{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:04:56Z","timestamp":1778904296335,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pbio.3000723","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000}}],"reference-count":125,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K22AI125473"],"award-info":[{"award-number":["K22AI125473"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI151171"],"award-info":[{"award-number":["R01AI151171"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001395","name":"Wisconsin Alumni Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013432","name":"National Center for Veterinary Parasitology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013432","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI117204"],"award-info":[{"award-number":["R21AI117204"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.3000723","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T13:33:31Z","timestamp":1591623211000},"page":"e3000723","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Genetic and functional diversification of chemosensory pathway receptors in mosquito-borne filarial nematodes"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-4190","authenticated-orcid":true,"given":"Nicolas J.","family":"Wheeler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3455-383X","authenticated-orcid":true,"given":"Zachary W.","family":"Heimark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-006X","authenticated-orcid":true,"given":"Paul M.","family":"Airs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6502-3284","authenticated-orcid":true,"given":"Alexis","family":"Mann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-9452","authenticated-orcid":true,"given":"Lyric C.","family":"Bartholomay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-1760","authenticated-orcid":true,"given":"Mostafa","family":"Zamanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"pbio.3000723.ref001","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"SL James","year":"2018","journal-title":"Lancet"},{"key":"pbio.3000723.ref002","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1365-3156.2005.01426.x","article-title":"Physical and psychosocial burden due to lymphatic filariasis as perceived by patients and medical experts","volume":"10","author":"A Krishna Kumari","year":"2005","journal-title":"Trop Med Int Health"},{"key":"pbio.3000723.ref003","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1371\/journal.pntd.0000237","article-title":"Stigma and the social burden of neglected tropical diseases","volume":"2","author":"MG Weiss","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"pbio.3000723.ref004","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40249-015-0068-7","article-title":"The burden of mental health in lymphatic filariasis","volume":"4","author":"TGN Ton","year":"2015","journal-title":"Infect Dis Poverty"},{"key":"pbio.3000723.ref005","unstructured":"World Health Organization. Weekly epidemiological record. 2018 Nov [cited 2019 Feb 16]. Report No. 44. Available from: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/275719\/WER9344.pdf?ua=1."},{"key":"pbio.3000723.ref006","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJMoa1706854","article-title":"A Trial of a Triple-Drug Treatment for Lymphatic Filariasis","volume":"379","author":"CL King","year":"2018","journal-title":"N Engl J Med"},{"key":"pbio.3000723.ref007","doi-asserted-by":"crossref","DOI":"10.1079\/9780851994215.0000","volume-title":"Nematode Parasites of Vertebrates: Their Development and Transmission","author":"RC Anderson","year":"2000"},{"key":"pbio.3000723.ref008","doi-asserted-by":"crossref","first-page":"e529","DOI":"10.1371\/journal.pntd.0000529","article-title":"Mosquito infection responses to developing filarial worms","volume":"3","author":"SM Erickson","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"pbio.3000723.ref009","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1017\/S0031182000064131","article-title":"The migration of infective larvae of Brugia pahangi within the mosquito, Aedes aegypti","volume":"92","author":"SW Lindsay","year":"1986","journal-title":"Parasitology"},{"key":"pbio.3000723.ref010","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0065-308X(08)60530-8","article-title":"Brugian filariasis: epidemiological and experimental studies","volume":"15","author":"DA Denham","year":"1977","journal-title":"Adv Parasitol"},{"key":"pbio.3000723.ref011","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cois.2014.08.006","article-title":"Infection barriers and responses in mosquito\u2014filarial worm interactions","volume":"3","author":"LC Bartholomay","year":"2014","journal-title":"Current Opinion in Insect Science"},{"key":"pbio.3000723.ref012","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1038\/s41467-019-10675-2","article-title":"Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels","volume":"10","author":"WW