{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:47:28Z","timestamp":1790768848858,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pbio.2002907","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000}}],"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.2002907","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T13:34:38Z","timestamp":1523885678000},"page":"e2002907","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content"],"prefix":"10.1371","volume":"16","author":[{"given":"Xiaomin","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook Wah","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Chieh","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene C.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arias","family":"Mifune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith E.","family":"Calvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frode","family":"Norheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna","family":"Abad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-5430","authenticated-orcid":true,"given":"Kathleen M.","family":"Giacomini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/cphy.c130024","article-title":"Energy metabolism in the liver","volume":"4","author":"L Rui","year":"2014","journal-title":"Compr Physiol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"LP Bechmann","year":"2012","journal-title":"J Hepatol"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"CJ Willer","year":"2013","journal-title":"Nat Genet"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCRESAHA.116.302888","article-title":"Are there genetic paths common to obesity, cardiovascular disease outcomes, and cardiovascular risk factors?","volume":"116","author":"T Rankinen","year":"2015","journal-title":"Circ Res"},{"issue":"38","key":"ref5","doi-asserted-by":"crossref","first-page":"E4006","DOI":"10.1073\/pnas.1413561111","article-title":"Genetic, anatomic, and clinical determinants of human serum sterol and vitamin D levels","volume":"111","author":"AR Stiles","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s11886-015-0610-z","article-title":"LDL, HDL, VLDL, and CVD Prevention: Lessons from Genetics?","volume":"17","author":"B Hewing","year":"2015","journal-title":"Curr Cardiol Rep"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13073-015-0172-0","article-title":"Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1","volume":"7","author":"T Seitz","year":"2015","journal-title":"Genome Med"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1073\/pnas.0730858100","article-title":"Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1","volume":"100","author":"Y Shu","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/00008571-200211000-00002","article-title":"Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences","volume":"12","author":"R Kerb","year":"2002","journal-title":"Pharmacogenetics"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bcp.2013.06.019","article-title":"Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration","volume":"86","author":"MV Tzvetkov","year":"2013","journal-title":"Biochem Pharmacol"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2217\/pgs.13.94","article-title":"OCT1 genetic variants influence the pharmacokinetics of morphine in children","volume":"14","author":"T Fukuda","year":"2013","journal-title":"Pharmacogenomics"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sj.clpt.6100275","article-title":"Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics","volume":"83","author":"Y Shu","year":"2008","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ajhg.2017.08.008","article-title":"Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport","volume":"101","author":"HI Kim","year":"2017","journal-title":"Am J Hum Genet"},{"issue":"27","key":"ref14","doi-asserted-by":"crossref","first-page":"9983","DOI":"10.1073\/pnas.1314939111","article-title":"OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin","volume":"111","author":"L Chen","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ecam\/nek009","article-title":"A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives","volume":"3","author":"D Lonsdale","year":"2006","journal-title":"Evid Based Complement Alternat Med"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00005072-197807000-00004","article-title":"Early edematous lesion of pyrithiamine induced acute thiamine deficient encephalopathy in the mouse","volume":"37","author":"I Watanabe","year":"1978","journal-title":"J Neuropathol Exp Neurol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"E578","DOI":"10.1152\/ajpendo.00093.2009","article-title":"The Randle cycle revisited: a new head for an old hat","volume":"297","author":"L Hue","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"7285","key":"ref18","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(63)91500-9","article-title":"The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus","volume":"1","author":"PJ Randle","year":"1963","journal-title":"Lancet"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.cell.2014.11.034","article-title":"Metabolic inflexibility: when mitochondrial indecision leads to metabolic gridlock","volume":"159","author":"DM Muoio","year":"2014","journal-title":"Cell"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3945\/an.114.007526","article-title":"Thiamin