{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:28:58Z","timestamp":1790206138159,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.2006519","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T17:22:46Z","timestamp":1536600166000},"page":"e2006519","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":67,"title":["Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-3899","authenticated-orcid":true,"given":"Haojun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Ralle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Wolfgang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Dhawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason L.","family":"Burkhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack H.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. William","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Haughey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Lutsenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"issue":"5 Suppl","key":"ref1","doi-asserted-by":"crossref","first-page":"1029S","DOI":"10.1093\/ajcn\/67.5.1029S","article-title":"Diagnosis and therapy of Menkes syndrome, a genetic form of copper deficiency","volume":"67","author":"SG Kaler","year":"1998","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s007950200007","article-title":"Wilson disease","volume":"35","author":"M Harada","year":"2002","journal-title":"Med Electron Microsc"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1442-200x.1999.01095.x","article-title":"Clinical manifestations and treatment of Menkes disease and its variants","volume":"41","author":"H Kodama","year":"1999","journal-title":"Pediatr Int"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"8343","DOI":"10.1074\/jbc.M607496200","article-title":"High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease","volume":"282","author":"D Huster","year":"2007","journal-title":"J Biol Chem"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1039\/b711118p","article-title":"Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism","volume":"3","author":"D Huster","year":"2007","journal-title":"Mol Biosyst"},{"issue":"1\u20133","key":"ref6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1385\/BTER:114:1:19","article-title":"Assessment of copper and lipid profile in obese children and adolescents","volume":"114","author":"SC Lima","year":"2006","journal-title":"Biol Trace Elem Res"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1111\/j.1600-6143.2010.03071.x","article-title":"Fulminant Wilson&apos;s disease requiring liver transplantation in one monozygotic twin despite identical genetic mutation","volume":"10","author":"KM Kegley","year":"2010","journal-title":"Am J Transplant"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000176990","article-title":"Copper deficiency effects on cardiovascular system and lipid metabolism in the rat; the role of dietary proteins and excessive zinc","volume":"29","author":"KL Stemmer","year":"1985","journal-title":"Ann Nutr Metab"},{"issue":"13\u201314","key":"ref9","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.clinbiochem.2010.06.016","article-title":"Effect of valproic acid treatment on copper availability in adult epileptic patients","volume":"43","author":"N Lampon","year":"2010","journal-title":"Clin Biochem"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1038\/ajg.2010.170","article-title":"A role for low hepatic copper concentrations in nonalcoholic Fatty liver disease","volume":"105","author":"E Aigner","year":"2010","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.gastro.2017.09.019","article-title":"The Function of ATPase Copper Transporter ATP7","volume":"154","author":"H Pierson","year":"2018","journal-title":"B in Intestine. Gastroenterology"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nchembio.2098","article-title":"Copper regulates cyclic-AMP-dependent lipolysis","volume":"12","author":"L Krishnamoorthy","year":"2016","journal-title":"Nat Chem Biol"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1248\/bpb.28.413","article-title":"Molecular cloning and characterization of rat semicarbazide-sensitive amine oxidase","volume":"28","author":"Y Ochiai","year":"2005","journal-title":"Biol Pharm Bull"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/002215540104900208","article-title":"Tissue activity and cellular localization of human semicarbazide-sensitive amine oxidase","volume":"49","author":"N Andres","year":"2001","journal-title":"J Histochem Cytochem"},{"issue":"2","key":"ref15","first-page":"172","article-title":"The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function","volume":"2","author":"T Noonan","year":"2013","journal-title":"Am J Clin Exp Immunol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2353\/ajpath.2009.080612","article-title":"Semicarbazide-sensitive amine oxidase\/vascular adhesion protein-1 deficiency reduces leukocyte infiltration into adipose tissue and favors fat deposition","volume":"174","author":"S Bour","year":"2009","journal-title":"Am J Pathol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.phrs.2009.12.014","article-title":"Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice","volume":"61","author":"Z Iffiu-Soltesz","year":"2010","journal-title":"Pharmacol Res"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s13105-012-0171-1","article-title":"Benzylamine antihyperglycemic effect is abolished by AOC3 gene invalidation in mice but not rescued by semicarbazide-sensitive amine oxidase expression under the control of aP2 promoter","volume":"68","author":"S Gres","year":"2012","journal-title":"J Physiol Biochem"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1021\/bi0021378","article-title":"The role of copper in topa quinone biogenesis and catalysis, as probed by azide inhibition of a copper amine oxidase from yeast","volume":"40","author":"B Schwartz","year":"2001","journal-title":"Biochemistry"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/MCB.23.3.1085-1094.2003","article-title":"Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone","volume":"23","author":"L Wilson-Fritch","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.jnutbio.2015.04.009","article-title":"Nutrigenomics analysis reveals that copper deficiency and dietary sucrose up-regulate inflammation, fibrosis and lipogenic pathways in a mature rat model of nonalcoholic fatty liver disease","volume":"26","author":"S Tallino","year":"2015","journal-title":"J Nutr Biochem"},{"issue":"Pt 2","key":"ref22","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/bj3580335","article-title":"Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells","volume":"358","author":"N Mercier","year":"2001","journal-title":"Biochem J"},{"issue":"14","key":"ref23","doi-asserted-by":"crossref","first-page":"8025","DOI":"10.1074\/jbc.273.14.8025","article-title":"Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells","volume":"273","author":"G Enrique-Tarancon","year":"1998","journal-title":"J Biol Chem"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.2527\/jas.2010-3395","article-title":"Copper and lipid metabolism in beef