{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:18:28Z","timestamp":1788373108002,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.pbio.3003649","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000}}],"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2021YFA1300302"],"award-info":[{"award-number":["2021YFA1300302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2025YFA1804302"],"award-info":[{"award-number":["2025YFA1804302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32293201"],"award-info":[{"award-number":["32293201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25D9014"],"award-info":[{"award-number":["U25D9014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Fundamental Research Projects","award":["202301AT070231"],"award-info":[{"award-number":["202301AT070231"]}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>\n                    Mitochondria catabolize nutrients by generating sequentially-ordered organic acid intermediates that are oxidized through the tricarboxylic acid cycle. Pathogenic accumulation of metabolic organic acids manifests as devastating organic acidemias\/acidurias and other severe diseases, but the underlying mechanisms are largely unknown. Using unbiased\n                    <jats:italic>C. elegans<\/jats:italic>\n                    genetic screening, we here reveal that mutations in the phosphoenolpyruvate carboxykinases PCK-1 and PCK-2 cause buildup of oxaloacetate, a key tricarboxylic acid cycle intermediate, leading to severe mitochondrial damage. Depletion of mitochondrial GOT-2.1 or GOT-2.2, which catalyze oxaloacetate conversion to aspartate, also causes oxaloacetate accumulation and defective mitochondria with disrupted cristae. We demonstrate that oxaloacetate binds the MICOS complex subunit CHCH-3\/MIC19 and inhibits its function of promoting IMMT-1\/MIC60-dependent membrane shaping and remodeling. In mammalian cells, aberrant OAA buildup similarly causes mitochondrial impairment through MIC19 and MIC60. These findings not only provide important mechanistic insights into mitochondrial damage in the context of defective oxaloacetate metabolism, but also suggest therapeutic strategies for oxaloacetate-related mitochondriopathies.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3003649","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:42:31Z","timestamp":1787938951000},"page":"e3003649","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxaloacetate damages mitochondria by perturbing MIC60-dependent membrane remodeling"],"prefix":"10.1371","volume":"24","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["Center for Life Sciences, School of Life Sciences"]},{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Shan","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["Center for Life Sciences, School of Life Sciences"]},{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["Center for Life Sciences, School of Life Sciences"]},{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijiao","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["Center for Life Sciences, School of Life Sciences"]},{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]},{"name":"Southwest United Graduate School","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["Center for Life Sciences, School of Life Sciences"]},{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Duan","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["Center for Life Sciences, School of Life Sciences"]},{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruofeng","family":"Tang","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehui","family":"Shi","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["Center for Life Sciences, School of Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["Center for Life Sciences, School of Life Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3360-3221","authenticated-orcid":true,"given":"Chonglin","family":"Yang","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"],"department":["MOE Key Laboratory of Major Diseases in Children, National Center for Children\u2019s Health, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"7","key":"pbio.3003649.ref001","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41556-018-0124-1","article-title":"The multifaceted contributions of mitochondria to cellular metabolism","volume":"20","author":"JB Spinelli","year":"2018","journal-title":"Nat Cell Biol"},{"issue":"1","key":"pbio.3003649.ref002","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","article-title":"Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency","volume":"155","author":"S Cogliati","year":"2013","journal-title":"Cell"},{"issue":"9","key":"pbio.3003649.ref003","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41580-025-00854-z","article-title":"Molecular machineries shaping the mitochondrial inner