{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T02:20:08Z","timestamp":1770690008763,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pbio.3000420","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000}}],"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"crossref","award":["XDB29030302"],"award-info":[{"award-number":["XDB29030302"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.3000420","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T17:31:59Z","timestamp":1566408719000},"page":"e3000420","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["TSC1\/mTOR-controlled metabolic\u2013epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis"],"prefix":"10.1371","volume":"17","author":[{"given":"Lei","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiping","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengdie","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haikun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-1312","authenticated-orcid":true,"given":"Qibin","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5304-243X","authenticated-orcid":true,"given":"Hui","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"issue":"4","key":"pbio.3000420.ref001","first-page":"719","volume":"45","author":"V Durai","year":"2016","journal-title":"Functions of Murine Dendritic Cells. Immunity"},{"key":"pbio.3000420.ref002","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev-immunol-020711-074929","article-title":"Molecular control of steady-state dendritic cell maturation and immune homeostasis","volume":"31","author":"GE Hammer","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"pbio.3000420.ref003","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-immunol-032713-120204","article-title":"Transcriptional Control of Dendritic Cell Development","volume":"34","author":"TL Murphy","year":"2016","journal-title":"Annu Rev Immunol"},{"issue":"8","key":"pbio.3000420.ref004","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nri3477","article-title":"The role of dendritic cells in autoimmunity","volume":"13","author":"D Ganguly","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"pbio.3000420.ref005","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nri3865","article-title":"The multifaceted biology of plasmacytoid dendritic cells","volume":"15","author":"M Swiecki","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"pbio.3000420.ref006","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"CD Surh","year":"2008","journal-title":"Immunity"},{"issue":"5","key":"pbio.3000420.ref007","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.it.2012.01.007","article-title":"CD8 T cell quiescence revisited","volume":"33","author":"SE Hamilton","year":"2012","journal-title":"Trends Immunol"},{"issue":"6","key":"pbio.3000420.ref008","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ni.2018","article-title":"Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells","volume":"12","author":"J Sprent","year":"2011","journal-title":"Nat Immunol"},{"issue":"3","key":"pbio.3000420.ref009","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.smim.2005.02.002","article-title":"Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells","volume":"17","author":"AR Almeida","year":"2005","journal-title":"Semin Immunol"},{"issue":"10","key":"pbio.3000420.ref010","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1084\/jem.20082553","article-title":"Self-class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels","volume":"206","author":"K Takada","year":"2009","journal-title":"J Exp Med"},{"issue":"48","key":"pbio.3000420.ref011","doi-asserted-by":"crossref","first-page":"20394","DOI":"10.1073\/pnas.0909954106","article-title":"Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo","volume":"106","author":"JS Do","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pbio.3000420.ref012","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ni.1695","article-title":"Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells","volume":"10","author":"M Guimond","year":"2009","journal-title":"Nat Immunol"},{"issue":"2","key":"pbio.3000420.ref013","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ni.2494","article-title":"IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death","volume":"14","author":"MY Kimura","year":"2013","journal-title":"Nat Immunol"},{"issue":"1","key":"pbio.3000420.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4110\/in.2011.11.1.1","article-title":"Seeing is believing: illuminating the source of in vivo interleukin-7","volume":"11","author":"GY Kim","year":"2011","journal-title":"Immune Netw"},{"issue":"5","key":"pbio.3000420.ref015","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1073\/pnas.0809559106","article-title":"Characterization of the thymic IL-7 niche in vivo","volume":"106","author":"NL Alves","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"pbio.3000420.ref016","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nri3771","article-title":"Dendritic cell metabolism","volume":"15","author":"EJ Pearce","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"pbio.3000420.ref017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"LA O'Neill","year":"2016","journal-title":"J Exp Med"},{"issue":"4","key":"pbio.3000420.ref018","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ni.2833","article-title":"TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation","volume":"15","author":"B Everts","year":"2014","journal-title":"Nat Immunol"},{"issue":"6355","key":"pbio.3000420.ref019","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1126\/science.aaj2155","article-title":"mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation","volume":"357","author":"C