{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:52:30Z","timestamp":1790959950657,"version":"4.1.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H05767"],"award-info":[{"award-number":["JP21H05767"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H05255"],"award-info":[{"award-number":["JP21H05255"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H04774"],"award-info":[{"award-number":["JP21H04774"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H04766"],"award-info":[{"award-number":["JP23H04766"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H06332"],"award-info":[{"award-number":["JP17H06332"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H02762"],"award-info":[{"award-number":["JP22H02762"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H04696"],"award-info":[{"award-number":["JP23H04696"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJCR1852"],"award-info":[{"award-number":["JPMJCR1852"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2114"],"award-info":[{"award-number":["JPMJSP2114"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21gm5010001"],"award-info":[{"award-number":["JP21gm5010001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22gm6110025"],"award-info":[{"award-number":["JP22gm6110025"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006324","name":"National Institute for Basic Biology","doi-asserted-by":"publisher","award":["23NIBB202"],"award-info":[{"award-number":["23NIBB202"]}],"id":[{"id":"10.13039\/501100006324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>Blastema formation is a crucial process that provides a cellular source for regenerating tissues and organs. While bilaterians have diversified blastema formation methods, its mechanisms in non-bilaterians remain poorly understood. Cnidarian jellyfish, or medusae, represent early-branching metazoans that exhibit complex morphology and possess defined appendage structures highlighted by tentacles with stinging cells (nematocytes). Here, we investigate the mechanisms of tentacle regeneration, using the hydrozoan jellyfish <jats:italic>Cladonema pacificum<\/jats:italic>. We show that proliferative cells accumulate at the tentacle amputation site and form a blastema composed of cells with stem cell morphology. Nucleoside pulse-chase experiments indicate that most repair-specific proliferative cells (RSPCs) in the blastema are distinct from resident stem cells. We further demonstrate that resident stem cells control nematogenesis and tentacle elongation during both homeostasis and regeneration as homeostatic stem cells, while RSPCs preferentially differentiate into epithelial cells in the newly formed tentacle, analogous to lineage-restricted stem\/progenitor cells observed in salamander limbs. Taken together, our findings propose a regeneration mechanism that utilizes both resident homeostatic stem cells (RHSCs) and RSPCs, which in conjunction efficiently enable functional appendage regeneration, and provide novel insight into the diversification of blastema formation across animal evolution.<\/jats:p>","DOI":"10.1371\/journal.pbio.3002435","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:24:41Z","timestamp":1703183081000},"page":"e3002435","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Distinct stem-like cell populations facilitate functional regeneration of the Cladonema medusa tentacle"],"prefix":"10.1371","volume":"21","author":[{"given":"Sosuke","family":"Fujita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mako","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Kumano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erina","family":"Kuranaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-5989","authenticated-orcid":true,"given":"Yu-ichiro","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"pbio.3002435.ref001","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/reg2.32","article-title":"The axolotl limb blastema: cellular and molecular mechanisms driving blastema formation and limb regeneration in tetrapods: The Axolotl Limb Blastema.","volume":"2","author":"C McCusker","year":"2015","journal-title":"Regeneration."