{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:18:12Z","timestamp":1791314292486,"version":"4.3.1"},"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2008,11,4]],"date-time":"2008-11-04T00:00:00Z","timestamp":1225756800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.0060264","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T12:21:40Z","timestamp":1225455700000},"page":"e264","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":255,"title":["Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae"],"prefix":"10.1371","volume":"6","author":[{"given":"Sasha F","family":"Levy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L","family":"Siegal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,11,4]]},"reference":[{"key":"journal-pbio-0060264-b001","author":"Wagner","year":"2005","journal-title":"Robustness and evolvability in living systems"},{"key":"journal-pbio-0060264-b002","first-page":"563","volume":"150","author":"Waddington","year":"1942","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b003","first-page":"235","author":"Siegal","year":"2006","journal-title":"Evolutionary genetics: concepts and case studies"},{"key":"journal-pbio-0060264-b004","first-page":"123","volume":"37","author":"Hansen","year":"2006","journal-title":"Annu Rev Ecol Evol Syst","ISSN":"https:\/\/id.crossref.org\/issn\/1543-592X","issn-type":"print"},{"key":"journal-pbio-0060264-b005","first-page":"1772","volume":"579","author":"Wagner","year":"2005","journal-title":"FEBS Lett","ISSN":"https:\/\/id.crossref.org\/issn\/0014-5793","issn-type":"print"},{"key":"journal-pbio-0060264-b006","first-page":"618","volume":"417","author":"Queitsch","year":"2002","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b007","first-page":"336","volume":"396","author":"Rutherford","year":"1998","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000075","volume":"1","author":"Milton","year":"2006","journal-title":"PLoS ONE"},{"key":"journal-pbio-0060264-b009","first-page":"116","volume":"285","author":"Wagner","year":"1999","journal-title":"J Exp Zool","ISSN":"https:\/\/id.crossref.org\/issn\/1097-010X","issn-type":"print"},{"key":"journal-pbio-0060264-b010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000076","volume":"1","author":"Carey","year":"2006","journal-title":"PLoS ONE"},{"key":"journal-pbio-0060264-b011","first-page":"11531","volume":"101","author":"Earl","year":"2004","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b012","first-page":"1359","volume":"170","author":"Masel","year":"2005","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060264-b013","first-page":"560","volume":"72","author":"King","year":"2007","journal-title":"Theor Popul Biol","ISSN":"https:\/\/id.crossref.org\/issn\/1096-0325","issn-type":"print"},{"key":"journal-pbio-0060264-b014","first-page":"468","volume":"17","author":"Meiklejohn","year":"2002","journal-title":"Trends Ecol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0169-5347","issn-type":"print"},{"key":"journal-pbio-0060264-b015","first-page":"10528","volume":"99","author":"Siegal","year":"2002","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b016","first-page":"549","volume":"424","author":"Bergman","year":"2003","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b017","first-page":"19015","volume":"102","author":"Ohya","year":"2005","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b018","first-page":"132","author":"Dworkin","year":"2005","journal-title":"Variation"},{"key":"journal-pbio-0060264-b019","first-page":"487","volume":"16","author":"Pan","year":"2004","journal-title":"Mol Cell","ISSN":"https:\/\/id.crossref.org\/issn\/1097-2765","issn-type":"print"},{"key":"journal-pbio-0060264-b020","first-page":"89","volume":"9","author":"Kolodner","year":"1999","journal-title":"Curr Opin Genet Dev","ISSN":"https:\/\/id.crossref.org\/issn\/0959-437X","issn-type":"print"},{"key":"journal-pbio-0060264-b021","first-page":"345","volume":"179","author":"Manukyan","year":"2008","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060264-b022","first-page":"296","volume":"271","author":"Minarikova","year":"2001","journal-title":"Exp Cell Res","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4827","issn-type":"print"},{"key":"journal-pbio-0060264-b023","first-page":"1811","volume":"304","author":"Raser","year":"2004","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pbio-0060264-b024","first-page":"699","volume":"437","author":"Colman-Lerner","year":"2005","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b025","first-page":"1069","volume":"124","author":"Pan","year":"2006","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"journal-pbio-0060264-b026","first-page":"41","volume":"411","author":"Jeong","year":"2001","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b027","first-page":"2364","volume":"294","author":"Tong","year":"2001","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pbio-0060264-b028","first-page":"83","volume":"129","author":"Siegal","year":"2007","journal-title":"Genetica","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6707","issn-type":"print"},{"key":"journal-pbio-0060264-b029","first-page":"1001","volume":"291","author":"Hartman","year":"2001","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pbio-0060264-b030","first-page":"896","volume":"38","author":"Lehner","year":"2006","journal-title":"Nat