{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:03:53Z","timestamp":1791486233169,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.pbio.3004016","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000}}],"reference-count":84,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Provincial Science and Technology Project at Southwest United Graduate School","award":["202302AP370005"],"award-info":[{"award-number":["202302AP370005"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32541028"],"award-info":[{"award-number":["32541028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yunnan Revitalization Talent Support Program","award":["K264202230211"],"award-info":[{"award-number":["K264202230211"]}]}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>\n                    The epidermis relies on collagen-rich extracellular matrices (ECMs) to maintain barrier integrity against pathogens. Lysosomes regulate cuticle collagen turnover, yet how neuronal signaling modulates epidermal lysosomal function and collagen organization during infection remains unclear. Using\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    PA14-\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    infection model, we demonstrate that pathogen-induced neuronal signaling disrupts epidermal lysosomal activity and collagen remodeling. PA14 infection triggers neurons to secrete NSIF-1 (Neuronal Secreted Immune Factor 1), which translocates to the epidermis and impairs lysosomal acidification, maturation, and degradation by suppressing the transcription factor ELT-3. This disruption leads to disorganized collagen structure, compromising cuticle integrity and host resistance. Genetic mutation of\n                    <jats:italic>nsif-1<\/jats:italic>\n                    restores lysosomal function, enhances collagen density, and improves survival, while neuron-specific\n                    <jats:italic>nsif-1<\/jats:italic>\n                    knockdown confirms its neuronal origin. Moreover, NSIF-1 inhibits ELT-3 nuclear localization, blocking its role in lysosomal-dependent ECM repair. Our study reveals a neuro-epidermal axis wherein pathogens exploit neuronal signals to disrupt lysosomal function and collagen homeostasis, identifying NSIF-1 and ELT-3 as potential targets to counteract infection-driven ECM dysregulation.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3004016","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:38:43Z","timestamp":1790098723000},"page":"e3004016","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pathogen subversion of neuro-epidermal signaling impairs lysosomal function to disrupt collagen homeostasis in Caenorhabditis elegans"],"prefix":"10.1371","volume":"24","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University","place":["Kunming, China"],"department":["School of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases"]},{"name":"Yunnan University","place":["Kunming, China"],"department":["School of Chemical Science and Technology, Key Laboratory of Medicinal Chemistry for Natural Resource - Ministry of Education"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Liu","sequence":"additional","affiliation":[{"name":"Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University","place":["Kunming, China"],"department":["School of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University","place":["Kunming, China"],"department":["School of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilie","family":"Xiao","sequence":"additional","affiliation":[{"name":"Yunnan University","place":["Kunming, China"],"department":["School of Chemical Science and Technology, Key Laboratory of Medicinal Chemistry for Natural Resource - Ministry of Education"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-1550","authenticated-orcid":true,"given":"Bin","family":"Qi","sequence":"additional","affiliation":[{"name":"Southwest United Graduate School, State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, Yunnan University","place":["Kunming, China"],"department":["School of Life Sciences, Center for Life Sciences, Yunnan Key Laboratory of Cell Metabolism and Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"issue":"24","key":"pbio.3004016.ref001","doi-asserted-by":"crossref","first-page":"14788","DOI":"10.1016\/S0021-9258(18)33349-0","article-title":"Fibronectin binding to Staphylococcus aureus","volume":"257","author":"RA Proctor","year":"1982","journal-title":"J Biol Chem"},{"issue":"1","key":"pbio.3004016.ref002","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1128\/iai.54.1.149-153.1986","article-title":"Degradation of soluble laminin and depletion of tissue-associated basement membrane laminin