{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:52:35Z","timestamp":1783633955300,"version":"3.55.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:00:00Z","timestamp":1115683200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.0030187","type":"journal-article","created":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T21:45:31Z","timestamp":1115156731000},"page":"e187","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":164,"title":["Determination of Stromal Signatures in Breast Carcinoma"],"prefix":"10.1371","volume":"3","author":[{"given":"Robert B","family":"West","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitry S. A","family":"Nuyten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subbaya","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten O","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L","family":"Corless","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Hernandez-Boussard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Goldblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick O","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"van de Vijver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"van de Rijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2005,5,10]]},"reference":[{"key":"JOURNAL-PBIO-0030187-B02","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/00000478-198908000-00003","volume":"13","author":"England","year":"1989","journal-title":"Am J Surg Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0147-5185","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B03","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-2559.1996.297345.x","volume":"28","author":"Fukunaga","year":"1996","journal-title":"Histopathology","ISSN":"https:\/\/id.crossref.org\/issn\/0309-0167","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B04","first-page":"169","volume":"9","author":"Moran","year":"1992","journal-title":"Semin Diagn Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0740-2570","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B05","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/00000478-199408000-00008","volume":"18","author":"van de Rijn","year":"1994","journal-title":"Am J Surg Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0147-5185","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B06","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1046\/j.1365-2559.1997.2400897.x","volume":"31","author":"Chan","year":"1997","journal-title":"Histopathology","ISSN":"https:\/\/id.crossref.org\/issn\/0309-0167","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B07","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/S0002-9440(10)65441-7","volume":"154","author":"Fletcher","year":"1999","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B08","first-page":"329","volume":"151","author":"Alman","year":"1997","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B09","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00019606-199704000-00005","volume":"6","author":"Alman","year":"1997","journal-title":"Diagn Mol Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/1052-9551","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1054\/bjoc.1999.1007","volume":"82","author":"Middleton","year":"2000","journal-title":"Br J Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0007-0920","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B11","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/S0002-9440(10)63593-6","volume":"163","author":"Linn","year":"2003","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B12","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(02)08270-3","volume":"359","author":"Nielsen","year":"2002","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B13","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B14","first-page":"71","volume":"2","author":"van de Rijn","year":"1994","journal-title":"Appl Immunohistochem","ISSN":"https:\/\/id.crossref.org\/issn\/1062-3345","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B15","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1056\/NEJMoa021967","volume":"347","author":"van de Vijver","year":"2002","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00428664","volume":"389","author":"Lagace","year":"1980","journal-title":"Virchows Arch A Pathol Anat Histol","ISSN":"https:\/\/id.crossref.org\/issn\/0340-1227","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"Perou","year":"2000","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B18","doi-asserted-by":"crossref","first-page":"12877","DOI":"10.1073\/pnas.162488599","volume":"99","author":"Chang","year":"2002","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B19","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1371\/journal.pbio.0020007","volume":"2","author":"Chang","year":"2004","journal-title":"PLoS Biol","ISSN":"https:\/\/id.crossref.org\/issn\/1545-7885","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.283.5398.83","volume":"283","author":"Iyer","year":"1999","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B21","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1073\/pnas.0409462102","volume":"102","author":"Chang","year":"2005","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2004.06.010","volume":"6","author":"Allinen","year":"2004","journal-title":"Cancer Cell","ISSN":"https:\/\/id.crossref.org\/issn\/1042-2196","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9440(10)63279-8","volume":"165","author":"West","year":"2004","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B24","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/S0002-9440(10)64434-3","volume":"161","author":"Liu","year":"2002","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"JOURNAL-PBIO-0030187-B25","doi-asserted-by":"crossref","first-page":"7780","DOI":"10.1038\/sj.onc.1208056","volume":"23","author":"Subramanian","year":"2004","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T15:47:05Z","timestamp":1550418425000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.0030187"}},"subtitle":[],"editor":[{"given":"Louis M.","family":"Staudt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2005,5,10]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,5,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.0030187","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,10]]}}}