{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:08:04Z","timestamp":1790665684066,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pbio.2003880","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000}}],"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.2003880","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T17:25:20Z","timestamp":1556126720000},"page":"e2003880","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Glutamatergic neurons of the gigantocellular reticular nucleus shape locomotor pattern and rhythm in the freely behaving mouse"],"prefix":"10.1371","volume":"17","author":[{"given":"Maxime","family":"Lemieux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-3414","authenticated-orcid":true,"given":"Frederic","family":"Bretzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1152\/jn.00034.2003","article-title":"Mechanism for activation of locomotor centers in the spinal cord by stimulation of the mesencephalic locomotor region","volume":"90","author":"BR Noga","year":"2003","journal-title":"Journal of neurophysiology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1523\/JNEUROSCI.11-06-01691.1991","article-title":"The effect of selective brainstem or spinal cord lesions on treadmill locomotion evoked by stimulation of the mesencephalic or pontomedullary locomotor regions","volume":"11","author":"BR Noga","year":"1991","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF00236281","article-title":"Reversible cooling of the brainstem reveals areas required for mesencephalic locomotor region evoked treadmill locomotion","volume":"56","author":"SJ Shefchyk","year":"1984","journal-title":"Experimental brain research"},{"issue":"208","key":"ref4","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005972","article-title":"Deep brain stimulation of the midbrain locomotor region improves paretic hindlimb function after spinal cord injury in rats","volume":"5","author":"LC Bachmann","year":"2013","journal-title":"Science translational medicine"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jneumeth.2004.04.009","article-title":"A reliable technique for the induction of locomotor-like activity in the in vitro neonatal rat spinal cord using brainstem electrical stimulation","volume":"139","author":"E Zaporozhets","year":"2004","journal-title":"Journal of neuroscience methods"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1152\/jn.1986.55.2.375","article-title":"Discharge patterns of reticulospinal and other reticular neurons in chronic, unrestrained cats walking on a treadmill","volume":"55","author":"T Drew","year":"1986","journal-title":"Journal of neurophysiology"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1152\/jn.2000.84.5.2237","article-title":"Vestibulospinal and reticulospinal neuronal activity during locomotion in the intact cat. I. Walking on a level surface","volume":"84","author":"K Matsuyama","year":"2000","journal-title":"Journal of neurophysiology"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1152\/jn.1993.69.6.2232","article-title":"Activity of medullary reticulospinal neurons during fictive locomotion","volume":"69","author":"MC Perreault","year":"1993","journal-title":"Journal of neurophysiology"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1152\/jn.2000.84.5.2257","article-title":"Vestibulospinal and reticulospinal neuronal activity during locomotion in the intact cat. II. Walking on an inclined plane","volume":"84","author":"K Matsuyama","year":"2000","journal-title":"Journal of neurophysiology"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1152\/jn.2001.85.2.679","article-title":"Contributions of the reticulospinal system to the postural adjustments occurring during voluntary gait modifications","volume":"85","author":"SD Prentice","year":"2001","journal-title":"Journal of neurophysiology"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1152\/jn.1991.66.3.919","article-title":"Functional organization within the medullary reticular formation of the intact unanesthetized cat. III. Microstimulation during locomotion","volume":"66","author":"T Drew","year":"1991","journal-title":"Journal of neurophysiology"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/jn.1984.52.4.653","article-title":"Phase-dependent responses evoked in limb muscles by stimulation of medullary reticular formation during locomotion in thalamic cats","volume":"52","author":"T Drew","year":"1984","journal-title":"Journal of neurophysiology"},{"key":"ref13","article-title":"Differential modulation of descending signals from the reticulospinal system during reaching and locomotion","author":"KS Dyson","year":"2014","journal-title":"Journal of neurophysiology"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1152\/jn.1994.71.1.229","article-title":"Microstimulation of the medullary reticular formation during fictive locomotion","volume":"71","author":"MC