{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:57:07Z","timestamp":1778731027671,"version":"3.51.4"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T00:00:00Z","timestamp":1323734400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.1001219","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T21:51:47Z","timestamp":1323813107000},"page":"e1001219","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Hyperactive Neuroendocrine Secretion Causes Size, Feeding, and Metabolic Defects of C. elegans Bardet-Biedl Syndrome Mutants"],"prefix":"10.1371","volume":"9","author":[{"given":"Brian H.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supriya","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaveh","family":"Ashrafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2011,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/jmg.36.6.437","article-title":"New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey.","volume":"36","author":"P. L Beales","year":"1999","journal-title":"J Med Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ajmg.c.30231","article-title":"Making sense of cilia in disease: the human ciliopathies.","volume":"151C","author":"K Baker","year":"2009","journal-title":"American Journal of Medical Genetics Part C, Seminars in Medical Genetics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1172\/JCI37041","article-title":"Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy.","volume":"119","author":"N. A Zaghloul","year":"2009","journal-title":"J Clin Invest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2007.03.053","article-title":"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.","volume":"129","author":"M. V Nachury","year":"2007","journal-title":"Cell"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.cell.2010.05.015","article-title":"The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.","volume":"141","author":"H Jin","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1073\/pnas.0711027105","article-title":"Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.","volume":"105","author":"N. F Berbari","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1083\/jcb.200909183","article-title":"The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella.","volume":"187","author":"K-F Lechtreck","year":"2009","journal-title":"J Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/nature02030","article-title":"Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.","volume":"425","author":"S. J Ansley","year":"2003","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"17524","DOI":"10.1073\/pnas.0706618104","article-title":"Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function.","volume":"104","author":"P. L Tan","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/hmg\/ddp031","article-title":"Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling.","volume":"18","author":"S Seo","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1172\/JCI32357","article-title":"Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome.","volume":"118","author":"K Rahmouni","year":"2008","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cub.2007.08.034","article-title":"Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease.","volume":"17","author":"J. R Davenport","year":"2007","journal-title":"Curr Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"16588","DOI":"10.1073\/pnas.0405496101","article-title":"Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin.","volume":"101","author":"D. Y Nishimura","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00439-006-0197-y","article-title":"Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity.","volume":"120","author":"E. R Eichers","year":"2006","journal-title":"Hum Genet"},{"key":"ref15","first-page":"1","article-title":"Chemosensation in C. elegans.","author":"C. I Bargmann","year":"2006","journal-title":"WormBook"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cmet.2008.06.005","article-title":"Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.","volume":"8","author":"E. R Greer","year":"2008","journal-title":"Cell Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cmet.2008.04.012","article-title":"Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.","volume":"7","author":"S Srinivasan","year":"2008","journal-title":"Cell Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1101\/gad.1194004","article-title":"Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.","volume":"18","author":"O. E Blacque","year":"2004","journal-title":"Genes Dev"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature03818","article-title":"Functional coordination of intraflagellar transport motors.","volume":"436","author":"G Ou","year":"2005","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1101\/gad.867301","article-title":"Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family.","volume":"15","author":"S. B Pierce","year":"2001","journal-title":"Genes Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1000213","DOI":"10.1371\/journal.pgen.1000213","article-title":"A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan.","volume":"4","author":"B. H Lee","year":"2008","journal-title":"PLoS Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.cell.2006.12.031","article-title":"ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.","volume":"128","author":"G Kao","year":"2007","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nn1810","article-title":"PKC-1 regulates secretion of neuropeptides.","volume":"10","author":"D Sieburth","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0012-1606(86)90314-3","article-title":"Mutant sensory cilia in the nematode Caenorhabditis elegans.","volume":"117","author":"L. A Perkins","year":"1986","journal-title":"Dev Biol"},{"key":"ref25","first-page":"1","article-title":"Dauer.","author":"P. J Hu","year":"2007","journal-title":"WormBook"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1113\/jphysiol.2007.138321","article-title":"Tomosyn negatively regulates both synaptic transmitter and neuropeptide release at the C. elegans neuromuscular junction.","volume":"585","author":"E. O Gracheva","year":"2007","journal-title":"J Physiol (Lond)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/genetics\/130.1.105","article-title":"Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.","volume":"130","author":"J. J Vowels","year":"1992","journal-title":"Genetics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/nn1140","article-title":"Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1.","volume":"6","author":"C