by Pseudomonas aeruginosa elastase and alkaline protease","volume":"54","author":"LW Heck","year":"1986","journal-title":"Infect Immun"},{"issue":"11","key":"pbio.3004016.ref003","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/cmi.12002","article-title":"Bacterial adhesion to animal tissues: protein determinants for recognition of extracellular matrix components","volume":"14","author":"C Chagnot","year":"2012","journal-title":"Cell Microbiol"},{"issue":"6","key":"pbio.3004016.ref004","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1111\/j.1574-6976.2012.00340.x","article-title":"Human pathogens utilize host extracellular matrix proteins laminin and collagen for adhesion and invasion of the host","volume":"36","author":"B Singh","year":"2012","journal-title":"FEMS Microbiol Rev"},{"issue":"7860","key":"pbio.3004016.ref005","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41586-021-03475-6","article-title":"The spatial landscape of lung pathology during COVID-19 progression","volume":"593","author":"AF Rendeiro","year":"2021","journal-title":"Nature"},{"issue":"8","key":"pbio.3004016.ref006","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1172\/JCI0216413","article-title":"Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis","volume":"110","author":"TW Schacker","year":"2002","journal-title":"J Clin Invest"},{"key":"pbio.3004016.ref007","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cimid.2017.02.001","article-title":"Wound healing in cutaneous leishmaniasis: a double edged sword of IL-10 and TGF-\u03b2","volume":"51","author":"A Abdoli","year":"2017","journal-title":"Comp Immunol Microbiol Infect Dis"},{"issue":"2","key":"pbio.3004016.ref008","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1534\/genetics.120.303125","article-title":"Cuticle collagen expression is regulated in response to environmental stimuli by the GATA transcription factor ELT-3 in Caenorhabditis elegans","volume":"215","author":"H Mesbahi","year":"2020","journal-title":"Genetics"},{"issue":"1","key":"pbio.3004016.ref009","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12915-024-01840-1","article-title":"ADARs regulate cuticle collagen expression and promote survival to pathogen infection","volume":"22","author":"A Dhakal","year":"2024","journal-title":"BMC Biol"},{"issue":"7541","key":"pbio.3004016.ref010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature14021","article-title":"Dauer-independent insulin\/IGF-1-signalling implicates collagen remodelling in longevity","volume":"519","author":"CY Ewald","year":"2015","journal-title":"Nature"},{"issue":"5","key":"pbio.3004016.ref011","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13815","article-title":"The longevity response to warm temperature is neurally controlled via the regulation of collagen genes","volume":"22","author":"SN Palani","year":"2023","journal-title":"Aging Cell"},{"issue":"11","key":"pbio.3004016.ref012","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw4717","article-title":"Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection","volume":"5","author":"D Sellegounder","year":"2019","journal-title":"Sci Adv"},{"issue":"37","key":"pbio.3004016.ref013","doi-asserted-by":"crossref","first-page":"27037","DOI":"10.1074\/jbc.M701088200","article-title":"Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein\/Endo180, cooperate in fibroblast-mediated collagen degradation","volume":"282","author":"DH Madsen","year":"2007","journal-title":"J Biol Chem"},{"issue":"11","key":"pbio.3004016.ref014","doi-asserted-by":"crossref","first-page":"7935","DOI":"10.1074\/jbc.M113.512780","article-title":"Complex determinants in specific members of the mannose receptor family govern collagen endocytosis","volume":"289","author":"HJ J\u00fcrgensen","year":"2014","journal-title":"J Biol Chem"},{"issue":"1","key":"pbio.3004016.ref015","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.yexcr.2003.10.008","article-title":"uPARAP\/endo180 directs lysosomal delivery and degradation of collagen IV","volume":"293","author":"L Kj\u00f8ller","year":"2004","journal-title":"Exp Cell Res"},{"issue":"11","key":"pbio.3004016.ref016","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500603","article-title":"Regulated lysosomal exocytosis mediates cancer progression","volume":"1","author":"E Machado","year":"2015","journal-title":"Sci Adv"},{"issue":"14","key":"pbio.3004016.ref017","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1242\/dev.108811","article-title":"mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis","volume":"141","author":"J Chen","year":"2014","journal-title":"Development"},{"issue":"1","key":"pbio.3004016.ref018","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2019.10.020","article-title":"An