deficiency in people with obesity","volume":"6","author":"JC Kerns","year":"2015","journal-title":"Adv Nutr"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jcrc.2013.06.008","article-title":"The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis","volume":"29","author":"A Moskowitz","year":"2014","journal-title":"J Crit Care"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4239\/wjd.v5.i3.288","article-title":"Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?","volume":"5","author":"L Pacal","year":"2014","journal-title":"World J Diabetes"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1007\/s00125-007-0771-4","article-title":"High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease","volume":"50","author":"PJ Thornalley","year":"2007","journal-title":"Diabetologia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4137\/CMED.S13573","article-title":"Metabolic Benefits of Six-month Thiamine Supplementation in Patients With and Without Diabetes Mellitus Type 2","volume":"7","author":"O Al-Attas","year":"2014","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1007\/s00394-013-0534-6","article-title":"High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial","volume":"52","author":"F Alaei Shahmiri","year":"2013","journal-title":"Eur J Nutr"},{"issue":"12","key":"ref26","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1007\/s00125-004-1582-5","article-title":"High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic rats","volume":"47","author":"R Babaei-Jadidi","year":"2004","journal-title":"Diabetologia"},{"issue":"7675","key":"ref27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic effects on gene expression across human tissues","volume":"550","author":"GTEx Consortium","year":"2017","journal-title":"Nature"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"e1002078","DOI":"10.1371\/journal.pgen.1002078","article-title":"Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue","volume":"7","author":"F Innocenti","year":"2011","journal-title":"PLoS Genet"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/jhg.2015.107","article-title":"Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study","volume":"60","author":"J Li","year":"2015","journal-title":"J Hum Genet"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1194\/jlr.M076232","article-title":"A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms","volume":"58","author":"S Mack","year":"2017","journal-title":"J Lipid Res"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1093\/eurheartj\/ehr350","article-title":"Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes","volume":"33","author":"Q Qi","year":"2012","journal-title":"Eur Heart J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"18092","DOI":"10.1038\/srep18092","article-title":"Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits","volume":"6","author":"Y Deming","year":"2016","journal-title":"Sci Rep"},{"key":"ref33","article-title":"Exome-wide association study of plasma lipids in >300,000 individuals","author":"DJ Liu","year":"2017","journal-title":"Nat Genet"},{"issue":"7307","key":"ref34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09270","article-title":"Biological, clinical and population relevance of 95 loci for blood lipids","volume":"466","author":"TM Teslovich","year":"2010","journal-title":"Nature"},{"issue":"6319","key":"ref35","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf6814","article-title":"Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study","volume":"354","author":"FE Dewey","year":"2016","journal-title":"Science"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ng.3300","article-title":"The impact of low-frequency and rare variants on lipid levels","volume":"47","author":"I Surakka","year":"2015","journal-title":"Nat Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"11122","DOI":"10.1038\/ncomms11122","article-title":"Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA","volume":"7","author":"J Kettunen","year":"2016","journal-title":"Nat Commun"},{"key":"ref38","article-title":"Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease","author":"X Lu","year":"2017","journal-title":"Nat Genet"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2337\/db09-1471","article-title":"A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes","volume":"59","author":"AA Butler","year":"2010","journal-title":"Diabetes"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nmeth.1806","article-title":"A guide to analysis of mouse energy metabolism","volume":"9","author":"MH Tschop","year":"2011","journal-title":"Nat Methods"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnut.2016.00016","article-title":"Thiamine Deficiency in Tropical Pediatrics: New Insights into a Neglected but Vital Metabolic Challenge","volume":"3","author":"L Hiffler","year":"2016","journal-title":"Front Nutr"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neuroscience.2014.02.033","article-title":"Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK","volume":"267","author":"M Liu","year":"2014","journal-title":"Neuroscience"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/tpj.2015.78","article-title":"Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses, and drug-drug interactions","volume":"15","author":"C Arimany-Nardi","year":"2015","journal-title":"Pharmacogenomics