{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:28:43Z","timestamp":1790778523057,"version":"4.1.0"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2015-05033"],"award-info":[{"award-number":["2015-05033"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000034","name":"Institute of Neurosciences, Mental Health and Addiction","doi-asserted-by":"publisher","award":["2010-04-01"],"award-info":[{"award-number":["2010-04-01"]}],"id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.3000516","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T14:36:38Z","timestamp":1574346998000},"page":"e3000516","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Data-driven analyses of motor impairments in animal models of neurological disorders"],"prefix":"10.1371","volume":"17","author":[{"given":"Hardeep","family":"Ryait","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-1780","authenticated-orcid":true,"given":"Edgar","family":"Bermudez-Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-1215","authenticated-orcid":true,"given":"Matthew","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshid","family":"Faraji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behroo","family":"Mirza Agha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gomez-Palacio Schjetnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Doan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Mohajerani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlinde A. S.","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian Q.","family":"Whishaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-5781","authenticated-orcid":true,"given":"Artur","family":"Luczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"issue":"3","key":"pbio.3000516.ref001","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.neuron.2016.12.041","article-title":"Neuroscience needs behavior: correcting a reductionist bias","volume":"93","author":"JW Krakauer","year":"2017","journal-title":"Neuron"},{"issue":"1","key":"pbio.3000516.ref002","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/ilar.39.1.20","article-title":"Why it is important to understand animal behavior","volume":"39","author":"J Mench","year":"1998","journal-title":"ILAR journal"},{"issue":"5","key":"pbio.3000516.ref003","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.neubiorev.2013.03.026","article-title":"A behavioral method for identifying recovery and compensation: hand use in a preclinical stroke model using the single pellet reaching task.","volume":"37","author":"M Alaverdashvili","year":"2013","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"pbio.3000516.ref004","first-page":"1545968318817823","article-title":"Characterizing Spontaneous Motor Recovery Following Cortical and Subcortical Stroke in the Rat","author":"S Karthikeyan","year":"2018","journal-title":"Neurorehabilitation and neural repair"},{"key":"pbio.3000516.ref005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbr.2018.02.025","article-title":"Qandeel, Whishaw IQ, Wallace DG. The structure of arm and hand movements in a spontaneous and food rewarded on-line string-pulling task by the mouse","volume":"345","author":"AA Blackwell","year":"2018","journal-title":"Behav Brain Res"},{"issue":"3","key":"pbio.3000516.ref006","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.neubiorev.2011.12.010","article-title":"The use of rodent skilled reaching as a translational model for investigating brain damage and disease.","volume":"36","author":"A Klein","year":"2012","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"pbio.3000516.ref007","doi-asserted-by":"crossref","first-page":"8581","DOI":"10.1038\/ncomms9581","article-title":"Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury","volume":"6","author":"JL Nielson","year":"2015","journal-title":"Nature communications"},{"issue":"111","key":"pbio.3000516.ref008","doi-asserted-by":"crossref","DOI":"10.3791\/53951","article-title":"A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test","author":"M Rattka","year":"2016","journal-title":"Journal of visualized experiments: JoVE"},{"issue":"1","key":"pbio.3000516.ref009","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbr.2009.05.035","article-title":"Similar hand shaping in reaching-for-food (skilled reaching) in rats and humans provides evidence of homology in release, collection, and manipulation movements","volume":"204","author":"L-AR Sacrey","year":"2009","journal-title":"Behavioural brain research"},{"issue":"41","key":"pbio.3000516.ref010","doi-asserted-by":"crossref","first-page":"13574","DOI":"10.1523\/JNEUROSCI.2500-14.2014","article-title":"Motor cortex is functionally organized as a set of spatially distinct representations for complex