{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:59:18Z","timestamp":1790362758379,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pbio.3003555","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000}}],"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C52879\/A29144"],"award-info":[{"award-number":["C52879\/A29144"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009794","name":"Breast Cancer Now","doi-asserted-by":"publisher","award":["2023.11PR1656"],"award-info":[{"award-number":["2023.11PR1656"]}],"id":[{"id":"10.13039\/100009794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011703","name":"Yorkshire Cancer Research","doi-asserted-by":"publisher","award":["YCRSPF\\2024\\100093"],"award-info":[{"award-number":["YCRSPF\\2024\\100093"]}],"id":[{"id":"10.13039\/100011703","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT093134AIA"],"award-info":[{"award-number":["WT093134AIA"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>Invasive breast and pancreatic cancer cells thrive within a collagen I-rich, poorly perfused extracellular matrix (ECM) network, necessitating robust metabolic adaptation to endure nutrient deficiency, such as glucose starvation. Here we demonstrate that collagen I is critical for the survival and growth of breast and pancreatic cancer cells. Mechanistically, collagen I promotes \u03b12 \u03b21 integrin-dependent S6 phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) and drives the membrane localisation of the LAT1\u22124F2hc amino acid transporter. This process ensures a sustained intracellular essential amino acid supply, further fuelling mTORC1 signalling and limiting autophagy. This collagen I-driven pathway is essential for cancer cell survival, as inhibiting the activity of \u03b12 \u03b21 integrin or the LAT1-4F2hc transporter significantly reduces cell growth and invasion in both 2D and 3D models. Finally, the clinical relevance of these transporters is underscored by the significant upregulation of LAT1-4F2hc expression in basal-like breast and pancreatic cancer patients, correlating with poor prognosis and drug resistance. Collectively, our findings highlight that targeting the LAT1\u22124F2hc transporter might represent a highly promising therapeutic strategy to limit cancer cell growth and invasion in highly fibrotic and nutrient-deprived tumours.<\/jats:p>","DOI":"10.1371\/journal.pbio.3003555","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:56:46Z","timestamp":1789754206000},"page":"e3003555","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Collagen I promotes cancer cell survival via amino acid import and mTORC1\/S6 activation"],"prefix":"10.1371","volume":"24","author":[{"given":"Mona","family":"Nazemi","sequence":"first","affiliation":[{"name":"University of Sheffield","place":["Sheffield, United Kingdom"],"department":["School of Biosciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bian","family":"Yanes","sequence":"additional","affiliation":[{"name":"University of Sheffield","place":["Sheffield, United Kingdom"],"department":["School of Biosciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vancauwenberghe","sequence":"additional","affiliation":[{"name":"University of Sheffield","place":["Sheffield, United Kingdom"],"department":["School of Biosciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeoluwa","family":"Oyelade","sequence":"additional","affiliation":[{"name":"University of Sheffield","place":["Sheffield, United Kingdom"],"department":["School of Biosciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Walker","sequence":"additional","affiliation":[{"name":"University of Sheffield","place":["Sheffield, United Kingdom"],"department":["School of Biosciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-8701","authenticated-orcid":true,"given":"Elena","family":"Rainero","sequence":"additional","affiliation":[{"name":"University of Sheffield","place":["Sheffield, United Kingdom"],"department":["School of Biosciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"pbio.3003555.ref001","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.2147\/IJGM.S463649","article-title":"Unveiling collagen\u2019s role in breast cancer: insights into expression patterns, functions and clinical implications","volume":"17","author":"X Li","year":"2024","journal-title":"Int J Gen Med"},{"issue":"2","key":"pbio.3003555.ref002","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/embor.2009.276","article-title":"Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing","volume":"11","author":"C Margadant","year":"2010","journal-title":"EMBO Rep"},{"issue":"5","key":"pbio.3003555.ref003","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ceb.2010.08.015","article-title":"Dynamic interplay between the collagen scaffold and tumor evolution","volume":"22","author":"M Egeblad","year":"2010","journal-title":"Curr Opin Cell Biol"},{"issue":"5","key":"pbio.3003555.ref004","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/modpathol.3880555","article-title":"Prognostic significance of fibrotic focus in invasive ductal carcinoma of the breast: a prospective observational study","volume":"15","author":"T Hasebe","year":"2002","journal-title":"Mod