},{"key":"pbio.3002435.ref002","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ydbio.2017.08.007","article-title":"The blastema and epimorphic regeneration in mammals","volume":"433","author":"AW Seifert","year":"2018","journal-title":"Dev Biol"},{"key":"pbio.3002435.ref003","doi-asserted-by":"crossref","first-page":"210126","DOI":"10.1098\/rsob.210126","article-title":"Appendage regeneration is context dependent at the cellular level.","volume":"11","author":"C. Aztekin","year":"2021","journal-title":"Open Biol"},{"key":"pbio.3002435.ref004","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.tree.2009.08.005","article-title":"Evolution of animal regeneration: re-emergence of a field","volume":"25","author":"AE Bely","year":"2010","journal-title":"Trends Ecol Evol"},{"key":"pbio.3002435.ref005","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.devcel.2011.06.016","article-title":"The Cellular Basis for Animal Regeneration","volume":"21","author":"EM Tanaka","year":"2011","journal-title":"Dev Cell"},{"key":"pbio.3002435.ref006","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1146\/annurev.cellbio.20.010403.095114","article-title":"FUNDAMENTALS OF PLANARIAN REGENERATION","volume":"20","author":"PW Reddien","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"key":"pbio.3002435.ref007","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.stem.2013.11.007","article-title":"Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species.","volume":"14","author":"T Sandoval-Guzm\u00e1n","year":"2014","journal-title":"Cell Stem Cell"},{"key":"pbio.3002435.ref008","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.devcel.2017.10.015","article-title":"Osteoblast Production by Reserved Progenitor Cells in Zebrafish Bone Regeneration and Maintenance","volume":"43","author":"K Ando","year":"2017","journal-title":"Dev Cell"},{"key":"pbio.3002435.ref009","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.devcel.2011.04.014","article-title":"Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin","volume":"20","author":"F Knopf","year":"2011","journal-title":"Dev Cell"},{"key":"pbio.3002435.ref010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/cells10020242","article-title":"Appendage Regeneration in Vertebrates: What Makes This Possible","volume":"10","author":"V Daponte","year":"2021","journal-title":"Cell"},{"key":"pbio.3002435.ref011","doi-asserted-by":"crossref","first-page":"20609","DOI":"10.1073\/pnas.1118017108","article-title":"Mouse digit tip regeneration is mediated by fate-restricted progenitor cells","volume":"108","author":"JA Lehoczky","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pbio.3002435.ref012","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1242\/dev.088260","article-title":"Mechanisms of tentacle morphogenesis in the sea anemone Nematostella vectensis","volume":"140","author":"AE Fritz","year":"2013","journal-title":"Development"},{"key":"pbio.3002435.ref013","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1242\/dev.048959","article-title":"Evolutionary crossroads in developmental biology: Cnidaria","volume":"138","author":"U Technau","year":"2011","journal-title":"Development"},{"key":"pbio.3002435.ref014","first-page":"758","article-title":"Regeneration Potential of Jellyfish: Cellular Mechanisms and Molecular Insights.","volume":"12","author":"S Fujita","year":"2021","journal-title":"Gen."},{"key":"pbio.3002435.ref015","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/dvdy.10227","article-title":"Cnidarians: An evolutionarily conserved model system for regeneration?","volume":"226","author":"TW Holstein","year":"2003","journal-title":"Dev Dyn"},{"key":"pbio.3002435.ref016","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.gde.2016.06.006","article-title":"The interstitial stem cells in Hydractinia and their role in regeneration","volume":"40","author":"JM Gahan","year":"2016","journal-title":"Curr Opin Genet Dev"},{"key":"pbio.3002435.ref017","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.3390\/cells10102692","article-title":"Nematostella vectensis, an Emerging Model for Deciphering the Molecular and Cellular Mechanisms Underlying Whole-Body Regeneration","volume":"10","author":"E. R\u00f6ttinger","year":"2021","journal-title":"Cell"},{"key":"pbio.3002435.ref018","first-page":"146","article-title":"Model systems for regeneration: Hydra.","author":"MC Vogg","year":"2019","journal-title":"Development"},{"key":"pbio.3002435.ref019","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.devcel.2009.07.014","article-title":"Apoptotic Cells Provide an Unexpected Source of Wnt3 Signaling to Drive Hydra Head Regeneration","volume":"17","author":"S Chera","year":"2009","journal-title":"Dev Cell"},{"key":"pbio.3002435.ref020","doi-asserted-by":"crossref","first-page":"e05506","DOI":"10.7554\/eLife.05506","article-title":"Distinct mechanisms underlie oral vs aboral regeneration in the cnidarian Hydractinia echinata.","volume":"4","author":"B Bradshaw","year":"2015","journal-title":"Elife."