Rogers","year":"2003","journal-title":"Nat Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/ng.2007.12","article-title":"Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response.","volume":"39","author":"J. M Gerdes","year":"2007","journal-title":"Nat Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"19637","DOI":"10.1074\/jbc.272.32.19637","article-title":"Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis.","volume":"272","author":"K Ann","year":"1997","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.devcel.2008.03.002","article-title":"Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans.","volume":"14","author":"S Mukhopadhyay","year":"2008","journal-title":"Dev Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1091\/mbc.E05-12-1170","article-title":"Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans.","volume":"17","author":"T. R Mahoney","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1000283","DOI":"10.1371\/journal.pgen.1000283","article-title":"Profiling synaptic proteins identifies regulators of insulin secretion and lifespan.","volume":"4","author":"Q Ch'ng","year":"2008","journal-title":"PLoS Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1600-0854.2004.00195.x","article-title":"Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.","volume":"5","author":"T. R Zahn","year":"2004","journal-title":"Traffic"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201012116","article-title":"MKS and NPHP modules cooperate to establish basal body\/transition zone membrane associations and ciliary gate function during ciliogenesis.","volume":"192","author":"C. L Williams","journal-title":"J Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/genetics\/139.1.171","article-title":"Mutations affecting the chemosensory neurons of Caenorhabditis elegans.","volume":"139","author":"T. A Starich","year":"1995","journal-title":"Genetics"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"R126","DOI":"10.1186\/gb-2006-7-12-r126","article-title":"Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics.","volume":"7","author":"N Chen","year":"2006","journal-title":"Genome Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ng1739","article-title":"Polygenic control of Caenorhabditis elegans fat storage.","volume":"38","author":"H. Y Mak","year":"2006","journal-title":"Nat Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1523\/JNEUROSCI.0044-09.2009","article-title":"Intraflagellar transport\/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans.","volume":"29","author":"M Moussaif","year":"2009","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8664","DOI":"10.1073\/pnas.0402354101","article-title":"Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly.","volume":"101","author":"K Mykytyn","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0896-6273(02)01093-0","article-title":"Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase.","volume":"36","author":"M Fujiwara","year":"2002","journal-title":"Neuron"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/genetics\/157.3.1179","article-title":"The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks.","volume":"157","author":"L Davis","year":"2001","journal-title":"Genetics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.cmet.2010.08.013","article-title":"Regulation of C. elegans fat uptake and storage by Acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.","volume":"12","author":"B. C Mullaney","journal-title":"Cell Metab"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nchembio.534","article-title":"A whole-organism screen identifies new regulators of fat storage.","volume":"7","author":"G. A Lemieux","journal-title":"Nat Chem Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1371\/journal.pbio.1000060","article-title":"Rictor\/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.","volume":"7","author":"K. T Jones","year":"2009","journal-title":"PLoS Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/genetics\/133.4.897","article-title":"The genetics of feeding in Caenorhabditis elegans.","volume":"133","author":"L Avery","year":"1993","journal-title":"Genetics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/jez.1402530305","article-title":"Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans.","volume":"253","author":"L Avery","year":"1990","journal-title":"J Exp Zool"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/35000609","article-title":"Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant.","volume":"403","author":"J. Y Sze","year":"2000","journal-title":"Nature"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"E528","DOI":"10.1210\/jc.2010-2290","article-title":"Patients with bardet-biedl syndrome have hyperleptinemia suggestive of leptin resistance.","volume":"96","author":"P. P Feuillan","journal-title":"J Clin Endocrinol Metab"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/hmg\/ddi468","article-title":"Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function.","volume":"15","author":"H-J Yen","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1523\/JNEUROSCI.4312-06.2007","article-title":"Caenorhabditis elegans integrates the signals of butanone and food to enhance chemotaxis to butanone.","volume":"27","author":"I Torayama","year":"2007","journal-title":"J Neurosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/ncb1977","article-title":"Intraflagellar transport is required for polarized recycling of the TCR\/CD3 complex to the immune synapse.","volume":"11","author":"F Finetti","year":"2009","journal-title":"Nat Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans.","volume":"77","author":"S Brenner","year":"1974","journal-title":"Genetics"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"13496","DOI":"10.1073\/pnas.0506234102","article-title":"A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49.","volume":"102","author":"M. R Van Gilst","year":"2005","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.1001219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T20:04:47Z","timestamp":1686513887000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.1001219"}},"subtitle":[],"editor":[{"given":"Stuart K.","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2011,12,13]]},"references-count":54,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.1001219","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,13]]}}}