{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:30:16Z","timestamp":1759530616410},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0107167","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T17:51:53Z","timestamp":1411408313000},"page":"e107167","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["The Effects of Age and Cytomegalovirus on Markers of Inflammation and Lymphocyte Populations in Captive Baboons"],"prefix":"10.1371","volume":"9","author":[{"given":"Erin L.","family":"Willis","sequence":"first","affiliation":[]},{"given":"Richard","family":"Eberle","sequence":"additional","affiliation":[]},{"given":"Roman F.","family":"Wolf","sequence":"additional","affiliation":[]},{"given":"Gary L.","family":"White","sequence":"additional","affiliation":[]},{"given":"Dianne","family":"McFarlane","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/path.2104","article-title":"Immunosenescence of ageing","volume":"211","author":"AL Gruver","year":"2007","journal-title":"J Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.jcpa.2009.09.005","article-title":"Senescence of the human immune system","volume":"142","author":"G Pawelec","year":"2010","journal-title":"J Comp Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1016\/j.jprot.2011.06.005","article-title":"Oxidative stress, inflamm-aging and immunosenescence","volume":"74","author":"ES Cannizzo","year":"2011","journal-title":"J Proteomics"},{"key":"ref4","first-page":"119","article-title":"Interim adjusted estimates of seasonal influenza vaccine effectiveness - United States, February 2013","volume":"62","year":"2013","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1086\/520200","article-title":"Reduction in functional antibody activity against Streptococcus pneumoniae in vaccinated elderly individuals highly correlates with decreased IgG antibody avidity","volume":"29","author":"S Romero-Steiner","year":"1999","journal-title":"Clin Infect Dis"},{"key":"ref6","unstructured":"Alberts B, Johnson A, Lewis J, Raff M, Roberts K, <etal>et al<\/etal>.. (2002) Lymphocytes and the Cellular Basis of Adaptive Immunity. Molecular Biology of the Cell. New York: Garland Science."},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Broere F, Apasov SG, Sitkovsky MV, Eden Wv (2011) T cell subsets and T cell-mediated immunity. In: F. PNijkamp, M. JParnham, editors. Principles of Immunopharmacology: 3rd revised and extended edition. Springer Basel AG. pp. 15\u201327.","DOI":"10.1007\/978-3-0346-0136-8_2"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.immunol.14.1.233","article-title":"CD28\/B7 system of T cell costimulation","volume":"14","author":"DJ Lenschow","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"ref9","unstructured":"Janeway CA Jr, Travers P, Walport M, Shlomchik MJ (2001) T cell-mediated cytotoxicity. Immunobiology: The Immune System in Health and Disease. New York: Garland Science."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"925135","DOI":"10.1155\/2012\/925135","article-title":"CD4(+)T cells: differentiation and functions","volume":"2012","author":"RV Luckheeram","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1128\/JVI.79.6.3675-3683.2005","article-title":"Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons","volume":"79","author":"G Almanzar","year":"2005","journal-title":"J Virol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1126\/science.1207120","article-title":"Life at the top: rank and stress in wild male baboons","volume":"333","author":"LR Gesquiere","year":"2011","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1073\/pnas.1202734109","article-title":"Social environment is associated with gene regulatory variation in the rhesus macaque immune system","volume":"109","author":"J Tung","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-4933-7-4","article-title":"The effect of ageing on human lymphocyte subsets: comparison of males and females","volume":"7","author":"J Yan","year":"2010","journal-title":"Immun Ageing"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/gerona\/glr146","article-title":"Age-associated alteration in innate immune response in captive baboons","volume":"66","author":"D McFarlane","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref16","first-page":"21","article-title":"Age- and gender-associated changes in the concentrations of serum TGF-1beta, DHEA-S and IGF-1 in healthy captive baboons (Papio hamadryas anubis)","volume":"195C","author":"EL Willis","year":"2013","journal-title":"Gen Comp Endocrinol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1128\/CDLI.10.5.870-875.2003","article-title":"Lymphocyte modulation in a baboon model of immunosenescence","volume":"10","author":"L Jayashankar","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1089\/1044549041562294","article-title":"Passage-dependent changes in baboon endothelial cells\u2013relevance to in vitro aging","volume":"23","author":"Q Shi","year":"2004","journal-title":"DNA Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4049\/jimmunol.181.1.109","article-title":"An age-old paradigm challenged: old baboons generate vigorous humoral immune responses to LcrV, a plague antigen","volume":"181","author":"S Stacy","year":"2008","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9591","DOI":"10.1073\/pnas.142675599","article-title":"The aging baboon: comparative demography in a non-human primate","volume":"99","author":"AM Bronikowski","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s007050170059","article-title":"Isolation and characterization of an endogenous cytomegalovirus (BaCMV) from baboons","volume":"146","author":"EL Blewett","year":"2001","journal-title":"Arch Virol"},{"key":"ref22","first-page":"168","article-title":"Serologic evaluation of clinical and subclinical secondary hepatic amyloidosis in rhesus macaques (Macaca mulatta)","volume":"59","author":"JG MacGuire","year":"2009","journal-title":"Comp Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1538\/expanim.47.159","article-title":"Age-related changes in major lymphocyte subsets in cynomolgus monkeys","volume":"47","author":"KH Nam","year":"1998","journal-title":"Exp Anim"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.vetimm.2008.04.005","article-title":"Flow cytometric characterization of T lymphocyte subsets in the peripheral blood of Chinese rhesus macaques: normal range, age- and sex-related differences","volume":"124","author":"CL Qiu","year":"2008","journal-title":"Vet