{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:19:06Z","timestamp":1788848346123,"version":"build-2803163510"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI101987"],"award-info":[{"award-number":["R21AI101987"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI120634"],"award-info":[{"award-number":["R01AI120634"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002570","name":"American Association of Immunologists","doi-asserted-by":"publisher","award":["AAI Careers in Immunology Fellowship Award"],"award-info":[{"award-number":["AAI Careers in Immunology Fellowship Award"]}],"id":[{"id":"10.13039\/100002570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.3000590","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T18:24:36Z","timestamp":1582050276000},"page":"e3000590","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases"],"prefix":"10.1371","volume":"18","author":[{"given":"Robin A.","family":"Welsh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianbin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8870-5993","authenticated-orcid":true,"given":"Catherine A.","family":"Foss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5270-3849","authenticated-orcid":true,"given":"Tatiana","family":"Boronina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3096-4754","authenticated-orcid":true,"given":"Robert N.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-1720","authenticated-orcid":true,"given":"Scheherazade","family":"Sadegh-Nasseri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"issue":"7882","key":"pbio.3000590.ref001","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(74)93310-8","article-title":"Letter: HL-A antigens and coeliac disease","volume":"2","author":"DJ Mulder","year":"1974","journal-title":"Lancet"},{"issue":"4","key":"pbio.3000590.ref002","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1056\/NEJM197107222850403","article-title":"Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease","volume":"285","author":"FC Grumet","year":"1971","journal-title":"N Engl J Med"},{"issue":"1","key":"pbio.3000590.ref003","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13059-017-1207-1","article-title":"The MHC locus and genetic susceptibility to autoimmune and infectious diseases","volume":"18","author":"V Matzaraki","year":"2017","journal-title":"Genome Biol"},{"issue":"0","key":"pbio.3000590.ref004","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coi.2014.12.005","article-title":"Determinants of immunodominance for CD4 T cells","volume":"34","author":"A Kim","year":"2015","journal-title":"Current Opinion in Immunology"},{"key":"pbio.3000590.ref005","article-title":"Selection of immunodominant epitopes during antigen processing is hierarchical","author":"S Sadegh-Nasseri","year":"2018","journal-title":"Mol Immunol"},{"issue":"7","key":"pbio.3000590.ref006","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41577-018-0003-9","article-title":"A cold-blooded view of adaptive immunity","volume":"18","author":"MF Flajnik","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"6326","key":"pbio.3000590.ref007","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/351485a0","article-title":"A novel class II MHC molecule with unusual tissue distribution","volume":"351","author":"L Karlsson","year":"1991","journal-title":"Nature"},{"issue":"3","key":"pbio.3000590.ref008","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/intimm\/9.3.355","article-title":"HLA-DO is an intracellular class II molecule with distinctive thymic expression","volume":"9","author":"DC Douek","year":"1997","journal-title":"Int Immunol"},{"issue":"1","key":"pbio.3000590.ref009","doi-asserted-by":"crossref","first-page":"13877","DOI":"10.1038\/s41598-019-50455-y","article-title":"Synergy between B cell receptor\/antigen uptake and MHCII peptide editing relies on HLA-DO tuning","volume":"9","author":"W Jiang","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"pbio.3000590.ref010","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.4049\/jimmunol.176.6.3536","article-title":"Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation","volume":"176","author":"TM Hornell","year":"2006","journal-title":"J Immunol"},{"issue":"6","key":"pbio.3000590.ref011","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.4049\/jimmunol.176.6.3548","article-title":"H2-O expression in primary dendritic cells","volume":"176","author":"X Chen","year":"2006","journal-title":"Journal of immunology"},{"issue":"3","key":"pbio.3000590.ref012","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.4049\/jimmunol.178.3.1488","article-title":"Expression patterns of H2-O in mouse B cells and dendritic cells correlate with cell function","volume":"178","author":"JL Fallas","year":"2007","journal-title":"J Immunol"},{"issue":"1","key":"pbio.3000590.ref013","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/gene.2009.69","article-title":"Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population","volume":"11","author":"RJ Reynolds","year":"2010","journal-title":"Genes and immunity"},{"issue":"2","key":"pbio.3000590.ref014","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ajhg.2016.06.019","article-title":"Contribution of a non-classical HLA gene, HLA-DOA, to the risk of rheumatoid arthritis","volume":"99","author":"Y Okada","year":"2016","journal-title":"Am J Hum