{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:14:59Z","timestamp":1791947699356,"version":"4.3.4"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["098051"],"award-info":[{"award-number":["098051"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["100699"],"award-info":[{"award-number":["100699"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_qA137918"],"award-info":[{"award-number":["MC_qA137918"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0300212"],"award-info":[{"award-number":["G0300212"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EC","award":["LSHG-CT-2006-037188"],"award-info":[{"award-number":["LSHG-CT-2006-037188"]}]},{"DOI":"10.13039\/501100000703","name":"Action on Hearing Loss","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0000934"],"award-info":[{"award-number":["G0000934"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["068545\/Z\/02"],"award-info":[{"award-number":["068545\/Z\/02"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["076113"],"award-info":[{"award-number":["076113"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000293","name":"Deafness Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000293","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Haigh Fellowship"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.3000194","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T13:36:24Z","timestamp":1554989784000},"page":"e3000194","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":125,"title":["Mouse screen reveals multiple new genes underlying mouse and human hearing loss"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-7347","authenticated-orcid":true,"given":"Neil J.","family":"Ingham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina A.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-1975","authenticated-orcid":true,"given":"Valerie E.","family":"Vancollie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-0870","authenticated-orcid":true,"given":"Victoria","family":"Rook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-8600","authenticated-orcid":true,"given":"Morag A.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4623-8642","authenticated-orcid":true,"given":"Annalisa","family":"Buniello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8038-8866","authenticated-orcid":true,"given":"Elisa","family":"Martelletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Preite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1370-2872","authenticated-orcid":true,"given":"Chi Chung","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0228-5081","authenticated-orcid":true,"given":"Felix D.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z\u04e7e","family":"Powis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"Suwannarat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8087-4530","authenticated-orcid":true,"given":"Christopher J.","family":"Lelliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally J.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline K.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-5359","authenticated-orcid":true,"given":"Karen P.","family":"Steel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"key":"ref1","article-title":"Dementia prevention, intervention, and care","author":"G Livingston","year":"2017","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/bmj.323.7312.536","article-title":"Prevalence of permanent childhood hearing impairment in the United Kingdom and implications for universal neonatal hearing screening: questionnaire based ascertainment study","volume":"323","author":"HM Fortnum","year":"2001","journal-title":"British Medical Journal"},{"key":"ref3","article-title":"Hearing in Adults","author":"AC Davis","year":"1995"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470942390.mo110059","article-title":"Using the Auditory Brainstem Response (ABR) to determine sensitivity of hearing in mutant mice","volume":"1","author":"NJ Ingham","year":"2011","journal-title":"Current Protocols in Mouse Biology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.cell.2013.06.022","article-title":"Genome-Wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes","volume":"154","author":"JK White","year":"2013","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10163","article-title":"A conditional knockout resource for the genome-wide study of mouse gene function","volume":"474","author":"WC Skarnes","year":"2011","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41467-017-00595-4","article-title":"A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction","volume":"8","author":"MR Bowl","year":"2017","journal-title":"Nat Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e91807","DOI":"10.1371\/journal.pone.0091807","article-title":"Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene","volume":"9","author":"S Maguire","year":"2014","journal-title":"PLoS ONE"},{"key":"ref9","article-title":"Data from: Mouse screen reveals multiple new genes underlying mouse and human hearing loss","author":"NJ Ingham","year":"2019","journal-title":"Dryad Digital Repository"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.15252\/emmm.201505523","article-title":"Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing","volume":"8","author":"A Buniello","year":"2016","journal-title":"EMBO Mol Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e1004688","DOI":"10.1371\/journal.pgen.1004688","article-title":"Spinster homolog 2 (Spns2) deficiency causes early onset progressive hearing loss.","volume":"10","author":"J