{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:50:38Z","timestamp":1790383838228,"version":"4.1.0"},"reference-count":100,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.2005326","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T17:24:36Z","timestamp":1559755476000},"page":"e2005326","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["NGL-3 in the regulation of brain development, Akt\/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors"],"prefix":"10.1371","volume":"17","author":[{"given":"Hyejin","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyong","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungdeok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihye","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanseul","family":"Kweon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haram","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muwon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5518-6584","authenticated-orcid":true,"given":"Eunjoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tins.2013.06.002","article-title":"Protein tyrosine phosphatases PTPdelta, PTPsigma, and LAR: presynaptic hubs for synapse organization","volume":"36","author":"H Takahashi","year":"2013","journal-title":"Trends in neurosciences"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.conb.2012.02.012","article-title":"The role of neurexins and neuroligins in the formation, maturation, and function of vertebrate synapses","volume":"22","author":"DD Krueger","year":"2012","journal-title":"Current opinion in neurobiology"},{"key":"ref3","article-title":"Genetics and Cell Biology of Building Specific Synapse Connectivity","author":"K Shen","year":"2010","journal-title":"Annual review of neuroscience"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tcb.2013.07.004","article-title":"LAR-RPTPs: synaptic adhesion molecules that shape synapse development","volume":"23","author":"JW Um","year":"2013","journal-title":"Trends in cell biology"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"a005694","DOI":"10.1101\/cshperspect.a005694","article-title":"Synaptic cell adhesion","volume":"4","author":"M Missler","year":"2012","journal-title":"Cold Spring Harbor perspectives in biology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/978-3-7091-0932-8_19","article-title":"Synaptic dysfunction and intellectual disability","volume":"970","author":"P Valnegri","year":"2012","journal-title":"Advances in experimental medicine and biology"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tins.2015.06.004","article-title":"The cellular and molecular landscape of neuroligins","volume":"38","author":"MA Bemben","year":"2015","journal-title":"Trends in neurosciences"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/nrn.2015.3","article-title":"Specification of synaptic connectivity by cell surface interactions","volume":"17","author":"J de Wit","year":"2016","journal-title":"Nature reviews Neuroscience"},{"key":"ref9","article-title":"The balancing act of GABAergic synapse organizers","author":"J Ko","year":"2015","journal-title":"Trends in molecular medicine"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2017.10.024","article-title":"Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits","volume":"171","author":"TC Sudhof","year":"2017","journal-title":"Cell"},{"key":"ref11","article-title":"Neural Glycosylphosphatidylinositol-Anchored Proteins in Synaptic Specification","author":"JW Um","year":"2017","journal-title":"Trends in cell biology"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrn2075","article-title":"Cell adhesion molecules: signalling functions at the synapse","volume":"8","author":"MB Dalva","year":"2007","journal-title":"Nature reviews Neuroscience"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.conb.2008.07.014","article-title":"Signaling by synaptogenic molecules","volume":"18","author":"T Biederer","year":"2008","journal-title":"Current opinion in neurobiology"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.conb.2010.08.016","article-title":"Synaptic organizing complexes","volume":"21","author":"TJ Siddiqui","year":"2011","journal-title":"Current opinion in neurobiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.conb.2017.02.002","article-title":"The C1q complement family of synaptic organizers: not just complementary","volume":"45","author":"M. Yuzaki","year":"2017","journal-title":"Current opinion in neurobiology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.conb.2017.03.005","article-title":"Synaptic adhesion molecules and excitatory synaptic transmission","volume":"45","author":"S Jang","year":"2017","journal-title":"Current opinion in neurobiology"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/nn1763","article-title":"NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation","volume":"9","author":"S Kim","year":"2006","journal-title":"Nature neuroscience"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/nn1148","article-title":"The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons","volume":"6","author":"JC Lin","year":"2003","journal-title":"Nature neuroscience"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcn.2009.05.008","article-title":"The