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M Cuervo","year":"2000","journal-title":"J Biol Chem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1128\/MCB.01227-08","article-title":"Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process.","volume":"29","author":"A Tonoki","year":"2009","journal-title":"Mol Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/S0960-9822(02)01146-6","article-title":"Transcriptional profile of aging in C. elegans.","volume":"12","author":"J Lund","year":"2002","journal-title":"Curr Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.neurobiolaging.2005.05.006","article-title":"Quantitative proteomics analysis of differential protein expression and oxidative modification of specific proteins in the brains of old mice.","volume":"27","author":"H. F Poon","year":"2006","journal-title":"Neurobiol Aging"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S0531-5565(01)00139-5","article-title":"Oxidative stress and protein aggregation during biological aging.","volume":"36","author":"T. C Squier","year":"2001","journal-title":"Exp Gerontol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1141448","article-title":"Adapting proteostasis for disease intervention.","volume":"319","author":"W. E Balch","year":"2008","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/gerona\/gln071","article-title":"Protein homeostasis and aging: taking care of proteins from the cradle to the grave.","volume":"64","author":"R. I Morimoto","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1073\/pnas.96.7.3590","article-title":"Designing conditions for in vitro formation of amyloid protofilaments and fibrils.","volume":"96","author":"F Chiti","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nchembio.131","article-title":"Amyloid formation by globular proteins under native conditions.","volume":"5","author":"F Chiti","year":"2009","journal-title":"Nat Chem Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1073\/pnas.0915166107","article-title":"Identifying the amylome, proteins capable of forming amyloid-like fibrils.","volume":"107","author":"L Goldschmidt","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","article-title":"Amyloids in bacterial inclusion bodies.","author":"N. S de Groot","year":"2009","journal-title":"Trends Biochem Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1371\/journal.pbio.0060195","article-title":"Bacterial inclusion bodies contain amyloid-like structure.","volume":"6","author":"L Wang","year":"2008","journal-title":"PLoS Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nature07195","article-title":"Misfolded proteins partition between two distinct quality control compartments.","volume":"454","author":"D Kaganovich","year":"2008","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1128\/MCB.01485-08","article-title":"Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress.","volume":"29","author":"F. 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R Kopito","year":"2000","journal-title":"Trends Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"37061","DOI":"10.1074\/jbc.M403672200","article-title":"Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection.","volume":"279","author":"L Liao","year":"2004","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.2741\/2973","article-title":"Proteomic identification of novel proteins associated with Lewy bodies.","volume":"13","author":"Q Xia","year":"2008","journal-title":"Front Biosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1096\/fj.04-3210fje","article-title":"Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein.","volume":"19","author":"Q Wang","year":"2005","journal-title":"Faseb J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.1124514","article-title":"Progressive disruption of cellular protein folding in models of polyglutamine diseases.","volume":"311","author":"T Gidalevitz","year":"2006","journal-title":"Science"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1073\/pnas.0307697101","article-title":"Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.","volume":"101","author":"E. A Nollen","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0076-6879(99)09008-4","article-title":"Purification of paired helical filament tau and normal tau from human brain tissue.","volume":"309","author":"V. M Lee","year":"1999","journal-title":"Methods Enzymol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1523\/JNEUROSCI.21-02-00372.2001","article-title":"Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.","volume":"21","author":"T Kawarabayashi","year":"2001","journal-title":"J Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9980","DOI":"10.1073\/pnas.1533448100","article-title":"Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.","volume":"100","author":"B. C Kraemer","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1074\/mcp.M700170-MCP200","article-title":"Quantitative analysis of synaptic phosphorylation and protein expression.","volume":"7","author":"J. C Trinidad","year":"2008","journal-title":"Mol Cell Proteomics"},{"key":"ref25","article-title":"Differential protein expression profiling by iTRAQ-2DLC-MS\/MS of human bladder cancer EJ138 cells transfected with the metastasis suppressor KiSS-1 gene.","author":"I Ruppen","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/pmic.200900711","article-title":"Temporal proteomic analysis of IGF-1R signalling in MCF-7 breast adenocarcinoma cells.","volume":"10","author":"J. P