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Growing evidence suggests that such modulation starts from early stages, already at the retina, but the underlying mechanisms remain elusive. Combining pharmacological and chemogenetic tools with single-unit extracellular recordings in awake head-fixed mice, here we identified that the visual responses of retinal ganglion cells and the lateral geniculate nucleus were both made weaker and slower by histaminergic projections from the tuberomammillary nucleus of the posterior hypothalamus. The observed changes in the visual responses were, however, not directly linked with histaminergic modulation of pupil dynamics or locomotion behavior. Instead, our computational modeling analysis suggests that the temporal response modulations arise from changes in the intrinsic properties of the circuit, such as gain modulation via the histamine H1 receptors in the retina. Facilitation of visual processing at low histamine levels may offer an ethological advantage, enabling animals to respond rapidly to visual threats during periods of reduced activity.<\/jats:p>","DOI":"10.1371\/journal.pbio.3003406","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T18:21:31Z","timestamp":1762280491000},"page":"e3003406","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["The central histaminergic system slows visual processing in the retina and lateral geniculate nucleus of awake mice"],"prefix":"10.1371","volume":"23","author":[{"given":"Matteo","family":"Tripodi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-1935","authenticated-orcid":true,"given":"Hiroki","family":"Asari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"issue":"2","key":"pbio.3003406.ref001","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrn1034","article-title":"The role of histamine and the tuberomamillary nucleus in the nervous system","volume":"4","author":"H Haas","year":"2003","journal-title":"Nat Rev Neurosci"},{"issue":"14","key":"pbio.3003406.ref002","article-title":"Whole-brain mapping of histaminergic projections in mouse brain","volume":"120","author":"W Lin","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pbio.3003406.ref003","first-page":"487","article-title":"Histamine immunoreactive axons in the macaque retina","volume":"40","author":"MJ Gastinger","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"pbio.3003406.ref004","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brainresrev.2006.08.004","article-title":"The evolution of the centrifugal visual system of vertebrates. 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