ECM-to-nucleus signaling pathway activates lysosomes for C. elegans larval development","volume":"52","author":"R Miao","year":"2020","journal-title":"Dev Cell"},{"issue":"1","key":"pbio.3004016.ref019","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41467-017-02448-6","article-title":"Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314","volume":"9","author":"KJ Blake","year":"2018","journal-title":"Nat Commun"},{"issue":"5","key":"pbio.3004016.ref020","article-title":"Blocking neuronal signaling to immune cells treats streptococcal invasive infection","volume":"173","author":"FA Pinho-Ribeiro","year":"2018","journal-title":"Cell"},{"issue":"7465","key":"pbio.3004016.ref021","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"IM Chiu","year":"2013","journal-title":"Nature"},{"issue":"6","key":"pbio.3004016.ref022","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.celrep.2017.10.050","article-title":"Distinct roles of sensory neurons in mediating pathogen avoidance and neuropeptide-dependent immune regulation","volume":"21","author":"X Cao","year":"2017","journal-title":"Cell Rep"},{"issue":"6030","key":"pbio.3004016.ref023","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1126\/science.1203411","article-title":"Neuronal GPCR controls innate immunity by regulating noncanonical unfolded protein response genes","volume":"332","author":"J Sun","year":"2011","journal-title":"Science"},{"issue":"5900","key":"pbio.3004016.ref024","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1126\/science.1163673","article-title":"Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1\/GPCR","volume":"322","author":"KL Styer","year":"2008","journal-title":"Science"},{"issue":"5","key":"pbio.3004016.ref025","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2018.04.017","article-title":"Intestinal epithelial wnt signaling mediates acetylcholine-triggered host defense against infection","volume":"48","author":"SA Labed","year":"2018","journal-title":"Immunity"},{"key":"pbio.3004016.ref026","doi-asserted-by":"crossref","first-page":"838525","DOI":"10.3389\/fimmu.2022.838525","article-title":"Properties, genetics and innate immune function of the cuticle in egg-laying species","volume":"13","author":"G Kulshreshtha","year":"2022","journal-title":"Front Immunol"},{"issue":"6","key":"pbio.3004016.ref027","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/wdev.77","article-title":"The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles","volume":"1","author":"AD Chisholm","year":"2012","journal-title":"Wiley Interdiscip Rev Dev Biol"},{"issue":"7","key":"pbio.3004016.ref028","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1128\/AEM.07486-11","article-title":"Caenorhabditis elegans, a model organism for investigating immunity","volume":"78","author":"EK Marsh","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"pbio.3004016.ref029","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12861-015-0076-7","article-title":"Morphologically defined sub-stages of C. elegans vulval development in the fourth larval stage","volume":"15","author":"DZL Mok","year":"2015","journal-title":"BMC Dev Biol"},{"issue":"4","key":"pbio.3004016.ref030","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1091\/mbc.e02-08-0479","article-title":"Two sets of interacting collagens form functionally distinct substructures within a Caenorhabditis elegans extracellular matrix","volume":"14","author":"L McMahon","year":"2003","journal-title":"Mol Biol Cell"},{"key":"pbio.3004016.ref031","doi-asserted-by":"crossref","unstructured":"Singh R, Sulston J. Some observations on moulting in Caenorhabditis elegans. 1978.","DOI":"10.1163\/187529278X00074"},{"issue":"4","key":"pbio.3004016.ref032","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyae072","article-title":"The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo","volume":"227","author":"MV Sundaram","year":"2024","journal-title":"Genetics"},{"issue":"1","key":"pbio.3004016.ref033","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0166-6851(94)90123-6","article-title":"The role of dityrosine formation in the crosslinking of CUT-2, the product of a second cuticlin gene of Caenorhabditis elegans","volume":"65","author":"F Lassandro","year":"1994","journal-title":"Mol Biochem Parasitol"},{"issue":"1","key":"pbio.3004016.ref034","doi-asserted-by":"crossref","first-page":"7506","DOI":"10.1038\/s41467-023-43058-9","article-title":"Nanoscale patterning of collagens in C. elegans apical extracellular matrix","volume":"14","author":"JRG Adams","year":"2023","journal-title":"Nat Commun"},{"issue":"21","key":"pbio.3004016.ref035","doi-asserted-by":"crossref","DOI":"10.1242\/dev.204330","article-title":"C. elegans