movements","volume":"34","author":"AR Brown","year":"2014","journal-title":"Journal of Neuroscience"},{"issue":"5","key":"pbio.3000516.ref011","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrn.2017.26","article-title":"Motor compensation and its effects on neural reorganization after stroke","volume":"18","author":"TA Jones","year":"2017","journal-title":"Nature Reviews Neuroscience"},{"issue":"1\u20132","key":"pbio.3000516.ref012","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0166-4328(97)00195-2","article-title":"The effects of unilateral pyramidal tract section on hindlimb motor performance in the rat","volume":"96","author":"G Metz","year":"1998","journal-title":"Behavioural brain research"},{"issue":"1\u20132","key":"pbio.3000516.ref013","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0031-9384(00)00371-1","article-title":"The effects of acute and chronic stress on motor and sensory performance in male Lewis rats","volume":"72","author":"GA Metz","year":"2001","journal-title":"Physiology & behavior"},{"issue":"2","key":"pbio.3000516.ref014","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-0270(02)00012-2","article-title":"Cortical and subcortical lesions impair skilled walking in the ladder rung walking test: a new task to evaluate fore-and hindlimb stepping, placing, and co-ordination","volume":"115","author":"GA Metz","year":"2002","journal-title":"Journal of neuroscience methods"},{"issue":"28","key":"pbio.3000516.ref015","article-title":"The ladder rung walking task: a scoring system and its practical application","author":"GA Metz","year":"2009","journal-title":"Journal of visualized experiments: JoVE"},{"issue":"2","key":"pbio.3000516.ref016","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.expneurol.2012.05.007","article-title":"Concurrent silent strokes impair motor function by limiting behavioral compensation","volume":"236","author":"J Faraji","year":"2012","journal-title":"Experimental neurology"},{"key":"pbio.3000516.ref017","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.lmot.2016.12.002","article-title":"Use of the parallel beam task for skilled walking in a rat model of cerebral ischemia: A qualitative approach.","volume":"61","author":"B Ficiur","year":"2018","journal-title":"Learning and Motivation"},{"key":"pbio.3000516.ref018","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3389\/fneur.2018.00923","article-title":"Improving Hand function of Severely Impaired Chronic Hemiparetic Stroke Individuals using Task Specific Training with the ReIn-Hand system: A Case Series","volume":"9","author":"C Carmona","year":"2018","journal-title":"Frontiers in neurology"},{"issue":"1","key":"pbio.3000516.ref019","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jneumeth.2006.05.007","article-title":"Changes in the kinematic structure and non-kinematic features of movements during skilled reaching after stroke: A laban movement analysis in two case studies","volume":"158","author":"A Foroud","year":"2006","journal-title":"Journal of neuroscience methods"},{"issue":"1","key":"pbio.3000516.ref020","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12938-018-0600-7","article-title":"Objective and automatic classification of Parkinson disease with Leap Motion controller","volume":"17","author":"A Butt","year":"2018","journal-title":"Biomedical engineering online"},{"issue":"2","key":"pbio.3000516.ref021","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbr.2008.07.015","article-title":"Bilateral impairments of skilled reach-to-eat in early Parkinson's disease patients presenting with unilateral or asymmetrical symptoms","volume":"194","author":"JB Doan","year":"2008","journal-title":"Behavioural brain research"},{"issue":"2","key":"pbio.3000516.ref022","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0166-4328(01)00479-X","article-title":"Impairment of pronation, supination, and body co-ordination in reach-to-grasp tasks in human Parkinson's disease (PD) reveals homology to deficits in animal models","volume":"133","author":"IQ Whishaw","year":"2002","journal-title":"Behavioural brain research"},{"issue":"2","key":"pbio.3000516.ref023","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.nbd.2010.11.002","article-title":"Proximal movements compensate for distal forelimb movement impairments in a reach-to-eat task in Huntington's disease: new insights into motor impairments in a real-world skill","volume":"41","author":"A Klein","year":"2011","journal-title":"Neurobiology of disease"},{"issue":"1","key":"pbio.3000516.ref024","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/00336297.1975.10519825","article-title":"Movement notation systems: An introduction","volume":"23","author":"S