Kilarski","year":"2019","journal-title":"Nat Commun"},{"key":"pbio.3000723.ref013","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/j.cub.2018.05.063","article-title":"A Critical Role for Thermosensation in Host Seeking by Skin-Penetrating Nematodes","volume":"28","author":"AS Bryant","year":"2018","journal-title":"Curr Biol"},{"key":"pbio.3000723.ref014","doi-asserted-by":"crossref","first-page":"e1004305","DOI":"10.1371\/journal.ppat.1004305","article-title":"Diverse host-seeking behaviors of skin-penetrating nematodes","volume":"10","author":"ML Castelletto","year":"2014","journal-title":"PLoS Pathog"},{"key":"pbio.3000723.ref015","doi-asserted-by":"crossref","first-page":"e1006675","DOI":"10.1371\/journal.ppat.1006675","article-title":"Targeted mutagenesis in a human-parasitic nematode","volume":"13","author":"SS Gang","year":"2017","journal-title":"PLoS Pathog"},{"key":"pbio.3000723.ref016","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molbiopara.2016.05.007","article-title":"Mechanisms of host seeking by parasitic nematodes","volume":"208","author":"SS Gang","year":"2016","journal-title":"Mol Biochem Parasitol"},{"key":"pbio.3000723.ref017","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ijpara.2017.01.008","article-title":"Venestatin, a Ca++-binding protein from the parasitic nematode Strongyloides venezuelensis, is involved in the larval migration process","volume":"47","author":"D Tsubokawa","year":"2017","journal-title":"Int J Parasitol"},{"key":"pbio.3000723.ref018","doi-asserted-by":"crossref","first-page":"e1006709","DOI":"10.1371\/journal.ppat.1006709","article-title":"Experience-dependent olfactory behaviors of the parasitic nematode Heligmosomoides polygyrus","volume":"13","author":"F Ruiz","year":"2017","journal-title":"PLoS Pathog"},{"key":"pbio.3000723.ref019","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1038\/s41598-017-06620-2","article-title":"Host seeking parasitic nematodes use specific odors to assess host resources","volume":"7","author":"T Baiocchi","year":"2017","journal-title":"Sci Rep"},{"key":"pbio.3000723.ref020","doi-asserted-by":"crossref","first-page":"E2324","DOI":"10.1073\/pnas.1211436109","article-title":"Olfaction shapes host\u2013parasite interactions in parasitic nematodes","volume":"109","author":"AR Dillman","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pbio.3000723.ref021","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.cub.2011.01.048","article-title":"A sensory code for host seeking in parasitic nematodes","volume":"21","author":"EA Hallem","year":"2011","journal-title":"Curr Biol"},{"key":"pbio.3000723.ref022","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ijpddr.2018.10.008","article-title":"Terror in the dirt: Sensory determinants of host seeking in soil-transmitted mammalian-parasitic nematodes","volume":"8","author":"AS Bryant","year":"2018","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"Suppl 1","key":"pbio.3000723.ref023","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1017\/S0031182014000791","article-title":"The evolution of parasitism in Nematoda","volume":"142","author":"M Blaxter","year":"2015","journal-title":"Parasitology"},{"key":"pbio.3000723.ref024","first-page":"427229","article-title":"Chemosensory structure and function in the filarial nematode, Brugia malayi","author":"LM Fraser","year":"2018","journal-title":"bioRxiv"},{"key":"pbio.3000723.ref025","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00436-003-0838-1","article-title":"Chemotactic response of Brugia pahangi infective larvae to jird serum in vitro","volume":"90","author":"NK Gunawardena","year":"2003","journal-title":"Parasitol Res"},{"key":"pbio.3000723.ref026","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.parint.2007.12.006","article-title":"In vitro chemotaxis of Brugia pahangi infective larvae to the sera and hemolymph of mammals and lower animals","volume":"57","author":"T Kusaba","year":"2008","journal-title":"Parasitol Int"},{"key":"pbio.3000723.ref027","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1017\/S0022149X11000605","article-title":"In vitro chemotactic responses of Brugia pahangi infective larvae to sodium ions","volume":"86","author":"Y Mitsui","year":"2012","journal-title":"J Helminthol"},{"key":"pbio.3000723.ref028","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/S0022149X00020307","article-title":"The development of Dirofilaria immitis in the mosquito Aedes aegypti","volume":"34","author":"AE Taylor","year":"1960","journal-title":"J Helminthol"},{"key":"pbio.3000723.ref029","author":"The C. elegans Research Community","year":"2006"},{"key":"pbio.3000723.ref030","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0896-6273(00)80202-0","article-title":"Mutations in a Cyclic Nucleotide\u2013Gated Channel Lead to Abnormal Thermosensation and Chemosensation in