},{"key":"pbio.3002435.ref021","article-title":"Synergic coordination of stem cells is required to induce a regenerative response in anthozoan cnidarians","author":"AR Amiel","year":"2019","journal-title":"bioRxiv"},{"key":"pbio.3002435.ref022","doi-asserted-by":"crossref","first-page":"R592","DOI":"10.1016\/j.cub.2013.03.057","article-title":"Jellyfish nervous systems","volume":"23","author":"T Katsuki","year":"2013","journal-title":"Curr Biol"},{"key":"pbio.3002435.ref023","first-page":"4","article-title":"Diversity of Cnidarian Muscles: Function, Anatomy, Development and Regeneration.","author":"L Lecl\u00e8re","year":"2017","journal-title":"Front Cell. Dev Biol"},{"key":"pbio.3002435.ref024","doi-asserted-by":"crossref","first-page":"e7579","DOI":"10.7717\/peerj.7579","article-title":"Cell proliferation controls body size growth, tentacle morphogenesis, and regeneration in hydrozoan jellyfish Cladonema pacificum.","volume":"7","author":"S Fujita","year":"2019","journal-title":"PeerJ"},{"key":"pbio.3002435.ref025","first-page":"58","article-title":"Regenerative Capacity of the Upside-down Jellyfish Cassiopea xamachana","author":"E Gamero-Mora","year":"2019","journal-title":"Zool Stud"},{"key":"pbio.3002435.ref026","doi-asserted-by":"crossref","first-page":"949233","DOI":"10.3389\/fmars.2022.949233","article-title":"Complete and rapid regeneration of fragments from the upside-down jellyfish Cassiopea.","volume":"9","author":"M Ostendarp","year":"2022","journal-title":"Front Mar Sci"},{"key":"pbio.3002435.ref027","doi-asserted-by":"crossref","first-page":"e54868","DOI":"10.7554\/eLife.54868","article-title":"Pattern regulation in a regenerating jellyfish.","volume":"9","author":"C Sinigaglia","year":"2020","journal-title":"Elife."},{"key":"pbio.3002435.ref028","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1086\/697071","article-title":"Regeneration of the Rhopalium and the Rhopalial Nervous System in the Box Jellyfish Tripedalia cystophora","volume":"234","author":"S-A Stamatis","year":"2018","journal-title":"Biol Bull"},{"key":"pbio.3002435.ref029","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ydbio.2004.06.018","article-title":"The Sine oculis\/Six class family of homeobox genes in jellyfish with and without eyes: development and eye regeneration","volume":"274","author":"M Stierwald","year":"2004","journal-title":"Dev Biol"},{"key":"pbio.3002435.ref030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jmor.1051670306","article-title":"Structure, histochemistry, ontogenetic development, and regeneration of the ocellus of Cladonema radiatum dujardin (cnidaria, hydrozoa, anthomedusae).","volume":"167","author":"C. Weber","year":"1981","journal-title":"J Morphol"},{"key":"pbio.3002435.ref031","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40851-019-0124-4","article-title":"Branching pattern and morphogenesis of medusa tentacles in the jellyfish Cladonema pacificum (Hydrozoa, Cnidaria).","volume":"5","author":"A Fujiki","year":"2019","journal-title":"Zoological Lett"},{"key":"pbio.3002435.ref032","doi-asserted-by":"crossref","first-page":"16049","DOI":"10.1038\/s41598-022-20476-1","article-title":"siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos","volume":"12","author":"T Masuda-Ozawa","year":"2022","journal-title":"Sci Rep"},{"key":"pbio.3002435.ref033","first-page":"145","article-title":"Identification of jellyfish neuropeptides that act directly as oocyte maturation-inducing hormones","author":"N Takeda","year":"2018","journal-title":"Development"},{"key":"pbio.3002435.ref034","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/00222937900770231","article-title":"he polyp and immature medusa stages of Cladonema californicum, Hyman, 1947 (Anthomedusae: Cladonemidae) with biological notes and a discussion of the taxonomy of the genus Cladonema","volume":"13","author":"JT Rees","year":"1979","journal-title":"J Nat Hist"},{"key":"pbio.3002435.ref035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cub.2007.11.059","article-title":"Evolution and Functional Diversity of Jellyfish Opsins","volume":"18","author":"H Suga","year":"2008","journal-title":"Curr Biol"},{"key":"pbio.3002435.ref036","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s13131-021-1900-5","article-title":"Discovery of Cladonema multiramosum sp. nov. (Cnidaria: Hydrozoa: Cladonematidae) using DNA barcoding and life cycle analyses.","volume":"41","author":"K Zhou","year":"2022","journal-title":"Acta Oceanol Sin"},{"key":"pbio.3002435.ref037","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ydbio.2007.12.023","article-title":"Ordered progression of nematogenesis from stem cells through differentiation stages in the tentacle bulb of Clytia hemisphaerica (Hydrozoa, Cnidaria).","volume":"315","author":"E Denker","year":"2008","journal-title":"Dev Biol"},{"key":"pbio.3002435.ref038","article-title":"Fluorescent In Situ Hybridization and 5-Ethynyl-2\u2019-Deoxyuridine Labeling for Stem-like Cells in the Hydrozoan Jellyfish Cladonema pacificum.","author":"S Fujita","year":"2022","journal-title":"J Vis Exp."