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McCloskey","year":"2014","journal-title":"EMBO Mol Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/sj.bjp.0706644","article-title":"A role for voltage-gated, but not Ca<sup>2+<\/sup>-activated, K<sup>+<\/sup> channels in regulating spontaneous contractile activity in myometrium from virgin and pregnant rats","volume":"147","author":"PI Aaronson","year":"2006","journal-title":"Br J Pharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1113\/jphysiol.2009.171272","article-title":"Loss of functional K<sup>+<\/sup> channels encoded by <italic>ether-\u00e0-go-go<\/italic>-related genes in mouse myometrium prior to labour onset","volume":"587","author":"IA Greenwood","year":"2009","journal-title":"J Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1095\/biolreprod.107.066423","article-title":"Overexpression of SK3 channels dampens uterine contractility to prevent preterm labor in mice","volume":"78","author":"SL Pierce","year":"2008","journal-title":"Biol Reprod"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1993.264.1.C1","article-title":"Uterine contraction and physiological-mechanisms of modulation","volume":"264","author":"S Wray","year":"1993","journal-title":"Am J Physiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1167\/iovs.04-1181","article-title":"ATP release through connexion hemichannels in corneal endothelial cells","volume":"46","author":"P Gomes","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.physiol.66.032102.150822","article-title":"Mechanism of rectification in inward-rectifier K<sup>+<\/sup> channels","volume":"66","author":"Z Lu","year":"2004","journal-title":"Ann Rev of Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"18724","DOI":"10.1073\/pnas.0506481102","article-title":"Gap junctional hemichannel-mediated ATP release an hearing controls in the inner ear","volume":"102","author":"H Zhao","year":"2005","journal-title":"PNAS"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1177\/1933719109344630","article-title":"Enhanced expression of P2X4 and P2X7 purinergic receptors in the myometrium of pregnant rats in preterm delivery models","author":"S Urabe","year":"2009","journal-title":"Reprod Sci"},{"issue":"4","key":"ref48","first-page":"R1117","article-title":"Functional expression of purinergic P2X7 receptors in pregnant rat myometrium","volume":"298","author":"H Miyoshi","year":"2010","journal-title":"Am J Physiol"},{"issue":"12","key":"ref49","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1177\/1933719112450333","article-title":"ATP-induced currents carried through P2X7 receptor in rat 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of the constant field equation to include both divalent and monovalent ions","volume":"9","author":"S Spangler","year":"1972","journal-title":"Ala J Med Sci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.biophys.37.032807.125859","article-title":"PIP<sub>2<\/sub> is a necessary cofactor for ion channel function: How and why","volume":"37","author":"B Hille","year":"2008","journal-title":"Annu Rev Biophys"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.bpj.2010.06.013","article-title":"Phosphatidylinositol-4,5-bisphosphate (PIP<sub>2<\/sub>) stabilizes the open pore conformation of the Kv11.1 (hERG) channel","volume":"99","author":"N Rodriguez","year":"2010","journal-title":"Biophys J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"C1001","DOI":"10.1152\/ajpcell.00250.2009","article-title":"Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate","volume":"297","author":"B Pattnaik","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1093\/emboj\/cdg526","article-title":"Phosphatidylinositol-4,5-bisphosphate, PIP<sub>2<\/sub>, controls KCNQ1\/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K<sup>+<\/sup> channels","volume":"22","author":"K Loussouarn","year":"2003","journal-title":"EMBO J"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"C235","DOI":"10.1152\/ajpcell.2000.278.2.C235","article-title":"Calcium sparks in smooth muscle","volume":"278","author":"J Jaggar","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ceca.2005.06.018","article-title":"Calcium signalling in smooth muscle","volume":"38","author":"S Wray","year":"2005","journal-title":"Cell 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release in skeletal muscle cells","volume":"269","author":"A Tsugorka","year":"1995","journal-title":"Science"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.270.5236.633","article-title":"Relaxation of arterial smooth muscle by calcium sparks","volume":"270","author":"M Nelson","year":"1995","journal-title":"Science"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0143-4160(03)00124-6","article-title":"Signalling between SR and plasmalemma in smooth muscle: sparks and the activation of Ca<sup>2+<\/sup>-sensitive ion channels","volume":"34","author":"G Wellman","year":"2003","journal-title":"Cell