C. elegans","volume":"17","author":"H Komatsu","year":"1996","journal-title":"Neuron"},{"key":"pbio.3000723.ref031","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0896-6273(00)80201-9","article-title":"A Putative Cyclic Nucleotide\u2013Gated Channel Is Required for Sensory Development and Function in C. elegans","volume":"17","author":"CM Coburn","year":"1996","journal-title":"Neuron"},{"key":"pbio.3000723.ref032","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1523\/JNEUROSCI.17-21-08259.1997","article-title":"OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans","volume":"17","author":"HA Colbert","year":"1997","journal-title":"J Neurosci"},{"key":"pbio.3000723.ref033","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0896-6273(02)00757-2","article-title":"Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons","volume":"35","author":"DM Tobin","year":"2002","journal-title":"Neuron"},{"key":"pbio.3000723.ref034","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0092-8674(93)90145-G","article-title":"A zonal organization of odorant receptor gene expression in the olfactory epithelium","volume":"73","author":"KJ Ressler","year":"1993","journal-title":"Cell"},{"key":"pbio.3000723.ref035","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90422-M","article-title":"Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium","volume":"74","author":"R Vassar","year":"1993","journal-title":"Cell"},{"key":"pbio.3000723.ref036","doi-asserted-by":"crossref","first-page":"e2004218","DOI":"10.1371\/journal.pbio.2004218","article-title":"An atlas of Caenorhabditis elegans chemoreceptor expression","volume":"16","author":"B Vidal","year":"2018","journal-title":"PLoS Biol"},{"key":"pbio.3000723.ref037","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/32160","article-title":"A molecular evolutionary framework for the phylum Nematoda","volume":"392","author":"ML Blaxter","year":"1998","journal-title":"Nature"},{"key":"pbio.3000723.ref038","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41588-018-0262-1","article-title":"International Helminth Genomes Consortium. Comparative genomics of the major parasitic worms","volume":"51","year":"2019","journal-title":"Nat Genet"},{"key":"pbio.3000723.ref039","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molbiopara.2016.11.005","article-title":"WormBase ParaSite\u2014a comprehensive resource for helminth genomics","volume":"215","author":"KL Howe","year":"2017","journal-title":"Mol Biochem Parasitol"},{"key":"pbio.3000723.ref040","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1741-7007-6-42","article-title":"The Caenorhabditis chemoreceptor gene families","volume":"6","author":"JH Thomas","year":"2008","journal-title":"BMC Biol"},{"key":"pbio.3000723.ref041","author":"The C. elegans Research Community","year":"2006"},{"key":"pbio.3000723.ref042","doi-asserted-by":"crossref","first-page":"e93048","DOI":"10.1371\/journal.pone.0093048","article-title":"Insights into the origin of nematode chemosensory GPCRs: putative orthologs of the Srw family are found across several phyla of protostomes","volume":"9","author":"A Krishnan","year":"2014","journal-title":"PLoS ONE"},{"key":"pbio.3000723.ref043","doi-asserted-by":"crossref","first-page":"16216","DOI":"10.1038\/nmicrobiol.2016.216","article-title":"The genome of Onchocerca volvulus, agent of river blindness","volume":"2","author":"JA Cotton","year":"2016","journal-title":"Nat Microbiol"},{"key":"pbio.3000723.ref044","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/ng.2585","article-title":"Genomics of Loa loa, a Wolbachia-free filarial parasite of humans","volume":"45","author":"CA Desjardins","year":"2013","journal-title":"Nat Genet"},{"issue":"Suppl 1","key":"pbio.3000723.ref045","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0031182014001516","article-title":"Preface. The evolution of parasite genomes and the origins of parasitism","volume":"142","author":"AP Jackson","year":"2015","journal-title":"Parasitology"},{"key":"pbio.3000723.ref046","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1534\/genetics.112.148809","article-title":"The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle","volume":"193","author":"J Srinivasan","year":"2013","journal-title":"Genetics"},{"key":"pbio.3000723.ref047","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1017\/S0031182000044127","article-title":"Ultrastructural and cytochemical studies on the sensory organelles and nervous system of Dipetalonema viteae (Nematoda: Filarioidea)","volume":"65","author":"DJ McLaren","year":"1972","journal-title":"Parasitology"},{"key":"pbio.3000723.ref048","first-page":"195","volume-title":"Advances in Parasitology","author":"DJ Mclaren","year":"1976"},{"key":"pbio.3000723.ref049","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s41467-018-03333-6","article-title":"Predator-secreted sulfolipids induce defensive responses in C. elegans","volume":"9","author":"Z