membrane","volume":"26","author":"O Daumke","year":"2025","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"pbio.3003649.ref004","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41580-022-00506-6","article-title":"Mechanisms of mitochondrial respiratory adaptation","volume":"23","author":"CF Bennett","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"pbio.3003649.ref005","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1016\/j.cell.2024.04.037","article-title":"Mitochondria at the crossroads of health and disease","volume":"187","author":"A Suomalainen","year":"2024","journal-title":"Cell"},{"issue":"10","key":"pbio.3003649.ref006","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1038\/s43587-025-00942-x","article-title":"Mitochondria-associated condensates maintain mitochondrial homeostasis and promote lifespan","volume":"5","author":"Y Bai","year":"2025","journal-title":"Nat Aging"},{"issue":"2","key":"pbio.3003649.ref007","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1083\/jcb.201807204","article-title":"The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis","volume":"218","author":"J Zhou","year":"2019","journal-title":"J Cell Biol"},{"issue":"3","key":"pbio.3003649.ref008","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jgg.2020.02.007","article-title":"Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditis elegans","volume":"47","author":"R Tang","year":"2020","journal-title":"J Genet Genomics"},{"issue":"7952","key":"pbio.3003649.ref009","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41586-023-05770-w","article-title":"Fumarate induces vesicular release of mtDNA to drive innate immunity","volume":"615","author":"V Zecchini","year":"2023","journal-title":"Nature"},{"issue":"4","key":"pbio.3003649.ref010","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41556-022-00883-2","article-title":"A feedback loop engaging propionate catabolism intermediates controls mitochondrial morphology","volume":"24","author":"J Zhou","year":"2022","journal-title":"Nat Cell Biol"},{"issue":"1","key":"pbio.3003649.ref011","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"I Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat Commun"},{"issue":"7","key":"pbio.3003649.ref012","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s42255-021-00424-5","article-title":"Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect","volume":"3","author":"EK Wiese","year":"2021","journal-title":"Nat Metab"},{"issue":"1","key":"pbio.3003649.ref013","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1038\/s41467-022-33987-2","article-title":"CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase","volume":"13","author":"JP L\u00f3pez-Alonso","year":"2022","journal-title":"Nat Commun"},{"issue":"2","key":"pbio.3003649.ref014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102838","article-title":"Regulation and function of the mammalian tricarboxylic acid cycle","volume":"299","author":"PK Arnold","year":"2023","journal-title":"J Biol Chem"},{"issue":"3","key":"pbio.3003649.ref015","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ajhg.2019.07.015","article-title":"Bi-allelic GOT2 mutations cause a treatable malate-aspartate shuttle-related encephalopathy","volume":"105","author":"CDM van Karnebeek","year":"2019","journal-title":"Am J Hum Genet"},{"issue":"11","key":"pbio.3003649.ref016","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/iub.2367","article-title":"The malate-aspartate shuttle (Borst cycle): how it started and developed into a major metabolic pathway","volume":"72","author":"P Borst","year":"2020","journal-title":"IUBMB Life"},{"issue":"14","key":"pbio.3003649.ref017","article-title":"Deletion of skeletal muscle mitochondrial glutamic-oxaloacetic transaminase (GOT2) enhances oxaloacetate inhibition of succinate dehydrogenase and alters substrate selectivity","volume":"39","author":"BD Fink","year":"2025","journal-title":"FASEB J"},{"key":"pbio.3003649.ref018","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00439-019-02063-z","article-title":"MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy","volume":"138","author":"MH Broeks","year":"2019","journal-title":"Hum Genet"},{"issue":"1","key":"pbio.3003649.ref019","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1038\/s41467-021-24859-2","article-title":"GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis","volume":"12","author":"DM Kremer","year":"2021","journal-title":"Nat Commun"},{"issue":"4","key":"pbio.3003649.ref020","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.molcel.2013.07.002","article-title":"Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth","volume":"51","author":"R Lin","year":"2013","journal-title":"Mol Cell"},{"key":"pbio.3003649.ref021","doi-asserted-by":"crossref","first-page":"1519046","DOI":"10.3389\/fonc.2024.1519046","article-title":"The role of GOT1 in cancer