{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:55:29Z","timestamp":1792468529845,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pbio.3002895","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000}}],"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009053","name":"The Wellcome Trust DBT India Alliance","doi-asserted-by":"publisher","award":["IA\/I\/19\/2\/504651"],"award-info":[{"award-number":["IA\/I\/19\/2\/504651"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017220","name":"Regional Centre for Biotechnology","doi-asserted-by":"publisher","award":["Core Institutional Funding"],"award-info":[{"award-number":["Core Institutional Funding"]}],"id":[{"id":"10.13039\/100017220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>Mitochondria regulate several physiological functions through mitochondrial Ca<jats:sup>2+<\/jats:sup> dynamics. However, role of mitochondrial Ca<jats:sup>2+<\/jats:sup> signaling in melanosome biology remains unknown. Here, we show that pigmentation requires mitochondrial Ca<jats:sup>2+<\/jats:sup> uptake. In vitro gain and loss of function studies demonstrate that mitochondrial Ca<jats:sup>2+<\/jats:sup> uniporter (MCU) is crucial for melanogenesis while MCU rheostat, MCUb negatively control melanogenesis. Zebrafish, MCU<jats:sup>+\/-<\/jats:sup> and MCUb<jats:sup>-\/-<\/jats:sup> mice models show that MCU complex drives pigmentation in vivo. Mechanistically, MCU silencing activates transcription factor NFAT2 to induce expression of keratin (5, 7, and 8) filaments. Interestingly, keratin5 in turn augments mitochondrial Ca<jats:sup>2+<\/jats:sup> uptake and potentiates melanogenesis by regulating melanosome biogenesis and maturation. Hence this signaling module acts as a negative feedback loop that fine-tunes both mitochondrial Ca<jats:sup>2+<\/jats:sup> signaling and pigmentation. Notably, mitoxantrone, an FDA approved drug that inhibits MCU, reduces pigmentation thereby highlighting therapeutic potential of targeting mitochondrial Ca<jats:sup>2+<\/jats:sup> uptake for clinical management of pigmentary disorders. Taken together, we reveal an MCU-NFAT2-Keratin5 driven signaling axis that acts as a critical determinant of mitochondrial Ca<jats:sup>2+<\/jats:sup> uptake and pigmentation. Given the vital role of mitochondrial Ca<jats:sup>2+<\/jats:sup> signaling and keratin filaments in cellular physiology, this feedback loop could be operational in a variety of other patho-physiological processes.<\/jats:p>","DOI":"10.1371\/journal.pbio.3002895","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T18:46:49Z","timestamp":1731350809000},"page":"e3002895","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-6405","authenticated-orcid":true,"given":"Jyoti","family":"Tanwar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriti","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshay","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paras","family":"Sehgal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyan","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farina","family":"Sultan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushka","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshu","family":"Priya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vamsi K.","family":"Yenamandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Raffaello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muniswamy","family":"Madesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Rizzuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Sivasubbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-9008","authenticated-orcid":true,"given":"Rajender K.","family":"Motiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"issue":"11","key":"pbio.3002895.ref001","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.cmet.2022.10.008","article-title":"Mitochondrial signal transduction","volume":"34","author":"M Picard","year":"2022","journal-title":"Cell Metab"},{"issue":"3","key":"pbio.3002895.ref002","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stem.2021.02.011","article-title":"Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate","volume":"28","author":"RP Chakrabarty","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"1","key":"pbio.3002895.ref003","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"I Martinez-Reyes","year":"2020","journal-title":"Nat Commun"},{"key":"pbio.3002895.ref004","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pharmthera.2018.07.001","article-title":"Mitochondrial Ca(2+) signaling","volume":"192","author":"T Pathak","year":"2018","journal-title":"Pharmacol Ther"},{"key":"pbio.3002895.ref005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-319-55330-6_2","article-title":"Mitochondrial