Liu","year":"2018","journal-title":"Nat Commun"},{"key":"pbio.3000723.ref050","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23770","article-title":"C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor","volume":"6","author":"A Tran","year":"2017","journal-title":"Elife"},{"key":"pbio.3000723.ref051","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1242\/jeb.01955","article-title":"Dietary choice behavior in Caenorhabditis elegans","volume":"209","author":"BB Shtonda","year":"2006","journal-title":"J Exp Biol"},{"key":"pbio.3000723.ref052","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.cub.2008.10.050","article-title":"Sensory regulation of C. elegans male mate-searching behavior","volume":"18","author":"A Barrios","year":"2008","journal-title":"Curr Biol"},{"key":"pbio.3000723.ref053","doi-asserted-by":"crossref","DOI":"10.1128\/MRA.01306-18","article-title":"Multispecies Transcriptomics Data Set of Brugia malayi, Its Wolbachia Endosymbiont wBm, and Aedes aegypti across the B. malayi Life Cycle","volume":"7","author":"M Chung","year":"2018","journal-title":"Microbiol Resour Announc"},{"key":"pbio.3000723.ref054","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/nn1886","article-title":"Caenorhabditis elegans TRPA-1 functions in mechanosensation","volume":"10","author":"KS Kindt","year":"2007","journal-title":"Nat Neurosci"},{"key":"pbio.3000723.ref055","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1085\/jgp.200709914","article-title":"Highly Ca2+-selective TRPM channels regulate IP3-dependent oscillatory Ca2+ signaling in the C. elegans intestine","volume":"131","author":"J Xing","year":"2008","journal-title":"J Gen Physiol"},{"key":"pbio.3000723.ref056","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1534\/genetics.113.152660","article-title":"Defining specificity determinants of cGMP mediated gustatory sensory transduction in Caenorhabditis elegans","volume":"194","author":"HK Smith","year":"2013","journal-title":"Genetics"},{"key":"pbio.3000723.ref057","doi-asserted-by":"crossref","first-page":"13135","DOI":"10.1038\/ncomms13135","article-title":"Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel","volume":"7","author":"A Upadhyay","year":"2016","journal-title":"Nat Commun"},{"key":"pbio.3000723.ref058","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1152\/jappl.1990.68.2.540","article-title":"Body composition and skin temperature variation","volume":"68","author":"J Frim","year":"1990","journal-title":"J Appl Physiol"},{"key":"pbio.3000723.ref059","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1242\/dev.028431","article-title":"Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans","volume":"136","author":"TL Vrablik","year":"2009","journal-title":"Development"},{"key":"pbio.3000723.ref060","doi-asserted-by":"crossref","first-page":"26163","DOI":"10.1074\/jbc.M115.662916","article-title":"Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans","volume":"290","author":"W Wang","year":"2015","journal-title":"J Biol Chem"},{"key":"pbio.3000723.ref061","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10522-009-9225-3","article-title":"Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16","volume":"11","author":"T Hashimoto","year":"2010","journal-title":"Biogerontology"},{"key":"pbio.3000723.ref062","doi-asserted-by":"crossref","first-page":"e1007561","DOI":"10.1371\/journal.pgen.1007561","article-title":"Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy","volume":"14","author":"K Schmeisser","year":"2018","journal-title":"PLoS Genet"},{"key":"pbio.3000723.ref063","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nchembio.1352","article-title":"Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide","volume":"9","author":"K Schmeisser","year":"2013","journal-title":"Nat Chem Biol"},{"key":"pbio.3000723.ref064","doi-asserted-by":"crossref","first-page":"e1001239","DOI":"10.1371\/journal.ppat.1001239","article-title":"Development of an in vivo RNAi protocol to investigate gene function in the filarial nematode, Brugia malayi","volume":"6","author":"C Song","year":"2010","journal-title":"PLoS Pathog"},{"key":"pbio.3000723.ref065","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1094\/MPMI-08-18-0226-R","article-title":"Homologs of Caenorhabditis elegans Chemosensory Genes Have Roles in Behavior and Chemotaxis in the Root-Knot Nematode Meloidogyne incognita","volume":"32","author":"TN Shivakumara","year":"2019","journal-title":"Mol Plant Microbe Interact"},{"key":"pbio.3000723.ref066","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.cub.2008.08.013","article-title":"3\u2032 UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline","volume":"18","author":"C Merritt","year":"2008","journal-title":"Curr Biol"},{"key":"pbio.3000723.ref067","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1371\/journal.pbio.0050237","article-title":"High-throughput in