NGL family of leucine-rich repeat-containing synaptic adhesion molecules","volume":"42","author":"J Woo","year":"2009","journal-title":"Molecular and cellular neurosciences"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mcn.2009.05.008","article-title":"The NGL family of leucine-rich repeat-containing synaptic adhesion molecules","volume":"42","author":"J Woo","year":"2009","journal-title":"Molecular and cellular neurosciences"},{"issue":"18","key":"ref21","doi-asserted-by":"crossref","first-page":"13966","DOI":"10.1074\/jbc.M109.061127","article-title":"Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation","volume":"285","author":"SK Kwon","year":"2010","journal-title":"The Journal of biological chemistry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nn.2279","article-title":"Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses","volume":"12","author":"J Woo","year":"2009","journal-title":"Nature neuroscience"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2010.12.024","article-title":"Postsynaptic TrkC and presynaptic PTPsigma function as a bidirectional excitatory synaptic organizing complex","volume":"69","author":"H Takahashi","year":"2011","journal-title":"Neuron"},{"issue":"24","key":"ref24","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1093\/hmg\/ddr418","article-title":"The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPdelta and RhoGAP2","volume":"20","author":"P Valnegri","year":"2011","journal-title":"Human molecular genetics"},{"issue":"38","key":"ref25","doi-asserted-by":"crossref","first-page":"13485","DOI":"10.1523\/JNEUROSCI.2136-11.2011","article-title":"IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase delta","volume":"31","author":"T Yoshida","year":"2011","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1523\/JNEUROSCI.4637-11.2012","article-title":"Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule","volume":"32","author":"T Yoshida","year":"2012","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nn.3040","article-title":"Selective control of inhibitory synapse development by Slitrk3-PTPdelta trans-synaptic interaction","volume":"15","author":"H Takahashi","year":"2012","journal-title":"Nature neuroscience"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1073\/pnas.1209881110","article-title":"Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases","volume":"110","author":"YS Yim","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref29","article-title":"Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion","author":"Y Li","year":"2015","journal-title":"Cell reports"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"26676","DOI":"10.1038\/srep26676","article-title":"SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development","volume":"6","author":"Y Choi","year":"2016","journal-title":"Scientific reports"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1146\/annurev.biochem.76.060805.160029","article-title":"The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View","volume":"76","author":"M Sheng","year":"2007","journal-title":"Annual review of biochemistry"},{"issue":"48","key":"ref32","doi-asserted-by":"crossref","first-page":"28596","DOI":"10.1074\/jbc.R115.652750","article-title":"Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications","volume":"290","author":"MP Lussier","year":"2015","journal-title":"The Journal of biological chemistry"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1523\/JNEUROSCI.21-09-03063.2001","article-title":"An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing","volume":"21","author":"DB Scott","year":"2001","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","article-title":"mTOR Signaling in Growth, Metabolism, and Disease","volume":"169","author":"RA Saxton","year":"2017","journal-title":"Cell"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2007.01.029","article-title":"LTP inhibits LTD in the hippocampus via regulation of GSK3beta","volume":"53","author":"S Peineau","year":"2007","journal-title":"Neuron"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrn2867","article-title":"Long-term depression in the CNS","volume":"11","author":"GL Collingridge","year":"2010","journal-title":"Nature reviews Neuroscience"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0166-2236(92)90049-E","article-title":"Protein kinase C modulation of NMDA currents: an important link for LTP induction","volume":"15","author":"Y Ben-Ari","year":"1992","journal-title":"Trends in neurosciences"},{"issue":"16","key":"ref38","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1021\/jm000117y","article-title":"3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth","volume":"43","author":"Y Hu","year":"2000","journal-title":"J Med Chem"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1535-6108(03)00303-9","article-title":"A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells","volume":"4","author":"TR Kau","year":"2003","journal-title":"Cancer cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"35660","DOI":"10.1038\/srep35660","article-title":"AKT\/GSK3beta signaling pathway is critically involved in human pluripotent stem cell survival","volume":"6","author":"L