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Jagannath","year":"2013","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cub.2009.12.034","article-title":"Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2","volume":"20","author":"S Shi","year":"2010","journal-title":"Curr Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"10074","DOI":"10.1073\/pnas.0601416103","article-title":"The BMAL1 C terminus regulates the circadian transcription feedback loop","volume":"103","author":"YB Kiyohara","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1046\/j.1365-2443.2000.00363.x","article-title":"Transactivation mechanisms of mouse clock transcription factors, mClock and mArnt3","volume":"5","author":"S Takahata","year":"2000","journal-title":"Genes 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Annayev","year":"2014","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/emboj.2012.1","article-title":"PML regulates PER2 nuclear localization and circadian function","volume":"31","author":"T Miki","year":"2012","journal-title":"EMBO J"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1101\/gad.564110","article-title":"The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors","volume":"24","author":"I Schmutz","year":"2010","journal-title":"Genes Dev"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature01314","article-title":"Rhythmic histone acetylation underlies transcription in the mammalian circadian clock","volume":"421","author":"J-P Etchegaray","year":"2003","journal-title":"Nature"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e1000052","DOI":"10.1371\/journal.pbio.1000052","article-title":"Network 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Neurosci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature11691","article-title":"Automated design of ligands to polypharmacological profiles","volume":"492","author":"J Besnard","year":"2012","journal-title":"Nature"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2011.10.002","article-title":"Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes","volume":"147","author":"NT Ingolia","year":"2011","journal-title":"Cell"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ng.846","article-title":"An integrated approach to characterize genetic interaction networks in yeast metabolism","volume":"43","author":"B Szappanos","year":"2011","journal-title":"Nat Genet"},{"key":"ref75","unstructured":"R Development Core Team (2011) R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing."},{"key":"ref76","unstructured":"Wu J, Irizarry RA, MacDonald J, Gentry J (n.d.) gcrma: background adjustment using sequence information (R package version 2.22.0)."},{"key":"ref77","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0748730410379711","article-title":"JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets","volume":"25","author":"ME Hughes","year":"2010","journal-title":"J Biol Rhythms"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","author":"WJ Youden","year":"1950","journal-title":"Cancer"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/bioinformatics\/btn654","article-title":"bioDBnet: the biological database network","volume":"25","author":"U Mudunuri","year":"2009","journal-title":"Bioinformatics"},{"key":"ref80","unstructured":"Dimitriadou E, Hornik K, Leisch F (n.d.) e1071: misc functions of the Department of Statistics (e1071), TU Wien. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cran.r-project.org\" xlink:type=\"simple\">http:\/\/cran.r-project.org<\/ext-link>."},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Baier D, Decker R, Schmidt-Thieme L, eds(2005) Data analysis and decision support. Berlin\/Heidelberg: Springer-Verlag. doi:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1007\/3-540-28397-8\" xlink:type=\"simple\">10.1007\/3-540-28397-8<\/ext-link>.","DOI":"10.1007\/3-540-28397-8"},{"key":"ref82","first-page":"528","article-title":"Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction","volume":"8","author":"RM Horton","year":"1990","journal-title":"Biotechniques"},{"issue":"3","key":"ref83","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ymeth.2009.03.001","article-title":"ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions","volume":"48","author":"D Schmidt","year":"2009","journal-title":"Methods"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/07420529609012662","article-title":"Methods of measuring phase shifts: why I continue to use an Aschoff type II procedure despite the skepticism of referees","volume":"13","author":"N Mrosovsky","year":"1996","journal-title":"Chronobiol Int"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/0748730413497190","article-title":"Photic phase-response curve in 2 strains of mice with impaired responsiveness to estrogens","volume":"28","author":"MS Blattner","year":"2013","journal-title":"J Biol Rhythms"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nprot.2006.37","article-title":"Production and purification of lentiviral vectors","volume":"1","author":"G Tiscornia","year":"2006","journal-title":"Nat Protoc"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/bioinformatics\/btn521","article-title":"WAVECLOCK: wavelet analysis of circadian oscillation","volume":"24","author":"TS Price","year":"2008","journal-title":"Bioinformatics"},{"key":"ref88","unstructured":"Bates D, Sarkar D (2007) lme4: linear mixed-effects models using S4 classes. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/CRAN.R-project.org\/\" xlink:type=\"simple\">http:\/\/CRAN.R-project.org\/<\/ext-link>"}],"container-title":["PLoS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.1001840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T18:05:15Z","timestamp":1589047515000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.1001840"}},"subtitle":[],"editor":[{"given":"Ueli","family":"Schibler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,4,15]]},"references-count":88,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.1001840","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,15]]}}}