Chen","year":"2014","journal-title":"PLoS Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e58156","DOI":"10.1371\/journal.pone.0058156","article-title":"Mcph1-deficient mice are a model for heritable otitis media","volume":"8","author":"J Chen","year":"2013","journal-title":"PLoS ONE"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1001\/archotol.1983.00800150026005","article-title":"Hereditary inner-ear abnormalities in animals. Relationships with human abnormalities","volume":"109","author":"KP Steel","year":"1983","journal-title":"Arch Otolaryngol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","year":"2015","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/hmg\/ddn402","article-title":"GRM7 variants confer susceptibility to age-related hearing impairment","volume":"18","author":"RA Friedman","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1093\/hmg\/ddv279","article-title":"Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss","volume":"24","author":"D Vuckovic","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1006371","DOI":"10.1371\/journal.pgen.1006371","article-title":"A Large Genome-Wide Association Study of Age-Related Hearing Impairment Using Electronic Health Records","volume":"12","author":"TJ Hoffmann","year":"2016","journal-title":"PLoS Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1210\/me.2007-0085","article-title":"Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2","volume":"21","author":"KR Johnson","year":"2007","journal-title":"Mol. Endocrinol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ajhg.2015.12.004","article-title":"Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2","volume":"98","author":"RL Santos-Cortez","year":"2016","journal-title":"Am J Hum Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"28964","DOI":"10.1038\/srep28964","article-title":"S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse","volume":"6","author":"NJ Ingham","year":"2016","journal-title":"Sci Rep"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"10690","DOI":"10.1074\/jbc.M700370200","article-title":"Deafness and stria vascularis defects in S1P2 receptor-null mice","volume":"282","author":"M Kono","year":"2007","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1523\/JNEUROSCI.4245-06.2007","article-title":"Sphingosine 1-Phosphate (S1P) Signaling Is Required for Maintenance of Hair Cells Mainly via Activation of S1P2","volume":"27","author":"DR Herr","year":"2007","journal-title":"J. Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1113\/jphysiol.2012.235846","article-title":"Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice","volume":"590","author":"MH Lu","year":"2012","journal-title":"J Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0896-6273(03)00228-9","article-title":"Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons","volume":"38","author":"HY Man","year":"2003","journal-title":"Neuron"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1126\/science.1201678","article-title":"AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization","volume":"332","author":"S Amato","year":"2011","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"11573","DOI":"10.1073\/pnas.0913138107","article-title":"A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors","volume":"107","author":"J Du","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.febslet.2009.12.061","article-title":"Dynamin-1 co-associates with native mouse brain BK Ca channels: Proteomics analysis of synaptic protein complexes","volume":"584","author":"G Gorini","year":"2010","journal-title":"FEBS letters"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1113\/jphysiol.2002.034801","article-title":"Developmental changes in the expression of potassium currents of embryonic, neonatal and mature mouse inner hair cells","volume":"548","author":"W Marcotti","year":"2003","journal-title":"J Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1096\/fj.11-200535","article-title":"Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing","volume":"26","author":"S Kurt","year":"2012","journal-title":"FASEB J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1152\/jn.00924.2012","article-title":"Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea","volume":"109","author":"SF Maison","year":"2013","journal-title":"J. Neurophysiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"12922","DOI":"10.1073\/pnas.0402660101","article-title":"Deletion of the Ca<sup>2+<\/sup>-activated potassium (BK) \u03b1-subunit but not the BK\u03b21-subunit leads to progressive hearing loss","volume":"101","author":"L R\u00fcttiger","year":"2004","journal-title":"Proc. Natl. Acad. Sci"},{"key":"ref32","first-page":"553","article-title":"Nucleocytoplasmic connections and deafness","volume":"123","author":"HJ Worman","year":"2013","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1073\/pnas.0808602106","article-title":"Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization","volume":"106","author":"KJ Roux","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","first-page":"740","article-title":"The LINC complex is essential for hearing","volume":"123","author":"HF Horn","year":"2013","journal-title":"J Clin Invest"},{"key":"ref35","first-page":"6877","article-title":"Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome","volume":"24","author":"US Melo","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00405-008-0739-0","article-title":"Sensorineural hearing loss in patients with chronic otitis media","volume":"266","author":"SS da Costa","year":"2008","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.pharmtox.40.1.617","article-title":"14-3-3 proteins: structure, function, and