{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:52:34Z","timestamp":1791517954502,"version":"4.3.4"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T00:00:00Z","timestamp":1228780800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.0060305","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T09:51:43Z","timestamp":1228470703000},"page":"e305","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":214,"title":["A Signaling Protease Required for Melanization in Drosophila Affects Resistance and Tolerance of Infections"],"prefix":"10.1371","volume":"6","author":[{"given":"Janelle S","family":"Ayres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2008,12,9]]},"reference":[{"key":"journal-pbio-0060305-b001","first-page":"235","volume":"9","author":"Schafer","year":"1971","journal-title":"Annu Rev Phytopathol","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4286","issn-type":"print"},{"key":"journal-pbio-0060305-b002","first-page":"161","volume":"5","author":"Clarke","year":"1984","journal-title":"Adv Plant Pathol"},{"key":"journal-pbio-0060305-b003","first-page":"565","volume":"31","author":"Stowe","year":"2000","journal-title":"Annu Rev Ecol Syst","ISSN":"https:\/\/id.crossref.org\/issn\/0066-4162","issn-type":"print"},{"key":"journal-pbio-0060305-b004","first-page":"11270","volume":"99","author":"Kover","year":"2002","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060305-b005","first-page":"12935","volume":"103","author":"Schwachtje","year":"2006","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060305-b006","first-page":"697","volume":"25","author":"Lemaitre","year":"2007","journal-title":"Annu Rev Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/0732-0582","issn-type":"print"},{"key":"journal-pbio-0060305-b007","first-page":"973","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"journal-pbio-0060305-b008","first-page":"9465","volume":"92","author":"Lemaitre","year":"1995","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060305-b009","first-page":"827","volume":"4","author":"Hedengren","year":"1999","journal-title":"Mol Cell","ISSN":"https:\/\/id.crossref.org\/issn\/1097-2765","issn-type":"print"},{"key":"journal-pbio-0060305-b010","first-page":"575","volume":"17","author":"Naitza","year":"2002","journal-title":"Immunity","ISSN":"https:\/\/id.crossref.org\/issn\/1074-7613","issn-type":"print"},{"key":"journal-pbio-0060305-b011","first-page":"640","volume":"416","author":"Gottar","year":"2002","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/1476-4687","issn-type":"print"},{"key":"journal-pbio-0060305-b012","first-page":"4059","volume":"71","author":"Lau","year":"2003","journal-title":"Infect Immun","ISSN":"https:\/\/id.crossref.org\/issn\/0019-9567","issn-type":"print"},{"key":"journal-pbio-0060305-b013","first-page":"526","volume":"20","author":"Corby-Harris","year":"2007","journal-title":"J Evol Biol","ISSN":"https:\/\/id.crossref.org\/issn\/1010-061X","issn-type":"print"},{"key":"journal-pbio-0060305-b014","first-page":"1977","volume":"16","author":"Dionne","year":"2006","journal-title":"Curr Biol","ISSN":"https:\/\/id.crossref.org\/issn\/0960-9822","issn-type":"print"},{"key":"journal-pbio-0060305-b015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0030041","volume":"3","author":"Schneider","year":"2007","journal-title":"PLoS Pathog"},{"key":"journal-pbio-0060305-b016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0020418","volume":"2","author":"Brandt","year":"2004","journal-title":"PLoS Biol"},{"key":"journal-pbio-0060305-b017","first-page":"1807","volume":"178","author":"Ayres","year":"2008","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060305-b018","first-page":"563","volume":"14","author":"Simms","year":"2000","journal-title":"Evol