Kleinman","year":"1975","journal-title":"Quest"},{"issue":"23","key":"pbio.3000516.ref025","doi-asserted-by":"crossref","first-page":"13982","DOI":"10.1073\/pnas.95.23.13982","article-title":"Movement analysis in infancy may be useful for early diagnosis of autism","volume":"95","author":"P Teitelbaum","year":"1998","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"pbio.3000516.ref026","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0166-4328(90)90053-H","article-title":"The structure of skilled forelimb reaching in the rat: a proximally driven movement with a single distal rotatory component","volume":"41","author":"IQ Whishaw","year":"1990","journal-title":"Behav Brain Res"},{"issue":"7","key":"pbio.3000516.ref027","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/nrn877","article-title":"Animal models of neurological deficits: how relevant is the rat?","volume":"3","author":"MA Cenci","year":"2002","journal-title":"Nature Reviews Neuroscience"},{"key":"pbio.3000516.ref028","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/7125057","article-title":"Understanding the mechanisms of recovery and\/or compensation following injury","volume":"2017","author":"MJ Hylin","year":"2017","journal-title":"Neural plasticity"},{"key":"pbio.3000516.ref029","first-page":"1097","volume-title":"Advances in neural information processing systems","author":"A Krizhevsky","year":"2012"},{"issue":"8","key":"pbio.3000516.ref030","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1109\/TPAMI.2012.231","article-title":"Learning hierarchical features for scene labeling","volume":"35","author":"C Farabet","year":"2013","journal-title":"IEEE transactions on pattern analysis and machine intelligence"},{"key":"pbio.3000516.ref031","first-page":"1791","volume-title":"Proceedings of the IEEE conference on computer vision and pattern recognition","author":"Y Taigman","year":"2014"},{"key":"pbio.3000516.ref032","first-page":"1026","volume-title":"Proceedings of the IEEE international conference on computer vision","author":"K He","year":"2015"},{"key":"pbio.3000516.ref033","first-page":"1653","volume-title":"Proceedings of the IEEE conference on computer vision and pattern recognition","author":"A Toshev","year":"2014"},{"key":"pbio.3000516.ref034","first-page":"1799","volume-title":"Advances in neural information processing systems","author":"JJ Tompson","year":"2014"},{"key":"pbio.3000516.ref035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-642-25446-8_4","volume-title":"International Workshop on Human Behavior Understanding","author":"M Baccouche","year":"2011"},{"key":"pbio.3000516.ref036","first-page":"2818","volume-title":"Proceedings of the IEEE conference on computer vision and pattern recognition","author":"C Szegedy","year":"2016"},{"issue":"23","key":"pbio.3000516.ref037","doi-asserted-by":"crossref","first-page":"8619","DOI":"10.1073\/pnas.1403112111","article-title":"Performance-optimized hierarchical models predict neural responses in higher visual cortex","volume":"111","author":"DL Yamins","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7","key":"pbio.3000516.ref038","doi-asserted-by":"crossref","first-page":"e0130140","DOI":"10.1371\/journal.pone.0130140","article-title":"On pixel-wise explanations for non-linear classifier decisions by layer-wise relevance propagation","volume":"10","author":"S Bach","year":"2015","journal-title":"PLoS ONE"},{"key":"pbio.3000516.ref039","author":"M Ancona","year":"2018"},{"key":"pbio.3000516.ref040","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.expneurol.2013.02.013","article-title":"Anatomical correlates of recovery in single pellet reaching in spinal cord injured rats","volume":"247","author":"C Hurd","year":"2013","journal-title":"Experimental neurology"},{"issue":"5","key":"pbio.3000516.ref041","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0028-3908(99)00259-2","article-title":"Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat","volume":"39","author":"IQ Whishaw","year":"2000","journal-title":"Neuropharmacology"},{"issue":"Nov","key":"pbio.3000516.ref042","first-page":"2579","article-title":"Visualizing data using t-SNE","volume":"9","author":"Maaten Lvd","year":"2008","journal-title":"Journal of machine learning research"},{"issue":"1","key":"pbio.3000516.ref043","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41592-018-0234-5","article-title":"Fast animal pose estimation using deep neural networks","volume":"16","author":"TD Pereira","year":"2019","journal-title":"Nature methods"},{"key":"pbio.3000516.ref044","first-page":"1546","author":"A Mathis","year":"2018"},{"issue":"2","key":"pbio.3000516.ref045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0169-7439(01)00155-1","article-title":"PLS-regression: a basic tool of chemometrics","volume":"58","author":"S