Immunol Immunopathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.4049\/jimmunol.0904193","article-title":"Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates","volume":"184","author":"L Cicin-Sain","year":"2013","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.4049\/jimmunol.1201867","article-title":"Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life","volume":"189","author":"MJ Smithey","year":"2012","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-2249.2001.01454.x","article-title":"Age-related autoantibody production in a nonhuman primate model","volume":"123","author":"R Attanasio","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7446","DOI":"10.4049\/jimmunol.174.11.7446","article-title":"The influence of age on T cell generation and TCR diversity","volume":"174","author":"K Naylor","year":"2005","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.1074\/jbc.273.14.8119","article-title":"Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity","volume":"273","author":"AN Vallejo","year":"1998","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1046\/j.1365-2567.1996.d01-689.x","article-title":"Expansion of cytotoxic CD8+ CD28- T cells in healthy ageing people, including centenarians","volume":"88","author":"FF Fagnoni","year":"1996","journal-title":"Immunology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"a002436","DOI":"10.1101\/cshperspect.a002436","article-title":"An enigmatic tail of CD28 signaling","volume":"2","author":"JS Boomer","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.4049\/jimmunol.168.11.5893","article-title":"Lack of antibody production following immunization in old age: association with CD8(+)CD28(\u2212) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines","volume":"168","author":"M Saurwein-Teissl","year":"2002","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1016\/S0264-410X(03)00309-8","article-title":"Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination\u2013an impact of immunosenescence","volume":"21","author":"P Trzonkowski","year":"2003","journal-title":"Vaccine"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molmed.2004.01.002","article-title":"T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection","volume":"10","author":"AN Vallejo","year":"2004","journal-title":"Trends Mol Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/rmv.598","article-title":"Cytomegalovirus and human immunosenescence","volume":"19","author":"G Pawelec","year":"2009","journal-title":"Rev Med Virol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.arr.2010.08.003","article-title":"Persistent viral infections and immune aging","volume":"10","author":"S Brunner","year":"2011","journal-title":"Ageing Res Rev"},{"key":"ref37","unstructured":"Jr. EM, Shenk T, Pass R (2007) Cytomegalovirus. Fields Virology. pp. 2701\u20132772."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"8218","DOI":"10.4049\/jimmunol.175.12.8218","article-title":"Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion","volume":"175","author":"JM Fletcher","year":"2005","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e71498","DOI":"10.1371\/journal.pone.0071498","article-title":"Decreased naive and increased memory CD4(+) T cells are associated with subclinical atherosclerosis: the multi-ethnic study of atherosclerosis","volume":"8","author":"NC Olson","year":"2013","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.4049\/jimmunol.1101165","article-title":"Functional exhaustion of CD4+ T lymphocytes during primary cytomegalovirus infection","volume":"189","author":"P Antoine","year":"2012","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1196\/annals.1396.043","article-title":"Cytomegalovirus infection: a driving force in human T cell immunosenescence","volume":"1114","author":"S Koch","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1023\/A:1006365324335","article-title":"The effect of dexamethasone on some immunological parameters in cattle","volume":"23","author":"BH Anderson","year":"1999","journal-title":"Vet Res Commun"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Zhang W, Brahmakshatriya V, Swain SL (2014) CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent. Exp Gerontol.","DOI":"10.1016\/j.exger.2014.01.002"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.febslet.2005.02.055","article-title":"Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity","volume":"579","author":"M De Martinis","year":"2005","journal-title":"FEBS Lett"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/MCO.0b013e32835ada13","article-title":"Inflamm-ageing","volume":"16","author":"E Cevenini","year":"2013","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-4933-2-8","article-title":"Innate immunity and inflammation in ageing: a key for understanding age-related diseases","volume":"2","author":"F Licastro","year":"2005","journal-title":"Immun Ageing"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1084\/jem.20070201","article-title":"Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells","volume":"205","author":"H Qiu","year":"2008","journal-title":"J Exp Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1631\/jzus.2005.B1045","article-title":"Acute phase reaction and acute phase proteins","volume":"6","author":"E Gruys","year":"2005","journal-title":"J Zhejiang Univ Sci B"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40520-013-0114-x","article-title":"C-reactive protein is independently associated with coronary atherosclerosis burden among octogenarians","volume":"26","author":"LA Quaglia","year":"2014","journal-title":"Aging Clin Exp Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1159\/000322092","article-title":"Systemic inflammation is associated with MCI and its subtypes: the Sydney Memory and Aging Study","volume":"30","author":"JN Trollor","year":"2010","journal-title":"Dement Geriatr Cogn Disord"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0107167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T20:07:24Z","timestamp":1598299644000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0107167"}},"subtitle":[],"editor":[{"given":"Jennifer Beam","family":"Dowd","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2014,9,22]]},"references-count":50,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2014,9,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0107167","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,22]]}}}