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We found\n                    <jats:italic>\n                      <jats:italic>P. hessleri<\/jats:italic>\n                    <\/jats:italic>\n                    accumulates exceptionally high level of toxic element arsenic (&gt;1% of wet weight) and tolerated elevated concentrations hydrogen sulphide. Using advanced microscopy, elementary analysis, and genomics and proteomics approaches, we identified a previously unrecognized arsenic-sulfide biomineralization process in\n                    <jats:italic>\n                      <jats:italic>P. hessleri<\/jats:italic>\n                    <\/jats:italic>\n                    . Our data suggest that arsenic accumulates within epithelial cell granules, where it likely reacts with sulphide diffused inward from the hydrothermal vent fluid, resulting in the intracellular formation of orpiment (As\u2082S\u2083) minerals. In this \u201cfighting poison with poison\u201d manner, the highly toxic arsenic and sulphide were simultaneously detoxified in the form of orpiment minerals within the intracellular granules of the single layer of epithelial cells. This process represents a remarkable adaptation to extreme chemical environments. Our study provides new insights into understanding animals\u2019 environment adaptation mechanisms and the diversity and plasticity of biomineralization.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3003291","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T17:21:33Z","timestamp":1756228893000},"page":"e3003291","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["A deep-sea hydrothermal vent worm detoxifies arsenic and sulfur by intracellular biomineralization of orpiment 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