,"title":["Mucosa-Associated Bacterial Diversity in Necrotizing Enterocolitis"],"prefix":"10.1371","volume":"9","author":[{"given":"Rachel","family":"Brower-Sinning","sequence":"first","affiliation":[]},{"given":"Diana","family":"Zhong","sequence":"additional","affiliation":[]},{"given":"Misty","family":"Good","sequence":"additional","affiliation":[]},{"given":"Brian","family":"Firek","sequence":"additional","affiliation":[]},{"given":"Robyn","family":"Baker","sequence":"additional","affiliation":[]},{"given":"Chhinder P.","family":"Sodhi","sequence":"additional","affiliation":[]},{"given":"David J.","family":"Hackam","sequence":"additional","affiliation":[]},{"given":"Michael J.","family":"Morowitz","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Necrotizing enterocolitis","volume":"364","author":"J Neu","year":"2011","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1542\/peds.2009-3149","article-title":"Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis","volume":"125","author":"MJ Morowitz","year":"2010","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/MPG.0b013e318227e518","article-title":"Pyrosequencing-based molecular monitoring of the intestinal bacterial colonization in preterm infants","volume":"53","author":"JY Chang","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1651-2227.2012.02801.x","article-title":"The preterm gut microbiota: changes associated with necrotizing enterocolitis and infection","volume":"101","author":"CJ Stewart","year":"2012","journal-title":"Acta Paediatr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jpeds.2010.09.007","article-title":"Dynamics and Clinical Evolution of Bacterial Gut Microflora in Extremely Premature Patients","volume":"158","author":"A Jacquot","year":"2011","journal-title":"J Pediatr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e20647","DOI":"10.1371\/journal.pone.0020647","article-title":"Fecal Microbiota in Premature Infants Prior to Necrotizing Enterocolitis","volume":"6","author":"V Mai","year":"2011","journal-title":"PLoS ONE"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/ismej.2009.37","article-title":"16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis","volume":"3","author":"Y Wang","year":"2009","journal-title":"ISME J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1203\/01.PDR.0000134251.45878.D5","article-title":"Early Intestinal Bacterial Colonization and Necrotizing Enterocolitis in Premature Infants: The Putative Role of Clostridium","volume":"56","author":"MF de la Cochetiere","year":"2004","journal-title":"Pediatr Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/apa.12059","article-title":"Intestinal microbial profiles in extremely preterm infants with and without necrotizing enterocolitis","volume":"102","author":"E Normann","year":"2012","journal-title":"Acta Paediatr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"F298","DOI":"10.1136\/archdischild-2012-302119","article-title":"Bacterial and fungal viability in the preterm gut: NEC and sepsis","volume":"98","author":"CJ Stewart","year":"2013","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/INF.0b013e318242534a","article-title":"Absence of Gastrointestinal Pathogens in Ileum Tissue Resected for Necrotizing Enterocolitis","volume":"31","author":"T Ullrich","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2180-11-73","article-title":"Community analysis of bacteria colonizing intestinal tissue of neonates with necrotizing enterocolitis","volume":"11","author":"B Smith","year":"2011","journal-title":"BMC Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"JG Caporaso","year":"2010","journal-title":"Nat Meth"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1093\/bioinformatics\/btr381","article-title":"UCHIME improves sensitivity and speed of chimera detection","volume":"27","author":"RC Edgar","year":"2011","journal-title":"Bioinformatics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"RC Edgar","year":"2010","journal-title":"Bioinformatics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Na\u00efve Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy","volume":"73","author":"Q Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1093\/cid\/cis580","article-title":"Intestinal Domination and the Risk of Bacteremia in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation","volume":"55","author":"Y Taur","year":"2012","journal-title":"Clin Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1172\/JCI43918","article-title":"Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans","volume":"120","author":"C Ubeda","year":"2010","journal-title":"J Clin Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"M Arumugam","year":"2011","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00431-007-0614-9","article-title":"Necrotizing enterocolitis of the neonate with Clostridium perfringens: diagnosis, clinical course, and role of alpha toxin","volume":"167","author":"E Dittmar","year":"2007","journal-title":"Eur J Pediatr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"T Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jpedsurg.2011.03.026","article-title":"Bacterial DNA content in the intestinal wall from infants with necrotizing enterocolitis","volume":"46","author":"BT Bucher","year":"2011","journal-title":"J Ped Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"CA Lozupone","year":"2012","journal-title":"Nature"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1073\/pnas.0904847106","article-title":"Human gut microbiome adopts an alternative state following small bowel transplantation","volume":"106(40)","author":"AL Hartman","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.chom.2010.08.004","article-title":"Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis","volume":"8","author":"WS Garrett","year":"2010","journal-title":"Cell Host Microbe"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.1232467","article-title":"Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut","volume":"339","author":"SE Winter","year":"2013","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e30594","DOI":"10.1371\/journal.pone.0030594","article-title":"Clostridia in Premature Neonates' Gut: Incidence, Antibiotic Susceptibility, and Perinatal Determinants Influencing Colonization","volume":"7","author":"L Ferraris","year":"2012","journal-title":"PLoS ONE"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/00005176-198508000-00017","article-title":"Enteric colonization in sporadic neonatal necrotizing enterocolitis","volume":"4","author":"JL Blakey","year":"1985","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1198469","article-title":"Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species","volume":"6015","author":"K Atarashi","year":"2011","journal-title":"Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpeds.2009.06.063","article-title":"Intestinal Microbial Ecology in Premature Infants Assessed with Non\u2013Culture-Based Techniques","volume":"156","author":"M Mshvildadze","year":"2010","journal-title":"J Pediatr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1073\/pnas.1000081107","article-title":"Succession of microbial consortia in the developing infant gut microbiome","volume":"108","author":"JE Koenig","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1371\/journal.pbio.0060280","article-title":"The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing","volume":"6","author":"L Dethlefsen","year":"2008","journal-title":"PLoS Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.chom.2012.10.012","article-title":"Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications","volume":"12","author":"F B\u00e4ckhed","year":"2012","journal-title":"Cell Host Microbe"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0105046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T17:39:28Z","timestamp":1650130768000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0105046"}},"subtitle":[],"editor":[{"given":"Bas E.","family":"Dutilh","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,9,9]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0105046","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,9]]}}}