Genet"},{"issue":"2","key":"pbio.3000590.ref015","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.immuni.2017.07.013","article-title":"Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob","volume":"47","author":"LK Denzin","year":"2017","journal-title":"Immunity"},{"issue":"4","key":"pbio.3000590.ref016","doi-asserted-by":"crossref","first-page":"e019406","DOI":"10.1136\/bmjopen-2017-019406","article-title":"Association between human leucocyte antigen-DO polymorphisms and interferon\/ribavirin treatment response in hepatitis C virus type 1 infection in Chinese population: a prospective study","volume":"8","author":"Y Yao","year":"2018","journal-title":"BMJ Open"},{"issue":"4","key":"pbio.3000590.ref017","first-page":"e0123513","article-title":"Association of polymorphisms in HLA antigen presentation-related genes with the outcomes of HCV infection","volume":"10","author":"P Huang","year":"2015","journal-title":"PLoS ONEPubMed Central PMCID"},{"issue":"5","key":"pbio.3000590.ref018","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbmt.2014.02.005","article-title":"Human leukocyte antigen-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies","volume":"20","author":"AN Kremer","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"pbio.3000590.ref019","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1172\/JCI40220","article-title":"Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence","volume":"120","author":"W Yi","year":"2010","journal-title":"J Clin Invest"},{"issue":"1","key":"pbio.3000590.ref020","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4049\/jimmunol.1200993","article-title":"Immunodeficiency and autoimmunity in H2-O-deficient mice","volume":"190","author":"Y Gu","year":"2013","journal-title":"Journal of immunology"},{"issue":"3","key":"pbio.3000590.ref021","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00251-018-01097-3","article-title":"What to do with HLA-DO\/H-2O two decades later","volume":"71","author":"R Welsh","year":"2019","journal-title":"Immunogenetics"},{"issue":"3","key":"pbio.3000590.ref022","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.4049\/jimmunol.173.3.1549","article-title":"Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation","volume":"173","author":"JL Fallas","year":"2004","journal-title":"J Immunol"},{"issue":"12","key":"pbio.3000590.ref023","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0960-9822(06)00414-3","article-title":"HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading","volume":"7","author":"SM van Ham","year":"1997","journal-title":"Curr Biol"},{"key":"pbio.3000590.ref024","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.coi.2013.11.005","article-title":"HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation","volume":"26","author":"ED Mellins","year":"2014","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"pbio.3000590.ref025","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nsmb.2460","article-title":"HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism","volume":"20","author":"AI Guce","year":"2013","journal-title":"Nature structural & molecular biology"},{"issue":"7","key":"pbio.3000590.ref026","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.cell.2012.11.025","article-title":"Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection","volume":"151","author":"W Pos","year":"2012","journal-title":"Cell"},{"issue":"11","key":"pbio.3000590.ref027","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1093\/emboj\/17.11.2971","article-title":"A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules","volume":"17","author":"H Kropshofer","year":"1998","journal-title":"Embo J"},{"issue":"8","key":"pbio.3000590.ref028","doi-asserted-by":"crossref","first-page":"e71228","DOI":"10.1371\/journal.pone.0071228","article-title":"HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation","volume":"8","author":"YO Poluektov","year":"2013","journal-title":"PLoS ONE"},{"issue":"6","key":"pbio.3000590.ref029","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nri3667","article-title":"Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)","volume":"14","author":"L Klein","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"pbio.3000590.ref030","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.4049\/jimmunol.0804087","article-title":"Autophagic compartments gain access to the MHC class II compartments in thymic epithelium","volume":"183","author":"M Kasai","year":"2009","journal-title":"J Immunol"},{"key":"pbio.3000590.ref031","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-59745-395-0_7","article-title":"Derivation, culture, and characterization of thymic epithelial cell lines","volume":"380","author":"M Kasai","year":"2007","journal-title":"Methods Mol Biol"},{"issue":"12","key":"pbio.3000590.ref032","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1002\/1521-4141(200012)30:12<3542::AID-IMMU3542>3.0.CO;2-N","article-title":"CLIP-derived self peptides bound to MHC class II molecules of medullary thymic epithelial cells differ from those of cortical thymic epithelial cells in their diversity, length, and C-terminal processing","volume":"30","author":"M Kasai","year":"2000","journal-title":"Eur J Immunol"},{"issue":"6","key":"pbio.3000590.ref033","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/(SICI)1521-4141(199806)28:06<1867::AID-IMMU1867>3.0.CO;2-K","article-title":"The antigen presentation pathway in medullary thymic epithelial cells, but not