metabolism","volume":"14","author":"H Peng","year":"2024","journal-title":"Front Oncol"},{"issue":"5","key":"pbio.3003649.ref022","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.07.031","article-title":"Dynamic acetylation of phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions","volume":"71","author":"P Latorre-Muro","year":"2018","journal-title":"Mol Cell"},{"key":"pbio.3003649.ref023","doi-asserted-by":"crossref","first-page":"101257","DOI":"10.1016\/j.molmet.2021.101257","article-title":"Phosphoenolpyruvate carboxykinase in cell metabolism: roles and mechanisms beyond gluconeogenesis","volume":"53","author":"S Yu","year":"2021","journal-title":"Mol Metab"},{"issue":"1","key":"pbio.3003649.ref024","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-nutr-061121-091507","article-title":"Gluconeogenesis flux in metabolic disease","volume":"43","author":"A Shah","year":"2023","journal-title":"Annu Rev Nutr"},{"issue":"1","key":"pbio.3003649.ref025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ymgme.2010.05.004","article-title":"Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis","volume":"101","author":"I Marin-Valencia","year":"2010","journal-title":"Mol Genet Metab"},{"issue":"5","key":"pbio.3003649.ref026","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/humu.20908","article-title":"Structural insights on pathogenic effects of novel mutations causing pyruvate carboxylase deficiency","volume":"30","author":"S Monnot","year":"2009","journal-title":"Hum Mutat"},{"issue":"6","key":"pbio.3003649.ref027","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/humu.23742","article-title":"Pyruvate carboxylase deficiency type A and type C: characterization of five novel pathogenic variants in PC and analysis of the genotype-phenotype correlation","volume":"40","author":"EG Coci","year":"2019","journal-title":"Hum Mutat"},{"key":"pbio.3003649.ref028","first-page":"100931","article-title":"Malate dehydrogenase 2 deficiency is an emerging cause of pediatric epileptic encephalopathy with a recognizable biochemical signature","volume":"33","author":"JRC Priestley","year":"2022","journal-title":"Mol Genet Metab Rep"},{"issue":"1","key":"pbio.3003649.ref029","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ajhg.2016.11.014","article-title":"Mutations in MDH2, encoding a krebs cycle enzyme, cause early-onset severe encephalopathy","volume":"100","author":"S Ait-El-Mkadem","year":"2017","journal-title":"Am J Hum Genet"},{"key":"pbio.3003649.ref030","first-page":"100814","article-title":"Triheptanoin - novel therapeutic approach for the ultra-rare disease mitochondrial malate dehydrogenase deficiency","volume":"29","author":"A Laemmle","year":"2021","journal-title":"Mol Genet Metab Rep"},{"key":"pbio.3003649.ref031","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.seizure.2023.11.003","article-title":"Developmental and epileptic encephalopathy 82 (DEE82) with novel compound heterozygous mutations of GOT2 gene","volume":"116","author":"\u00d6Y \u00c7apan","year":"2024","journal-title":"Seizure"},{"issue":"3","key":"pbio.3003649.ref032","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ymgme.2014.04.001","article-title":"Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity","volume":"113","author":"DR Adams","year":"2014","journal-title":"Mol Genet Metab"},{"issue":"1","key":"pbio.3003649.ref033","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ymgme.2016.03.001","article-title":"Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis","volume":"118","author":"S Santra","year":"2016","journal-title":"Mol Genet Metab"},{"issue":"4","key":"pbio.3003649.ref034","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ymgme.2017.02.003","article-title":"Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction","volume":"120","author":"P Vieira","year":"2017","journal-title":"Mol Genet Metab"},{"issue":"3","key":"pbio.3003649.ref035","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s13238-021-00881-4","article-title":"A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis","volume":"13","author":"T Ma","year":"2022","journal-title":"Protein Cell"},{"issue":"12","key":"pbio.3003649.ref036","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.tcb.2020.08.008","article-title":"Cristae membrane dynamics \u2013 a paradigm change","volume":"30","author":"AK Kondadi","year":"2020","journal-title":"Trends Cell Biol"},{"issue":"4","key":"pbio.3003649.ref037","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1083\/jcb.201609046","article-title":"The MICOS component Mic60 displays a conserved membrane-bending activity that is necessary for normal cristae morphology","volume":"216","author":"D Tarasenko","year":"2017","journal-title":"J Cell Biol"},{"issue":"14","key":"pbio.3003649.ref038","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019104105","article-title":"MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation","volume":"39","author":"T