Murphy","year":"2010","journal-title":"Proteomics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1074\/mcp.M400129-MCP200","article-title":"Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents.","volume":"3","author":"P. L Ross","year":"2004","journal-title":"Mol Cell Proteomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0012-1606(84)90077-0","article-title":"A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegans.","volume":"106","author":"T Doniach","year":"1984","journal-title":"Dev Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e1000295","DOI":"10.1371\/journal.pgen.1000295","article-title":"Apoptosis maintains oocyte quality in aging Caenorhabditis elegans females.","volume":"4","author":"S Andux","year":"2008","journal-title":"PLoS Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1083\/jcb.146.3.645","article-title":"Insoluble gamma-tubulin-containing structures are anchored to the apical network of intermediate filaments in polarized CACO-2 epithelial cells.","volume":"146","author":"P. J Salas","year":"1999","journal-title":"J Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"9525","DOI":"10.1074\/jbc.M109.096586","article-title":"The 90-kDa heat shock protein Hsp90 protects tubulin against thermal denaturation.","volume":"285","author":"F Weis","year":"2010","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1083\/jcb.143.7.1883","article-title":"Aggresomes: a cellular response to misfolded proteins.","volume":"143","author":"J. A Johnston","year":"1998","journal-title":"J Cell Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1046\/j.1471-4159.1997.69062506.x","article-title":"Casein kinase 1 is tightly associated with paired-helical filaments isolated from Alzheimer's disease brain.","volume":"69","author":"J Kuret","year":"1997","journal-title":"J Neurochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neulet.2007.11.066","article-title":"Casein kinase 1 alpha associates with the tau-bearing lesions of inclusion body myositis.","volume":"431","author":"T. J Kannanayakal","year":"2008","journal-title":"Neurosci Lett"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb1459","article-title":"Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos.","volume":"8","author":"F Motegi","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrn1007","article-title":"Unfolding the role of protein misfolding in neurodegenerative diseases.","volume":"4","author":"C Soto","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0076-6879(06)12016-9","article-title":"Modeling polyglutamine pathogenesis in C. elegans.","volume":"412","author":"H. R Brignull","year":"2006","journal-title":"Methods Enzymol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"37195","DOI":"10.1074\/jbc.M604863200","article-title":"Removal of pattern-breaking sequences in microtubule binding repeats produces instantaneous tau aggregation and toxicity.","volume":"281","author":"A. I Iliev","year":"2006","journal-title":"J Biol Chem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nmeth1062","article-title":"Bright monomeric red fluorescent protein with an extended fluorescence lifetime.","volume":"4","author":"E. M Merzlyak","year":"2007","journal-title":"Nat Methods"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"14914","DOI":"10.1073\/pnas.0902882106","article-title":"Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging.","volume":"106","author":"A Ben-Zvi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/366461a0","article-title":"A C. elegans mutant that lives twice as long as wild type.","volume":"366","author":"C Kenyon","year":"1993","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans.","volume":"99","author":"J. F Morley","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1126\/science.1124646","article-title":"Opposing activities protect against age-onset proteotoxicity.","volume":"313","author":"E Cohen","year":"2006","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/genetics\/139.4.1567","article-title":"Genes that regulate both development and longevity in Caenorhabditis elegans.","volume":"139","author":"P. L Larsen","year":"1995","journal-title":"Genetics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/genetics\/150.1.129","article-title":"Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.","volume":"150","author":"D Gems","year":"1998","journal-title":"Genetics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1126\/science.1074240","article-title":"Timing requirements for insulin\/IGF-1 signaling in C. elegans.","volume":"298","author":"A Dillin","year":"2002","journal-title":"Science"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cub.2007.08.058","article-title":"The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling.","volume":"17","author":"W. M Shaw","year":"2007","journal-title":"Curr Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1073\/pnas.92.20.9368","article-title":"Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.","volume":"92","author":"C. D Link","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"13746","DOI":"10.1074\/jbc.M900480200","article-title":"Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells.","volume":"284","author":"M Kaminska","year":"2009","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.153.1.169","article-title":"Nucleolar components involved in ribosome biogenesis cycle between the nucleolus and nucleoplasm in interphase cells.","volume":"153","author":"D Chen","year":"2001","journal-title":"J Cell Biol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/genetics\/161.3.1101","article-title":"Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.","volume":"161","author":"D