{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T18:09:00Z","timestamp":1779386940744,"version":"3.53.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Ministry of Science and Technology","award":["2023YFC2305900 and 2023YFA1801000"],"award-info":[{"award-number":["2023YFC2305900 and 2023YFA1801000"]}]},{"name":"the Key Research and Development Program sponsored by the Shanghai Pilot Program for Basic Research - Fudan University","award":["22TQ015"],"award-info":[{"award-number":["22TQ015"]}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>\n                    Ticks transmit numerous viruses that pose significant threats to human and animal health, however, the molecular interactions between ticks and viruses remain poorly understood. Using Langat virus (LGTV)\u2014a surrogate for tick-borne encephalitis virus (TBEV), we show that the JAK\/STAT pathway promotes viral infection in\n                    <jats:italic>Haemaphysalis longicornis<\/jats:italic>\n                    . Rather than directly interacting with viral proteins, this proviral effect is mediated by a low-density lipoprotein receptor-related protein (LRP), whose expression is regulated by STAT. Silencing\n                    <jats:italic>LRP<\/jats:italic>\n                    in\n                    <jats:italic>H. longicornis<\/jats:italic>\n                    reduced LGTV infection, while ectopic expression of\n                    <jats:italic>LRP<\/jats:italic>\n                    enhanced it. Unlike its mammalian counterparts,\n                    <jats:italic>H. longicornis<\/jats:italic>\n                    LRP lacks a transmembrane domain and localizes intracellularly. Functionally, LRP promotes lipophagy, leading to lipid droplets breakdown and providing energy to support viral replication. Together, these findings reveal a non-canonical mechanism by which the JAK\/STAT pathway facilitates LGTV replication through STAT-dependent regulation of an atypical, intracellular LRP that drives lipophagy.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3003797","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:21:58Z","timestamp":1779384118000},"page":"e3003797","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["A non-canonical JAK\/STAT pathway promotes viral replication through the lipoprotein receptor-related protein in 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