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Enzymol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software.","volume":"40","author":"AJ McCoy","year":"2007","journal-title":"J Appl Crystallogr"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1107\/S0907444992008886","article-title":"Automated refinement of protein models.","volume":"49","author":"VS Lamzin","year":"1993","journal-title":"Acta Crystallogr D"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1107\/S0108767390010224","article-title":"Improved methods for building protein models in electron density maps and the location of errors in these models.","volume":"47 (Pt 2)","author":"TA Jones","year":"1991","journal-title":"Acta Crystallogr A"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likehood method.","volume":"53","author":"GN Murshudov","year":"1997","journal-title":"Acta Crystallogr D"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1107\/S0108768198003243","article-title":"Correlation of internal torsional motion with overall molecular motion in crystals.","volume":"54","author":"V Schomaker","year":"1998","journal-title":"Acta Crystallogr B"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1107\/S0907444903008126","article-title":"A graphical user interface to the CCP4 program suite.","volume":"59","author":"E Potterton","year":"2003","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1021\/bi00713a027","article-title":"Determination of the helix and beta form of proteins in aqueous solution by circular dichroism.","volume":"13","author":"YH Chen","year":"1974","journal-title":"Biochemistry"},{"key":"ref89","article-title":"Biophysical Chemistry.","volume":"III","author":"C Cantor","year":"1980"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0006-3495(81)84753-4","article-title":"Analysis of data from the analytical ultracentrifuge by nonlinear least-squares techniques.","volume":"36","author":"ML Johnson","year":"1981","journal-title":"Biophys J"},{"key":"ref91","first-page":"90","article-title":"Computer-aided interpretation of analytical sedimentation data for proteins.","author":"TM Laue","year":"1992","journal-title":"Analytical Ultracentrifugation in Biochemistry and Polymer Science"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/viro.1999.0024","article-title":"The use of a quantitative fusion assay to evaluate HN-receptor interaction for human parainfluenza virus type 3.","volume":"265","author":"S Levin Perlman","year":"1999","journal-title":"Virology"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"14764","DOI":"10.1073\/pnas.94.26.14764","article-title":"A system for functional analysis of Ebola virus glycoprotein.","volume":"94","author":"A Takada","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nature03838","article-title":"EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus.","volume":"436","author":"OA Negrete","year":"2005","journal-title":"Nature"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/nar\/24.6.1171","article-title":"Alpha complementation of LacZ in mammalian cells.","volume":"24","author":"P Moosmann","year":"1996","journal-title":"Nucleic Acids Res"}],"container-title":["PLoS 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