Romorini","year":"2016","journal-title":"Scientific reports"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2004.09.012","article-title":"LTP and LTD: an embarrassment of riches","volume":"44","author":"RC Malenka","year":"2004","journal-title":"Neuron"},{"issue":"8","key":"ref42","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/ng.190","article-title":"PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome","volume":"40","author":"B Schormair","year":"2008","journal-title":"Nature genetics"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/mds.23459","article-title":"Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome","volume":"26","author":"Q Yang","year":"2011","journal-title":"Movement disorders: official journal of the Movement Disorder Society"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.sleep.2012.03.012","article-title":"Restless legs syndrome in Czech patients with multiple sclerosis: an epidemiological and genetic study","volume":"13","author":"J Vavrova","year":"2012","journal-title":"Sleep Med"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/mp.2009.57","article-title":"Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes","volume":"15","author":"J Elia","year":"2010","journal-title":"Molecular psychiatry"},{"issue":"7304","key":"ref46","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09146","article-title":"Functional impact of global rare copy number variation in autism spectrum disorders","volume":"466","author":"D Pinto","year":"2010","journal-title":"Nature"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.neuron.2011.11.007","article-title":"High frequencies of de novo CNVs in bipolar disorder and schizophrenia","volume":"72","author":"D Malhotra","year":"2011","journal-title":"Neuron"},{"issue":"7215","key":"ref48","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nature07456","article-title":"Neuroligins and neurexins link synaptic function to cognitive disease","volume":"455","author":"TC Sudhof","year":"2008","journal-title":"Nature"},{"issue":"4","key":"ref49","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.neuron.2015.07.033","article-title":"Excitatory\/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders","volume":"87","author":"SB Nelson","year":"2015","journal-title":"Neuron"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/bies.201500004","article-title":"Neuronal hyperactivity\u2014A key defect in Alzheimer's disease?","volume":"37","author":"MA Busche","year":"2015","journal-title":"Bioessays"},{"issue":"7363","key":"ref51","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nature10360","article-title":"Neocortical excitation\/inhibition balance in information processing and social dysfunction","volume":"477","author":"O Yizhar","year":"2011","journal-title":"Nature"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1152\/physrev.00016.2007","article-title":"Dendritic excitability and synaptic plasticity","volume":"88","author":"PJ Sjostrom","year":"2008","journal-title":"Physiological reviews"},{"issue":"4931","key":"ref53","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.2573153","article-title":"Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons","volume":"246","author":"P Sah","year":"1989","journal-title":"Science"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nn1178","article-title":"LTP is accompanied by an enhanced local excitability of pyramidal neuron dendrites","volume":"7","author":"A Frick","year":"2004","journal-title":"Nature neuroscience"},{"issue":"21","key":"ref55","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1523\/JNEUROSCI.20-21-07871.2000","article-title":"Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus","volume":"20","author":"H Awad","year":"2000","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"6710","key":"ref56","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/24790","article-title":"Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein","volume":"396","author":"M Migaud","year":"1998","journal-title":"Nature"},{"issue":"4","key":"ref57","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nn1416","article-title":"LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses","volume":"8","author":"AW Dunah","year":"2005","journal-title":"Nature neuroscience"},{"issue":"12","key":"ref58","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1093\/emboj\/19.12.2775","article-title":"Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice","volume":"19","author":"N Uetani","year":"2000","journal-title":"The EMBO journal"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/6859","article-title":"Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma","volume":"21","author":"M Elchebly","year":"1999","journal-title":"Nature genetics"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/6866","article-title":"Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma","volume":"21","author":"MJ Wallace","year":"1999","journal-title":"Nature genetics"},{"issue":"6468","key":"ref61","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/368249a0","article-title":"Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements","volume":"368","author":"R