vivo analysis of gene expression in Caenorhabditis elegans","volume":"5","author":"R Hunt-Newbury","year":"2007","journal-title":"PLoS Biol"},{"key":"pbio.3000723.ref068","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0092-8674(00)81068-5","article-title":"odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl","volume":"84","author":"P Sengupta","year":"1996","journal-title":"Cell"},{"key":"pbio.3000723.ref069","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.1176331","article-title":"Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans","volume":"326","author":"K Kim","year":"2009","journal-title":"Science"},{"key":"pbio.3000723.ref070","doi-asserted-by":"crossref","first-page":"ra39","DOI":"10.1126\/scisignal.2005136","article-title":"Screening of odor-receptor pairs in Caenorhabditis elegans reveals different receptors for high and low odor concentrations","volume":"7","author":"G Taniguchi","year":"2014","journal-title":"Sci Signal"},{"key":"pbio.3000723.ref071","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature10378","article-title":"Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes","volume":"477","author":"PT McGrath","year":"2011","journal-title":"Nature"},{"key":"pbio.3000723.ref072","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41586-018-0546-8","article-title":"A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans","volume":"562","author":"EJ Dennis","year":"2018","journal-title":"Nature"},{"key":"pbio.3000723.ref073","doi-asserted-by":"crossref","first-page":"23618","DOI":"10.1074\/jbc.M116.741132","article-title":"The Signaling Pathway of Caenorhabditis elegans Mediates Chemotaxis Response to the Attractant 2-Heptanone in a Trojan Horse-like Pathogenesis","volume":"291","author":"C Zhang","year":"2016","journal-title":"J Biol Chem"},{"key":"pbio.3000723.ref074","doi-asserted-by":"crossref","first-page":"9917","DOI":"10.1073\/pnas.1202216109","article-title":"Interaction of structure-specific and promiscuous G-protein\u2013coupled receptors mediates small-molecule signaling in Caenorhabditis elegans","volume":"109","author":"D Park","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pbio.3000723.ref075","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.21454","article-title":"Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior","volume":"5","author":"JS Greene","year":"2016","journal-title":"Elife"},{"key":"pbio.3000723.ref076","article-title":"SRD-1 in AWA neurons is the receptor for female volatile sex pheromones in C. elegans males","volume":"20","author":"X Wan","year":"2019","journal-title":"EMBO Rep"},{"key":"pbio.3000723.ref077","article-title":"The G-protein coupled receptor SRX-97 is required for concentration dependent sensing of Benzaldehyde in Caenorhabditis elegans","author":"NY Kadam","year":"2020","journal-title":"bioRxiv"},{"key":"pbio.3000723.ref078","doi-asserted-by":"crossref","first-page":"e0006509","DOI":"10.1371\/journal.pntd.0006509","article-title":"Development of a toolkit for piggyBac-mediated integrative transfection of the human filarial parasite Brugia malayi","volume":"12","author":"C Liu","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pbio.3000723.ref079","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature02714","article-title":"Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue","volume":"430","author":"JM Gray","year":"2004","journal-title":"Nature"},{"key":"pbio.3000723.ref080","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1534\/genetics.111.127100","article-title":"Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans","volume":"188","author":"DA Glauser","year":"2011","journal-title":"Genetics"},{"key":"pbio.3000723.ref081","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.emboj.7600493","article-title":"In vivo imaging of C. elegans ASH neurons: cellular response and adaptation to chemical repellents","volume":"24","author":"MA Hilliard","year":"2005","journal-title":"EMBO J"},{"key":"pbio.3000723.ref082","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neulet.2016.08.037","article-title":"The cyclic nucleotide gated channel subunit CNG-1 instructs behavioral outputs in Caenorhabditis elegans by coincidence detection of nutritional status and olfactory input","volume":"632","author":"C He","year":"2016","journal-title":"Neurosci Lett"},{"key":"pbio.3000723.ref083","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41598-017-00126-7","article-title":"Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans","volume":"7","author":"DM O\u2019Halloran","year":"2017","journal-title":"Sci Rep"},{"key":"pbio.3000723.ref084","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1078\/0944-2006-00125","article-title":"Parasitic worms: strategies of host finding, recognition and invasion","volume":"106","author":"W Haas","year":"2003","journal-title":"Zoology"},{"key":"pbio.3000723.ref085","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1111\/febs.13781","article-title":"Prospects