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Given the known roles in autoimmunity of pro-inflammatory T helper 1 (Th)1 and Th17 cells, and anti-inflammatory Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory cells, we established a triple reporter mouse for\n                    <jats:italic>Ifng<\/jats:italic>\n                    ,\n                    <jats:italic>Il17<\/jats:italic>\n                    and\n                    <jats:italic>Foxp3,<\/jats:italic>\n                    and subjected it to experimental autoimmune encephalomyelitis (EAE) to characterize the miRNomes of the corresponding CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell subsets. We identified 110 miRNAs differentially expressed between the pro-inflammatory (Th1 and Th17 cells) and the Treg cell subsets\n                    <jats:italic>.<\/jats:italic>\n                    Among these, we found novel functions for miR-122-5p and miR-1247 as regulators of Th17 cell proliferation and Th1 cell differentiation, thus impacting the course or severity of EAE, respectively. Importantly, their expression patterns suggest miR-122-5p and miR-1247 act as peripheral brakes to CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell pathogenicity that are subverted in the inflamed central nervous system.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3003271","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:34:41Z","timestamp":1786383281000},"page":"e3003271","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["A microRNA atlas of CD4+ T cell subsets in experimental autoimmune encephalomyelitis identifies regulators of disease 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