epicuticlins define specific compartments in the apical extracellular matrix and function in wound repair","volume":"151","author":"M Pooranachithra","year":"2024","journal-title":"Development"},{"issue":"3","key":"pbio.3004016.ref036","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyaa047","article-title":"Specific collagens maintain the cuticle permeability barrier in Caenorhabditis elegans","volume":"217","author":"A Sandhu","year":"2021","journal-title":"Genetics"},{"issue":"1","key":"pbio.3004016.ref037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008857","article-title":"Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans","volume":"5","author":"E Kage-Nakadai","year":"2010","journal-title":"PloS One"},{"issue":"7","key":"pbio.3004016.ref038","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cub.2008.02.079","article-title":"Distinct innate immune responses to infection and wounding in the C. elegans epidermis","volume":"18","author":"N Pujol","year":"2008","journal-title":"Curr Biol"},{"issue":"7","key":"pbio.3004016.ref039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000105","article-title":"Anti-fungal innate immunity in C. elegans is enhanced by evolutionary diversification of antimicrobial peptides","volume":"4","author":"N Pujol","year":"2008","journal-title":"PLoS Pathog"},{"issue":"4","key":"pbio.3004016.ref040","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1534\/genetics.105.053637","article-title":"The C terminus of collagen SQT-3 has complex and essential functions in nematode collagen assembly","volume":"172","author":"J Novelli","year":"2006","journal-title":"Genetics"},{"issue":"4","key":"pbio.3004016.ref041","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1534\/genetics.118.301631","article-title":"BMP signaling determines body size via transcriptional regulation of collagen genes in Caenorhabditis elegans","volume":"210","author":"U Madaan","year":"2018","journal-title":"Genetics"},{"issue":"5","key":"pbio.3004016.ref042","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1042\/BST20160159","article-title":"Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer","volume":"44","author":"E Rainero","year":"2016","journal-title":"Biochem Soc Trans"},{"issue":"4","key":"pbio.3004016.ref043","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005377","article-title":"A noncanonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells","volume":"16","author":"S Srinivasan","year":"2018","journal-title":"PLoS Biol"},{"key":"pbio.3004016.ref044","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/ni.2957","article-title":"Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans","volume":"15","author":"O Zugasti","year":"2014","journal-title":"Nat Immunol"},{"key":"pbio.3004016.ref045","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.45047","article-title":"Microtubule plus-end dynamics link wound repair to the innate immune response","volume":"9","author":"C Taffoni","year":"2020","journal-title":"eLife"},{"key":"pbio.3004016.ref046","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75906","article-title":"Meisosomes, folded membrane microdomains between the apical extracellular matrix and epidermis","volume":"12","author":"D Aggad","year":"2023","journal-title":"Elife"},{"key":"pbio.3004016.ref047","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/bs.ctdb.2020.12.007","article-title":"Innate immunity in C. elegans","volume":"144","author":"CN Martineau","year":"2021","journal-title":"Curr Top Dev Biol"},{"issue":"4","key":"pbio.3004016.ref048","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1534\/genetics.118.300827","article-title":"A damage sensor associated with the cuticle coordinates three core environmental stress responses in Caenorhabditis elegans","volume":"208","author":"W Dodd","year":"2018","journal-title":"Genetics"},{"issue":"7","key":"pbio.3004016.ref049","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cub.2008.02.079","article-title":"Distinct innate immune responses to infection and wounding in the C. elegans epidermis","volume":"18","author":"N Pujol","year":"2008","journal-title":"Curr Biol"},{"issue":"3","key":"pbio.3004016.ref050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1011593","article-title":"A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans","volume":"21","author":"T Sonntag","year":"2025","journal-title":"PLoS Genet"},{"issue":"3","key":"pbio.3004016.ref051","article-title":"Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector","volume":"6","author":"L Xu","year":"2010","journal-title":"PLoS