Pathol"},{"issue":"2","key":"pbio.3003555.ref005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/bies.10230","article-title":"Fibrillar collagen: the key to vertebrate evolution? A tale of molecular incest","volume":"25","author":"RP Boot-Handford","year":"2003","journal-title":"Bioessays"},{"issue":"5797","key":"pbio.3003555.ref006","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1126\/science.1131000","article-title":"Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures","volume":"314","author":"CM Nelson","year":"2006","journal-title":"Science"},{"issue":"15","key":"pbio.3003555.ref007","doi-asserted-by":"crossref","first-page":"4672","DOI":"10.1073\/pnas.79.15.4672","article-title":"Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture","volume":"79","author":"HG Hall","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"pbio.3003555.ref008","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cub.2013.03.032","article-title":"Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules","volume":"23","author":"DG Brownfield","year":"2013","journal-title":"Curr Biol"},{"issue":"49","key":"pbio.3003555.ref009","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1038\/onc.2009.299","article-title":"Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage","volume":"28","author":"PP Provenzano","year":"2009","journal-title":"Oncogene"},{"issue":"1","key":"pbio.3003555.ref010","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1741-7015-4-38","article-title":"Collagen reorganization at the tumor-stromal interface facilitates local invasion","volume":"4","author":"PP Provenzano","year":"2006","journal-title":"BMC Med"},{"issue":"5","key":"pbio.3003555.ref011","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.cell.2009.10.027","article-title":"Matrix crosslinking forces tumor progression by enhancing integrin signaling","volume":"139","author":"KR Levental","year":"2009","journal-title":"Cell"},{"issue":"3","key":"pbio.3003555.ref012","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.ajpath.2010.11.076","article-title":"Aligned collagen is a prognostic signature for survival in human breast carcinoma","volume":"178","author":"MW Conklin","year":"2011","journal-title":"Am J Pathol"},{"issue":"39","key":"pbio.3003555.ref013","doi-asserted-by":"crossref","first-page":"19609","DOI":"10.1073\/pnas.1908626116","article-title":"Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells","volume":"116","author":"C Tian","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"pbio.3003555.ref014","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jconrel.2004.07.008","article-title":"Type I collagen can function as a reservoir of basic fibroblast growth factor","volume":"99","author":"A Kanematsu","year":"2004","journal-title":"J Control Release"},{"issue":"12","key":"pbio.3003555.ref015","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.15252\/embr.201439246","article-title":"The extracellular matrix modulates the hallmarks of cancer","volume":"15","author":"MW Pickup","year":"2014","journal-title":"EMBO Rep"},{"issue":"10","key":"pbio.3003555.ref016","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202050635","article-title":"Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take","volume":"21","author":"P Altea-Manzano","year":"2020","journal-title":"EMBO Rep"},{"key":"pbio.3003555.ref017","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fonc.2018.00117","article-title":"Influence of the tumor microenvironment on cancer cells metabolic reprogramming","volume":"8","author":"V Gouirand","year":"2018","journal-title":"Front Oncol"},{"issue":"10","key":"pbio.3003555.ref018","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1101\/gad.1415606","article-title":"Genetics and biology of pancreatic ductal adenocarcinoma","volume":"20","author":"AF Hezel","year":"2006","journal-title":"Genes Dev"},{"issue":"8","key":"pbio.3003555.ref019","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.035758","article-title":"Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies","volume":"11","author":"A Muir","year":"2018","journal-title":"Dis Model Mech"},{"issue":"2","key":"pbio.3003555.ref020","article-title":"Metabolic reprogramming in cancer: mechanisms and therapeutics","volume":"4","author":"S Nong","year":"2023","journal-title":"MedComm (2020)"},{"key":"pbio.3003555.ref021","doi-asserted-by":"crossref","first-page":"730726","DOI":"10.3389\/fcell.2021.730726","article-title":"Metabolites profiling of melanoma interstitial fluids reveals uridine diphosphate as potent immune modulator capable of limiting tumor growth","volume":"9","author":"E Vecchio","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"pbio.3003555.ref022","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","article-title":"The hallmarks of cancer metabolism: still emerging","volume":"34","author":"NN Pavlova","year":"2022","journal-title":"Cell Metab"},{"issue":"1","key":"pbio.3003555.ref023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002406","article-title":"The extracellular matrix supports breast cancer cell growth under amino acid starvation by promoting tyrosine catabolism","volume":"22","author":"M