Wold","year":"2001","journal-title":"Chemometrics and intelligent laboratory systems"},{"issue":"5","key":"pbio.3000516.ref046","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1523\/JNEUROSCI.19-05-01885.1999","article-title":"Complete compensation in skilled reaching success with associated impairments in limb synergies, after dorsal column lesion in the rat","volume":"19","author":"JE McKenna","year":"1999","journal-title":"Journal of Neuroscience"},{"key":"pbio.3000516.ref047","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnins.2016.00005","article-title":"A proposal for a rat model of spinal cord injury featuring the rubrospinal tract and its contributions to locomotion and skilled hand movement","volume":"10","author":"R Morris","year":"2016","journal-title":"Frontiers in neuroscience"},{"issue":"2","key":"pbio.3000516.ref048","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/neuros\/nyy537","article-title":"Ultra-Early (< 12 Hours) Surgery Correlates With Higher Rate of American Spinal Injury Association Impairment Scale Conversion After Cervical Spinal Cord Injury","volume":"85","author":"JF Burke","year":"2019","journal-title":"Neurosurgery"},{"key":"pbio.3000516.ref049","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00702-018-1886-0","article-title":"On the neuronal circuitry mediating l-DOPA-induced dyskinesia","volume":"125","author":"MA Cenci","year":"2018","journal-title":"Journal of neural transmission"},{"issue":"16","key":"pbio.3000516.ref050","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1089\/neu.2018.5906","article-title":"Rehabilitative Training in Animal Models of Spinal Cord Injury","volume":"35","author":"A Torres-Esp\u00edn","year":"2018","journal-title":"Journal of neurotrauma"},{"issue":"9","key":"pbio.3000516.ref051","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/bjsports-2015-094913","article-title":"How reliable are Functional Movement Screening scores? A systematic review of rater reliability","volume":"50","author":"RW Moran","year":"2016","journal-title":"Br J Sports Med"},{"key":"pbio.3000516.ref052","first-page":"193","volume-title":"Proceedings of the 7th IEEE\/ACM International Symposium on Mixed and Augmented Reality. IEEE Computer Society","author":"F Zhou","year":"2008"},{"issue":"7","key":"pbio.3000516.ref053","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.tree.2014.05.004","article-title":"Automated image-based tracking and its application in ecology","volume":"29","author":"AI Dell","year":"2014","journal-title":"Trends in ecology & evolution"},{"issue":"1","key":"pbio.3000516.ref054","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuron.2014.09.005","article-title":"Toward a science of computational ethology","volume":"84","author":"DJ Anderson","year":"2014","journal-title":"Neuron"},{"issue":"10","key":"pbio.3000516.ref055","doi-asserted-by":"crossref","first-page":"e78460","DOI":"10.1371\/journal.pone.0078460","article-title":"A 3D-video-based computerized analysis of social and sexual interactions in rats","volume":"8","author":"J Matsumoto","year":"2013","journal-title":"PLoS ONE"},{"key":"pbio.3000516.ref056","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1109\/CVPR.2010.5540094","volume-title":"Computer Vision and Pattern Recognition (CVPR), 2010 IEEE Conference","author":"P Doll\u00e1r","year":"2010"},{"key":"pbio.3000516.ref057","doi-asserted-by":"crossref","first-page":"e07892","DOI":"10.7554\/eLife.07892","article-title":"A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice","volume":"4","author":"AS Machado","year":"2015","journal-title":"Elife"},{"issue":"5","key":"pbio.3000516.ref058","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0149-7634(01)00022-7","article-title":"SEE: a tool for the visualization and analysis of rodent exploratory behavior.","volume":"25","author":"D Drai","year":"2001","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"pbio.3000516.ref059","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1601-183X.2006.00228.x","article-title":"A hitchhiker's guide to behavioral analysis in laboratory rodents","volume":"5","author":"N Sousa","year":"2006","journal-title":"Genes, Brain and Behavior"},{"issue":"8","key":"pbio.3000516.ref060","doi-asserted-by":"crossref","first-page":"e41642","DOI":"10.1371\/journal.pone.0041642","article-title":"Automated tracking of animal posture and movement during exploration and sensory orientation behaviors","volume":"7","author":"A Gomez-Marin","year":"2012","journal-title":"PLoS ONE"},{"issue":"1","key":"pbio.3000516.ref061","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12915-017-0377-3","article-title":"OptiMouse: a comprehensive open source program for reliable detection and analysis of mouse