and challenges of CRISPR\/Cas genome editing for the study and control of neglected vector-borne nematode diseases","volume":"283","author":"M Zamanian","year":"2016","journal-title":"FEBS J"},{"key":"pbio.3000723.ref086","doi-asserted-by":"crossref","first-page":"e1261","DOI":"10.1371\/journal.pntd.0001261","article-title":"The NIH-NIAID Filariasis Research Reagent Resource Center","volume":"5","author":"ML Michalski","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"pbio.3000723.ref087","first-page":"407","article-title":"Studies on the feeding response of mosquitoes to nutritive solutions in a new membrane feeder","volume":"24","author":"LC Rutledge","year":"1964","journal-title":"Mosquito News"},{"key":"pbio.3000723.ref088","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1093\/jee\/46.4.624","article-title":"Determination of a Physiological Saline Solution for Aedes aegypti (L.)","volume":"46","author":"RO Hayes","year":"1953","journal-title":"J Econ Entomol"},{"key":"pbio.3000723.ref089","first-page":"451","volume-title":"Methods in Cell Biology","author":"C Mello","year":"1995"},{"key":"pbio.3000723.ref090","doi-asserted-by":"crossref","first-page":"e0006368","DOI":"10.1371\/journal.pntd.0006368","article-title":"Discovery of genomic intervals that underlie nematode responses to benzimidazoles","volume":"12","author":"M Zamanian","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"pbio.3000723.ref091","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"pbio.3000723.ref092","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1093\/nar\/gkt263","article-title":"Challenges in homology search: HMMER3 and convergent evolution of coiled-coil regions","volume":"41","author":"J Mistry","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"pbio.3000723.ref093","doi-asserted-by":"crossref","first-page":"D290","DOI":"10.1093\/nar\/gkr1065","article-title":"The Pfam protein families database","volume":"40","author":"M Punta","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"pbio.3000723.ref094","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/1471-2105-10-421","article-title":"BLAST+: architecture and applications","volume":"10","author":"C Camacho","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"pbio.3000723.ref095","doi-asserted-by":"crossref","first-page":"D463","DOI":"10.1093\/nar\/gkp952","article-title":"WormBase: a comprehensive resource for nematode research","volume":"38","author":"TW Harris","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"pbio.3000723.ref096","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: improvements in performance and usability","volume":"30","author":"K Katoh","year":"2013","journal-title":"Mol Biol Evol"},{"key":"pbio.3000723.ref097","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"pbio.3000723.ref098","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/bioinformatics\/17.9.849","article-title":"The HMMTOP transmembrane topology prediction server","volume":"17","author":"GE Tusn\u00e1dy","year":"2001","journal-title":"Bioinformatics"},{"key":"pbio.3000723.ref099","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1093\/bioinformatics\/btp348","article-title":"trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses","volume":"25","author":"S Capella-Guti\u00e9rrez","year":"2009","journal-title":"Bioinformatics"},{"key":"pbio.3000723.ref100","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies","volume":"32","author":"L-T Nguyen","year":"2014","journal-title":"Mol Biol Evol"},{"key":"pbio.3000723.ref101","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nmeth.4285","article-title":"ModelFinder: fast model selection for accurate phylogenetic estimates","volume":"14","author":"S Kalyaanamoorthy","year":"2017","journal-title":"Nat Methods"},{"key":"pbio.3000723.ref102","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/molbev\/msx281","article-title":"UFBoot2: Improving the Ultrafast Bootstrap Approximation","volume":"35","author":"DT Hoang","year":"2018","journal-title":"Mol Biol Evol"},{"key":"pbio.3000723.ref103","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/10665270050514918","article-title":"Modeling amino acid replacement","volume":"7","author":"T M\u00fcller","year":"2000","journal-title":"J Comput Biol"},{"key":"pbio.3000723.ref104","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/genetics\/139.2.993","article-title":"A space-time process model for the evolution of DNA sequences","volume":"139","author":"Z Yang","year":"1995","journal-title":"Genetics"},{"key":"pbio.3000723.ref105","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1093\/molbev\/mss140","article-title":"The influence of rate heterogeneity among sites on the time dependence of molecular rates","volume":"29","author":"J Soubrier","year":"2012","journal-title":"Mol Biol