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Although LITAF and its homolog CDIP1 were previously identified as host receptors that promote HBL\u2011induced cytolysis, mice lacking both proteins remain only partially protected, indicating the existence of additional determinants of susceptibility. Using genome\u2011wide CRISPR knockout screens in\n                    <jats:italic>Litaf<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    \/\n                    <jats:italic>Cdip1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mouse embryonic fibroblasts and human HT1080 cells, we identify caveolin\u20111 (CAV1), a caveola\u2011associated membrane protein, as a third conserved host factor required for HBL cytolytic activity. Confocal imaging and co\u2011immunoprecipitation analyses show that CAV1 colocalizes with HBL and physically associates with the toxin at the plasma membrane. Notably, mice lacking all three factors (Litaf\/Cdip1\/Cav1 triple knockouts) are completely resistant to HBL toxin challenge, establishing CAV1 as an additional host factor mediating HBL toxin cytotoxicity. These findings define a tripartite host factor system required for HBL toxin activity and position CAV1 as an additional host determinant to\n                    <jats:italic>B. cereus<\/jats:italic>\n                    virulence.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3003957","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T17:44:06Z","timestamp":1787334246000},"page":"e3003957","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Caveolin 1 is a conserved host factor mediating Bacillus cereus hemolysin BL toxin cytolytic 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