Calcium Handling in Physiology and Disease","volume":"982","author":"V Granatiero","year":"2017","journal-title":"Adv Exp Med Biol"},{"issue":"11","key":"pbio.3002895.ref006","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","article-title":"The machineries, regulation and cellular functions of mitochondrial calcium","volume":"19","author":"C Giorgi","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"pbio.3002895.ref007","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cophys.2020.08.010","article-title":"Regulation of Ca(2+) exchanges and signaling in mitochondria","volume":"17","author":"EJ Carvalho","year":"2020","journal-title":"Curr Opin Physio"},{"issue":"6","key":"pbio.3002895.ref008","doi-asserted-by":"crossref","DOI":"10.3390\/cells10061317","article-title":"Mitochondrial Ca(2+) Signaling in Health, Disease and Therapy","volume":"10","author":"L Modesti","year":"2021","journal-title":"Cells"},{"issue":"7","key":"pbio.3002895.ref009","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s43587-023-00436-8","article-title":"Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging","volume":"3","author":"PV Seegren","year":"2023","journal-title":"Nat Aging"},{"issue":"12","key":"pbio.3002895.ref010","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1158\/0008-5472.CAN-21-3230","article-title":"Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer","volume":"82","author":"X Wang","year":"2022","journal-title":"Cancer Res"},{"issue":"7360","key":"pbio.3002895.ref011","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature10234","article-title":"Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter","volume":"476","author":"JM Baughman","year":"2011","journal-title":"Nature"},{"issue":"7360","key":"pbio.3002895.ref012","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10230","article-title":"A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter","volume":"476","author":"D De Stefani","year":"2011","journal-title":"Nature"},{"key":"pbio.3002895.ref013","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mito.2020.12.001","article-title":"Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics","volume":"57","author":"J Tanwar","year":"2021","journal-title":"Mitochondrion"},{"issue":"9","key":"pbio.3002895.ref014","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrm4039","article-title":"The molecular era of the mitochondrial calcium uniporter","volume":"16","author":"KJ Kamer","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6164","key":"pbio.3002895.ref015","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.1242993","article-title":"EMRE is an essential component of the mitochondrial calcium uniporter complex","volume":"342","author":"Y Sancak","year":"2013","journal-title":"Science"},{"issue":"5949","key":"pbio.3002895.ref016","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1126\/science.1175145","article-title":"Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+\/H+ antiporter","volume":"326","author":"D Jiang","year":"2009","journal-title":"Science"},{"issue":"1","key":"pbio.3002895.ref017","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1073\/pnas.0908099107","article-title":"NCLX is an essential component of mitochondrial Na+\/Ca2+ exchange","volume":"107","author":"R Palty","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pbio.3002895.ref018","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.yjmcc.2014.10.013","article-title":"The mitochondrial calcium uniporter: mice can live and die without it","volume":"78","author":"JL Harrington","year":"2015","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"pbio.3002895.ref019","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbrc.2014.04.144","article-title":"Unresolved questions from the analysis of mice lacking MCU expression","volume":"449","author":"E Murphy","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"pbio.3002895.ref020","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nchembio.1548","article-title":"Multifaceted pathways protect human skin from UV radiation","volume":"10","author":"VT Natarajan","year":"2014","journal-title":"Nat Chem Biol"},{"issue":"Pt 24","key":"pbio.3002895.ref021","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1242\/jcs.040667","article-title":"Melanosomes at a glance","volume":"121","author":"C Wasmeier","year":"2008","journal-title":"J Cell Sci"},{"issue":"4","key":"pbio.3002895.ref022","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cub.2014.01.007","article-title":"Mitochondria and melanosomes establish physical contacts modulated by Mfn2 and involved in organelle biogenesis","volume":"24","author":"T Daniele","year":"2014","journal-title":"Curr