body and nose positions","volume":"15","author":"Y Ben-Shaul","year":"2017","journal-title":"BMC biology"},{"issue":"99","key":"pbio.3000516.ref062","doi-asserted-by":"crossref","first-page":"20140672","DOI":"10.1098\/rsif.2014.0672","article-title":"Mapping the stereotyped behaviour of freely moving fruit flies","volume":"11","author":"GJ Berman","year":"2014","journal-title":"Journal of The Royal Society Interface"},{"issue":"6","key":"pbio.3000516.ref063","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.neuron.2015.11.031","article-title":"Mapping sub-second structure in mouse behavior","volume":"88","author":"AB Wiltschko","year":"2015","journal-title":"Neuron"},{"key":"pbio.3000516.ref064","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnsys.2019.00020","article-title":"DeepBehavior: A deep learning toolbox for automated analysis of animal and human behavior imaging data","volume":"13","author":"A Arac","year":"2019","journal-title":"Frontiers in systems neuroscience"},{"key":"pbio.3000516.ref065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/ncomms1064","article-title":"Automated home-cage behavioural phenotyping of mice","volume":"1","author":"H Jhuang","year":"2010","journal-title":"Nature communications"},{"issue":"2","key":"pbio.3000516.ref066","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1136\/jnnp-2013-306881","article-title":"Clinical neurology: why this still matters in the 21st century","volume":"86","author":"DJ Nicholl","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"pbio.3000516.ref067","article-title":"Deep inside convolutional networks: Visualising image classification models and saliency maps","author":"K Simonyan","year":"2014"},{"key":"pbio.3000516.ref068","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbr.2013.07.022","article-title":"Beyond the silence: bilateral somatosensory stimulation enhances skilled movement quality and neural density in intact behaving rats","volume":"253","author":"J Faraji","year":"2013","journal-title":"Behavioural brain research"},{"issue":"2","key":"pbio.3000516.ref069","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0166-4328(00)00245-X","article-title":"Skilled reaching an action pattern: stability in rat (Rattus norvegicus) grasping movements as a function of changing food pellet size","volume":"116","author":"GA Metz","year":"2000","journal-title":"Behav Brain Res"},{"issue":"1","key":"pbio.3000516.ref070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbr.2005.03.002","article-title":"Motor improvements after focal cortical ischemia in adult rats are mediated by compensatory mechanisms","volume":"162","author":"GA Metz","year":"2005","journal-title":"Behav Brain Res"},{"key":"pbio.3000516.ref071","first-page":"290","article-title":"Direct Current Stimulation Improves Limb Use After Stroke by Enhancing Inter-hemispheric Coherence.","volume":"79","author":"AGP Schjetnan","year":"2019","journal-title":"Acta Neurobiologiae Experimentalis"},{"issue":"1","key":"pbio.3000516.ref072","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/2040-7378-2-18","article-title":"Stress-induced glucocorticoid receptor activation determines functional recovery following ischemic stroke","volume":"2","author":"FC Zucchi","year":"2010","journal-title":"Experimental & translational stroke medicine"},{"issue":"4","key":"pbio.3000516.ref073","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ipm.2009.03.002","article-title":"A systematic analysis of performance measures for classification tasks","volume":"45","author":"M Sokolova","year":"2009","journal-title":"Information processing & management"},{"issue":"2","key":"pbio.3000516.ref074","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1207\/s15327906mbr0102_10","article-title":"The scree test for the number of factors","volume":"1","author":"RB Cattell","year":"1966","journal-title":"Multivariate behavioral research"},{"issue":"7553","key":"pbio.3000516.ref075","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","article-title":"Deep learning","volume":"521","author":"Y LeCun","year":"2015","journal-title":"Nature"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3002521","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000}},{"DOI":"10.1371\/journal.pbio.3004030","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T14:37:24Z","timestamp":1574347044000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000516"}},"subtitle":[],"editor":[{"given":"James","family":"Ashe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,21]]},"references-count":75,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3000516","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pbio.3002521","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,21]]}}}