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Across a human population sample, natural variation in the ratios of M and L cone subtypes was associated with a noncoding polymorphism in the <jats:italic>NR2F2<\/jats:italic> gene, a mediator of RA signaling. Our data suggest that RA promotes M cone fate early in development to generate the pattern of M and L cones across the human retina.<\/jats:p>","DOI":"10.1371\/journal.pbio.3002464","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T18:22:43Z","timestamp":1704997363000},"page":"e3002464","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Retinoic acid signaling regulates spatiotemporal specification of human green and red cones"],"prefix":"10.1371","volume":"22","author":[{"given":"Sarah E.","family":"Hadyniak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna F. 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