Stephan","year":"2020","journal-title":"EMBO J"},{"key":"pbio.3003649.ref039","doi-asserted-by":"crossref","first-page":"15258","DOI":"10.1038\/ncomms15258","article-title":"Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions","volume":"8","author":"M Hessenberger","year":"2017","journal-title":"Nat Commun"},{"issue":"35","key":"pbio.3003649.ref040","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo4946","article-title":"Structural insights into crista junction formation by the Mic60-Mic19 complex","volume":"8","author":"T Bock-Bierbaum","year":"2022","journal-title":"Sci Adv"},{"issue":"8","key":"pbio.3003649.ref041","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"J Eberhardt","year":"2021","journal-title":"J Chem Inform Model"},{"issue":"2","key":"pbio.3003649.ref042","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"O Trott","year":"2010","journal-title":"J Comput Chem"},{"issue":"1","key":"pbio.3003649.ref043","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0021-9258(17)33923-6","article-title":"Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP)","volume":"251","author":"M Jomain-Baum","year":"1976","journal-title":"J Biol Chem"},{"issue":"1","key":"pbio.3003649.ref044","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0014-5793(75)80214-6","article-title":"3-Mercaptopicolinic acid, a preferential inhibitor of the cytosolic phosphoenolpyruvate carboxykinase","volume":"58","author":"BH Robinson","year":"1975","journal-title":"FEBS Lett"},{"key":"pbio.3003649.ref045","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07739","article-title":"MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture","volume":"4","author":"JR Friedman","year":"2015","journal-title":"Elife"},{"issue":"1","key":"pbio.3003649.ref046","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00441-016-2433-7","article-title":"The MICOS complex of human mitochondria","volume":"367","author":"V Kozjak-Pavlovic","year":"2017","journal-title":"Cell Tissue Res"},{"issue":"51","key":"pbio.3003649.ref047","doi-asserted-by":"crossref","first-page":"19932","DOI":"10.1074\/jbc.RA118.005144","article-title":"Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration","volume":"293","author":"BD Fink","year":"2018","journal-title":"J Biol Chem"},{"issue":"11","key":"pbio.3003649.ref048","doi-asserted-by":"crossref","first-page":"11696","DOI":"10.1096\/fj.201900690R","article-title":"Modulation of complex II-energized respiration in muscle, heart, and brown adipose mitochondria by oxaloacetate and complex I electron flow","volume":"33","author":"BD Fink","year":"2019","journal-title":"FASEB J"},{"issue":"10","key":"pbio.3003649.ref049","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1038\/s41564-025-02107-3","article-title":"Oxaloacetate sensing promotes innate immune antiviral defence against influenza virus infection","volume":"10","author":"S Jin","year":"2025","journal-title":"Nat Microbiol"},{"key":"pbio.3003649.ref050","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2147\/OTT.S382161","article-title":"Spotlight on GOT2 in cancer metabolism","volume":"16","author":"SA Kerk","year":"2023","journal-title":"Onco Targets Ther"},{"issue":"1","key":"pbio.3003649.ref051","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1471-4159.2007.04556.x","article-title":"Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain","volume":"102","author":"P Guidetti","year":"2007","journal-title":"J Neurochem"},{"issue":"4","key":"pbio.3003649.ref052","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.molcel.2010.01.015","article-title":"The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans","volume":"37","author":"CM Haynes","year":"2010","journal-title":"Mol Cell"},{"issue":"1","key":"pbio.3003649.ref053","doi-asserted-by":"crossref","first-page":"102088","DOI":"10.1016\/j.xpro.2023.102088","article-title":"Protocol for mitochondrial isolation and sub-cellular localization assay for mitochondrial proteins","volume":"4","author":"D Zhou","year":"2023","journal-title":"STAR Protoc"},{"issue":"16","key":"pbio.3003649.ref054","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"GM Morris","year":"2009","journal-title":"J Comput Chem"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3003649","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3003649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:56:21Z","timestamp":1788371781000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3003649"}},"subtitle":[],"editor":[{"given":"Johannes M.","family":"Herrmann","sequence":"first","affiliation":[{"name":"University of Kaiserslautern: Technische Universitat Kaiserslautern","place":["GERMANY"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":54,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3003649","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}