Biol"},{"issue":"4","key":"pbio.3002895.ref023","doi-asserted-by":"crossref","DOI":"10.3390\/cells11040701","article-title":"Mitofusin-2 Negatively Regulates Melanogenesis by Modulating Mitochondrial ROS Generation","volume":"11","author":"J Tanwar","year":"2022","journal-title":"Cells"},{"issue":"6","key":"pbio.3002895.ref024","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1073\/pnas.1304988111","article-title":"IFN-gamma signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation","volume":"111","author":"VT Natarajan","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"pbio.3002895.ref025","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201797597","article-title":"STIM1 activation of adenylyl cyclase 6 connects Ca(2+) and cAMP signaling during melanogenesis","volume":"37","author":"RK Motiani","year":"2018","journal-title":"EMBO J"},{"issue":"12","key":"pbio.3002895.ref026","doi-asserted-by":"crossref","first-page":"102681","DOI":"10.1016\/j.jbc.2022.102681","article-title":"MITF is a novel transcriptional regulator of the calcium sensor STIM1: Significance in physiological melanogenesis","volume":"298","author":"J Tanwar","year":"2022","journal-title":"J Biol Chem"},{"issue":"5","key":"pbio.3002895.ref027","doi-asserted-by":"crossref","first-page":"e3001634","DOI":"10.1371\/journal.pbio.3001634","article-title":"Temporal analysis of melanogenesis identifies fatty acid metabolism as key skin pigment regulator","volume":"20","author":"F Sultan","year":"2022","journal-title":"PLoS Biol"},{"key":"pbio.3002895.ref028","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1038\/ncomms5153","article-title":"Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA","volume":"5","author":"J Suzuki","year":"2014","journal-title":"Nat Commun"},{"key":"pbio.3002895.ref029","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cophys.2020.08.012","article-title":"Pathophysiological significance of calcium signaling at Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs)","volume":"17","author":"SA N Sharma","year":"2020","journal-title":"Current Opinion in Phys Ther"},{"issue":"17","key":"pbio.3002895.ref030","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1038\/emboj.2013.157","article-title":"The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit","volume":"32","author":"A Raffaello","year":"2013","journal-title":"EMBO J"},{"issue":"707","key":"pbio.3002895.ref031","doi-asserted-by":"crossref","first-page":"eabf3838","DOI":"10.1126\/scisignal.abf3838","article-title":"The dominant-negative mitochondrial calcium uniporter subunit MCUb drives macrophage polarization during skeletal muscle regeneration","volume":"14","author":"S Feno","year":"2021","journal-title":"Sci Signal"},{"issue":"3","key":"pbio.3002895.ref032","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-0749.2006.00307.x","article-title":"Regulation of pigmentation in zebrafish melanophores","volume":"19","author":"DW Logan","year":"2006","journal-title":"Pigment Cell Res"},{"key":"pbio.3002895.ref033","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1242\/dev.123.1.369","article-title":"Zebrafish pigmentation mutations and the processes of neural crest development","volume":"123","author":"RN Kelsh","year":"1996","journal-title":"Development"},{"issue":"2","key":"pbio.3002895.ref034","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41418-018-0191-7","article-title":"Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference","volume":"26","author":"G Gherardi","year":"2019","journal-title":"Cell Death Differ"},{"issue":"3","key":"pbio.3002895.ref035","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1086\/500850","article-title":"Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease","volume":"78","author":"RC Betz","year":"2006","journal-title":"Am J Hum Genet"},{"issue":"4","key":"pbio.3002895.ref036","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1002\/(SICI)1096-8628(19991008)86:4<376::AID-AJMG12>3.0.CO;2-W","article-title":"Epidermolysis bullosa simplex with mottled pigmentation: clinical aspects and confirmation of the P24L mutation in the KRT5 gene in further patients","volume":"86","author":"U Moog","year":"1999","journal-title":"Am J Med Genet"},{"issue":"3","key":"pbio.3002895.ref037","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/pcmr.12844","article-title":"Epidermal keratin 5 expression and distribution is under dermal influence","volume":"33","author":"M Cario","year":"2020","journal-title":"Pigment Cell Melanoma Res"},{"issue":"11","key":"pbio.3002895.ref038","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1091\/mbc.E19-10-0565","article-title":"A role for keratins in supporting mitochondrial organization and function in skin keratinocytes","volume":"31","author":"K Steen","year":"2020","journal-title":"Mol