Garigan","year":"2002","journal-title":"Genetics"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature01135","article-title":"Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.","volume":"419","author":"L. A Herndon","year":"2002","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1034\/j.1600-0854.2002.30602.x","article-title":"Hassles with taking out the garbage: aggravating aggresomes.","volume":"3","author":"R Garcia-Mata","year":"2002","journal-title":"Traffic"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00418-006-0266-2","article-title":"Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry.","volume":"127","author":"A Scharf","year":"2007","journal-title":"Histochem Cell Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1601-183X.2004.00105.x","article-title":"Invertebrate models of Alzheimer's disease.","volume":"4","author":"C. D Link","year":"2005","journal-title":"Genes Brain Behav"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0197-4580(00)00237-2","article-title":"Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.","volume":"22","author":"C. D Link","year":"2001","journal-title":"Neurobiol Aging"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery.","volume":"4","author":"G Dennis Jr","year":"2003","journal-title":"Genome Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1371\/journal.pgen.0030056","article-title":"Lifespan regulation by evolutionarily conserved genes essential for viability.","volume":"3","author":"S. P Curran","year":"2007","journal-title":"PLoS Genet"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1371\/journal.pgen.0010017","article-title":"New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen.","volume":"1","author":"M Hansen","year":"2005","journal-title":"PLoS Genet"},{"key":"ref60","article-title":"Lifespan Extension by Conditions that Inhibit Translation in C. elegans.","author":"M Hansen","year":"2006","journal-title":"Aging Cell"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1474-9726.2006.00266.x","article-title":"Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.","volume":"6","author":"K. Z Pan","year":"2007","journal-title":"Aging Cell"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cub.2009.08.016","article-title":"Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain.","volume":"19","author":"J. M Copeland","year":"2009","journal-title":"Curr Biol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1006\/bbrc.2002.6717","article-title":"Isolation of the interacting molecules with GEX-3 by a novel functional screening.","volume":"292","author":"D Tsuboi","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1101\/gad.955702","article-title":"The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans.","volume":"16","author":"M. C Soto","year":"2002","journal-title":"Genes Dev"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S0960-9822(03)00372-5","article-title":"C. elegans PAT-6\/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo.","volume":"13","author":"X Lin","year":"2003","journal-title":"Curr Biol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/embor.2008.56","article-title":"PeptideAtlas: a resource for target selection for emerging targeted proteomics workflows.","volume":"9","author":"E. W Deutsch","year":"2008","journal-title":"EMBO Rep"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/jmbi.1999.3091","article-title":"Protein secondary structure prediction based on position-specific scoring matrices.","volume":"292","author":"D. T Jones","year":"1999","journal-title":"J Mol Biol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0969-2126(97)00260-8","article-title":"CATH\u2013a hierarchic classification of protein domain structures.","volume":"5","author":"C. A Orengo","year":"1997","journal-title":"Structure"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature01789","article-title":"Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans.","volume":"424","author":"C. T Murphy","year":"2003","journal-title":"Nature"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1126\/science.1087782","article-title":"Autophagy genes are essential for dauer development and life-span extension in C. elegans.","volume":"301","author":"A Melendez","year":"2003","journal-title":"Science"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.1083614","article-title":"DAF-16 target genes that control C. elegans life-span and metabolism.","volume":"300","author":"S. S Lee","year":"2003","journal-title":"Science"},{"key":"ref72","article-title":"Insulin\/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity.","author":"S Henis-Korenblit","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"569","DOI":"10.4161\/auto.4776","article-title":"Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans.","volume":"3","author":"M. L Florez-McClure","year":"2007","journal-title":"Autophagy"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0021-9258(18)53882-5","article-title":"Small heat shock proteins are molecular chaperones.","volume":"268","author":"U Jakob","year":"1993","journal-title":"J Biol Chem"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/ncb1477","article-title":"The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.","volume":"8","author":"S Tam","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/ncb1478","article-title":"Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.","volume":"8","author":"A Kitamura","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1091\/mbc.E05-06-0520","article-title":"The thioredoxin system protects ribosomes against