Calcium"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","first-page":"C1346","DOI":"10.1152\/ajpcell.1998.274.5.C1346","article-title":"Frequency modulation of Ca<sup>2+<\/sup> sparks is involved in regulation of arterial diameter by cyclic nucleotides","volume":"274","author":"V Porter","year":"1998","journal-title":"Cell Physiol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1126\/science.274.5289.998","article-title":"Laser capture microdissection","volume":"274","author":"M Emmert-Buck","year":"1996","journal-title":"Science"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1098\/rsta.2008.0301","article-title":"Markov models for ion channels: Versatility versus identifiability and speed","volume":"367","author":"M Fink","year":"2009","journal-title":"Phys Trans R Soc A"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1152\/jn.00079.2006","article-title":"Efficient estimation of detailed single-neuron models","volume":"96","author":"Q Huys","year":"2006","journal-title":"J Neurophysiol"},{"key":"ref70","article-title":"Mathematical Models of Biological Systems","author":"HA van den Berg","year":"2011"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.envsoft.2010.04.012","article-title":"How to avoid a perfunctory sensitivity analysis","volume":"25","author":"A Saltelli","year":"2010","journal-title":"Environ Modell Software"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.future.2011.09.006","article-title":"A local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling","volume":"29","author":"AA Sher","year":"2013","journal-title":"Future Gener Comp Sy"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bpj.2008.10.056","article-title":"Parameter sensitivity analysis in electrophysiological models using multivariate regression","volume":"96","author":"EA Sobie","year":"2009","journal-title":"Biophys 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Reprod"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/0896-6273(94)90418-9","article-title":"Cloning, expression, and distribution of functionally distinct Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> channel isoforms from human brain","volume":"13","author":"J Tseng-Crank","year":"1994","journal-title":"Neuron"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0165-0270(91)90017-T","article-title":"Low access resistance perforated patch recordings using amphotericin B","volume":"37","author":"J Rae","year":"1991","journal-title":"J Neurosc Methods"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/340642a0","article-title":"A novel potassium channel with delayed rectifier properties isolated from rat-brain by expression cloning","volume":"340","author":"GC Frech","year":"1989","journal-title":"Nature"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1469-7793.1999.0769p.x","article-title":"Voltage-gated K<sup>+<\/sup> currents in freshly isolated myocytes of the pregnant human myometrium","volume":"518","author":"GA Knock","year":"1999","journal-title":"J Physiol"},{"key":"ref81","first-page":"MPOS8","article-title":"Gating kinetics of the rat Kv2.1 potassium channel expressed in <italic>Xenopus<\/italic> oocytes","volume":"72","author":"KG Klemic","year":"1997","journal-title":"Biophys J"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0006-3495(81)84750-9","article-title":"Inactivation of voltage-gated delayed potassium current in molluscan neurons\u2014a kinetic model","volume":"36","author":"RW Aldrich","year":"1981","journal-title":"Biophys J"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"18154","DOI":"10.1074\/jbc.M213117200","article-title":"Structural determinants of the regulation of the voltage-gated potassium channel Kv2.1 by the modulatory alpha-subunit Kv9.3","volume":"278","author":"D Kerschensteiner","year":"2003","journal-title":"J Biol Chem"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0014-5793(96)01316-6","article-title":"Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current","volume":"399","author":"MA Post","year":"1996","journal-title":"FEBS Lett"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-5193(88)80093-6","article-title":"Kinetic analysis of incomplete current tracings according to the Hodgkin-Huxley model","volume":"130","author":"C Bonifazzi","year":"1988","journal-title":"J Theor Biol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1529\/biophysj.105.059378","article-title":"Time- and voltage-dependent components of Kv4.3 inactivation","volume":"89","author":"SM Wang","year":"2005","journal-title":"Biophys J"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbrc.2006.06.004","article-title":"KCNE3 is an inhibitory subunit of the kv4.3 potassium channel","volume":"346","author":"A Lundby","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0092-8674(95)90340-2","article-title":"A mechanistic link between an inherited and an acquired cardiac-arrhythmia\u2014hERG encodes the <italic>I<\/italic><sub><italic>KR<\/italic><\/sub> potassium channel","volume":"81","author":"MC