Biol Cell"},{"issue":"3","key":"pbio.3002895.ref039","doi-asserted-by":"crossref","DOI":"10.3390\/cells5030030","article-title":"Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function","volume":"5","author":"N Schwarz","year":"2016","journal-title":"Cells"},{"issue":"10","key":"pbio.3002895.ref040","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1096\/fj.201700095R","article-title":"Keratins regulate beta-cell mitochondrial morphology, motility, and homeostasis","volume":"31","author":"JSG Silvander","year":"2017","journal-title":"FASEB J"},{"issue":"4","key":"pbio.3002895.ref041","doi-asserted-by":"crossref","first-page":"101174","DOI":"10.1016\/j.jbc.2021.101174","article-title":"The Mitochondrial Ca(2+) uniporter is a central regulator of interorganellar Ca(2+) transfer and NFAT activation","volume":"297","author":"RE Yoast","year":"2021","journal-title":"J Biol Chem"},{"issue":"W1","key":"pbio.3002895.ref042","doi-asserted-by":"crossref","first-page":"W490","DOI":"10.1093\/nar\/gkx376","article-title":"ConTra v3: a tool to identify transcription factor binding sites across species, update 2017","volume":"45","author":"L Kreft","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"pbio.3002895.ref043","doi-asserted-by":"crossref","first-page":"D92","DOI":"10.1093\/nar\/gku1111","article-title":"The Eukaryotic Promoter Database: expansion of EPDnew and new promoter analysis tools","volume":"43","author":"R Dreos","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"pbio.3002895.ref044","doi-asserted-by":"crossref","first-page":"W247","DOI":"10.1093\/nar\/gkp464","article-title":"Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes","volume":"37","author":"F Zambelli","year":"2009","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"pbio.3002895.ref045","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"JA Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"pbio.3002895.ref046","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1034\/j.1600-0749.2003.00081.x","article-title":"Effect of cyclosporin A on melanogenesis in cultured human melanocytes","volume":"16","author":"JY Lee","year":"2003","journal-title":"Pigment Cell Res"},{"issue":"4","key":"pbio.3002895.ref047","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.molcel.2017.07.019","article-title":"Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening","volume":"67","author":"DM Arduino","year":"2017","journal-title":"Mol Cell"},{"key":"pbio.3002895.ref048","doi-asserted-by":"crossref","first-page":"102705","DOI":"10.1016\/j.ceca.2023.102705","article-title":"A novel gain of function mutation in TPC2 reiterates pH-pigmentation interplay: Emerging role of ionic homeostasis as a master pigmentation regulator","volume":"111","author":"N Sharma","year":"2023","journal-title":"Cell Calcium"},{"key":"pbio.3002895.ref049","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.abb.2014.06.020","article-title":"Ion transport in pigmentation","volume":"563","author":"NW Bellono","year":"2014","journal-title":"Arch Biochem Biophys"},{"issue":"6","key":"pbio.3002895.ref050","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1073\/pnas.1215555110","article-title":"UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes","volume":"110","author":"NW Bellono","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"pbio.3002895.ref051","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41419-019-1478-4","article-title":"Keratinocyte differentiation promotes ER stress-dependent lysosome biogenesis","volume":"10","author":"S Mahanty","year":"2019","journal-title":"Cell Death Dis"},{"issue":"2","key":"pbio.3002895.ref052","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.65.2.481","article-title":"Changes in distribution pattern of cytoplasmic filaments in human melanocytes during ultraviolet-mediated melanin pigmentation. The role of the 100-Angstrom filaments in the elongation of melanocytic dendrites and in the movement and transfer of melanosomes","volume":"65","author":"K Jimbow","year":"1975","journal-title":"J Cell Biol"},{"key":"pbio.3002895.ref053","doi-asserted-by":"crossref","first-page":"734078","DOI":"10.3389\/fphar.2021.734078","article-title":"Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo","volume":"12","author":"H Wu","year":"2021","journal-title":"Front Pharmacol"},{"issue":"8","key":"pbio.3002895.ref054","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1177\/0271678X16682250","article-title":"Global ablation of the mitochondrial calcium uniporter increases glycolysis in cortical neurons subjected to energetic stressors","volume":"37","author":"M Nichols","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"pbio.3002895.ref055","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41419-018-0607-9","article-title":"Tamoxifen-induced