stress-induced aggregation.","volume":"17","author":"J. D Rand","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"23802","DOI":"10.1074\/jbc.M500356200","article-title":"Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.","volume":"280","author":"D. C David","year":"2005","journal-title":"J Biol Chem"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1749-6632.1999.tb07824.x","article-title":"Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.","volume":"893","author":"M. P Mattson","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1385\/NMM:4:1-2:21","article-title":"Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases.","volume":"4","author":"M Hashimoto","year":"2003","journal-title":"Neuromolecular Med"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1074\/jbc.M105326200","article-title":"Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors.","volume":"277","author":"H. J Lee","year":"2002","journal-title":"J Biol Chem"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ncb863","article-title":"Polyglutamine protein aggregates are dynamic.","volume":"4","author":"S Kim","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1074\/jbc.275.1.409","article-title":"Activity and regulation of the centrosome-associated proteasome.","volume":"275","author":"R. P Fabunmi","year":"2000","journal-title":"J Biol Chem"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.","volume":"431","author":"M Arrasate","year":"2004","journal-title":"Nature"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.","volume":"416","author":"D. M Walsh","year":"2002","journal-title":"Nature"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","article-title":"Protein misfolding, functional amyloid, and human disease.","volume":"75","author":"F Chiti","year":"2006","journal-title":"Annu Rev Biochem"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"17624","DOI":"10.1074\/jbc.M800281200","article-title":"Phosphorylation by casein kinase 1 regulates tonicity-induced osmotic response element-binding protein\/tonicity enhancer-binding protein nucleocytoplasmic trafficking.","volume":"283","author":"S Xu","year":"2008","journal-title":"J Biol Chem"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"23293","DOI":"10.1074\/jbc.270.40.23293","article-title":"Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis.","volume":"270","author":"R Beyaert","year":"1995","journal-title":"J Biol Chem"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"30844","DOI":"10.1074\/jbc.M404651200","article-title":"Casein kinase 1alpha interacts with retinoid X receptor and interferes with agonist-induced apoptosis.","volume":"279","author":"Y Zhao","year":"2004","journal-title":"J Biol Chem"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/protein\/gzp037","article-title":"Short protein segments can drive a non-fibrillizing protein into the amyloid state.","volume":"22","author":"P. K Teng","year":"2009","journal-title":"Protein Eng Des Sel"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.1021\/bi034028+","article-title":"A peptide motif consisting of glycine, alanine, and valine is required for the fibrillization and cytotoxicity of human alpha-synuclein.","volume":"42","author":"H. N Du","year":"2003","journal-title":"Biochemistry"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nsb1195-990","article-title":"Structural model for the beta-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide.","volume":"2","author":"P. T Lansbury Jr","year":"1995","journal-title":"Nat Struct Biol"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"e8130","DOI":"10.1371\/journal.pone.0008130","article-title":"Characterization of detergent-insoluble proteins in ALS indicates a causal link between nitrative stress and aggregation in pathogenesis.","volume":"4","author":"M Basso","year":"2009","journal-title":"PLoS One"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.","volume":"305","author":"A Krogh","year":"2001","journal-title":"J Mol Biol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","article-title":"Improved prediction of signal peptides: SignalP 3.0.","volume":"340","author":"J. D Bendtsen","year":"2004","journal-title":"J Mol Biol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","article-title":"Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.","volume":"22","author":"W Li","year":"2006","journal-title":"Bioinformatics"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"D476","DOI":"10.1093\/nar\/gki107","article-title":"Inparanoid: a comprehensive database of eukaryotic orthologs.","volume":"33","author":"K. P O'Brien","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/45544","article-title":"Regulation of lifespan by sensory perception in Caenorhabditis elegans.","volume":"402","author":"J Apfeld","year":"1999","journal-title":"Nature"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.1000450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T09:36:38Z","timestamp":1636018598000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.1000450"}},"subtitle":[],"editor":[{"given":"Julie","family":"Ahringer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2010,8,10]]},"references-count":98,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2010,8,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.1000450","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.4877956.793489872","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.4877956.14304055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.4877956.4806054","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,10]]}}}