Sanguinetti","year":"1995","journal-title":"Cell"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature04710","article-title":"hERG potassium channels and cardiac arrhythmia","volume":"440","author":"MC Sanguinetti","year":"2006","journal-title":"Nature"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/384078a0","article-title":"KvLQT1 and IsK (minK) proteins associate to form the <italic>I<\/italic><sub>Ks<\/sub> cardiac potassium current","volume":"384","author":"J Barhanin","year":"1996","journal-title":"Nature"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/384080a0","article-title":"Coassembly of KvLQT1 and mink (IsK) proteins to form cardiac I<sub><italic>Ks<\/italic><\/sub> potassium channel","volume":"384","author":"MC Sanguinetti","year":"1996","journal-title":"Nature"},{"issue":"3","key":"ref92","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1582-4934.2010.01021.x","article-title":"The contribution of Kv7 channels to pregnant mouse and human myometrial contractility","volume":"15","author":"L McCallum","year":"2010","journal-title":"J Cell Mol Med"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/35003200","article-title":"A constitutively open potassium channel formed by KCNQ1 and KCNE3","volume":"403","author":"BC Schr\u0153der","year":"2000","journal-title":"Nature"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1113\/jphysiol.2002.017301","article-title":"KCNE4 is an inhibitory subunit to the KCNQ1 channel","volume":"542","author":"M Grunnet","year":"2002","journal-title":"J Physiol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1113\/jphysiol.2008.161281","article-title":"KCNE4 domains required for inhibition of KCNQ1","volume":"587","author":"LJ Manderfield","year":"2009","journal-title":"J Physiol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4161\/chan.3.4.9477","article-title":"Gating currents from neuronal Kv7.4 channels general features and correlation with the ionic conductance","volume":"3","author":"F Miceli","year":"2009","journal-title":"Channels"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1126\/science.1857984","article-title":"A component of calcium- activated potassium channels encoded encoded by the <italic>Drosophila<\/italic>-Slo locus","volume":"253","author":"NS Atkinson","year":"1991","journal-title":"Science"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1126\/science.7687074","article-title":"mSlo, a complex mouse gene encoding mouse gene encoding Maxi calcium-activated potassium channels","volume":"261","author":"A Butler","year":"1993","journal-title":"Science"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/hmg\/3.8.1239","article-title":"Cloning and characterization of human and mouse homologs of the drosophila calcium-activated potassium channel gene, slowpoke","volume":"3","author":"L Pallanck","year":"1994","journal-title":"Hum Mol Genet"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1085\/jgp.116.3.411","article-title":"Role of the beta1 subunit in large-conductance Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> channel gating energetics\u2014mechanisms of enhanced Ca<sup>2+<\/sup> sensitivity","volume":"116","author":"DH Cox","year":"2000","journal-title":"J Gen Physiol"},{"key":"ref101","first-page":"A328","article-title":"<italic>\u03b2<\/italic>-subunits increase the calcium sensitivity of mSlo by stabilizing bursting kinetics","volume":"76","author":"CM Nimigean","year":"1999","journal-title":"Biophys J"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1085\/jgp.115.6.719","article-title":"Functional coupling of the <italic>\u03b2<\/italic>1 subunit to the large conductance Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> channel in the absence of Ca<sup>2+<\/sup> increased Ca<sup>2+<\/sup> sensitivity from a Ca<sup>2+<\/sup>-independent mechanism","volume":"115","author":"CM Nimigean","year":"2000","journal-title":"J Gen Physiol"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1523\/JNEUROSCI.19-13-05255.1999","article-title":"Molecular basis for the inactivation of Ca<sup>2+<\/sup>- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells","volume":"19","author":"XM Xia","year":"1999","journal-title":"J Neurosci"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1523\/JNEUROSCI.20-10-03563.2000","article-title":"A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels","volume":"20","author":"TM Weiger","year":"2000","journal-title":"J Neurosci"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"H2565","DOI":"10.1152\/ajpheart.01376.2007","article-title":"Mathematical model of the neonatal mouse ventricular action potential","volume":"294","author":"LJ Wang","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref106","first-page":"A1242","article-title":"Modulation of uterine contractility by small-conductance Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> SK3 channels","volume":"20","author":"A Brown","year":"2006","journal-title":"FASEB J"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"C836","DOI":"10.1152\/ajpcell.2001.280.4.C836","article-title":"Cloning