{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:44:54Z","timestamp":1792100694191,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.pbio.3002196","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000}}],"reference-count":11,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson\u2019s","doi-asserted-by":"publisher","award":["000478"],"award-info":[{"award-number":["000478"]}],"id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018231","name":"Aligning Science Across Parkinson\u2019s","doi-asserted-by":"publisher","award":["000478"],"award-info":[{"award-number":["000478"]}],"id":[{"id":"10.13039\/100018231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>The genetics of Parkinson\u2019s disease has been key to unravelling the PINK1-dependent mitophagy process. Here, we discuss the implications of a 2010 <jats:italic>PLOS Biology<\/jats:italic> paper that shed light on the functional importance of PINK1 in the mitophagy cascade.<\/jats:p>","DOI":"10.1371\/journal.pbio.3002196","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T18:21:45Z","timestamp":1688062905000},"page":"e3002196","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["PINK1: From Parkinson\u2019s disease to mitophagy and back again"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-6843","authenticated-orcid":true,"given":"Benjamin","family":"O\u2019Callaghan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1401-9656","authenticated-orcid":true,"given":"Helene","family":"Plun-Favreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"pbio.3002196.ref001","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.200809125","article-title":"Parkin is recruited selectively to impaired mitochondria and promotes their autophagy","volume":"183","author":"D Narendra","year":"2008","journal-title":"J Cell Biol"},{"key":"pbio.3002196.ref002","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/ncb2012","article-title":"PINK1\/Parkin-mediated mitophagy is dependent on VDAC1 and p62\/SQSTM1","volume":"12","author":"S Geisler","year":"2010","journal-title":"Nat Cell Biol"},{"key":"pbio.3002196.ref003","doi-asserted-by":"crossref","first-page":"e1000298","DOI":"10.1371\/journal.pbio.1000298","article-title":"PINK1 is selectively stabilized on impaired mitochondria to activate parkin","volume":"8","author":"DP Narendra","year":"2010","journal-title":"PLoS Biol"},{"key":"pbio.3002196.ref004","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ceb.2017.03.013","article-title":"PINK1 and Parkin: emerging themes in mitochondrial homeostasis","volume":"45","author":"TG McWilliams","year":"2017","journal-title":"Curr Opin Cell Biol"},{"key":"pbio.3002196.ref005","doi-asserted-by":"crossref","first-page":"100209","DOI":"10.1074\/jbc.REV120.014294","article-title":"Targeting mitophagy in Parkinson\u2019s disease","volume":"296","author":"EH Clark","year":"2021","journal-title":"J Biol Chem"},{"key":"pbio.3002196.ref006","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","article-title":"Identification of novel risk loci, causal insights, and heritable risk for Parkinson\u2019s disease: a meta-analysis of genome-wide association studies","volume":"18","author":"MA Nalls","year":"2019","journal-title":"Lancet Neurol"},{"key":"pbio.3002196.ref007","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1093\/brain\/awac325","article-title":"Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson\u2019s disease at 16q11.2 and MAPT H1 loci","volume":"145","author":"MPM Soutar","year":"2022","journal-title":"Brain"},{"key":"pbio.3002196.ref008","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cmet.2017.12.008","article-title":"Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand","volume":"27","author":"TG McWilliams","year":"2018","journal-title":"Cell Metab"},{"key":"pbio.3002196.ref009","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING- induced inflammation","volume":"561","author":"DA Sliter","year":"2018","journal-title":"Nature"},{"key":"pbio.3002196.ref010","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1093\/brain\/awaa246","article-title":"Mitochondrial damage-associated inflammation highlights biomarkers in PRKN\/PINK1 parkinsonism","volume":"143","author":"M Borsche","year":"2020","journal-title":"Brain"},{"key":"pbio.3002196.ref011","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.cell.2016.05.039","article-title":"Parkinson\u2019s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation","volume":"166","author":"D Matheoud","year":"2016","journal-title":"Cell"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3002196","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3002196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T18:14:30Z","timestamp":1689185670000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3002196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,29]]},"references-count":11,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3002196","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pbio.3002196","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,29]]}}}