cattle: a review","volume":"89","author":"TE Engle","year":"2011","journal-title":"J Anim Sci"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0271-5317(01)00332-3","article-title":"Effect of pharmacological concentrations of dietary copper on lipid and cholesterol metabolism in pigs","volume":"21","author":"TA SJ Armstrong","journal-title":"Nutrition Research"},{"issue":"1","key":"ref26","first-page":"44","article-title":"Utilization of Bio-Mos Mannan Oligosaccharide and Bioplex Copper in Broiler Diets","volume":"2","author":"FC Waldroup PW","journal-title":"International Journal of Poultry Science"},{"issue":"14","key":"ref27","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1074\/jbc.272.14.9388","article-title":"Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane","volume":"272","author":"NJ Morris","year":"1997","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"ref28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1042\/bj3500171","article-title":"Substrates of semicarbazide-sensitive amine oxidase co-operate with vanadate to stimulate tyrosine phosphorylation of insulin-receptor-substrate proteins, phosphoinositide 3-kinase activity and GLUT4 translocation in adipose cells","volume":"350","author":"G Enrique-Tarancon","year":"2000","journal-title":"Biochem J"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00702-007-0671-2","article-title":"Semicarbazide-sensitive amine oxidase substrates fail to induce insulin-like effects in fat cells from AOC3 knockout mice","volume":"114","author":"S Bour","year":"2007","journal-title":"J Neural Transm (Vienna)"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1172\/JCI73722","article-title":"Vascular adhesion protein-1 promotes liver inflammation and drives hepatic fibrosis","volume":"125","author":"CJ Weston","year":"2015","journal-title":"J Clin Invest"},{"issue":"30","key":"ref31","doi-asserted-by":"crossref","first-page":"31902","DOI":"10.1074\/jbc.M404570200","article-title":"Role of insulin action and cell size on protein expression patterns in adipocytes","volume":"279","author":"M Bluher","year":"2004","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2119\/molmed.2014.00219","article-title":"A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity","volume":"21","author":"C Hammer","year":"2015","journal-title":"Mol Med"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1172\/JCI12749","article-title":"Thrombospondins as matricellular modulators of cell function","volume":"107","author":"P Bornstein","year":"2001","journal-title":"J Clin Invest"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2337\/db06-0822","article-title":"Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period","volume":"56","author":"AS Bickerton","year":"2007","journal-title":"Diabetes"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.4049\/jimmunol.1003713","article-title":"Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase","volume":"186","author":"H Fan","year":"2011","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1465-9921-10-33","article-title":"Macrophage CD74 contributes to MIF-induced pulmonary inflammation","volume":"10","author":"K Takahashi","year":"2009","journal-title":"Respir Res"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"e0142367","DOI":"10.1371\/journal.pone.0142367","article-title":"Primary Amine Oxidase of Escherichia coli Is a Metabolic Enzyme that Can Use a Human Leukocyte Molecule as a Substrate","volume":"10","author":"H Elovaara","year":"2015","journal-title":"PLoS ONE"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"e90544","DOI":"10.1371\/journal.pone.0090544","article-title":"Upregulated copper transporters in hypoxia-induced pulmonary hypertension","volume":"9","author":"AM Zimnicka","year":"2014","journal-title":"PLoS ONE"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"10640","DOI":"10.1038\/ncomms10640","article-title":"Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway","volume":"7","author":"Y Hatori","year":"2016","journal-title":"Nat Commun"},{"issue":"32","key":"ref40","doi-asserted-by":"crossref","first-page":"16644","DOI":"10.1074\/jbc.M116.727248","article-title":"The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria","volume":"291","author":"A Bhattacharjee","year":"2016","journal-title":"J Biol Chem"},{"issue":"15","key":"ref41","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1128\/MCB.00166-16","article-title":"Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series","volume":"36","author":"CE Bowman","year":"2016","journal-title":"Mol Cell Biol"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1172\/JCI22681","article-title":"Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization","volume":"115","author":"H Kanda","year":"2005","journal-title":"J Clin Invest"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"J Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1051\/jp4:20030160","article-title":"S. V. MAPS: A set of software tools for analysis and visualization of 3D X-ray fluorescence data sets","volume":"104","year":"2003","journal-title":"J Phys IV France"},{"key":"ref45","author":"NRCUCftUotGftCaUoL","year":"2011"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1021\/pr300624g","article-title":"Statistical inference from multiple iTRAQ experiments without using common reference standards","volume":"12","author":"SM Herbrich","year":"2013","journal-title":"J Proteome Res"},{"issue":"17","key":"ref47","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1212\/WNL.0b013e3182a9565e","article-title":"A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects","volume":"81","author":"VV Bandaru","year":"2013","journal-title":"Neurology"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ana.10828","article-title":"Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia","volume":"55","author":"NJ Haughey","year":"2004","journal-title":"Ann Neurol"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/acel.12275","article-title":"Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging","volume":"14","author":"MM Mielke","year":"2015","journal-title":"Aging Cell"},{"issue":"18","key":"ref50","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1212\/01.wnl.0000260610.79853.47","article-title":"Associative and predictive biomarkers of dementia in HIV-1-infected patients","volume":"68","author":"VV Bandaru","year":"2007","journal-title":"Neurology"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s11481-011-9289-0","article-title":"A failure to normalize biochemical and metabolic insults during morphine withdrawal disrupts synaptic repair in mice transgenic for HIV-gp120","volume":"6","author":"VV Bandaru","year":"2011","journal-title":"J Neuroimmune Pharmacol"}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.2006519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:41:44Z","timestamp":1661996504000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.2006519"}},"subtitle":[],"editor":[{"given":"Jason","family":"Locasale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.2006519","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,10]]}}}