regulation","volume":"40","author":"H Fu","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/376188a0","article-title":"Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways","volume":"376","author":"B Xiao","year":"1995","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes","volume":"101","author":"AI Su","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"8549","DOI":"10.1038\/ncomms9549","article-title":"RFX transcription factors are essential for hearing in mice","volume":"6","author":"R Elkon","year":"2015","journal-title":"Nat Commun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/ng1169","article-title":"14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome","volume":"34","author":"K Toyo-oka","year":"2003","journal-title":"Nat Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e52410","DOI":"10.1371\/journal.pone.0052410","article-title":"Robust and sensitive analysis of mouse knockout phenotypes","volume":"7","author":"NA Karp","year":"2012","journal-title":"PLoS ONE"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis","volume":"102","author":"HF Schuknecht","year":"1993","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"7587","DOI":"10.1523\/JNEUROSCI.0389-10.2010","article-title":"Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons","volume":"30","author":"BN Buran","year":"2010","journal-title":"J Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1601-183X.2010.00583.x","article-title":"A locus for an auditory processing deficit and language impairment in an extended pedigree maps to 12p13.31-q14.3","volume":"9","author":"L Addis","year":"2010","journal-title":"Genes Brain Behav"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng1226","article-title":"Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss","volume":"35","author":"K Noben-Trauth","year":"2003","journal-title":"Nat. Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.heares.2010.05.002","article-title":"Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL\/6J mice","volume":"268","author":"KR Johnson","year":"2010","journal-title":"Hear. Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1111\/j.1460-9568.2006.05134.x","article-title":"Contralateral inhibitory and excitatory frequency response maps in the mammalian cochlear nucleus","volume":"24","author":"NJ Ingham","year":"2006","journal-title":"Eur J Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00335-013-9467-x","article-title":"Molecular characterization of mutant mouse strains generated from the EUCOMM\/KOMP-CSD ES cell resource","volume":"24","author":"E Ryder","year":"2013","journal-title":"Mamm. Genome"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2004.08.011","article-title":"A physiological place\u2013frequency map of the cochlea in the CBA\/J mouse","volume":"202","author":"M M\u00fcller","year":"2005","journal-title":"Hear, Res"},{"key":"ref51","first-page":"137","article-title":"Reeves, RH. Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice","volume":"217","author":"JT Richtsmeier","year":"2000","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"12168","DOI":"10.1523\/JNEUROSCI.2513-13.2014","article-title":"14-3-3\u03b5 and \u03b6 regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain","volume":"34","author":"K Toyo-oka","year":"2014","journal-title":"J Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1093\/bioinformatics\/btp498","article-title":"Next generation software for functional trend analysis","volume":"25","author":"GF Berriz","year":"2009","journal-title":"Bioinformatics"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"F Supek","year":"2011","journal-title":"PLoS ONE"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/gim.2014.154","article-title":"Enhanced utility of family-centered diagnostic exome sequencing with inheritance model-based analysis: results from 500 unselected families with undiagnosed genetic conditions","volume":"17","author":"KD Farwell","year":"2015","journal-title":"Genet Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"M Kircher","year":"2014","journal-title":"Nat Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/humu.22844","article-title":"GeneMatcher: A matching tool for connecting investigators with an interest in the same gene","volume":"36","author":"N Sobreira","year":"2015","journal-title":"Hum. Mutat"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/14992020701647942","article-title":"Is the relation of social class to change in hearing threshold levels from childhood to middle age explained by noise, smoking, and drinking behaviour?","volume":"47","author":"R Ecob","year":"2008","journal-title":"Int. J. Audiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/ije\/dyl309","article-title":"Lifecourse influences on health among British adults: effects of region of residence in childhood and adulthood","volume":"36","author":"DP Strachan","year":"2007","journal-title":"Int. J. Epidemiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2077.e1","DOI":"10.1016\/j.neurobiolaging.2013.02.009","article-title":"Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice","volume":"34","author":"LS Nolan","year":"2013","journal-title":"Neurobiol Aging"}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.3000194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:01:11Z","timestamp":1588964471000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000194"}},"subtitle":[],"editor":[{"given":"Thomas C.","family":"Freeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,11]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3000194","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,11]]}}}