J"},{"issue":"50","key":"ref44","doi-asserted-by":"crossref","first-page":"15772","DOI":"10.1021\/bi971845z","article-title":"Molecular mechanism of regulation of the pyruvate dehydrogenase complex from E. coli","volume":"36","author":"J Hennig","year":"1997","journal-title":"Biochemistry"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1203\/00006450-197307000-00003","article-title":"The effect of thiamine treatment on the activity of pyruvate dehydrogenase: relation of the treatment of Leigh's encephalomyelopathy","volume":"7","author":"FA Hommes","year":"1973","journal-title":"Pediatr Res"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ab.2009.03.040","article-title":"Monitoring phosphorylation of the pyruvate dehydrogenase complex","volume":"389","author":"MJ Rardin","year":"2009","journal-title":"Anal Biochem"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2337\/db10-0593","article-title":"Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis","volume":"60","author":"J Huang","year":"2011","journal-title":"Diabetes"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.cmet.2012.04.005","article-title":"Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility","volume":"15","author":"DM Muoio","year":"2012","journal-title":"Cell Metab"},{"key":"ref49","article-title":"Biochemistry","year":"2002"},{"issue":"12","key":"ref50","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.2337\/db13-0880","article-title":"Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis","volume":"62","author":"A von Wilamowitz-Moellendorff","year":"2013","journal-title":"Diabetes"},{"issue":"9\u201310","key":"ref51","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1242\/dmm.006239","article-title":"Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice","volume":"3","author":"JE Ayala","year":"2010","journal-title":"Dis Model Mech"},{"issue":"6852","key":"ref52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/35093050","article-title":"Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1","volume":"413","author":"JC Yoon","year":"2001","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev.nutr.27.061406.093734","article-title":"Regulation of lipolysis in adipocytes","volume":"27","author":"RE Duncan","year":"2007","journal-title":"Annu Rev Nutr"},{"issue":"9","key":"ref54","doi-asserted-by":"crossref","first-page":"e76060","DOI":"10.1371\/journal.pone.0076060","article-title":"Adipose weight gain during chronic insulin treatment of mice results from changes in lipid storage without affecting de novo synthesis of palmitate","volume":"8","author":"H Frikke-Schmidt","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2337\/diabetes.55.01.06.db05-0982","article-title":"Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin","volume":"55","author":"EE Kershaw","year":"2006","journal-title":"Diabetes"},{"issue":"10","key":"ref56","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.2337\/db11-0425","article-title":"Fatty acids, obesity, and insulin resistance: time for a reevaluation","volume":"60","author":"F Karpe","year":"2011","journal-title":"Diabetes"},{"issue":"5","key":"ref57","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2337\/diabetes.49.5.677","article-title":"Fuel selection in human skeletal muscle in insulin resistance: a reexamination","volume":"49","author":"DE Kelley","year":"2000","journal-title":"Diabetes"},{"issue":"46","key":"ref58","doi-asserted-by":"crossref","first-page":"16508","DOI":"10.1073\/pnas.1419104111","article-title":"Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance","volume":"111","author":"Y Rahimi","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"ref59","doi-asserted-by":"crossref","first-page":"12578","DOI":"10.1074\/jbc.M111.309559","article-title":"Acetyl-CoA carboxylase 2-\/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions","volume":"287","author":"L Abu-Elheiga","year":"2012","journal-title":"J Biol Chem"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.2337\/db12-0325","article-title":"VASP increases hepatic fatty acid oxidation by activating AMPK in mice","volume":"62","author":"S Tateya","year":"2013","journal-title":"Diabetes"},{"issue":"28","key":"ref61","doi-asserted-by":"crossref","first-page":"18933","DOI":"10.1074\/jbc.M512831200","article-title":"Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle","volume":"281","author":"TL Martin","year":"2006","journal-title":"J Biol Chem"},{"key":"ref62","article-title":"Animal and human calorimetry","author":"JA McLean","year":"1989"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-7075-11-10","article-title":"The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility","volume":"11","author":"S Zhang","year":"2014","journal-title":"Nutr Metab (Lond)"},{"issue":"5","key":"ref64","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2337\/diabetes.49.5.775","article-title":"Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding","volume":"49","author":"MJ Holness","year":"2000","journal-title":"Diabetes"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1038\/ncomms3316","article-title":"Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization","volume":"4","author":"Y Izumida","year":"2013","journal-title":"Nat Commun"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1161\/ATVBAHA.114.303458","article-title":"All low-density lipoprotein