Evol"},{"key":"pbio.3000723.ref106","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/sysbio\/sys029","article-title":"MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space","volume":"61","author":"F Ronquist","year":"2012","journal-title":"Syst Biol"},{"key":"pbio.3000723.ref107","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/2041-210X.12628","article-title":"ggtree: an r package for visualization and annotation of phylogenetic trees with their covariates and other associated data","volume":"8","author":"G Yu","year":"2017","journal-title":"Methods Ecol Evol"},{"key":"pbio.3000723.ref108","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"AM Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"pbio.3000723.ref109","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"D Kim","year":"2015","journal-title":"Nat Methods"},{"key":"pbio.3000723.ref110","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"M Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"key":"pbio.3000723.ref111","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nbt.3820","article-title":"Nextflow enables reproducible computational workflows","volume":"35","author":"P Di Tommaso","year":"2017","journal-title":"Nat Biotechnol"},{"key":"pbio.3000723.ref112","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gr.092759.109","article-title":"Circos: an information aesthetic for comparative genomics","volume":"19","author":"M Krzywinski","year":"2009","journal-title":"Genome Res"},{"key":"pbio.3000723.ref113","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijpddr.2014.08.003","article-title":"Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: \u201cThe Worminator.\u201d","volume":"4","author":"B Storey","year":"2014","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"pbio.3000723.ref114","doi-asserted-by":"crossref","first-page":"e1494","DOI":"10.1371\/journal.pntd.0001494","article-title":"WormAssay: a novel computer application for whole-plate motion-based screening of macroscopic parasites","volume":"6","author":"C Marcellino","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"pbio.3000723.ref115","volume-title":"R for Data Science: Import, Tidy, Transform, Visualize, and Model Data","author":"H Wickham","year":"2016"},{"key":"pbio.3000723.ref116","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"pbio.3000723.ref117","doi-asserted-by":"crossref","first-page":"e0004311","DOI":"10.1371\/journal.pntd.0004311","article-title":"The Effect of In Vitro Cultivation on the Transcriptome of Adult Brugia malayi","volume":"10","author":"C Ballesteros","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"pbio.3000723.ref118","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1093\/nar\/gks596","article-title":"Primer3\u2014new capabilities and interfaces","volume":"40","author":"A Untergasser","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"pbio.3000723.ref119","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"H Thorvaldsd\u00f3ttir","year":"2013","journal-title":"Brief Bioinform"},{"key":"pbio.3000723.ref120","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"SF Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"pbio.3000723.ref121","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuron.2016.05.023","article-title":"TMC-1 Mediates Alkaline Sensation in C. elegans through Nociceptive Neurons","volume":"91","author":"X Wang","year":"2016","journal-title":"Neuron"},{"key":"pbio.3000723.ref122","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nature07886","article-title":"A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans","volume":"458","author":"EZ Macosko","year":"2009","journal-title":"Nature"},{"key":"pbio.3000723.ref123","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant-selective genes and neurons mediate olfaction in C. elegans","volume":"74","author":"CI Bargmann","year":"1993","journal-title":"Cell"},{"key":"pbio.3000723.ref124","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0092-8674(95)90162-0","article-title":"Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans","volume":"83","author":"ER Troemel","year":"1995","journal-title":"Cell"},{"key":"pbio.3000723.ref125","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1073\/pnas.90.6.2227","article-title":"A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans","volume":"90","author":"JM Kaplan","year":"1993","journal-title":"Proc Natl Acad Sci U S A"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3000723","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T04:04:56Z","timestamp":1616126696000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3000723"}},"subtitle":[],"editor":[{"given":"Piali","family":"Sengupta","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":125,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3000723","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/683060","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]}}}