Genet","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"journal-pbio-0060264-b031","first-page":"348","volume":"26","author":"Sangster","year":"2004","journal-title":"Bioessays","ISSN":"https:\/\/id.crossref.org\/issn\/0265-9247","issn-type":"print"},{"key":"journal-pbio-0060264-b032","first-page":"D535","volume":"34","author":"Stark","year":"2006","journal-title":"Nucleic Acids Res","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"key":"journal-pbio-0060264-b033","first-page":"631","volume":"440","author":"Gavin","year":"2006","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b034","first-page":"637","volume":"440","author":"Krogan","year":"2006","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b035","first-page":"2185","volume":"309","author":"Cowen","year":"2005","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pbio-0060264-b036","first-page":"937","volume":"174","author":"Bobula","year":"2006","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060264-b037","first-page":"15724","volume":"100","author":"Warringer","year":"2003","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b038","first-page":"1915","volume":"169","author":"Deutschbauer","year":"2005","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060264-b039","first-page":"1243","volume":"105","author":"Kafri","year":"2008","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b040","first-page":"256","volume":"19","author":"Gu","year":"2002","journal-title":"Mol Biol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0737-4038","issn-type":"print"},{"key":"journal-pbio-0060264-b041","first-page":"63","volume":"421","author":"Gu","year":"2003","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b042","first-page":"1151","volume":"290","author":"Lynch","year":"2000","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pbio-0060264-b043","first-page":"327","volume":"23","author":"Drummond","year":"2006","journal-title":"Mol Biol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0737-4038","issn-type":"print"},{"key":"journal-pbio-0060264-b044","first-page":"927","volume":"158","author":"Pal","year":"2001","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060264-b045","first-page":"1456","volume":"15","author":"Byrne","year":"2005","journal-title":"Genome Res","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"key":"journal-pbio-0060264-b046","first-page":"840","volume":"441","author":"Newman","year":"2006","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b047","first-page":"R258","volume":"8","author":"McGary","year":"2007","journal-title":"Genome Biol","ISSN":"https:\/\/id.crossref.org\/issn\/1465-6914","issn-type":"print"},{"key":"journal-pbio-0060264-b048","first-page":"1073","volume":"411","author":"Myung","year":"2001","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b049","first-page":"1449","volume":"159","author":"Scholes","year":"2001","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060264-b050","first-page":"197","volume":"178","author":"Nyswaner","year":"2008","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060264-b051","first-page":"552","volume":"297","author":"Kolodner","year":"2002","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pbio-0060264-b052","first-page":"122","volume":"1","author":"Richard","year":"2000","journal-title":"EMBO Rep","ISSN":"https:\/\/id.crossref.org\/issn\/1469-221X","issn-type":"print"},{"key":"journal-pbio-0060264-b053","first-page":"986","volume":"37","author":"Verstrepen","year":"2005","journal-title":"Nat Genet","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"journal-pbio-0060264-b054","first-page":"18058","volume":"101","author":"Fondon","year":"2004","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b055","first-page":"8658","volume":"101","author":"Askree","year":"2004","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b056","volume":"2","author":"Snyder","year":"2006","journal-title":"PLoS Genet"},{"key":"journal-pbio-0060264-b057","first-page":"555","volume":"94","author":"Weinert","year":"1998","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"journal-pbio-0060264-b058","first-page":"2237","volume":"16","author":"Bender","year":"2002","journal-title":"Genes Dev","ISSN":"https:\/\/id.crossref.org\/issn\/0890-9369","issn-type":"print"},{"key":"journal-pbio-0060264-b059","first-page":"3422","volume":"18","author":"Hiramoto","year":"1999","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"journal-pbio-0060264-b060","first-page":"3427","volume":"18","author":"Matsuda","year":"1999","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"journal-pbio-0060264-b061","first-page":"1671","volume":"9","author":"Strissel","year":"2000","journal-title":"Hum Mol