{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:15:00Z","timestamp":1790745300722,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pbio.3003627","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000}}],"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM0709077"],"award-info":[{"award-number":["GM0709077"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI117911"],"award-info":[{"award-number":["AI117911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>\n                    Neurodegenerative diseases are often associated with oxidative stress, and while probiotics may influence neuronal health, the underlying mechanisms remain poorly understood. Using the\n                    <jats:italic>sod-1<\/jats:italic>\n                    A4V\n                    <jats:sup>M<\/jats:sup>\n                    amyotrophic lateral sclerosis (ALS) model in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    , we investigated the protective effects of the probiotic\n                    <jats:italic>Enterococcus faecium<\/jats:italic>\n                    against oxidative stress-induced neurodegeneration. Animals fed\n                    <jats:italic>E. faecium<\/jats:italic>\n                    showed reduced motor neuron degeneration under oxidative stress compared to those maintained on a standard\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    diet. Transcriptome analysis revealed a significant enrichment of oxidoreductase genes, including cytochrome P450 (\n                    <jats:italic>cyp<\/jats:italic>\n                    ) genes. RNAi-mediated knockdown of\n                    <jats:italic>cyp<\/jats:italic>\n                    genes impaired\n                    <jats:italic>E. faecium<\/jats:italic>\n                    -mediated neuroprotection, and this loss correlated with increased reactive oxygen species (ROS) levels. We identified the conserved nuclear hormone receptor NHR-86 as a key regulator of\n                    <jats:italic>cyp<\/jats:italic>\n                    gene expression and neuroprotection. Loss of\n                    <jats:italic>nhr-86<\/jats:italic>\n                    abolished the probiotic\u2019s protective benefits, while transgenic expression of\n                    <jats:italic>nhr-86<\/jats:italic>\n                    restored\n                    <jats:italic>cyp<\/jats:italic>\n                    induction and neuronal resilience. Importantly, intestinal expression of NHR-86 was sufficient to restore CYP induction and neuronal resilience, whereas neuronal knockdown had no effect, indicating that gut NHR-86 activity is essential for this protective pathway. These findings reveal a previously uncharacterized NHR-CYP regulatory axis activated by an intestinal probiotic, highlighting a mechanistic link between microbial signals and host neuroprotection.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3003627","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T21:02:38Z","timestamp":1769806958000},"page":"e3003627","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["A gut-activated NHR-86\u2013CYP pathway mediates the neuroprotective effects of Enterococcus faecium probiotics in a nematode model of amyotrophic lateral sclerosis"],"prefix":"10.1371","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2981-1582","authenticated-orcid":true,"given":"Yu","family":"Sang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5975-3352","authenticated-orcid":true,"given":"Alejandro","family":"Aballay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"pbio.3003627.ref001","doi-asserted-by":"crossref","first-page":"1126002","DOI":"10.3389\/fnagi.2023.1126002","article-title":"Beta cortical oscillatory activities and their relationship to postural control in a standing balance demanding test: influence of aging","volume":"15","author":"Y Hu","year":"2023","journal-title":"Front 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