},{"key":"pbio.3002435.ref039","article-title":"Repetitive accumulation of interstitial cells generates the branched structure of Cladonema medusa tentacles","volume":"148","author":"S Hou","year":"2021","journal-title":"Development"},{"key":"pbio.3002435.ref040","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-213X-12-34","article-title":"Cell proliferation is necessary for the regeneration of oral structures in the anthozoan cnidarian Nematostella vectensis","volume":"12","author":"YJ Passamaneck","year":"2012","journal-title":"BMC Dev Biol"},{"key":"pbio.3002435.ref041","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1387\/ijdb.180111bg","article-title":"Non-developmental dimensions of adult regeneration in Hydra","volume":"62","author":"B Galliot","year":"2018","journal-title":"Int J Dev Biol"},{"key":"pbio.3002435.ref042","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF00026448","article-title":"Polyp regeneration from isolated tentacles of Aurelia scyphistomae: a role for gating mechanisms and cell division","volume":"216","author":"GE Lesh-Laurie","year":"1991","journal-title":"Hydrobiologia"},{"key":"pbio.3002435.ref043","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1073\/pnas.0712168105","article-title":"A chemical method for fast and sensitive detection of DNA synthesis in vivo","volume":"105","author":"A Salic","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pbio.3002435.ref044","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1440-169X.2011.01254.x","article-title":"Role of c-Jun N-terminal kinase activation in blastema formation during planarian regeneration: JNK activation in planarian regeneration","volume":"53","author":"J Tasaki","year":"2011","journal-title":"Dev Growth Differ"},{"key":"pbio.3002435.ref045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00427-012-0429-1","article-title":"Stem cell dynamics in Cnidaria: are there unifying principles?","volume":"223","author":"DA Gold","year":"2013","journal-title":"Dev Genes Evol"},{"key":"pbio.3002435.ref046","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ydbio.2012.01.018","article-title":"Maternally localized germ plasm mRNAs and germ cell\/stem cell formation in the cnidarian Clytia","volume":"364","author":"L Lecl\u00e8re","year":"2012","journal-title":"Dev Biol"},{"key":"pbio.3002435.ref047","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh1683","article-title":"Whole-animal multiplexed single-cell RNA-seq reveals transcriptional shifts across Clytia medusa cell types","volume":"7","author":"T Chari","year":"2021","journal-title":"Sci Adv"},{"key":"pbio.3002435.ref048","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1387\/ijdb.123502gp","article-title":"Hydractinia, a pioneering model for stem cell biology and reprogramming somatic cells to pluripotency","volume":"56","author":"G Plickert","year":"2012","journal-title":"Int J Dev Biol"},{"key":"pbio.3002435.ref049","doi-asserted-by":"crossref","first-page":"e1608","DOI":"10.1242\/dev.101246","article-title":"New roles for Nanos in neural cell fate determination revealed by studies in a cnidarian","volume":"140","author":"J Kanska","year":"2013","journal-title":"Development"},{"key":"pbio.3002435.ref050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10735-018-9761-8","article-title":"BrdU\/EdU dual labeling to determine the cell-cycle dynamics of defined cellular subpopulations.","volume":"49","author":"L Harris","year":"2018","journal-title":"J Mol Histol"},{"key":"pbio.3002435.ref051","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12983-021-00396-y","article-title":"Cellular proliferation dynamics during regeneration in Syllis malaquini (Syllidae, Annelida).","volume":"18","author":"RP Ribeiro","year":"2021","journal-title":"Front Zool"},{"key":"pbio.3002435.ref052","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nmeth741","article-title":"Stem cell proliferative history in tissue revealed by temporal