Pathog"},{"issue":"1","key":"pbio.3004016.ref052","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1073\/pnas.1413764111","article-title":"Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes","volume":"112","author":"A Sreelatha","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"48","key":"pbio.3004016.ref053","doi-asserted-by":"crossref","first-page":"19371","DOI":"10.1073\/pnas.1109201108","article-title":"Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H -ATPase to inhibit phagosome acidification","volume":"108","author":"D Wong","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"pbio.3004016.ref054","article-title":"A Bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy","volume":"178","author":"Y Xu","year":"2019","journal-title":"Cell"},{"key":"pbio.3004016.ref055","article-title":"Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans","volume":"9","author":"Y Sun","year":"2020","journal-title":"Elife"},{"issue":"7","key":"pbio.3004016.ref056","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nn.3126","article-title":"pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity","volume":"15","author":"Y Li","year":"2012","journal-title":"Nat Neurosci"},{"issue":"4","key":"pbio.3004016.ref057","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.chom.2013.03.003","article-title":"Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death","volume":"13","author":"NV Kirienko","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"2","key":"pbio.3004016.ref058","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cell.2014.09.011","article-title":"Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans","volume":"159","author":"JD Meisel","year":"2014","journal-title":"Cell"},{"issue":"25","key":"pbio.3004016.ref059","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn0014","article-title":"Olfaction regulates peripheral mitophagy and mitochondrial function","volume":"10","author":"JG Dishart","year":"2024","journal-title":"Sci Adv"},{"issue":"1","key":"pbio.3004016.ref060","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1038\/s41467-024-53093-9","article-title":"ASI-RIM neuronal axis regulates systemic mitochondrial stress response via TGF-\u03b2 signaling cascade","volume":"15","author":"Z Wang","year":"2024","journal-title":"Nat Commun"},{"issue":"12","key":"pbio.3004016.ref061","doi-asserted-by":"crossref","first-page":"115021","DOI":"10.1016\/j.celrep.2024.115021","article-title":"Probiotics-sensing mechanism in neurons that initiates gut mitochondrial surveillance for pathogen defense","volume":"43","author":"H Liu","year":"2024","journal-title":"Cell Rep"},{"issue":"21","key":"pbio.3004016.ref062","article-title":"Two sensory neurons coordinate the systemic mitochondrial stress response via GPCR signaling in C. elegans","volume":"57","author":"Y Liu","year":"2022","journal-title":"Dev Cell"},{"issue":"6515","key":"pbio.3004016.ref063","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/373573a0","article-title":"Protein modules and signalling networks","volume":"373","author":"T Pawson","year":"1995","journal-title":"Nature"},{"issue":"4","key":"pbio.3004016.ref064","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41587-019-0036-z","article-title":"SignalP 5.0 improves signal peptide predictions using deep neural networks","volume":"37","author":"JJ Almagro Armenteros","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"3","key":"pbio.3004016.ref065","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.neuron.2018.07.042","article-title":"The CeNGEN project: the complete gene expression map of an entire nervous system","volume":"99","author":"M Hammarlund","year":"2018","journal-title":"Neuron"},{"key":"pbio.3004016.ref066","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1038\/ncomms3660","article-title":"Visualization and targeted disruption of protein interactions in living cells","volume":"4","author":"HD Herce","year":"2013","journal-title":"Nat Commun"},{"issue":"6","key":"pbio.3004016.ref067","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/s41556-022-00926-8","article-title":"Lysosome lipid signalling from the periphery to neurons regulates longevity","volume":"24","author":"M Savini","year":"2022","journal-title":"Nat Cell Biol"},{"issue":"23","key":"pbio.3004016.ref068","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.1523\/JNEUROSCI.1466-07.2007","article-title":"UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans","volume":"27","author":"S Speese","year":"2007","journal-title":"J Neurosci"},{"issue":"23","key":"pbio.3004016.ref069","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1523\/JNEUROSCI.21-23-09265.2001","article-title":"The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans","volume":"21","author":"J