that in cortical thymic epithelial cells, conforms to the endocytic pathway","volume":"28","author":"M Kasai","year":"1998","journal-title":"Eur J Immunol"},{"issue":"2","key":"pbio.3000590.ref034","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/cimm.1997.1192","article-title":"Selective antigen presenting activity of cortical thymic epithelial cells against CD4+ T cells associated with both lack of costimulatory molecules and inefficient presentation of MHC-peptide ligands","volume":"181","author":"R Kaneda","year":"1997","journal-title":"Cell Immunol"},{"issue":"9","key":"pbio.3000590.ref035","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1002\/eji.1830260921","article-title":"Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells","volume":"26","author":"M Kasai","year":"1996","journal-title":"Eur J Immunol"},{"issue":"18","key":"pbio.3000590.ref036","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1002\/j.1460-2075.1996.tb00862.x","article-title":"HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport","volume":"15","author":"M Liljedahl","year":"1996","journal-title":"The EMBO journal"},{"issue":"9","key":"pbio.3000590.ref037","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/bioinformatics\/btx820","article-title":"An automated benchmarking platform for MHC class II binding prediction methods","volume":"34","author":"M Andreatta","year":"2018","journal-title":"Bioinformatics"},{"key":"pbio.3000590.ref038","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/1471-2105-11-568","article-title":"Peptide binding predictions for HLA DR, DP and DQ molecules","volume":"11","author":"P Wang","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"pbio.3000590.ref039","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/ni1409","article-title":"In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides","volume":"8","author":"GE Hammer","year":"2007","journal-title":"Nat Immunol"},{"issue":"2","key":"pbio.3000590.ref040","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/cyto.a.21010","article-title":"Interpretation of cellular proliferation data: avoid the panglossian","volume":"79","author":"M. Roederer","year":"2011","journal-title":"Cytometry A"},{"issue":"6","key":"pbio.3000590.ref041","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/art.24501","article-title":"Autoimmune regulator controls T cell help for pathogenetic autoantibody production in collagen-induced arthritis","volume":"60","author":"IK Campbell","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"6","key":"pbio.3000590.ref042","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1084\/jem.185.6.1113","article-title":"An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen","volume":"185","author":"EF Rosloniec","year":"1997","journal-title":"J Exp Med"},{"key":"pbio.3000590.ref043","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1038\/ncomms6369","article-title":"Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources","volume":"5","author":"A Kim","year":"2014","journal-title":"Nature communications"},{"issue":"6","key":"pbio.3000590.ref044","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1007\/s11307-019-01318-5","article-title":"Imaging and characterization of macrophage distribution in mouse models of human prostate cancer","volume":"21","author":"BT Copeland","year":"2019","journal-title":"Mol Imaging Biol"},{"key":"pbio.3000590.ref045","doi-asserted-by":"crossref","DOI":"10.1201\/9781315533247","volume-title":"Janeway's Immunobiology","author":"K Murphy","year":"2016"},{"issue":"1","key":"pbio.3000590.ref046","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/bc3005842","article-title":"Direct detection of collagenous proteins by fluorescently labeled collagen mimetic peptides","volume":"24","author":"Y Li","year":"2013","journal-title":"Bioconjug Chem"},{"issue":"37","key":"pbio.3000590.ref047","doi-asserted-by":"crossref","first-page":"14767","DOI":"10.1073\/pnas.1209721109","article-title":"Targeting collagen strands by photo-triggered triple-helix hybridization","volume":"109","author":"Y Li","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"22","key":"pbio.3000590.ref048","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1002\/adfm.201101163","article-title":"Matrix-Bound VEGF Mimetic Peptides: Design and Endothelial Cell Activation in Collagen Scaffolds","volume":"21","author":"TR Chan","year":"2011","journal-title":"Adv Funct Mater"},{"key":"pbio.3000590.ref049","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/978-1-4939-9095-5_10","article-title":"In Situ Detection of Degraded and Denatured Collagen via Triple Helical Hybridization: New Tool in Histopathology","volume":"1944","author":"Y Li","year":"2019","journal-title":"Methods Mol Biol"},{"key":"pbio.3000590.ref050","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biomaterials.2018.08.039","article-title":"Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging","volume":"183","author":"LL Bennink","year":"2018","journal-title":"Biomaterials"},{"key":"pbio.3000590.ref051","doi-asserted-by":"crossref","first-page":"14913","DOI":"10.1038\/ncomms14913","article-title":"Molecular level detection and localization of mechanical damage in collagen enabled by collagen hybridizing peptides","volume":"8","author":"JL Zitnay","year":"2017","journal-title":"Nat