Nazemi","year":"2024","journal-title":"PLoS Biol"},{"issue":"1","key":"pbio.3003555.ref024","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80622-4","article-title":"Structural basis of collagen recognition by integrin alpha2beta1","volume":"101","author":"J Emsley","year":"2000","journal-title":"Cell"},{"issue":"24","key":"pbio.3003555.ref025","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2010.10.059","article-title":"Adhesion signalling complexes","volume":"20","author":"A Byron","year":"2010","journal-title":"Curr Biol"},{"issue":"12","key":"pbio.3003555.ref026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002930","article-title":"Novel kinase regulators of extracellular matrix internalisation identified by high-content screening modulate invasive carcinoma cell migration","volume":"22","author":"ML Martinez","year":"2024","journal-title":"PLoS Biol"},{"key":"pbio.3003555.ref027","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41420-020-0260-9","article-title":"How does mTOR sense glucose starvation? AMPK is the usual suspect","volume":"6","author":"G Leprivier","year":"2020","journal-title":"Cell Death Discov"},{"key":"pbio.3003555.ref028","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0303-7207(99)00061-1","article-title":"Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction","volume":"151","author":"M Fr\u00f6din","year":"1999","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"pbio.3003555.ref029","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202004010","article-title":"mTORC1 activity is supported by spatial association with focal adhesions","volume":"220","author":"Y Rabanal-Ruiz","year":"2021","journal-title":"J Cell Biol"},{"key":"pbio.3003555.ref030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-157-4_4","article-title":"LC3 and autophagy","volume":"445","author":"I Tanida","year":"2008","journal-title":"Methods Mol Biol"},{"issue":"4","key":"pbio.3003555.ref031","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jmb.2016.11.027","article-title":"The interconnections between autophagy and integrin-mediated cell adhesion","volume":"429","author":"A Vlahakis","year":"2017","journal-title":"J Mol Biol"},{"issue":"4","key":"pbio.3003555.ref032","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.molcel.2016.09.037","article-title":"An autophagic flux probe that releases an internal control","volume":"64","author":"T Kaizuka","year":"2016","journal-title":"Mol Cell"},{"issue":"22","key":"pbio.3003555.ref033","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2024.10.009","article-title":"mTORC1 restricts TFE3 activity by auto-regulating its presence on lysosomes","volume":"84","author":"S Zwakenberg","year":"2024","journal-title":"Mol Cell"},{"issue":"37","key":"pbio.3003555.ref034","doi-asserted-by":"crossref","first-page":"23629","DOI":"10.1074\/jbc.273.37.23629","article-title":"Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)","volume":"273","author":"Y Kanai","year":"1998","journal-title":"J Biol Chem"},{"issue":"3","key":"pbio.3003555.ref035","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","article-title":"Bidirectional transport of amino acids regulates mTOR and autophagy","volume":"136","author":"P Nicklin","year":"2009","journal-title":"Cell"},{"issue":"11","key":"pbio.3003555.ref036","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1002\/ijc.32369","article-title":"ROCplot.org: validating predictive biomarkers of chemotherapy\/hormonal therapy\/anti-HER2 therapy using transcriptomic data of 3,104 breast cancer patients","volume":"145","author":"JT Fekete","year":"2019","journal-title":"Int J Cancer"},{"issue":"15","key":"pbio.3003555.ref037","doi-asserted-by":"crossref","first-page":"11969","DOI":"10.3390\/ijms241511969","article-title":"Glucose deprivation induces cancer cell death through failure of ROS regulation","volume":"24","author":"M Kang","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"pbio.3003555.ref038","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1083\/jcb.149.2.431","article-title":"Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization","volume":"149","author":"AP Gilmore","year":"2000","journal-title":"J Cell Biol"},{"issue":"18","key":"pbio.3003555.ref039","article-title":"Connecting single-cell ATP dynamics to overflow metabolism, cell growth, and the cell cycle in Escherichia coli","volume":"32","author":"W-H Lin","year":"2022","journal-title":"Curr Biol"},{"key":"pbio.3003555.ref040","doi-asserted-by":"crossref","first-page":"16031","DOI":"10.1038\/ncomms16031","article-title":"Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions","volume":"8","author":"O Olivares","year":"2017","journal-title":"Nat Commun"},{"issue":"2","key":"pbio.3003555.ref041","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cell.2015.06.017","article-title":"The utilization of extracellular proteins as nutrients is suppressed by mTORC1","volume":"162","author":"W Palm","year":"2015","journal-title":"Cell"},{"issue":"17","key":"pbio.3003555.ref042","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1091\/mbc.E19-12-0709","article-title":"Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology","volume":"31","author":"VW