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This study describes a potential molecular mechanism of this adjustment by investigating the climate-dependent regulation of\n                    <jats:italic>SUCROSE TRANSPORTER 2<\/jats:italic>\n                    (\n                    <jats:italic>SUC2<\/jats:italic>\n                    ) in the model plant\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    . SUC2 is responsible for loading photosynthetically-produced sucrose into the leaf vascular system. Its protein and mRNA abundance in\n                    <jats:italic>A. thaliana<\/jats:italic>\n                    natural accessions were found to correlate with leaf sucrose export and summer temperature. Exploration of methylome data and epigenome editing experiments suggested that epigenetic marks on\n                    <jats:italic>SUC2\u2019s<\/jats:italic>\n                    exon 2 contributed to the climate-dependent expression of\n                    <jats:italic>SUC2<\/jats:italic>\n                    . Two siRNAs were identified as mediators of\n                    <jats:italic>SUC2<\/jats:italic>\n                    methylations and their respective origins localized to the\n                    <jats:italic>SUC5<\/jats:italic>\n                    and\n                    <jats:italic>SUC8<\/jats:italic>\n                    genes. The analysis of plants with reduced or enhanced\n                    <jats:italic>SUC5<\/jats:italic>\n                    or\n                    <jats:italic>SUC8<\/jats:italic>\n                    transcriptional activity corroborated the link to\n                    <jats:italic>SUC2<\/jats:italic>\n                    methylation. Besides illustrating a novel regulatory strategy of carbon export from leaves, our results establish exon methylation mediated by gene-derived siRNAs as yet another potential mechanism for plant adaptation.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3003919","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:46:43Z","timestamp":1785433603000},"page":"e3003919","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["siRNA-guided DNA-methylation at a sucrose transporter gene potentially contributes to climatic plant 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