halogenated thymidine analog discrimination","volume":"2","author":"CJ Vega","year":"2005","journal-title":"Nat Methods"},{"key":"pbio.3002435.ref053","first-page":"203","article-title":"Regulation of interstitial cell differentiation in Hydra attenuata: II. Correlation of the axial position of the interstitial cell with nematocyte differentiation. Wilhelm Roux\u2019","volume":"181","author":"HR Bode","year":"1977","journal-title":"Arch Androl"},{"key":"pbio.3002435.ref054","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1242\/bio.201410512","article-title":"Slow-cycling stem cells in hydra contribute to head regeneration","volume":"3","author":"N Govindasamy","year":"2014","journal-title":"Biol Open"},{"key":"pbio.3002435.ref055","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ydbio.2019.09.001","article-title":"Molecular characterisation of a cellular conveyor belt in Clytia medusae","volume":"456","author":"T Condamine","year":"2019","journal-title":"Dev Biol"},{"key":"pbio.3002435.ref056","doi-asserted-by":"crossref","first-page":"30076","DOI":"10.1074\/jbc.M109.044503","article-title":"The Proteasome Is an Integral Part of Solar Ultraviolet A Radiation-induced Gene Expression","volume":"284","author":"B Catalgol","year":"2009","journal-title":"J Biol Chem"},{"key":"pbio.3002435.ref057","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.dnarep.2008.05.004","article-title":"Inhibition of S-phase progression triggered by UVA-induced ROS does not require a functional DNA damage checkpoint response in mammalian cells","volume":"7","author":"P-M Girard","year":"2008","journal-title":"DNA Repair"},{"key":"pbio.3002435.ref058","first-page":"71","article-title":"Cellular UV damage responses\u2014Functions of tumor suppressor p53","volume":"1755","author":"L Latonen","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"pbio.3002435.ref059","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1128\/MCB.01046-10","article-title":"Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila","volume":"31","author":"Y Nakajima","year":"2011","journal-title":"Mol Cell Biol"},{"key":"pbio.3002435.ref060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/cyto.990090208","article-title":"High-speed photodamage cell selection using bromodeoxyuridine\/Hoechst 33342 photosensitized cell killing.","volume":"9","author":"H Herweijer","year":"1988","journal-title":"Cytometry"},{"key":"pbio.3002435.ref061","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1011-1344(04)00122-8","article-title":"DNA ligand Hoechst-33342 enhances UV induced cytotoxicity in human glioma cell lines","volume":"77","author":"S Singh","year":"2004","journal-title":"J Photochem Photobiol B Biol"},{"key":"pbio.3002435.ref062","article-title":"Pluripotent, germ cell competent adult stem cells underlie cnidarian plant-like life history","author":"\u00c1 Varley","year":"2022","journal-title":"Dev Biol"},{"key":"pbio.3002435.ref063","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.semcdb.2009.09.008","article-title":"Immortality and the base of multicellular life: Lessons from cnidarian stem cells","volume":"20","author":"H Watanabe","year":"2009","journal-title":"Semin Cell Dev Biol"},{"key":"pbio.3002435.ref064","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1440-169X.2011.01250.x","article-title":"Injury-induced activation of the MAPK\/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration","volume":"53","author":"S Chera","year":"2011","journal-title":"Dev Growth Differ"},{"key":"pbio.3002435.ref065","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1387\/ijdb.113476cd","article-title":"Interstitial stem cells in Hydra: multipotency and decision-making","volume":"56","author":"CN David","year":"2012","journal-title":"Int J Dev Biol"},{"key":"pbio.3002435.ref066","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1201\/9780429445446-4","volume-title":"Deferring Development","author":"N Nakanishi","year":"2019","edition":"1"},{"key":"pbio.3002435.ref067","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(84)90275-7","article-title":"Isolated, mononucleated, striated muscle can undergo pluripotent transdifferentiation and form a complex regenerate","volume":"38","author":"V Schmid","year":"1984","journal-title":"Cell"},{"key":"pbio.3002435.ref068","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.142.3598.1481","article-title":"Dedifferentiation and Redifferentiation of Cells in Hydra viridis","volume":"142","author":"J