Tang","year":"2020","journal-title":"Mol Biol Cell"},{"issue":"45","key":"pbio.3003555.ref043","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1073\/pnas.1716173114","article-title":"Twenty-five years of mTOR: uncovering the link from nutrients to growth","volume":"114","author":"DM Sabatini","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pbio.3003555.ref044","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00424-014-1583-2","article-title":"Glucose deprivation promotes activation of mTOR signaling pathway and protein synthesis in rat skeletal muscle cells","volume":"467","author":"MC Miniaci","year":"2015","journal-title":"Pflugers Arch"},{"issue":"1","key":"pbio.3003555.ref045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41588-020-00753-3","article-title":"The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer","volume":"53","author":"AK Najumudeen","year":"2021","journal-title":"Nat Genet"},{"issue":"5","key":"pbio.3003555.ref046","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.112.265587","article-title":"Functional redundancy of SWI\/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart","volume":"111","author":"MS Willis","year":"2012","journal-title":"Circ Res"},{"issue":"1","key":"pbio.3003555.ref047","doi-asserted-by":"crossref","first-page":"13539","DOI":"10.1038\/s41598-025-98170-1","article-title":"ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K\/AKT\/mTORC1 signaling pathway","volume":"15","author":"M Zhang","year":"2025","journal-title":"Sci Rep"},{"issue":"13","key":"pbio.3003555.ref048","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2021.05.010","article-title":"Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner","volume":"56","author":"C Karabiyik","year":"2021","journal-title":"Dev Cell"},{"issue":"11","key":"pbio.3003555.ref049","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41374-019-0281-2","article-title":"Thy-1 depletion and integrin \u03b23 upregulation-mediated PI3K-Akt-mTOR pathway activation inhibits lung fibroblast autophagy in lipopolysaccharide-induced pulmonary fibrosis","volume":"99","author":"H Wan","year":"2019","journal-title":"Lab Invest"},{"key":"pbio.3003555.ref050","doi-asserted-by":"crossref","first-page":"110170","DOI":"10.1016\/j.cellsig.2021.110170","article-title":"Cell adhesion suppresses autophagy via Src\/FAK-mediated phosphorylation and inhibition of AMPK","volume":"89","author":"M Zhao","year":"2022","journal-title":"Cell Signal"},{"key":"pbio.3003555.ref051","doi-asserted-by":"crossref","first-page":"1015500","DOI":"10.3389\/fphys.2022.1015500","article-title":"Role of AMPK in autophagy","volume":"13","author":"S Wang","year":"2022","journal-title":"Front Physiol"},{"issue":"4","key":"pbio.3003555.ref052","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2023.01.011","article-title":"Exercise-activated hepatic autophagy via the FN1-\u03b15\u03b21 integrin pathway drives metabolic benefits of exercise","volume":"35","author":"K Kuramoto","year":"2023","journal-title":"Cell Metab"},{"issue":"6","key":"pbio.3003555.ref053","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70361","article-title":"DDR2-mediated autophagy inhibition contributes to angiotensin II-induced adventitial remodeling","volume":"15","author":"G Huang","year":"2025","journal-title":"Clin Transl Med"},{"issue":"1","key":"pbio.3003555.ref054","doi-asserted-by":"crossref","first-page":"105739","DOI":"10.1016\/j.isci.2022.105739","article-title":"Erythroid SLC7A5\/SLC3A2 amino acid carrier controls red blood cell size and maturation","volume":"26","author":"A Bouthelier","year":"2022","journal-title":"iScience"},{"issue":"5","key":"pbio.3003555.ref055","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/bcpt.13821","article-title":"The human LAT1-4F2hc (SLC7A5-SLC3A2) transporter complex: physiological and pathophysiological implications","volume":"133","author":"J Kahlhofer","year":"2023","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"pbio.3003555.ref056","doi-asserted-by":"crossref","first-page":"14570","DOI":"10.1038\/s41598-022-18779-4","article-title":"N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98)","volume":"12","author":"L Console","year":"2022","journal-title":"Sci Rep"},{"issue":"20","key":"pbio.3003555.ref057","doi-asserted-by":"crossref","first-page":"7573","DOI":"10.3390\/ijms21207573","article-title":"The heavy chain 4F2hc modulates the substrate affinity and specificity of the light chains LAT1 and LAT2","volume":"21","author":"S Kantipudi","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"7750","key":"pbio.3003555.ref058","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-019-1011-z","article-title":"Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex","volume":"568","author":"R Yan","year":"2019","journal-title":"Nature"},{"issue":"5","key":"pbio.3003555.ref059","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1074\/jbc.270.5.2320","article-title":"Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes","volume":"270","author":"EF Blommaart","year":"1995","journal-title":"J Biol Chem"},{"key":"pbio.3003555.ref060","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/1476-4598-12-169","article-title":"CD98hc (SLC3A2) drives integrin-dependent renal cancer cell behavior","volume":"12","author":"M Poettler","year":"2013","journal-title":"Mol Cancer"},{"issue":"33","key":"pbio.3003555.ref061","doi-asserted-by":"crossref","first-page":"24477","DOI":"10.1074\/jbc.M702877200","article-title":"CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling","volume":"282","author":"GW Prager","year":"2007","journal-title":"J Biol Chem"},{"issue":"52","key":"pbio.3003555.ref062","doi-asserted-by":"crossref","first-page":"54731","DOI":"10.1074\/jbc.M408700200","article-title":"CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation","volume":"279","author":"NC Henderson","year":"2004","journal-title":"J Biol Chem"},{"issue":"2","key":"pbio.3003555.ref063","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1073\/pnas.0404852102","article-title":"CD98hc (SLC3A2) mediates integrin signaling","volume":"102","author":"CC Feral","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"42","key":"pbio.3003555.ref064","doi-asserted-by":"crossref","first-page":"39282","DOI":"10.1074\/jbc.M105077200","article-title":"CD98-mediated links between amino acid transport and beta 1 integrin distribution in polarized columnar epithelia","volume":"276","author":"D Merlin","year":"2001","journal-title":"J Biol Chem"},{"issue":"6","key":"pbio.3003555.ref065","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.celrep.2017.04.042","article-title":"mTORC1 balances cellular amino acid supply with demand for protein synthesis through post-transcriptional control of ATF4","volume":"19","author":"Y Park","year":"2017","journal-title":"Cell Rep"},{"issue":"5","key":"pbio.3003555.ref066","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.3892\/or.2017.5530","article-title":"SLC3A2 is upregulated in human osteosarcoma and promotes tumor growth through the PI3K\/Akt signaling pathway","volume":"37","author":"B Zhu","year":"2017","journal-title":"Oncol Rep"},{"issue":"1","key":"pbio.3003555.ref067","doi-asserted-by":"crossref","first-page":"15758","DOI":"10.1038\/s41598-024-66484-1","article-title":"Elevated SLC3A2 associated with poor prognosis and enhanced malignancy in gliomas","volume":"14","author":"Y Xu","year":"2024","journal-title":"Sci Rep"},{"issue":"10","key":"pbio.3003555.ref068","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102428","article-title":"The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer","volume":"20","author":"P Hafliger","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"pbio.3003555.ref069","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12935-024-03365-7","article-title":"SLC7A5 correlated with malignancies and immunotherapy response in bladder cancer","volume":"24","author":"C Zhang","year":"2024","journal-title":"Cancer Cell Int"},{"key":"pbio.3003555.ref070","first-page":"100814","article-title":"Prognostic value of large amino acid transporter type 1 (LAT1) expression in pulmonary adenocarcinoma: A tissue microarray study","volume":"39","author":"A Terao","year":"2024","journal-title":"Cancer Treat Res Commun"},{"issue":"1","key":"pbio.3003555.ref071","doi-asserted-by":"crossref","first-page":"13946","DOI":"10.1038\/s41598-023-40971-3","article-title":"Estrous cycle dependent expression of oxycodone conditioned reward in rats","volume":"13","author":"JA Babb","year":"2023","journal-title":"Sci Rep"},{"issue":"4","key":"pbio.3003555.ref072","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.3390\/ijms21041407","article-title":"Co-expression effect of SLC7A5\/SLC3A2 to predict response to endocrine therapy in oestrogen-receptor-positive breast cancer","volume":"21","author":"LH Alfarsi","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"pbio.3003555.ref073","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3892\/or.2021.8228","article-title":"SLC7A5 is linked to increased expression of genes related to proliferation and hypoxia in estrogen\u2011receptor\u2011positive breast cancer","volume":"47","author":"R T\u00f6rnroos","year":"2022","journal-title":"Oncol Rep"},{"issue":"34","key":"pbio.3003555.ref074","doi-asserted-by":"crossref","first-page":"14240","DOI":"10.1074\/jbc.M117.798405","article-title":"The glutamate\/cystine antiporter SLC7A11\/xCT enhances cancer cell dependency on glucose by exporting glutamate","volume":"292","author":"P Koppula","year":"2017","journal-title":"J Biol Chem"},{"issue":"7","key":"pbio.3003555.ref075","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"J Schindelin","year":"2012","journal-title":"Nat Methods"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3003555","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3003555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:01:32Z","timestamp":1790359292000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3003555"}},"subtitle":[],"editor":[{"given":"Albana","family":"Gattelli","sequence":"first","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas: Consejo Nacional de Investigaciones Cientificas y Tecnicas","place":["ARGENTINA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":75,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3003555","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,18]]}}}