Perreault","year":"1994","journal-title":"Journal of neurophysiology"},{"issue":"37","key":"ref15","doi-asserted-by":"crossref","first-page":"14681","DOI":"10.1523\/JNEUROSCI.5231-12.2013","article-title":"Lhx3-Chx10 reticulospinal neurons in locomotor circuits","volume":"33","author":"F Bretzner","year":"2013","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.cell.2015.10.074","article-title":"Descending Command Neurons in the Brainstem that Halt Locomotion","volume":"163","author":"J Bouvier","year":"2015","journal-title":"Cell"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mcn.2010.06.016","article-title":"A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons","volume":"45","author":"L Borgius","year":"2010","journal-title":"Molecular and cellular neurosciences"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mcn.2004.06.016","article-title":"Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons","volume":"28","author":"AC Cepeda-Nieto","year":"2005","journal-title":"Molecular and cellular neurosciences"},{"issue":"7680","key":"ref19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature24064","article-title":"Locomotor speed control circuits in the caudal brainstem","volume":"551","author":"P Capelli","year":"2017","journal-title":"Nature"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuron.2011.05.028","article-title":"Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons","volume":"71","author":"L Vong","year":"2011","journal-title":"Neuron"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1749-6632.1998.tb09039.x","article-title":"How do we approach the locomotor network in the mammalian spinal cord?","volume":"860","author":"H Hultborn","year":"1998","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnins.2016.00042","article-title":"Speed-Dependent Modulation of the Locomotor Behavior in Adult Mice Reveals Attractor and Transitional Gaits","volume":"10","author":"M Lemieux","year":"2016","journal-title":"Frontiers in neuroscience"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuron.2011.06.004","article-title":"Optogenetics in neural systems","volume":"71","author":"O Yizhar","year":"2011","journal-title":"Neuron"},{"issue":"21","key":"ref24","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1523\/JNEUROSCI.4203-15.2016","article-title":"Optogenetic Interrogation of Functional Synapse Formation by Corticospinal Tract Axons in the Injured Spinal Cord","volume":"36","author":"N Jayaprakash","year":"2016","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"7338","key":"ref25","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature09820","article-title":"Amygdala circuitry mediating reversible and bidirectional control of anxiety","volume":"471","author":"KM Tye","year":"2011","journal-title":"Nature"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0896-6273(00)80301-3","article-title":"Heterogeneous release properties of visualized individual hippocampal synapses","volume":"18","author":"VN Murthy","year":"1997","journal-title":"Neuron"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0896-6273(95)90223-6","article-title":"Facilitation and depression at single central synapses","volume":"14","author":"CF Stevens","year":"1995","journal-title":"Neuron"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1460-9568.2005.03932.x","article-title":"Modulation of synaptic transmission in neocortex by network activities","volume":"21","author":"S Crochet","year":"2005","journal-title":"The European journal of neuroscience"},{"issue":"6683","key":"ref29","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/30735","article-title":"Visual input evokes transient and strong shunting inhibition in visual cortical neurons","volume":"393","author":"LJ Borg-Graham","year":"1998","journal-title":"Nature"},{"issue":"22","key":"ref30","first-page":"9517","article-title":"Synaptic integration in striate cortical simple cells. The Journal of neuroscience: the official journal of the","volume":"18","author":"JA Hirsch","year":"1998","journal-title":"Society for Neuroscience"},{"issue":"17","key":"ref31","doi-asserted-by":"crossref","first-page":"10251","DOI":"10.1073\/pnas.95.17.10251","article-title":"Synaptic signaling in an active central network only moderately changes passive membrane properties","volume":"95","author":"M Raastad","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"27","key":"ref32","doi-asserted-by":"crossref","first-page":"6316","DOI":"10.1523\/JNEUROSCI.0843-05.2005","article-title":"Periodic high-conductance states in spinal neurons during scratch-like network activity in adult turtles","volume":"25","author":"A Alaburda","year":"2005","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1152\/jn.1990.64.3.782","article-title":"Functional organization within the medullary reticular formation of intact unanesthetized cat. II. Electromyographic activity evoked by