{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:00:37Z","timestamp":1790262037979,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pbio.3000318","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000}}],"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 NS079955"],"award-info":[{"award-number":["R01 NS079955"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.3000318","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T13:24:28Z","timestamp":1560864268000},"page":"e3000318","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated \u03b1-Synuclein"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-8446","authenticated-orcid":true,"given":"Melissa","family":"Birol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawomir P.","family":"Wojcik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Miranker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1741-0650","authenticated-orcid":true,"given":"Elizabeth","family":"Rhoades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/35081564","article-title":"Alpha-synuclein and neurodegenerative diseases","volume":"2","author":"M Goedert","year":"2001","journal-title":"Nat Rev Neurosci"},{"issue":"47","key":"ref2","doi-asserted-by":"crossref","first-page":"20051","DOI":"10.1073\/pnas.0908005106","article-title":"Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells","volume":"106","author":"KC Luk","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nm.3457","article-title":"Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases","volume":"20","author":"JL Guo","year":"2014","journal-title":"Nat Med"},{"issue":"7588","key":"ref4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature16531","article-title":"Structural disorder of monomeric alpha-synuclein persists in mammalian cells","volume":"530","author":"FX Theillet","year":"2016","journal-title":"Nature"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1074\/jbc.M113.512459","article-title":"N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound alpha-synuclein and increases its affinity for physiological membranes","volume":"289","author":"I Dikiy","year":"2014","journal-title":"J Biol Chem"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0896-6273(95)90040-3","article-title":"Characterization of a novel protein regulated during the critical period for song learning in the zebra finch","volume":"15","author":"JM George","year":"1995","journal-title":"Neuron"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e00592","DOI":"10.7554\/eLife.00592","article-title":"Native alpha-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2\/VAMP2","volume":"2","author":"J Diao","year":"2013","journal-title":"Elife"},{"issue":"30","key":"ref8","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.1523\/JNEUROSCI.1594-04.2004","article-title":"Lipid rafts mediate the synaptic localization of alpha-synuclein","volume":"24","author":"DL Fortin","year":"2004","journal-title":"J Neurosci"},{"issue":"6307","key":"ref9","article-title":"Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3","volume":"353","author":"X Mao","year":"2016","journal-title":"Science"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"9008","DOI":"10.1038\/s41598-017-08720-5","article-title":"Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type","volume":"7","author":"E Ihse","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"e2000374","DOI":"10.1371\/journal.pbio.2000374","article-title":"The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease","volume":"15","author":"RM de Oliveira","year":"2017","journal-title":"PLoS Biol"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/brain\/awx056","article-title":"Glycation potentiates alpha-synuclein-associated neurodegeneration in synucleinopathies","volume":"140","author":"H Vicente Miranda","year":"2017","journal-title":"Brain"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12035-012-8330-5","article-title":"alpha-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration","volume":"47","author":"K Beyer","year":"2013","journal-title":"Mol Neurobiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1038\/srep05797","article-title":"Quantitative measurement of intact alpha-synuclein proteoforms from post-mortem control and Parkinson&apos;s disease brain tissue by intact protein mass spectrometry","volume":"4","author":"JF Kellie","year":"2014","journal-title":"Sci Rep"},{"issue":"40","key":"ref15","doi-asserted-by":"crossref","first-page":"29739","DOI":"10.1074\/jbc.M600933200","article-title":"Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease","volume":"281","author":"JP Anderson","year":"2006","journal-title":"J Biol Chem"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1073\/pnas.0406976102","article-title":"Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson&apos;s disease-linked mutations","volume":"102","author":"W Li","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tibs.2012.02.003","article-title":"Protein N-terminal acetyltransferases: when the start matters","volume":"37","author":"KK Starheim","year":"2012","journal-title":"Trends Biochem