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J"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tibs.2012.11.001","article-title":"Translational control at the synapse: role of RNA regulators","volume":"38","author":"A Iacoangeli","year":"2013","journal-title":"Trends Biochem Sci"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuron.2012.01.030","article-title":"TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction","volume":"74","author":"J Penney","year":"2012","journal-title":"Neuron"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1002\/j.1460-2075.1992.tb05508.x","article-title":"mRNAs containing extensive secondary structure in their 5\u2032 non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E","volume":"11","author":"AE Koromilas","year":"1992","journal-title":"EMBO J"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"14002","DOI":"10.1074\/jbc.273.22.14002","article-title":"4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family","volume":"273","author":"F Poulin","year":"1998","journal-title":"J Biol Chem"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0014-5793(02)03694-3","article-title":"Localisation and regulation of the eIF4E-binding protein 4E-BP3","volume":"532","author":"M Kleijn","year":"2002","journal-title":"FEBS Lett"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1101\/gad.341505","article-title":"4E-BP functions as a metabolic brake used under stress conditions but not during normal growth","volume":"19","author":"AA Teleman","year":"2005","journal-title":"Genes Dev"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2010.10.007","article-title":"FOXO\/4E-BP signaling in drosophila muscles regulates organism-wide proteostasis during aging","volume":"143","author":"F Demontis","year":"2010","journal-title":"Cell"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nm1001-1128","article-title":"Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1","volume":"7","author":"K Tsukiyama-Kohara","year":"2001","journal-title":"Nat Med"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1172\/JCI29528","article-title":"Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2","volume":"117","author":"O Le Bacquer","year":"2007","journal-title":"J Clin Invest"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1158\/0008-5472.CAN-12-2395","article-title":"eIF4E\/4E-BP ratio predicts the efficacy of mTOR targeted therapies","volume":"72","author":"T Alain","year":"2012","journal-title":"Cancer Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1741-7015-7-14","article-title":"Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy","volume":"7","author":"C Millino","year":"2009","journal-title":"BMC Medicine"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1242\/jcs.097998","article-title":"The translational repressor 4E-BP mediates hypoxia-induced defects in myotome cells","volume":"125","author":"M Hidalgo","year":"2012","journal-title":"J Cell Sci"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1093\/emboj\/20.22.6414","article-title":"Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway","volume":"20","author":"H Wu","year":"2001","journal-title":"EMBO J"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"133","DOI":"10.18632\/aging.100436","article-title":"Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting","volume":"4","author":"AM Shum","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1101\/gad.1338705","article-title":"Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2","volume":"19","author":"O Nakagawa","year":"2005","journal-title":"Genes Dev"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1242\/dev.077875","article-title":"The conserved transcription factor Mef2 has multiple roles in adult Drosophila musculature formation","volume":"139","author":"C Soler","year":"2012","journal-title":"Development"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.cell.2012.11.040","article-title":"Multiple Autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95","volume":"151","author":"NP Tsai","year":"2012","journal-title":"Cell"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1126\/science.276.5317.1404","article-title":"Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C","volume":"276","author":"Q Lin","year":"1997","journal-title":"Science"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"18097","DOI":"10.1073\/pnas.1012826107","article-title":"Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy","volume":"107","author":"T Konno","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cardiores.2007.02.007","article-title":"Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility","volume":"74","author":"YX Wang","year":"2007","journal-title":"Cardiovasc Res"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1242\/dev.120.5.1251","article-title":"Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis","volume":"120","author":"DG Edmondson","year":"1994","journal-title":"Development"},{"key":"ref102","first-page":"161","article-title":"Muscular adaptations to resistance exercise in the elderly","volume":"4","author":"MV Narici","year":"2004","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/ptj\/73.6.361","article-title":"Effects of age and resistance training on skeletal muscle: a review","volume":"73","author":"JF Hopp","year":"1993","journal-title":"Phys Ther"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1242\/dev.123.1.345","article-title":"Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation","volume":"123","author":"T Piotrowski","year":"1996","journal-title":"Development"},{"key":"ref105","unstructured":"Westerfield M (2000) The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio). Univ of Oregon Press, Eugene."},{"key":"ref106","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/BF01843575","article-title":"Localization of epitopes and functional effects of two novel monoclonal antibodies against skeletal muscle myosin","volume":"11","author":"M Dan-Goor","year":"1990","journal-title":"J Muscle Res Cell Motil"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1261\/rna.79407","article-title":"Isolation of polysome-bound mRNA from solid tissues amenable for RT-PCR and profiling experiments","volume":"13","author":"MJ del Prete","year":"2007","journal-title":"RNA"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cub.2012.01.031","article-title":"Proteomic analysis of mammalian primary cilia","volume":"22","author":"H Ishikawa","year":"2012","journal-title":"Curr Biol"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.1001679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T05:35:23Z","timestamp":1646804123000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.1001679"}},"subtitle":[],"editor":[{"given":"Derek L.","family":"Stemple","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,10,15]]},"references-count":108,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.1001679","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,15]]}}}