microstimulation","volume":"64","author":"T Drew","year":"1990","journal-title":"Journal of neurophysiology"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/jn.1990.64.3.767","article-title":"Functional organization within the medullary reticular formation of intact unanesthetized cat. I. Movements evoked by microstimulation","volume":"64","author":"T Drew","year":"1990","journal-title":"Journal of neurophysiology"},{"issue":"Pt 21","key":"ref35","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1113\/jphysiol.2008.158105","article-title":"Differential origin of reticulospinal drive to motoneurons innervating trunk and hindlimb muscles in the mouse revealed by optical recording","volume":"586","author":"K Szokol","year":"2008","journal-title":"The Journal of physiology"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2009.01.018","article-title":"Imaging synaptically mediated responses produced by brainstem inputs onto identified spinal neurons in the neonatal mouse","volume":"180","author":"K Szokol","year":"2009","journal-title":"Journal of neuroscience methods"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1152\/jn.1982.48.3.737","article-title":"Setting and resetting of level of postural muscle tone in decerebrate cat by stimulation of brain stem","volume":"48","author":"S Mori","year":"1982","journal-title":"Journal of neurophysiology"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0168-0102(93)90090-D","article-title":"Pontine-induced generalized suppression of postural muscle tone in a reflexively standing acute decerebrate cat","volume":"17","author":"T Oka","year":"1993","journal-title":"Neuroscience research"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1152\/ajplegacy.1953.176.1.52","article-title":"Control of posture by reticular formation and cerebellum in the intract, anesthetized and unanesthetized and in the decerebrated cat","volume":"176","author":"JM Sprague","year":"1954","journal-title":"The American journal of physiology"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0306-4522(00)00586-8","article-title":"Medullary reticulospinal tract mediating the generalized motor inhibition in cats: parallel inhibitory mechanisms acting on motoneurons and on interneuronal transmission in reflex pathways","volume":"103","author":"K Takakusaki","year":"2001","journal-title":"Neuroscience"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1046\/j.1460-9568.2003.02973.x","article-title":"Networks of inhibitory and excitatory commissural interneurons mediating crossed reticulospinal actions","volume":"18","author":"BA Bannatyne","year":"2003","journal-title":"The European journal of neuroscience"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1523\/JNEUROSCI.23-05-01867.2003","article-title":"Neuronal basis of crossed actions from the reticular formation on feline hindlimb motoneurons","volume":"23","author":"E Jankowska","year":"2003","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"22","key":"ref43","doi-asserted-by":"crossref","first-page":"8041","DOI":"10.1523\/JNEUROSCI.23-22-08041.2003","article-title":"Are crossed actions of reticulospinal and vestibulospinal neurons on feline motoneurons mediated by the same or separate commissural neurons?","volume":"23","author":"P Krutki","year":"2003","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"12","key":"ref44","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1523\/JNEUROSCI.5486-10.2011","article-title":"Organization of functional synaptic connections between medullary reticulospinal neurons and lumbar descending commissural interneurons in the neonatal mouse","volume":"31","author":"K Szokol","year":"2011","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nn.4266","article-title":"Biophysical constraints of optogenetic inhibition at presynaptic terminals","volume":"19","author":"M Mahn","year":"2016","journal-title":"Nat Neurosci"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0306-4522(93)90160-H","article-title":"Mechanisms of supraspinal correction of locomotor activity generator","volume":"52","author":"AM Degtyarenko","year":"1993","journal-title":"Neuroscience"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0006-8993(72)90139-4","article-title":"The effect of different descending systems on flexor and extensor activity during locomotion","volume":"40","author":"GN Orlovsky","year":"1972","journal-title":"Brain research"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nn.2482","article-title":"Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion","volume":"13","author":"M Hagglund","year":"2010","journal-title":"Nat Neurosci"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1152\/jn.00136.2005","article-title":"Stimulation of the parapyramidal region of the neonatal rat brain stem produces locomotor-like activity involving spinal 5-HT7 and 5-HT2A receptors","volume":"94","author":"J