Commun"},{"issue":"10","key":"pbio.3000590.ref052","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.1021\/acsnano.7b03150","article-title":"In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides","volume":"11","author":"J Hwang","year":"2017","journal-title":"ACS Nano"},{"issue":"1","key":"pbio.3000590.ref053","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/eji.200324669","article-title":"Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38\u201351 peptide","volume":"34","author":"TR Petersen","year":"2004","journal-title":"Eur J Immunol"},{"issue":"2","key":"pbio.3000590.ref054","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/eji.200535363","article-title":"Anatomy of T cell autoimmunity to myelin oligodendrocyte glycoprotein (MOG): prime role of MOG44F in selection and control of MOG-reactive T cells in H-2b mice","volume":"36","author":"A Ben-Nun","year":"2006","journal-title":"Eur J Immunol"},{"issue":"6468","key":"pbio.3000590.ref055","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/368215a0","article-title":"Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide","volume":"368","author":"LJ Stern","year":"1994","journal-title":"Nature"},{"issue":"6","key":"pbio.3000590.ref056","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1111\/j.1471-4159.1988.tb01153.x","article-title":"Expression and localization of myelin basic protein in oligodendrocytes and transfected fibroblasts","volume":"51","author":"E Barbarese","year":"1988","journal-title":"J Neurochem"},{"issue":"9","key":"pbio.3000590.ref057","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1084\/jem.20021603","article-title":"Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis","volume":"197","author":"E Bettelli","year":"2003","journal-title":"J Exp Med"},{"issue":"5335","key":"pbio.3000590.ref058","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1126\/science.278.5335.106","article-title":"Negative regulation by HLA-DO of MHC class II-restricted antigen processing","volume":"278","author":"LK Denzin","year":"1997","journal-title":"Science"},{"issue":"28","key":"pbio.3000590.ref059","doi-asserted-by":"crossref","first-page":"11276","DOI":"10.1073\/pnas.1113966109","article-title":"Mapping the HLA-DO\/HLA-DM complex by FRET and mutagenesis","volume":"109","author":"T Yoon","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"15","key":"pbio.3000590.ref060","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1016\/j.molimm.2008.06.017","article-title":"Characterization of intracellular HLA-DR, DM and DO profile in K562 and HL-60 leukemic cells","volume":"45","author":"L Papadimitriou","year":"2008","journal-title":"Mol Immunol"},{"issue":"7","key":"pbio.3000590.ref061","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.4049\/jimmunol.161.7.3282","article-title":"The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules","volume":"161","author":"C Hammond","year":"1998","journal-title":"J Immunol"},{"issue":"6234","key":"pbio.3000590.ref062","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.aaa7017","article-title":"Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance","volume":"348","author":"S Yang","year":"2015","journal-title":"Science"},{"issue":"4","key":"pbio.3000590.ref063","doi-asserted-by":"crossref","first-page":"e1000048","DOI":"10.1371\/journal.pcbi.1000048","article-title":"A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach","volume":"4","author":"P Wang","year":"2008","journal-title":"PLoS Comput Biol"},{"key":"pbio.3000590.ref064","article-title":"HLA-DO modulates the diversity of the MHC-II self-peptidome","author":"PP Nanaware","year":"2018","journal-title":"Mol Cell Proteomics"},{"key":"pbio.3000590.ref065","article-title":"Directing T cell fate: How thymic antigen presenting cells coordinate thymocyte selection","author":"ER Breed","year":"2017","journal-title":"Semin Cell Dev Biol"},{"issue":"83","key":"pbio.3000590.ref066","article-title":"Imaging denatured collagen strands in vivo and ex vivo via photo-triggered hybridization of caged collagen mimetic peptides","author":"Y Li","year":"2014","journal-title":"Journal of visualized experiments: JoVE"},{"issue":"8","key":"pbio.3000590.ref067","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1074\/jbc.M113.530808","article-title":"Definition of the native and denatured type II collagen binding site for fibronectin using a recombinant collagen system","volume":"289","author":"B An","year":"2014","journal-title":"J Biol Chem"},{"issue":"17","key":"pbio.3000590.ref068","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"AI Nesvizhskii","year":"2003","journal-title":"Anal Chem"},{"key":"pbio.3000590.ref069","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-61737-979-6_2","article-title":"In vitro Treg suppression assays","volume":"707","author":"LW Collison","year":"2011","journal-title":"Methods Mol Biol"},{"issue":"4","key":"pbio.3000590.ref070","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nprot.2009.9","article-title":"Tracking epitope-specific T cells","volume":"4","author":"JJ Moon","year":"2009","journal-title":"Nat Protoc"}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T02:52:32Z","timestamp":1695783152000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000590"}},"subtitle":[],"editor":[{"given":"Philippa","family":"Marrack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":70,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3000590","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]}}}