Klein","year":"1994","journal-title":"Nature"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cub.2009.12.030","article-title":"A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation","volume":"20","author":"A Pavlowsky","year":"2010","journal-title":"Current biology: CB"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"6613","DOI":"10.1038\/srep06613","article-title":"IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours","volume":"4","author":"M Yasumura","year":"2014","journal-title":"Scientific reports"},{"issue":"5","key":"ref64","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.2125","article-title":"Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice","volume":"16","author":"SV Shmelkov","year":"2010","journal-title":"Nature medicine"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/mp.2008.97","article-title":"Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities","volume":"15","author":"K Katayama","year":"2010","journal-title":"Molecular psychiatry"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.tibs.2004.03.006","article-title":"Advances in protein kinase B signalling: AKTion on multiple fronts","volume":"29","author":"DP Brazil","year":"2004","journal-title":"Trends in biochemical sciences"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1006\/excr.1999.4690","article-title":"The regulation and activities of the multifunctional serine\/threonine kinase Akt\/PKB","volume":"253","author":"ES Kandel","year":"1999","journal-title":"Experimental cell research"},{"issue":"10","key":"ref68","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","article-title":"Akt signalling in health and disease","volume":"23","author":"I Hers","year":"2011","journal-title":"Cellular signalling"},{"issue":"5300","key":"ref69","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1126\/science.275.5300.661","article-title":"Regulation of neuronal survival by the serine-threonine protein kinase Akt","volume":"275","author":"H Dudek","year":"1997","journal-title":"Science"},{"issue":"1","key":"ref70","first-page":"299","article-title":"Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injury","volume":"20","author":"ZZ Chong","year":"2005","journal-title":"Histology and histopathology"},{"issue":"3","key":"ref71","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12031-016-0872-y","article-title":"Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases","volume":"61","author":"L Wang","year":"2017","journal-title":"Journal of molecular neuroscience: MN"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnmol.2012.00033","article-title":"AKT\/GSK3 signaling pathway and schizophrenia","volume":"5","author":"ES Emamian","year":"2012","journal-title":"Frontiers in molecular neuroscience"},{"issue":"8","key":"ref73","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrn2870","article-title":"GSK3 signalling in neural development","volume":"11","author":"EM Hur","year":"2010","journal-title":"Nature reviews Neuroscience"},{"issue":"2","key":"ref74","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1073\/pnas.1214718110","article-title":"Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling","volume":"110","author":"EC Budreck","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"33","key":"ref75","doi-asserted-by":"crossref","first-page":"13764","DOI":"10.1073\/pnas.1111093108","article-title":"Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function","volume":"108","author":"M Etherton","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"ref76","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.neuron.2009.12.019","article-title":"LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation","volume":"64","author":"J de Wit","year":"2009","journal-title":"Neuron"},{"issue":"5","key":"ref77","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tins.2012.03.003","article-title":"EphBs: an integral link between synaptic function and synaptopathies","volume":"35","author":"SI Sheffler-Collins","year":"2012","journal-title":"Trends in neurosciences"},{"issue":"5","key":"ref78","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.neuron.2012.01.018","article-title":"FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development","volume":"73","author":"ML O'Sullivan","year":"2012","journal-title":"Neuron"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.neuro.25.112701.142758","article-title":"AMPA receptor trafficking and synaptic plasticity","volume":"25","author":"R Malinow","year":"2002","journal-title":"Annual review of neuroscience"},{"issue":"3","key":"ref80","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.conb.2011.12.006","article-title":"Regulation of AMPA receptor trafficking and synaptic plasticity","volume":"22","author":"V Anggono","year":"2012","journal-title":"Current opinion in neurobiology"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.24.1.1","article-title":"PDZ domains and the organization of supramolecular complexes","volume":"24","author":"M Sheng","year":"2001","journal-title":"Annual review of neuroscience"},{"issue":"12","key":"ref82","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a005678","article-title":"The postsynaptic organization of synapses","volume":"3","author":"M Sheng","year":"2011","journal-title":"Cold