{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:56:55Z","timestamp":1791395815401,"version":"4.3.3"},"reference-count":12,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.3004001","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:24:36Z","timestamp":1791393876000},"page":"e3004001","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Better antibodies, better science"],"prefix":"10.1371","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-0022","authenticated-orcid":true,"given":"Johan","family":"Duch\u00eane","sequence":"first","affiliation":[{"name":"German Center for Cardiovascular Research (DZHK)","place":["Munich, Germany"],"department":["Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University (LMU), LMU Open Science Center (OSC)"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"issue":"7","key":"pbio.3004001.ref001","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.stem.2021.11.010","article-title":"Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1","volume":"29","author":"A Rot","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"12","key":"pbio.3004001.ref002","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41419-024-07273-6","article-title":"Why Bax detection in >1400 publications might be flawed","volume":"15","author":"K Entrop","year":"2024","journal-title":"Cell Death Dis"},{"issue":"8037","key":"pbio.3004001.ref003","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/d41586-024-03590-0","article-title":"The antibodies don\u2019t work! The race to rid labs of molecules that ruin experiments","volume":"635","author":"D Kwon","year":"2024","journal-title":"Nature"},{"key":"pbio.3004001.ref004","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.91645.2","article-title":"Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications","volume":"12","author":"R Ayoubi","year":"2023","journal-title":"Elife"},{"issue":"7552","key":"pbio.3004001.ref005","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/521274a","article-title":"Reproducibility crisis: blame it on the antibodies","volume":"521","author":"M Baker","year":"2015","journal-title":"Nature"},{"issue":"7537","key":"pbio.3004001.ref006","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/518027a","article-title":"Reproducibility: Standardize antibodies used in research","volume":"518","author":"A Bradbury","year":"2015","journal-title":"Nature"},{"issue":"10","key":"pbio.3004001.ref007","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nmeth.3995","article-title":"A proposal for validation of antibodies","volume":"13","author":"M Uhlen","year":"2016","journal-title":"Nat Methods"},{"issue":"6","key":"pbio.3004001.ref008","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/s41596-024-01095-8","article-title":"A consensus platform for antibody characterization","volume":"20","author":"R Ayoubi","year":"2025","journal-title":"Nat Protoc"},{"issue":"10","key":"pbio.3004001.ref009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003984","article-title":"Inadequate antibody validation places substantial numbers of animal and human tissue samples at risk of waste","volume":"24","author":"MC Biddle","year":"2026","journal-title":"PLoS Biol"},{"issue":"10","key":"pbio.3004001.ref010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003981","article-title":"Actionable solutions to address antibody validation failures","volume":"24","author":"KB Blades","year":"2026","journal-title":"PLoS Biol"},{"issue":"7910","key":"pbio.3004001.ref011","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41586-022-04654-9","article-title":"Design of protein-binding proteins from the target structure alone","volume":"605","author":"L Cao","year":"2022","journal-title":"Nature"},{"issue":"8084","key":"pbio.3004001.ref012","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41586-025-09429-6","article-title":"One-shot design of functional protein binders with BindCraft","volume":"646","author":"M Pacesa","year":"2025","journal-title":"Nature"}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3004001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:24:38Z","timestamp":1791393878000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3004001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,7]]},"references-count":12,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3004001","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,7]]}}}