Ecol","ISSN":"https:\/\/id.crossref.org\/issn\/0269-7653","issn-type":"print"},{"key":"journal-pbio-0060305-b019","first-page":"1973","volume":"48","author":"Simms","year":"1994","journal-title":"Evolution","ISSN":"https:\/\/id.crossref.org\/issn\/0014-3820","issn-type":"print"},{"key":"journal-pbio-0060305-b020","first-page":"1024","volume":"54","author":"Tiffin","year":"2000","journal-title":"Evolution","ISSN":"https:\/\/id.crossref.org\/issn\/0014-3820","issn-type":"print"},{"key":"journal-pbio-0060305-b021","first-page":"116","volume":"198","author":"Cerenius","year":"2004","journal-title":"Immunol Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0105-2896","issn-type":"print"},{"key":"journal-pbio-0060305-b022","first-page":"573","volume":"5","author":"Meister","year":"2003","journal-title":"Cell Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/1462-5814","issn-type":"print"},{"key":"journal-pbio-0060305-b023","first-page":"2","volume":"15","author":"Sugumaran","year":"2002","journal-title":"Pigment Cell Res","ISSN":"https:\/\/id.crossref.org\/issn\/0893-5785","issn-type":"print"},{"key":"journal-pbio-0060305-b024","first-page":"231","volume":"7","author":"Leclerc","year":"2006","journal-title":"EMBO Rep","ISSN":"https:\/\/id.crossref.org\/issn\/1469-221X","issn-type":"print"},{"key":"journal-pbio-0060305-b025","first-page":"28097","volume":"281","author":"Tang","year":"2006","journal-title":"J Biol Chem","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"journal-pbio-0060305-b026","first-page":"263","volume":"29","author":"Cerenius","year":"2008","journal-title":"Trends Immunol","ISSN":"https:\/\/id.crossref.org\/issn\/1471-4906","issn-type":"print"},{"key":"journal-pbio-0060305-b027","first-page":"1392","volume":"8","author":"Volz","year":"2006","journal-title":"Cell Microbiol","ISSN":"https:\/\/id.crossref.org\/issn\/1462-5814","issn-type":"print"},{"key":"journal-pbio-0060305-b028","first-page":"2419","volume":"104","author":"Eleftherianos","year":"2006","journal-title":"Proc Natl Acad Sci U S A","ISSN":"https:\/\/id.crossref.org\/issn\/1091-6490","issn-type":"print"},{"key":"journal-pbio-0060305-b029","first-page":"33593","volume":"282","author":"Liu","year":"2007","journal-title":"J Bio Chem","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"journal-pbio-0060305-b030","first-page":"192","volume":"21","author":"Christensen","year":"2006","journal-title":"Trends Parasitol","ISSN":"https:\/\/id.crossref.org\/issn\/1471-4922","issn-type":"print"},{"key":"journal-pbio-0060305-b031","first-page":"151","volume":"28","author":"Pentz","year":"1990","journal-title":"Biochem Genet","ISSN":"https:\/\/id.crossref.org\/issn\/0006-2928","issn-type":"print"},{"key":"journal-pbio-0060305-b032","first-page":"65","volume":"243","author":"Sorrentino","year":"2002","journal-title":"Dev Biol","ISSN":"https:\/\/id.crossref.org\/issn\/1095-564X","issn-type":"print"},{"key":"journal-pbio-0060305-b033","first-page":"325","volume":"168","author":"Milchanowski","year":"2004","journal-title":"Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0016-6731","issn-type":"print"},{"key":"journal-pbio-0060305-b034","first-page":"2521","volume":"132","author":"Jung","year":"2005","journal-title":"Development","ISSN":"https:\/\/id.crossref.org\/issn\/1011-6370","issn-type":"print"},{"key":"journal-pbio-0060305-b035","first-page":"91","volume":"188","author":"Rizki","year":"1980","journal-title":"Willhelm Roux's Arch","ISSN":"https:\/\/id.crossref.org\/issn\/0340-0794","issn-type":"print"},{"key":"journal-pbio-0060305-b036","first-page":"200","volume":"45","author":"Gajewski","year":"2007","journal-title":"Genesis","ISSN":"https:\/\/id.crossref.org\/issn\/1061-2289","issn-type":"print"},{"key":"journal-pbio-0060305-b037","first-page":"51","volume":"54","author":"Roy","year":"2000","journal-title":"Evolution","ISSN":"https:\/\/id.crossref.org\/issn\/0014-3820","issn-type":"print"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:22:46Z","timestamp":1589030566000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.0060305"}},"subtitle":[],"editor":[{"given":"Daniel","family":"Promislow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2008,12,9]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2008,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.0060305","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1139101.596215","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,9]]}}}