Genet","ISSN":"https:\/\/id.crossref.org\/issn\/1460-2083","issn-type":"print"},{"key":"journal-pbio-0060264-b062","first-page":"307","volume":"408","author":"Vogelstein","year":"2000","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b063","first-page":"2707","volume":"103","author":"Bao","year":"2006","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b064","first-page":"375","volume":"61","author":"Malone","year":"1990","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"journal-pbio-0060264-b065","first-page":"257","volume":"10","author":"Waddington","year":"1961","journal-title":"Adv Genet","ISSN":"https:\/\/id.crossref.org\/issn\/0065-2660","issn-type":"print"},{"key":"journal-pbio-0060264-b066","first-page":"2075","volume":"309","author":"Kussell","year":"2005","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pbio-0060264-b067","first-page":"575","volume":"15","author":"Landry","year":"2006","journal-title":"Mol Ecol","ISSN":"https:\/\/id.crossref.org\/issn\/0962-1083","issn-type":"print"},{"key":"journal-pbio-0060264-b068","first-page":"403","volume":"10","author":"Mortimer","year":"2000","journal-title":"Genome Res","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"key":"journal-pbio-0060264-b069","first-page":"2529","volume":"60","author":"Debat","year":"2006","journal-title":"Evolution Int J Org Evolution","ISSN":"https:\/\/id.crossref.org\/issn\/0014-3820","issn-type":"print"},{"key":"journal-pbio-0060264-b070","first-page":"13396","volume":"100","author":"Milton","year":"2003","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b071","first-page":"3513","volume":"58","author":"Samakovli","year":"2007","journal-title":"J Exp Bot","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0957","issn-type":"print"},{"key":"journal-pbio-0060264-b072","first-page":"1005","volume":"156","author":"Palecek","year":"2000","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060264-b073","first-page":"507","volume":"63","author":"Bishop","year":"2007","journal-title":"Mol Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/0950-382X","issn-type":"print"},{"key":"journal-pbio-0060264-b074","first-page":"17614","volume":"103","author":"Sawyer","year":"2006","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.0030031","volume":"3","author":"Nogami","year":"2007","journal-title":"PLoS Genet"},{"key":"journal-pbio-0060264-b076","first-page":"711","volume":"5","author":"Breslow","year":"2008","journal-title":"Nat Methods","ISSN":"https:\/\/id.crossref.org\/issn\/1548-7105","issn-type":"print"},{"key":"journal-pbio-0060264-b077","doi-asserted-by":"crossref","DOI":"10.1002\/9780470316801","author":"Kaufman","year":"1990","journal-title":"Finding groups in data: an introduction to cluster analysis"},{"key":"journal-pbio-0060264-b078","first-page":"575","volume":"73","author":"van der Laan","year":"2003","journal-title":"Journal of Statistical Computation and Simulation","ISSN":"https:\/\/id.crossref.org\/issn\/0094-9655","issn-type":"print"},{"key":"journal-pbio-0060264-b079","first-page":"35","volume":"40","author":"Freeman","year":"1977","journal-title":"Sociometry","ISSN":"https:\/\/id.crossref.org\/issn\/0038-0431","issn-type":"print"},{"key":"journal-pbio-0060264-b080","first-page":"440","volume":"393","author":"Watts","year":"1998","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b081","first-page":"387","volume":"418","author":"Giaever","year":"2002","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b082","first-page":"808","volume":"303","author":"Tong","year":"2004","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0193-4511","issn-type":"print"},{"key":"journal-pbio-0060264-b083","first-page":"717","volume":"95","author":"Holstege","year":"1998","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"journal-pbio-0060264-b084","first-page":"737","volume":"425","author":"Ghaemmaghami","year":"2003","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b085","first-page":"5483","volume":"102","author":"Wall","year":"2005","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060264-b086","first-page":"617","volume":"428","author":"Kellis","year":"2004","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060264-b087","first-page":"555","volume":"13","author":"Yang","year":"1997","journal-title":"Comput Appl Biosci","ISSN":"https:\/\/id.crossref.org\/issn\/1460-2059","issn-type":"print"},{"key":"journal-pbio-0060264-b088","first-page":"32","volume":"17","author":"Yang","year":"2000","journal-title":"Mol Biol Evol","ISSN":"https:\/\/id.crossref.org\/issn\/0737-4038","issn-type":"print"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T02:48:26Z","timestamp":1550198906000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.0060264"}},"subtitle":[],"editor":[{"given":"Andre","family":"Levchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,11,4]]},"references-count":88,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2008,11,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.0060264","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1137950.595054","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,4]]}}}