Kass","year":"2001","journal-title":"J Neurosci"},{"issue":"4","key":"pbio.3004016.ref070","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0092-8674(00)81182-4","article-title":"The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9","volume":"93","author":"B Conradt","year":"1998","journal-title":"Cell"},{"issue":"25","key":"pbio.3004016.ref071","doi-asserted-by":"crossref","first-page":"10171","DOI":"10.1073\/pnas.0900604106","article-title":"Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs","volume":"106","author":"S Kosugi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pbio.3004016.ref072","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/bioinformatics\/btv667","article-title":"WormExp: a web-based application for a Caenorhabditis elegans-specific gene expression enrichment analysis","volume":"32","author":"W Yang","year":"2016","journal-title":"Bioinformatics"},{"issue":"4","key":"pbio.3004016.ref073","doi-asserted-by":"crossref","DOI":"10.1080\/21624054.2015.1118607","article-title":"GATA transcription factors as tissue-specific master regulators for induced responses","volume":"4","author":"DH Block","year":"2015","journal-title":"Worm"},{"key":"pbio.3004016.ref074","article-title":"Collagen binding adhesin restricts Staphylococcus aureus skin infection","author":"M Bhattacharya","year":"2024","journal-title":"bioRxiv"},{"issue":"2","key":"pbio.3004016.ref075","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1128\/IAI.71.2.1008-1010.2003","article-title":"Migration through the extracellular matrix by the parasitic protozoan Leishmania is enhanced by surface metalloprotease gp63","volume":"71","author":"BS McGwire","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"pbio.3004016.ref076","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1128\/iai.62.1.152-161.1994","article-title":"The Staphylococcus aureus collagen adhesin is a virulence determinant in experimental septic arthritis","volume":"62","author":"JM Patti","year":"1994","journal-title":"Infect Immun"},{"issue":"10","key":"pbio.3004016.ref077","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1038\/s41564-024-01769-9","article-title":"Staphylococcus aureus adapts to exploit collagen-derived proline during chronic infection","volume":"9","author":"A Urso","year":"2024","journal-title":"Nat Microbiol"},{"issue":"18","key":"pbio.3004016.ref078","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.3390\/cells12182223","article-title":"C. elegans hemidesmosomes sense collagen damage to trigger innate immune response in the epidermis","volume":"12","author":"Y Zhu","year":"2023","journal-title":"Cells"},{"issue":"6","key":"pbio.3004016.ref079","article-title":"Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models","volume":"6","author":"L Yu","year":"2020","journal-title":"Sci Adv"},{"issue":"42","key":"pbio.3004016.ref080","doi-asserted-by":"crossref","first-page":"18016","DOI":"10.1073\/pnas.1008946107","article-title":"Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation","volume":"107","author":"P Guo","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"pbio.3004016.ref081","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1534\/genetics.115.178335","article-title":"Streamlined genome engineering with a self-excising drug selection cassette","volume":"200","author":"DJ Dickinson","year":"2015","journal-title":"Genetics"},{"issue":"6920","key":"pbio.3004016.ref082","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"RS Kamath","year":"2003","journal-title":"Nature"},{"key":"pbio.3004016.ref083","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1101\/gr.2505604","article-title":"Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library","volume":"14","author":"J-F Rual","year":"2004","journal-title":"Genome Res"},{"issue":"2","key":"pbio.3004016.ref084","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1073\/pnas.96.2.715","article-title":"Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis","volume":"96","author":"MW Tan","year":"1999","journal-title":"Proc Natl Acad Sci U S A"}],"updated-by":[{"DOI":"10.1371\/journal.pbio.3004016","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000}}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3004016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:00:41Z","timestamp":1791482441000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.3004016"}},"subtitle":[],"editor":[{"given":"Mark J","family":"Alkema","sequence":"first","affiliation":[{"name":"UMass Chan Medical School","place":["UNITED STATES OF AMERICA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":84,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.3004016","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}