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Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens","volume":"26","author":"N.V. Serbina","year":"2008","journal-title":"Annu Rev Immunol"},{"issue":"5455","key":"ref6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1126\/science.287.5455.1037","article-title":"Polarization of chemoattractant receptor signaling during neutrophil chemotaxis","volume":"287","author":"G. Servant","year":"2000","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.cb.04.110188.003245","article-title":"Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium","volume":"4","author":"P.N. 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Isberg","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"19","key":"ref16","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1073\/pnas.94.19.10385","article-title":"Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death","volume":"94","author":"D.M. Monack","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6755","key":"ref17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/44593","article-title":"Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes","volume":"401","author":"A. Vazquez-Torres","year":"1999","journal-title":"Nature"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018499","article-title":"Immunity and Immunopathology in the Tuberculous Granuloma","volume":"5","author":"A.J. 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Barker","year":"1982","journal-title":"American Journal of Physiology"},{"issue":"7101","key":"ref25","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature04925","article-title":"Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN","volume":"442","author":"M. Zhao","year":"2006","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(03)58001-2","article-title":"A role for endogenous electric fields in wound healing","volume":"58","author":"R. Nuccitelli","year":"2003","journal-title":"Curr Top Dev Biol"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1523\/JNEUROSCI.1877-14.2015","article-title":"Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation","volume":"35","author":"V.P. 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Hoare","year":"2015","journal-title":"J Leukoc Biol"},{"key":"ref35","first-page":"261","article-title":"Of mice, calves, and men. Comparison of the mouse typhoid model with other Salmonella infections","volume":"473","author":"R.M. Tsolis","year":"1999","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1128\/IAI.01369-10","article-title":"How To Become a Top Model: Impact of Animal Experimentation on Human Salmonella Disease Research","volume":"79","author":"R.M. Tsolis","year":"2011","journal-title":"Infection and Immunity"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0264-410X(93)90016-Q","article-title":"Evaluation of Shigella vaccine safety and efficacy in an intranasally challenged mouse model","volume":"11","author":"C.P. Mallett","year":"1993","journal-title":"Vaccine"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1128\/IAI.63.12.4837-4848.1995","article-title":"Pathogenesis of defined invasion mutants of Yersinia enterocolitica in a BALB\/c mouse model of infection","volume":"63","author":"J.C. Pepe","year":"1995","journal-title":"Infect Immun"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1699-0463.1993.tb00130.x","article-title":"Experimental Yersinia enterocolitica infection in rodents: a model for human yersiniosis","volume":"101","author":"J. Heesemann","year":"1993","journal-title":"APMIS"},{"issue":"3","key":"ref40","first-page":"a009977","article-title":"In vitro and in vivo model systems for studying enteropathogenic Escherichia coli infections","volume":"3","author":"R.J. Law","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nprot.2007.91","article-title":"Non-invasive measurement of bioelectric currents with a vibrating probe","volume":"2","author":"B. Reid","year":"2007","journal-title":"Nat Protoc"},{"key":"ref42","article-title":"Airway Epithelial Wounds in Rhesus Monkey Generate Ionic Currents That Guide Cell Migration to Promote Healing","author":"Y.H. Sun","year":"2011","journal-title":"J Appl Physiol"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1096\/fj.04-2325com","article-title":"Wound healing in rat cornea: the role of electric currents","volume":"19","author":"B. Reid","year":"2005","journal-title":"FASEB J"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ydbio.2009.08.028","article-title":"Electric currents in Xenopus tadpole tail regeneration","volume":"335","author":"B. Reid","year":"2009","journal-title":"Developmental Biology"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"G1151","DOI":"10.1152\/ajpgi.90649.2008","article-title":"A guide to Ussing chamber studies of mouse intestine","volume":"296","author":"L.L. Clarke","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00006565-199608000-00012","article-title":"An uncommon presentation of Salmonella","volume":"12","author":"A. Deutsch","year":"1996","journal-title":"Pediatr Emerg Care"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1139\/y78-070","article-title":"Transmucosal potential-difference profile in rat upper gastrointestinal tract. A simple model for testing gastric effects of pharmacologic agents","volume":"56","author":"A. Tarnawski","year":"1978","journal-title":"Can J Physiol Pharmacol"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1365-2982.2007.00941.x","article-title":"Elevated motility-related transmucosal potential difference in the upper small intestine in the