Sci"},{"issue":"6056","key":"ref18","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1209307","article-title":"N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex","volume":"334","author":"DC Scott","year":"2011","journal-title":"Science"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/pro.2056","article-title":"N-Terminal acetylation is critical for forming alpha-helical oligomer of alpha-synuclein","volume":"21","author":"AJ Trexler","year":"2012","journal-title":"Protein Sci"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/pro.2088","article-title":"N-terminal acetylation of alpha-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer","volume":"21","author":"L Kang","year":"2012","journal-title":"Protein Sci"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/nprot.2014.143","article-title":"Addition of exogenous alpha-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous alpha-synuclein to Lewy body and Lewy neurite-like aggregates","volume":"9","author":"LA Volpicelli-Daley","year":"2014","journal-title":"Nat Protoc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3389\/fnins.2018.00344","article-title":"Import and Export of Misfolded alpha-Synuclein","volume":"12","author":"L Rodriguez","year":"2018","journal-title":"Front Neurosci"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1021\/ja510391n","article-title":"Fluorescence correlation spectroscopy reveals highly efficient cytosolic delivery of certain penta-arg proteins and stapled peptides","volume":"137","author":"JR LaRochelle","year":"2015","journal-title":"J Am Chem Soc"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/s41598-018-19823-y","article-title":"Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo","volume":"8","author":"R Svarcbahs","year":"2018","journal-title":"Sci Rep"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.neuron.2014.04.047","article-title":"Distinct tau prion strains propagate in cells and mice and define different tauopathies","volume":"82","author":"DW Sanders","year":"2014","journal-title":"Neuron"},{"issue":"35","key":"ref26","doi-asserted-by":"crossref","first-page":"E4949","DOI":"10.1073\/pnas.1513426112","article-title":"Propagation of prions causing synucleinopathies in cultured cells","volume":"112","author":"AL Woerman","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"33","key":"ref27","doi-asserted-by":"crossref","first-page":"E3138","DOI":"10.1073\/pnas.1301440110","article-title":"Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds","volume":"110","author":"BB Holmes","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nrm3383","article-title":"Vertebrate protein glycosylation: diversity, synthesis and function","volume":"13","author":"KW Moremen","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/19336896.2017.1334748","article-title":"The cellular prion protein (PrP(C)) as neuronal receptor for alpha-synuclein","volume":"11","author":"L Urrea","year":"2017","journal-title":"Prion"},{"issue":"19","key":"ref30","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.15252\/embj.201591397","article-title":"alpha-synuclein assemblies sequester neuronal alpha3-Na+\/K+-ATPase and impair Na+ gradient","volume":"34","author":"AN Shrivastava","year":"2015","journal-title":"EMBO J"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/anie.200803898","article-title":"Proteomic analysis of plasma membrane vesicles","volume":"48","author":"B Bauer","year":"2009","journal-title":"Angew Chem Int Ed Engl"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1529\/biophysj.105.079251","article-title":"Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy","volume":"90","author":"E Rhoades","year":"2006","journal-title":"Biophys J"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1006\/jmbi.2001.4538","article-title":"Conformational properties of alpha-synuclein in its free and lipid-associated states","volume":"307","author":"D Eliezer","year":"2001","journal-title":"Journal of molecular biology"},{"issue":"14","key":"ref34","doi-asserted-by":"crossref","first-page":"9251","DOI":"10.1074\/jbc.M512292200","article-title":"Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles","volume":"281","author":"F Kamp","year":"2006","journal-title":"J Biol Chem"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1021\/bi900114z","article-title":"Alpha-synuclein binds large unilamellar vesicles as an extended helix","volume":"48","author":"AJ Trexler","year":"2009","journal-title":"Biochemistry"},{"issue":"7362","key":"ref36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature10324","article-title":"alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation","volume":"477","author":"T Bartels","year":"2011","journal-title":"Nature"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1007\/s11064-011-0527-x","article-title":"Identification of novel alpha-synuclein isoforms in human brain tissue by using an online nanoLC-ESI-FTICR-MS method","volume":"36","author":"A Ohrfelt","year":"2011","journal-title":"Neurochem Res"},{"issue":"9","key":"ref38","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.tibs.2016.07.005","article-title":"First