particles are not created equal","volume":"34","author":"RM Krauss","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/01.ATV.17.6.1082","article-title":"Associations of age, adiposity, menopause, and alcohol intake with low-density lipoprotein subclasses","volume":"17","author":"PT Williams","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1172\/JCI116541","article-title":"Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles","volume":"92","author":"GM Reaven","year":"1993","journal-title":"J Clin Invest"},{"issue":"12","key":"ref69","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1093\/jn\/104.12.1690","article-title":"Effects of thiamin deficiency and thiamin antagonists on serum and liver cholesterol levels and on cholesterol biosynthesis in rats","volume":"104","author":"CJ Gubler","year":"1974","journal-title":"J Nutr"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"12360","DOI":"10.1038\/ncomms12360","article-title":"An exome array study of the plasma metabolome","volume":"7","author":"EP Rhee","year":"2016","journal-title":"Nat Commun"},{"issue":"2","key":"ref71","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrg.2016.142","article-title":"Dissecting the genetics of complex traits using summary association statistics","volume":"18","author":"B Pasaniuc","year":"2017","journal-title":"Nat Rev Genet"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrm2336","article-title":"Cellular cholesterol trafficking and compartmentalization","volume":"9","author":"E Ikonen","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1194\/jlr.R200004-JLR200","article-title":"Metabolic origins and clinical significance of LDL heterogeneity","volume":"43","author":"KK Berneis","year":"2002","journal-title":"J Lipid Res"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0022-2275(20)39764-9","article-title":"Overproduction of small very low density lipoproteins (Sf 20\u201360) in moderate hypercholesterolemia: relationships between apolipoprotein B kinetics and plasma lipoproteins","volume":"36","author":"A Gaw","year":"1995","journal-title":"J Lipid Res"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pediatrneurol.2014.03.025","article-title":"Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence","volume":"51","author":"W Renthal","year":"2014","journal-title":"Pediatr Neurol"},{"issue":"2","key":"ref76","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S1464793105006974","article-title":"The evolution of human fatness and susceptibility to obesity: an ethological approach","volume":"81","author":"JC Wells","year":"2006","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"2","key":"ref77","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/alcalc\/agh106","article-title":"Thiamine administration in alcohol-dependent patients","volume":"40","author":"R Agabio","year":"2005","journal-title":"Alcohol Alcohol"},{"issue":"12","key":"ref78","doi-asserted-by":"crossref","first-page":"e53175","DOI":"10.1371\/journal.pone.0053175","article-title":"Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes","volume":"7","author":"JR Larkin","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"ref79","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.pcl.2009.07.002","article-title":"Nutritional deficiencies in obesity and after bariatric surgery","volume":"56","author":"SA Xanthakos","year":"2009","journal-title":"Pediatr Clin North Am"},{"issue":"10","key":"ref80","article-title":"Effect of High Dose Thiamine Therapy on Risk Factors in Type 2","volume":"03","author":"SS Alam","year":"2012","journal-title":"Diabetics. J Diabetes Metab"},{"issue":"3","key":"ref81","first-page":"153","article-title":"The impact of thiamine treatment in the diabetes mellitus","volume":"4","author":"KV Luong","year":"2012","journal-title":"J Clin Med Res"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"D799","DOI":"10.1093\/nar\/gku1202","article-title":"GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes","volume":"43","author":"JD Eicher","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"ref83","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1172\/JCI30558","article-title":"Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action","volume":"117","author":"Y Shu","year":"2007","journal-title":"J Clin Invest"},{"issue":"11","key":"ref84","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/jcph.144","article-title":"Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans","volume":"53","author":"KA Kim","year":"2013","journal-title":"J Clin Pharmacol"},{"issue":"6","key":"ref85","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/ajcn\/71.6.1611","article-title":"Reduced LDL particle size in children consuming a very-low-fat diet is related to parental LDL-subclass patterns","volume":"71","author":"DM Dreon","year":"2000","journal-title":"Am J Clin Nutr"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.2002907","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.2002907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T22:05:38Z","timestamp":1720217138000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.2002907"}},"subtitle":[],"editor":[{"given":"Nicole","family":"Soranzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":85,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.2002907","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]}}}