irritable bowel syndrome","volume":"19","author":"M.H. Larsson","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1113\/jphysiol.1981.sp014003","article-title":"Human intestinal potential difference: recording method and biophysical implications","volume":"321","author":"R.F. Gustke","year":"1981","journal-title":"J Physiol"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/0016-5085(87)90632-9","article-title":"Repair of rabbit duodenal mucosa after acid injury in vivo and in vitro","volume":"92","author":"W. Feil","year":"1987","journal-title":"Gastroenterology"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF01869406","article-title":"Electrical properties and active solute transport in rat small intestine. II. Conductive properties of transepithelial routes","volume":"31","author":"Y. Okada","year":"1977","journal-title":"J Membr Biol"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF01869405","article-title":"Electrical properties and active solute transport in rat small intestine. I. Potential profile changes associated with sugar and amino acid transports","volume":"31","author":"Y. Okada","year":"1977","journal-title":"J Membr Biol"},{"issue":"4","key":"ref53","first-page":"335","article-title":"Effects of sodium artesunate on electrical properties and Na+,K(+)-ATPase activities of mouse small intestine]","volume":"11","author":"J.Y. Wang","year":"1990","journal-title":"Zhongguo Yao Li Xue Bao"},{"issue":"8","key":"ref54","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1093\/ps\/78.8.1126","article-title":"Electrical properties of the intestinal mucosa of the chicken and the effects of luminal glucose","volume":"78","author":"C. Amat","year":"1999","journal-title":"Poultry Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fphys.2012.00388","article-title":"Intestinal fluid absorption in anadromous salmonids: importance of tight junctions and aquaporins","volume":"3","author":"K.S. Sundell","year":"2012","journal-title":"Front Physiol"},{"issue":"Pt 1","key":"ref56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1101\/SQB.1988.053.01.006","article-title":"Galvanotaxis in bacteria","volume":"53","author":"J. Adler","year":"1988","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"5","key":"ref57","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/S0002-9440(10)65410-7","article-title":"The development of M cells in Peyer's patches is restricted to specialized dome-associated crypts","volume":"154","author":"A. Gebert","year":"1999","journal-title":"American Journal of Pathology"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/BF01534578","article-title":"Transmucosal potential difference in experimental colitis in rats","volume":"19","author":"E. Buch","year":"1995","journal-title":"Inflammation"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.semcdb.2008.12.009","article-title":"Electrical fields in wound healing-An overriding signal that directs cell migration","volume":"20","author":"M. Zhao","year":"2009","journal-title":"Semin Cell Dev Biol"},{"issue":"11","key":"ref60","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.tim.2009.08.008","article-title":"Life in the inflamed intestine, Salmonella style","volume":"17","author":"R.L. Santos","year":"2009","journal-title":"Trends Microbiol"},{"issue":"7314","key":"ref61","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature09415","article-title":"Gut inflammation provides a respiratory electron acceptor for Salmonella","volume":"467","author":"S.E. Winter","year":"2010","journal-title":"Nature"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1152\/ajplegacy.1953.175.1.113","article-title":"Electrical potential differences across the normal aorta and aortic grafts of dogs","volume":"175","author":"P.N. Sawyer","year":"1953","journal-title":"Am J Physiol"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1152\/ajplegacy.1953.175.1.108","article-title":"Relations of abnormal and injury electric potential differences to intravascular thrombosis","volume":"175","author":"P.N. Sawyer","year":"1953","journal-title":"Am J Physiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1152\/ajplegacy.1960.198.5.1006","article-title":"Effect of small electric currents on intravascular thrombosis in the visualized rat mesentery","volume":"198","author":"P.N. Sawyer","year":"1960","journal-title":"Am J Physiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00000658-196101000-00004","article-title":"The electric current of injured tissue and vascular occlusion","volume":"153","author":"P.N. Sawyer","year":"1961","journal-title":"Ann Surg"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.coi.2004.12.004","article-title":"Antigen presentation and recognition in bacterial infections","volume":"17","author":"S.H. Kaufmann","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2172-14-6","article-title":"Characterization of murine macrophages from bone marrow, spleen and peritoneum","volume":"14","author":"C. Wang","year":"2013","journal-title":"BMC Immunol"},{"key":"ref68","first-page":"93","article-title":"Molecular mechanisms of Salmonella virulence and host resistance","volume":"337","author":"Y. Valdez","year":"2009","journal-title":"Curr Top Microbiol Immunol"},{"issue":"6","key":"ref69","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1128\/IAI.65.6.2254-2259.1997","article-title":"Synergistic effect of mutations in invA and lpfC on the ability of Salmonella typhimurium to cause murine typhoid","volume":"65","author":"A.J. Baumler","year":"1997","journal-title":"Infect