Things First: Vital Protein Marks by N-Terminal Acetyltransferases","volume":"41","author":"H Aksnes","year":"2016","journal-title":"Trends Biochem Sci"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s12276-018-0116-z","article-title":"Spotlight on protein N-terminal acetylation","volume":"50","author":"R Ree","year":"2018","journal-title":"Exp Mol Med"},{"issue":"20","key":"ref40","doi-asserted-by":"crossref","first-page":"9730","DOI":"10.1016\/S0021-9258(18)47995-1","article-title":"Altered actin and troponin binding of amino-terminal variants of chicken striated muscle alpha-tropomyosin expressed in Escherichia coli","volume":"262","author":"SE Hitchcock-DeGregori","year":"1987","journal-title":"J Biol Chem"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.bbapap.2016.06.007","article-title":"The world of protein acetylation","volume":"1864","author":"A Drazic","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrm3920","article-title":"Intrinsically disordered proteins in cellular signalling and regulation","volume":"16","author":"PE Wright","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"ref43","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.bpj.2017.05.006","article-title":"Heterogeneous Tau-Tubulin Complexes Accelerate Microtubule Polymerization","volume":"112","author":"XH Li","year":"2017","journal-title":"Biophys J"},{"issue":"7389","key":"ref44","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10879","article-title":"Phase transitions in the assembly of multivalent signalling proteins","volume":"483","author":"P Li","year":"2012","journal-title":"Nature"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.cell.2015.09.047","article-title":"Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors","volume":"163","author":"S Milles","year":"2015","journal-title":"Cell"},{"key":"ref46","article-title":"Essentials of Glycobiology","author":"A Varki","year":"2009"},{"issue":"29","key":"ref47","doi-asserted-by":"crossref","first-page":"6271","DOI":"10.1039\/C8SC01875H","article-title":"Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation","volume":"9","author":"DD Park","year":"2018","journal-title":"Chem Sci"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061136","article-title":"Comparative Study of Lectin Domains in Model Species: New Insights into Evolutionary Dynamics","volume":"18","author":"S Van Holle","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"34","key":"ref49","doi-asserted-by":"crossref","first-page":"13465","DOI":"10.1021\/ja203979j","article-title":"The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse alpha-synuclein","volume":"133","author":"L Kang","year":"2011","journal-title":"J Am Chem Soc"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nsmb.3194","article-title":"Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein","volume":"23","author":"MD Tuttle","year":"2016","journal-title":"Nat Struct Mol Biol"},{"issue":"9","key":"ref51","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/s41422-018-0075-x","article-title":"Amyloid fibril structure of alpha-synuclein determined by cryo-electron microscopy","volume":"28","author":"Y Li","year":"2018","journal-title":"Cell Res"},{"key":"ref52","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.36402","article-title":"Cryo-EM structure of alpha-synuclein fibrils","volume":"7","author":"R Guerrero-Ferreira","year":"2018","journal-title":"Elife"},{"issue":"32","key":"ref53","doi-asserted-by":"crossref","first-page":"28080","DOI":"10.1074\/jbc.M111.237859","article-title":"Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases","volume":"286","author":"TL Yap","year":"2011","journal-title":"J Biol Chem"},{"issue":"5785","key":"ref54","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1126\/science.1129462","article-title":"Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson&apos;s models","volume":"313","author":"AA Cooper","year":"2006","journal-title":"Science"},{"issue":"7","key":"ref55","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.bpj.2010.07.056","article-title":"Effects of curvature and composition on alpha-synuclein binding to lipid vesicles","volume":"99","author":"ER Middleton","year":"2010","journal-title":"Biophys J"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nprot.2012.059","article-title":"Elucidating membrane structure and protein behavior using giant plasma membrane vesicles","volume":"7","author":"E Sezgin","year":"2012","journal-title":"Nat Protoc"},{"issue":"7","key":"ref57","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3000318","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.3000318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T12:52:24Z","timestamp":1609937544000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000318"}},"subtitle":[],"editor":[{"given":"Gillian P.","family":"Bates","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":57,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3000318","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/407247","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]}}}