knockdown of the mitochondrial calcium uniporter in Thy1-expressing neurons protects mice from hypoxic\/ischemic brain injury","volume":"9","author":"M Nichols","year":"2018","journal-title":"Cell Death Dis"},{"key":"pbio.3002895.ref056","doi-asserted-by":"crossref","first-page":"114329","DOI":"10.1016\/j.expneurol.2023.114329","article-title":"The effect of regulating MCU expression on experimental ischemic brain injury","volume":"362","author":"J Qin","year":"2023","journal-title":"Exp Neurol"},{"issue":"1","key":"pbio.3002895.ref057","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.celrep.2015.06.017","article-title":"The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition","volume":"12","author":"TS Luongo","year":"2015","journal-title":"Cell Rep"},{"issue":"1","key":"pbio.3002895.ref058","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.celrep.2015.06.002","article-title":"The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart","volume":"12","author":"JQ Kwong","year":"2015","journal-title":"Cell Rep"},{"issue":"7","key":"pbio.3002895.ref059","article-title":"Current Concepts of Vitiligo Immunopathogenesis","volume":"10","author":"N Hlaca","year":"2022","journal-title":"Biomedicine"},{"issue":"10","key":"pbio.3002895.ref060","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.pt.2023.07.005","article-title":"Immune dysregulation and inflammation causing hypopigmentation in post kala-azar dermal leishmaniasis: partners in crime?","volume":"39","author":"R Sengupta","year":"2023","journal-title":"Trends Parasitol"},{"issue":"6","key":"pbio.3002895.ref061","doi-asserted-by":"crossref","first-page":"797","DOI":"10.15252\/embj.201592481","article-title":"Mitochondria control store-operated Ca(2+) entry through Na(+) and redox signals","volume":"36","author":"T Ben-Kasus Nissim","year":"2017","journal-title":"EMBO J"},{"issue":"2","key":"pbio.3002895.ref062","doi-asserted-by":"crossref","first-page":"101604","DOI":"10.1016\/j.jbc.2022.101604","article-title":"MCU (mitochondrial Ca(2+) uniporter) makes the calcium go round","volume":"298","author":"GC Walters","year":"2022","journal-title":"J Biol Chem"},{"issue":"9","key":"pbio.3002895.ref063","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nri2152","article-title":"Calcium signalling in lymphocyte activation and disease","volume":"7","author":"S. Feske","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"17","key":"pbio.3002895.ref064","doi-asserted-by":"crossref","first-page":"9079","DOI":"10.1073\/pnas.93.17.9079","article-title":"The genetic basis of epidermolysis bullosa simplex with mottled pigmentation","volume":"93","author":"J Uttam","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pbio.3002895.ref065","doi-asserted-by":"crossref","first-page":"102456","DOI":"10.1016\/j.ceca.2021.102456","article-title":"Emergence of repurposed drugs as modulators of MCU channel for clinical therapeutics","volume":"99","author":"N Vishnu","year":"2021","journal-title":"Cell Calcium"},{"issue":"12","key":"pbio.3002895.ref066","doi-asserted-by":"crossref","first-page":"109275","DOI":"10.1016\/j.celrep.2021.109275","article-title":"Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter","volume":"35","author":"A De Mario","year":"2021","journal-title":"Cell Rep"},{"issue":"2","key":"pbio.3002895.ref067","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1046\/j.1523-1747.2000.00860.x","article-title":"Downregulation of tyrosinase activity in human melanocyte cell cultures by yohimbine","volume":"114","author":"BB Fuller","year":"2000","journal-title":"J Invest Dermatol"},{"issue":"26","key":"pbio.3002895.ref068","doi-asserted-by":"crossref","first-page":"27774","DOI":"10.1074\/jbc.M401786200","article-title":"Down-regulation of melanogenesis by phospholipase D2 through ubiquitin proteasome-mediated degradation of tyrosinase","volume":"279","author":"A Kageyama","year":"2004","journal-title":"J Biol Chem"},{"issue":"7458","key":"pbio.3002895.ref069","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"TW Chen","year":"2013","journal-title":"Nature"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3002895","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3002895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T19:02:43Z","timestamp":1732215763000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3002895"}},"subtitle":[],"editor":[{"given":"Bimal N.","family":"Desai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":69,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3002895","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pbio.3002895","asserted-by":"object"}]},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]}}}