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In a melanoma mouse model induced by\n                    <jats:italic>BRaf<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>CA<\/jats:italic>\n                    <\/jats:sup>\n                    mutation and\n                    <jats:italic>Pten<\/jats:italic>\n                    -deficiency, we observed that PLK1 overexpression mediated metabolic reprogramming to markedly accelerate tumor growth, promote metastasis, and shortened mice survival. Mechanistically, PLK1 stabilizes BTB domain and CNC homolog 1 (BACH1), which serves as a crucial transcription factor for genes involved in cancer metabolism and metastasis. Moreover, the PLK1\/BACH1 axis confers resistance to Vemurafenib, a BRAF\n                    <jats:sup>V600E<\/jats:sup>\n                    inhibitor, in melanoma. In light of this finding, we attempted an innovative pharmacological combination targeting both BRAF\n                    <jats:sup>V600E<\/jats:sup>\n                    and PLK1, identifying a synergistic efficiency to this approach to suppress tumor growth. Overall, we have discovered a novel function of PLK1 that is independent of the cell cycle, which could pave new ways for melanoma therapies.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3003490","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T18:27:39Z","timestamp":1764008859000},"page":"e3003490","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1"],"prefix":"10.1371","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-6606","authenticated-orcid":true,"given":"Fengyi","family":"Mao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek 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