Haynes","year":"1963","journal-title":"Science"},{"key":"pbio.3002435.ref069","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmor.1051200102","article-title":"A histological and ultrastructural study of germinal differentiation of interstitial cells arising from gland cells in Hydra viridis","volume":"120","author":"AL Burnett","year":"1966","journal-title":"J Morphol"},{"key":"pbio.3002435.ref070","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0012-1606(66)90018-2","article-title":"A histological and ultrastructural study of dedifferentiation and redifferentiation of digestive and gland cells in Hydra viridis","volume":"14","author":"LE Davis","year":"1966","journal-title":"Dev Biol"},{"key":"pbio.3002435.ref071","doi-asserted-by":"crossref","first-page":"112687","DOI":"10.1016\/j.celrep.2023.112687","article-title":"Senescence-induced cellular reprogramming drives cnidarian whole-body regeneration","volume":"42","author":"M Salinas-Saavedra","year":"2023","journal-title":"Cell Rep"},{"key":"pbio.3002435.ref072","doi-asserted-by":"crossref","first-page":"11069","DOI":"10.1038\/ncomms11069","article-title":"A developmentally regulated switch from stem cells to dedifferentiation for limb muscle regeneration in newts","volume":"7","author":"HV Tanaka","year":"2016","journal-title":"Nat Commun"},{"key":"pbio.3002435.ref073","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-cellbio-120420-114855","article-title":"Tissue Homeostasis and Non-Homeostasis: From Cell Life Cycles to Organ States","volume":"38","author":"LE O\u2019Brien","year":"2022","journal-title":"Annu Rev Cell Dev Biol"},{"key":"pbio.3002435.ref074","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.1243529","article-title":"A Common Cellular Basis for Muscle Regeneration in Arthropods and Vertebrates","volume":"343","author":"N Konstantinides","year":"2014","journal-title":"Science"},{"key":"pbio.3002435.ref075","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11802-011-1837-y","article-title":"Patterns and cellular mechanisms of arm regeneration in adult starfish Asterias rollestoni bell.","volume":"10","author":"T Fan","year":"2011","journal-title":"J Ocean Univ China"},{"key":"pbio.3002435.ref076","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1387\/ijdb.180048ho","article-title":"Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus","volume":"62","author":"T Bando","year":"2018","journal-title":"Int J Dev Biol"},{"key":"pbio.3002435.ref077","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1242\/dev.75.1.151","article-title":"Blastema formation and cell division during cockroach limb regeneration","volume":"75","author":"PR Truby","year":"1983","journal-title":"Development"},{"key":"pbio.3002435.ref078","doi-asserted-by":"crossref","first-page":"e1211","DOI":"10.7717\/peerj.1211","article-title":"Transdifferentiation is a driving force of regeneration in Halisarca dujardini (Demospongiae, Porifera).","volume":"3","author":"IE Borisenko","year":"2015","journal-title":"PeerJ."},{"key":"pbio.3002435.ref079","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12915-019-0695-8","article-title":"Regeneration in the ctenophore Mnemiopsis leidyi occurs in the absence of a blastema, requires cell division, and is temporally separable from wound healing.","volume":"17","author":"J Ramon-Mateu","year":"2019","journal-title":"BMC Biol."},{"key":"pbio.3002435.ref080","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41559-019-0853-y","article-title":"Medusozoan genomes inform the evolution of the jellyfish body plan","volume":"3","author":"K Khalturin","year":"2019","journal-title":"Nat Ecol Evol"},{"key":"pbio.3002435.ref081","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1126\/science.1139158","article-title":"Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization","volume":"317","author":"NH Putnam","year":"2007","journal-title":"Science"},{"key":"pbio.3002435.ref082","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.tig.2010.10.002","article-title":"A genomic view of 500 million years of cnidarian evolution","volume":"27","author":"RE Steele","year":"2011","journal-title":"Trends Genet"}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3002435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:25:27Z","timestamp":1703183127000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3002435"}},"subtitle":[],"editor":[{"given":"Kimberly L.","family":"Cooper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":82,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3002435","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,21]]}}}