Spring Harbor perspectives in biology"},{"issue":"4","key":"ref83","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1601-183X.2007.00361.x","article-title":"Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness","volume":"7","author":"W Zhang","year":"2008","journal-title":"Genes, brain, and behavior"},{"issue":"47","key":"ref84","doi-asserted-by":"crossref","first-page":"15779","DOI":"10.1523\/JNEUROSCI.1141-14.2014","article-title":"Netrin-G\/NGL complexes encode functional synaptic diversification","volume":"34","author":"H Matsukawa","year":"2014","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"13","key":"ref85","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1016\/j.celrep.2018.05.087","article-title":"NGL-2 Deletion Leads to Autistic-like Behaviors Responsive to NMDAR Modulation","volume":"23","author":"SM Um","year":"2018","journal-title":"Cell reports"},{"issue":"4","key":"ref86","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.neuron.2012.10.013","article-title":"NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons","volume":"76","author":"LA DeNardo","year":"2012","journal-title":"Neuron"},{"issue":"5221","key":"ref87","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1126\/science.7618085","article-title":"Strain-dependent epithelial defects in mice lacking the EGF receptor","volume":"269","author":"M Sibilia","year":"1995","journal-title":"Science"},{"issue":"5221","key":"ref88","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.7618084","article-title":"Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype","volume":"269","author":"DW Threadgill","year":"1995","journal-title":"Science"},{"issue":"4","key":"ref89","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0306-4522(97)00165-6","article-title":"Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses","volume":"80","author":"EH Owen","year":"1997","journal-title":"Neuroscience"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev.pharmtox.011008.145634","article-title":"Akt\/GSK3 signaling in the action of psychotropic drugs","volume":"49","author":"JM Beaulieu","year":"2009","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fnmol.2012.00013","article-title":"A pivotal role of GSK-3 in synaptic plasticity","volume":"5","author":"CA Bradley","year":"2012","journal-title":"Frontiers in molecular neuroscience"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fnmol.2011.00038","article-title":"Beyond cAMP: The Regulation of Akt and GSK3 by Dopamine Receptors","volume":"4","author":"JM Beaulieu","year":"2011","journal-title":"Frontiers in molecular neuroscience"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnmol.2011.00017","article-title":"GSK3 and Alzheimer's Disease: Facts and Fiction","volume":"4","author":"A Kremer","year":"2011","journal-title":"Frontiers in molecular neuroscience"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2012.00001","article-title":"GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder","volume":"5","author":"AJ Valvezan","year":"2012","journal-title":"Frontiers in molecular neuroscience"},{"key":"ref95","article-title":"PTPRD: neurobiology, genetics, and initial pharmacology of a pleiotropic contributor to brain phenotypes","author":"GR Uhl","year":"2019","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"1633","key":"ref96","doi-asserted-by":"crossref","first-page":"20130158","DOI":"10.1098\/rstb.2013.0158","article-title":"Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin\/gamma-secretase","volume":"369","author":"H Lee","year":"2014","journal-title":"Philosophical transactions of the Royal Society of London Series B"},{"issue":"1\u20132","key":"ref97","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jns.2006.11.021","article-title":"Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators","volume":"259","author":"VW Yong","year":"2007","journal-title":"Journal of the neurological sciences"},{"issue":"11","key":"ref98","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrn3320","article-title":"Synaptic circuit remodelling by matrix metalloproteinases in health and disease","volume":"13","author":"GW Huntley","year":"2012","journal-title":"Nature reviews Neuroscience"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"681385","DOI":"10.1155\/2011\/681385","article-title":"Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy","volume":"2011","author":"H Mizoguchi","year":"2011","journal-title":"Biochemistry research international"},{"issue":"2","key":"ref100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrneurol.2009.218","article-title":"The secretases: enzymes with therapeutic potential in Alzheimer disease","volume":"6","author":"B De Strooper","year":"2010","journal-title":"Nat Rev Neurol"}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.2005326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:44:56Z","timestamp":1589031896000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.2005326"}},"subtitle":[],"editor":[{"given":"Matthew","family":"Dalva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,5]]},"references-count":100,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.2005326","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,5]]}}}