Sinclair","year":"2017","journal-title":"Science"},{"issue":"5","key":"pbio.3000420.ref020","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.immuni.2017.04.028","article-title":"MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells","volume":"46","author":"RG Jones","year":"2017","journal-title":"Immunity"},{"issue":"7708","key":"pbio.3000420.ref021","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41586-018-0177-0","article-title":"Hippo\/Mst signalling couples metabolic state and immune function of CD8alpha(+) dendritic cells","volume":"558","author":"X Du","year":"2018","journal-title":"Nature"},{"issue":"6","key":"pbio.3000420.ref022","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2015.05.014","article-title":"Acetyl coenzyme A: a central metabolite and second messenger","volume":"21","author":"F Pietrocola","year":"2015","journal-title":"Cell Metab"},{"issue":"11","key":"pbio.3000420.ref023","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019463","article-title":"Metabolic Signaling to Chromatin","volume":"8","author":"SL Berger","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"pbio.3000420.ref024","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tibs.2017.11.004","article-title":"Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation","volume":"43","author":"S Sivanand","year":"2018","journal-title":"Trends in biochemical sciences"},{"issue":"6311","key":"pbio.3000420.ref025","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.aaf6284","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"M Peng","year":"2016","journal-title":"Science"},{"key":"pbio.3000420.ref026","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.11612","article-title":"Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation","volume":"5","author":"AJ Covarrubias","year":"2016","journal-title":"Elife"},{"issue":"11","key":"pbio.3000420.ref027","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.it.2016.08.009","article-title":"mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function","volume":"37","author":"N Sukhbaatar","year":"2016","journal-title":"Trends Immunol"},{"issue":"50","key":"pbio.3000420.ref028","doi-asserted-by":"crossref","first-page":"E4894","DOI":"10.1073\/pnas.1308905110","article-title":"Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells","volume":"110","author":"Y Wang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pbio.3000420.ref029","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4049\/jimmunol.1201443","article-title":"Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA","volume":"191","author":"H Pan","year":"2013","journal-title":"J Immunol"},{"issue":"1","key":"pbio.3000420.ref030","doi-asserted-by":"crossref","first-page":"e2553","DOI":"10.1038\/cddis.2016.487","article-title":"Tsc1 expression by dendritic cells is required to preserve T-cell homeostasis and response","volume":"8","author":"Y Luo","year":"2017","journal-title":"Cell Death Dis"},{"issue":"7","key":"pbio.3000420.ref031","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/ni946","article-title":"Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells","volume":"4","author":"B Seddon","year":"2003","journal-title":"Nat Immunol"},{"issue":"6","key":"pbio.3000420.ref032","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.4049\/jimmunol.1302847","article-title":"Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function","volume":"192","author":"J Mu","year":"2014","journal-title":"J Immunol"},{"issue":"4","key":"pbio.3000420.ref033","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.4049\/jimmunol.1402520","article-title":"Fibroblastic reticular cells: organization and regulation of the T lymphocyte life cycle","volume":"194","author":"FD Brown","year":"2015","journal-title":"J Immunol"},{"issue":"11","key":"pbio.3000420.ref034","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.it.2016.08.010","article-title":"Present Yourself! By MHC Class I and MHC Class II Molecules","volume":"37","author":"KL Rock","year":"2016","journal-title":"Trends Immunol"},{"issue":"1","key":"pbio.3000420.ref035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4049\/jimmunol.175.1.201","article-title":"MHC class I-positive dendritic cells (DC) control CD8 T cell homeostasis in vivo: T cell lymphopenia as a prerequisite for DC-mediated homeostatic proliferation of naive CD8 T cells","volume":"175","author":"A Gruber","year":"2005","journal-title":"J Immunol"},{"issue":"5","key":"pbio.3000420.ref036","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/80868","article-title":"Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo","volume":"1","author":"KS Schluns","year":"2000","journal-title":"Nat Immunol"},{"issue":"4","key":"pbio.3000420.ref037","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.immuni.2015.09.006","article-title":"PI3-Kinase-gamma Has a Distinct and Essential Role in Lung-Specific Dendritic Cell Development","volume":"43","author":"SP Nobs","year":"2015","journal-title":"Immunity"},{"key":"pbio.3000420.ref038","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1038\/ncomms6138","article-title":"LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling","volume":"5","author":"JM Scheffler","year":"2014","journal-title":"Nat Commun"},{"issue":"10","key":"pbio.3000420.ref039","doi-asserted-by":"crossref","first-page":"4736","DOI":"10.4049\/jimmunol.1200069","article-title":"Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production","volume":"188","author":"M Ohtani","year":"2012","journal-title":"J Immunol"},{"issue":"4","key":"pbio.3000420.ref040","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.immuni.2015.03.003","article-title":"Homeostatic NF-kappaB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance","volume":"42","author":"M