Liu","year":"2005","journal-title":"Journal of neurophysiology"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.cub.2013.03.066","article-title":"Hindbrain V2a neurons in the excitation of spinal locomotor circuits during zebrafish swimming","volume":"23","author":"Y Kimura","year":"2013","journal-title":"Current biology: CB"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1073\/pnas.1012185108","article-title":"A structural and functional ground plan for neurons in the hindbrain of zebrafish","volume":"108","author":"A Kinkhabwala","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1152\/jn.01381.2007","article-title":"Neurons in the pontomedullary reticular formation signal posture and movement both as an integrated behavior and independently","volume":"100","author":"B Schepens","year":"2008","journal-title":"Journal of neurophysiology"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1152\/jn.91013.2008","article-title":"The pontomedullary reticular formation contributes to the compensatory postural responses observed following removal of the support surface in the standing cat","volume":"101","author":"PJ Stapley","year":"2009","journal-title":"Journal of neurophysiology"},{"issue":"11","key":"ref54","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.celrep.2016.05.029","article-title":"A Specific Population of Reticulospinal Neurons Controls the Termination of Locomotion","volume":"15","author":"L Juvin","year":"2016","journal-title":"Cell reports"},{"issue":"10","key":"ref55","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1523\/JNEUROSCI.22-10-04229.2002","article-title":"Sensory activation and role of inhibitory reticulospinal neurons that stop swimming in hatchling frog tadpoles","volume":"22","author":"R Perrins","year":"2002","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"20","key":"ref56","first-page":"2610","article-title":"A Hardwired Circuit Supplemented with Endocannabinoids Encodes Behavioral Choice in Zebrafish. Current biology","volume":"25","author":"J Song","year":"2015","journal-title":"CB"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0301-0082(87)90010-4","article-title":"Integration of posture and locomotion in acute decerebrate cats and in awake, freely moving cats","volume":"28","author":"S Mori","year":"1987","journal-title":"Progress in neurobiology"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0306-4522(03)00542-6","article-title":"Medullary reticulospinal tract mediating a generalized motor inhibition in cats: III. Functional organization of spinal interneurons in the lower lumbar segments","volume":"121","author":"K Takakusaki","year":"2003","journal-title":"Neuroscience"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2007.10.018","article-title":"Different patterns of freezing behavior organized in the periaqueductal gray of rats: association with different types of anxiety","volume":"188","author":"ML Brandao","year":"2008","journal-title":"Behavioural brain research"},{"issue":"20","key":"ref60","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/j.cub.2013.08.015","article-title":"Rapid innate defensive responses of mice to looming visual stimuli","volume":"23","author":"M Yilmaz","year":"2013","journal-title":"Current biology: CB"},{"issue":"23","key":"ref61","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.1523\/JNEUROSCI.0445-12.2012","article-title":"Irregular Breathing in Mice following Genetic Ablation of V2a Neurons","volume":"32","author":"SA Crone","year":"2012","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1523\/JNEUROSCI.4885-09.2010","article-title":"Readiness discharge for spontaneous initiation of walking in crayfish","volume":"30","author":"K Kagaya","year":"2010","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"7","key":"ref63","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2108\/zsj.30.591","article-title":"Characterization of locomotor-related spike activity in protocerebrum of freely walking cricket","volume":"30","author":"K Kai","year":"2013","journal-title":"Zoolog Sci"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.cub.2018.02.007","article-title":"Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse","volume":"28","author":"N Josset","year":"2018","journal-title":"Current biology: CB"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.2003880","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.2003880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:54:12Z","timestamp":1589025252000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.2003880"}},"subtitle":[],"editor":[{"given":"Marie-Claude","family":"Perreault","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,24]]},"references-count":64,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.2003880","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pbio.2003880","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,24]]}}}