Immun"},{"issue":"11","key":"ref70","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/cm.20227","article-title":"Electric field-induced polarization of charged cell surface proteins does not determine the direction of galvanotaxis","volume":"64","author":"E.I. Finkelstein","year":"2007","journal-title":"Cell Motil Cytoskeleton"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0006-3495(81)84838-2","article-title":"The role of electro-osmosis in the electric-field-induced movement of charged macromolecules on the surfaces of cells","volume":"34","author":"S. McLaughlin","year":"1981","journal-title":"Biophys J"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/jlb.41.2.143","article-title":"Surface charge of resident, elicited, and activated mouse peritoneal macrophages","volume":"41","author":"F.C. Silva Filho","year":"1987","journal-title":"J Leukoc Biol"},{"issue":"12","key":"ref73","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1074\/mcp.M116.063206","article-title":"Salmonella Typhimurium Enzymatically Landscapes the Host Intestinal Epithelial Cell (IEC) Surface Glycome to Increase Invasion","volume":"15","author":"D. Park","year":"2016","journal-title":"Mol Cell Proteomics"},{"issue":"6","key":"ref74","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1128\/JVI.72.6.4643-4649.1998","article-title":"Infection of glial cells by the human polyomavirus JC is mediated by an N-linked glycoprotein containing terminal alpha(2\u20136)-linked sialic acids","volume":"72","author":"C.K. Liu","year":"1998","journal-title":"J Virol"},{"issue":"2","key":"ref75","first-page":"89","article-title":"Acid stress responses of Salmonella and E-coli: Survival mechanisms, regulation, and implications for pathogenesis","volume":"39","author":"J.W. Foster","year":"2001","journal-title":"Journal of Microbiology"},{"issue":"2","key":"ref76","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1128\/jb.172.2.771-778.1990","article-title":"Adaptive acidification tolerance response of Salmonella typhimurium","volume":"172","author":"J.W. Foster","year":"1990","journal-title":"J Bacteriol"},{"issue":"2","key":"ref77","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4161\/viru.19029","article-title":"Acidic pH induced STM1485 gene is essential for intracellular replication of Salmonella","volume":"3","author":"U.S. Allam","year":"2012","journal-title":"Virulence"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1046\/j.1365-2958.1999.01527.x","article-title":"pH-dependent secretion of SseB, a product of the SPI-2 type III secretion system of Salmonella typhimurium","volume":"33","author":"C.R. Beuzon","year":"1999","journal-title":"Mol Microbiol"},{"issue":"4","key":"ref79","doi-asserted-by":"crossref","first-page":"e1002116","DOI":"10.1371\/journal.pbio.1002116","article-title":"A FRET-based DNA biosensor tracks OmpR-dependent acidification of Salmonella during macrophage infection","volume":"13","author":"S. Chakraborty","year":"2015","journal-title":"PLoS Biol"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nmat3891","article-title":"Galvanotactic control of collective cell migration in epithelial monolayers","volume":"13","author":"D.J. Cohen","year":"2014","journal-title":"Nat Mater"},{"issue":"7","key":"ref81","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cub.2013.02.026","article-title":"Keratocyte fragments and cells utilize competing pathways to move in opposite directions in an electric field","volume":"23","author":"Y. Sun","year":"2013","journal-title":"Curr Biol"},{"issue":"11","key":"ref82","doi-asserted-by":"crossref","first-page":"e1000671","DOI":"10.1371\/journal.ppat.1000671","article-title":"The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration","volume":"5","author":"L.M. McLaughlin","year":"2009","journal-title":"PLoS Pathog"},{"issue":"Pt 5","key":"ref83","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1099\/mic.0.058115-0","article-title":"Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors","volume":"158","author":"R. Figueira","year":"2012","journal-title":"Microbiology"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"D490","DOI":"10.1093\/nar\/gkt1178","article-title":"The carbohydrate-active enzymes database (CAZy) in 2013","volume":"42","author":"V. Lombard","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"29525","DOI":"10.1038\/srep29525","article-title":"Salmonella Degrades the Host Glycocalyx Leading to Altered Infection and Glycan Remodeling","volume":"6","author":"N. Arabyan","year":"2016","journal-title":"Sci Rep"},{"issue":"33","key":"ref86","doi-asserted-by":"crossref","first-page":"34589","DOI":"10.1074\/jbc.M403830200","article-title":"Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion","volume":"279","author":"A.N. Weber","year":"2004","journal-title":"J Biol Chem"},{"issue":"3","key":"ref87","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1074\/jbc.M109910200","article-title":"MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor","volume":"277","author":"J. da Silva Correia","year":"2002","journal-title":"J Biol Chem"},{"issue":"4","key":"ref88","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1017\/S0950268807009338","article-title":"Part I. Analysis of data gaps pertaining to Salmonella enterica serotype Typhi infections in low and medium human development index countries, 1984\u20132005","volume":"136","author":"J.A. Crump","year":"2008","journal-title":"Epidemiol Infect"},{"issue":"1","key":"ref89","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1083\/jcb.98.1.296","article-title":"Embryonic fibroblast motility and orientation can be