Baratin","year":"2015","journal-title":"Immunity"},{"issue":"10","key":"pbio.3000420.ref041","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/eji.200324273","article-title":"Death of peripheral CD8+ T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL","volume":"33","author":"MA Markiewicz","year":"2003","journal-title":"Eur J Immunol"},{"issue":"10","key":"pbio.3000420.ref042","doi-asserted-by":"crossref","first-page":"6428","DOI":"10.4049\/jimmunol.175.10.6428","article-title":"CD11chigh Dendritic Cell Ablation Impairs Lymphopenia-Driven Proliferation of Naive and Memory CD8+ T Cells","volume":"175","author":"T Zaft","year":"2005","journal-title":"The Journal of Immunology"},{"issue":"6","key":"pbio.3000420.ref043","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.cell.2011.11.021","article-title":"Sec22b regulates phagosomal maturation and antigen crosspresentation by dendritic cells","volume":"147","author":"I Cebrian","year":"2011","journal-title":"Cell"},{"issue":"6415","key":"pbio.3000420.ref044","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1126\/science.aat5030","article-title":"WDFY4 is required for cross-presentation in response to viral and tumor antigens","volume":"362","author":"DJ Theisen","year":"2018","journal-title":"Science"},{"issue":"11","key":"pbio.3000420.ref045","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/ni1513","article-title":"Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells","volume":"8","author":"A Link","year":"2007","journal-title":"Nat Immunol"},{"issue":"3","key":"pbio.3000420.ref046","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1084\/jem.20082394","article-title":"Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity","volume":"206","author":"C Ohnmacht","year":"2009","journal-title":"J Exp Med"},{"issue":"6","key":"pbio.3000420.ref047","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.immuni.2008.10.012","article-title":"Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome","volume":"29","author":"T Birnberg","year":"2008","journal-title":"Immunity"},{"issue":"4","key":"pbio.3000420.ref048","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.20160062","article-title":"Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation","volume":"213","author":"J Loschko","year":"2016","journal-title":"J Exp Med"},{"issue":"6","key":"pbio.3000420.ref049","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.4049\/jimmunol.1302801","article-title":"Oxidized lipids block antigen cross-presentation by dendritic cells in cancer","volume":"192","author":"R Ramakrishnan","year":"2014","journal-title":"J Immunol"},{"issue":"7","key":"pbio.3000420.ref050","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.cell.2015.05.025","article-title":"ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis","volume":"161","author":"JR Cubillos-Ruiz","year":"2015","journal-title":"Cell"},{"issue":"5","key":"pbio.3000420.ref051","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/11.5.525","article-title":"A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells","volume":"11","author":"DJ Kwiatkowski","year":"2002","journal-title":"Human molecular genetics"},{"issue":"21","key":"pbio.3000420.ref052","doi-asserted-by":"crossref","first-page":"9508","DOI":"10.1128\/MCB.24.21.9508-9516.2004","article-title":"Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development","volume":"24","author":"YG Gangloff","year":"2004","journal-title":"Molecular and cellular biology"},{"issue":"7327","key":"pbio.3000420.ref053","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nature09584","article-title":"mTORC1 controls fasting-induced ketogenesis and its modulation by ageing","volume":"468","author":"S Sengupta","year":"2010","journal-title":"Nature"},{"issue":"7","key":"pbio.3000420.ref054","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20062648","article-title":"Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen","volume":"204","author":"ML Caton","year":"2007","journal-title":"J Exp Med"},{"issue":"4","key":"pbio.3000420.ref055","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"BE Clausen","year":"1999","journal-title":"Transgenic research"},{"issue":"1","key":"pbio.3000420.ref056","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1711.1998.00709.x","article-title":"Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements","volume":"76","author":"MJ Barnden","year":"1998","journal-title":"Immunology and cell biology"},{"issue":"1","key":"pbio.3000420.ref057","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"T cell receptor antagonist peptides induce positive selection","volume":"76","author":"KA Hogquist","year":"1994","journal-title":"Cell"},{"issue":"6","key":"pbio.3000420.ref058","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ni.3155","article-title":"Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses","volume":"16","author":"Z Deng","year":"2015","journal-title":"Nat Immunol"},{"issue":"5","key":"pbio.3000420.ref059","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1084\/jem.20161149","article-title":"Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7\/9-elicited IFN response in pDCs","volume":"214","author":"S Ma","year":"2017","journal-title":"J Exp Med"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3000420","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.3000420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:41:02Z","timestamp":1589046062000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000420"}},"subtitle":[],"editor":[{"given":"Avinash","family":"Bhandoola","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":59,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,8,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3000420","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pbio.3000420","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]}}}