influenced by physiological electric fields","volume":"98","author":"C.A. Erickson","year":"1984","journal-title":"J Cell Biol"},{"issue":"6","key":"ref90","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1083\/jcb.129.6.1667","article-title":"The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium","volume":"129","author":"L. Wu","year":"1995","journal-title":"J Cell Biol"},{"issue":"6","key":"ref91","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1083\/jcb.200112070","article-title":"Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis","volume":"157","author":"M. Zhao","year":"2002","journal-title":"J Cell Biol"},{"issue":"378","key":"ref92","article-title":"A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum","volume":"8","author":"R.C. Gao","year":"2015","journal-title":"Science Signaling"},{"issue":"4","key":"ref93","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1099\/mic.0.000601","article-title":"Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe","volume":"164","author":"S.V. Gordon","year":"2018","journal-title":"Microbiology"},{"key":"ref94","article-title":"Single cell wound generates electric current circuit and cell membrane potential variations that requires calcium influx","author":"G. Luxardi","year":"2014","journal-title":"Integr Biol (Camb)"},{"issue":"41","key":"ref95","doi-asserted-by":"crossref","first-page":"17733","DOI":"10.1073\/pnas.1006098107","article-title":"Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia","volume":"107","author":"L.A. Knodler","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref96","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chom.2014.07.002","article-title":"Noncanonical inflammasome activation of caspase-4\/caspase-11 mediates epithelial defenses against enteric bacterial pathogens","volume":"16","author":"L.A. Knodler","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"5","key":"ref97","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1073\/pnas.0406873102","article-title":"Brucella coopts the small GTPase Sar1 for intracellular replication","volume":"102","author":"J. Celli","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref98","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1111\/j.1365-2958.2008.06487.x","article-title":"Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system","volume":"70","author":"M.F. de Jong","year":"2008","journal-title":"Mol Microbiol"},{"issue":"5781","key":"ref99","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/287440a0","article-title":"Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci","volume":"287","author":"A.D. O'Brien","year":"1980","journal-title":"Nature"},{"issue":"3","key":"ref100","doi-asserted-by":"crossref","first-page":"e0003611","DOI":"10.1371\/journal.pntd.0003611","article-title":"Signatures of adaptation in human invasive Salmonella Typhimurium ST313 populations from sub-Saharan Africa","volume":"9","author":"C.K. Okoro","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref101","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.chom.2017.01.009","article-title":"Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells","volume":"21","author":"S.E. Carden","year":"2017","journal-title":"Cell Host Microbe"},{"issue":"47","key":"ref102","doi-asserted-by":"crossref","first-page":"17915","DOI":"10.1073\/pnas.0604054103","article-title":"Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells","volume":"103","author":"M.J. Worley","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref103","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1401s83","article-title":"The isolation and characterization of murine macrophages","author":"X. Zhang","year":"2008","journal-title":"Curr Protoc Immunol"},{"issue":"9","key":"ref104","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1128\/IAI.70.9.4826-4832.2002","article-title":"virB-Mediated survival of Brucella abortus in mice and macrophages is independent of a functional inducible nitric oxide synthase or NADPH oxidase in macrophages","volume":"70","author":"Y.H. Sun","year":"2002","journal-title":"Infect Immun"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"8532","DOI":"10.1038\/ncomms9532","article-title":"KCNJ15\/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis","volume":"6","author":"K. Nakajima","year":"2015","journal-title":"Nat Commun"},{"issue":"Pt 6","key":"ref106","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1242\/jcs.109.6.1405","article-title":"Orientation and directed migration of cultured corneal epithelial cells in small electric fields are serum dependent","volume":"109","author":"M. Zhao","year":"1996","journal-title":"J Cell Sci"},{"issue":"6","key":"ref107","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/nprot.2007.205","article-title":"Application of direct current electric fields to cells and tissues in vitro and modulation of wound electric field in vivo","volume":"2","author":"B. Song","year":"2007","journal-title":"Nat Protoc"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-60761-198-1_5","article-title":"Electrotaxis and wound healing: experimental methods to study electric fields as a directional signal for cell migration","volume":"571","author":"G. Tai","year":"2009","journal-title":"Methods Mol Biol"},{"issue":"2","key":"ref109","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/cm.970190207","article-title":"Neural crest cell galvanotaxis: new data and a novel approach to the analysis of both galvanotaxis and chemotaxis","volume":"19","author":"H. 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