and functional expression of a liver isoform of the small conductance Ca<sup>2+<\/sup>-activated K<sup>+<\/sup> channel SK3","volume":"280","author":"ET Barfod","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref108","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.274.21.14838","article-title":"hSK4\/hIK1, a Calmodulin-binding K<sub>Ca<\/sub> channel in human T lymphocytes","volume":"274","author":"R Khanna","year":"1999","journal-title":"J Biol Chem"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0896-6273(00)80480-8","article-title":"A novel inward rectifier K<sup>+<\/sup> channel with unique pore properties","volume":"20","author":"G Krapivinsky","year":"1998","journal-title":"Neuron"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1469-7793.1998.803bg.x","article-title":"Properties of voltage-activated <inline-formula id=\"pcbi.1004828.e132\"><alternatives><graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"pcbi.1004828.e132g\" mimetype=\"image\" position=\"anchor\" xlink:href=\"info:doi\/10.1371\/journal.pcbi.1004828.e132\" xlink:type=\"simple\"><\/graphic><mml:math display=\"inline\" id=\"M132\"><mml:msubsup><mml:mtext>Ca<\/mml:mtext> <mml:mi>i<\/mml:mi> <mml:mrow><mml:mn>2<\/mml:mn> <mml:mo>+<\/mml:mo><\/mml:mrow><\/mml:msubsup><\/mml:math><\/alternatives><\/inline-formula> transients in single smooth muscle cells isolated from pregnant rat uterus","volume":"511","author":"AV Shmigol","year":"1998","journal-title":"J Physiol"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"H1625","DOI":"10.1152\/ajpheart.1997.272.4.H1625","article-title":"Mechanisms of inactivation of L-type calcium channels in human atrial myocytes","volume":"272","author":"H Sun","year":"1997","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1113\/jphysiol.2007.132126","article-title":"Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium","volume":"581","author":"AM Blanks","year":"2007","journal-title":"J Physiol"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0026-895X(24)13257-9","article-title":"Isoform-specific inhibition of L-type calcium channels by dihydropyridines is independent of isoform-specific gating properties","volume":"53","author":"H Hu","year":"1998","journal-title":"Molecular Pharmacology"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1469-7793.2001.0707h.x","article-title":"Simultaneous measurements of changes in sarcoplasmic reticulum and cytosolic Ca<sup>2+<\/sup> in rat uterine smooth muscle cells","volume":"531","author":"AV Shmigol","year":"2001","journal-title":"J Physiol"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/01.RES.74.6.1071","article-title":"A dynamic model of the cardiac ventricular action-potential. I. Simulations of ionic currents and concentration changes","volume":"74","author":"CH Luo","year":"1994","journal-title":"Circ Res"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/jtbi.1997.0487","article-title":"A conservation principle and its effect on the formulation of Na-Ca exchanger current in cardiac cells","volume":"189","author":"A Varghese","year":"1997","journal-title":"J Theoret Biol"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00424-003-1224-7","article-title":"Electrophysiological characterization and functional importance of calcium-activated chloride channel in rat uterine myocytes","volume":"448","author":"K Jones","year":"2004","journal-title":"Pfl\u00fcgers Arch"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1523\/JNEUROSCI.19-06-01912.1999","article-title":"Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family","volume":"19","author":"JH Lee","year":"1999","journal-title":"J Neurosci"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/368018a0","article-title":"Connexins in disease","volume":"368","author":"M Bennett","year":"1994","journal-title":"Nature"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1083\/jcb.129.3.805","article-title":"Specific permeability and selective formation of gap junction channels in connexin-trasfected HeLa cells","volume":"129","author":"C Elfgang","year":"1995","journal-title":"J Cell Biol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.bi.65.070196.002355","article-title":"Connexins, connexons, and intercellular communication","volume":"65","author":"D Goodenough","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.103.1.123","article-title":"Molecular cloning of cDNA for rat liver gap junction protein","volume":"103","author":"D Paul","year":"1986","journal-title":"J Cell Biol"},{"key":"ref123","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0002-9378(94)70284-5","article-title":"Expression of the gap junction connexin-43 is increased in the human myometrium toward term and with onset of labor","volume":"170","author":"L Chow","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0002-9378(11)91453-7","article-title":"An immunohistochemical and immunocytologic study of increase in myometrial gap junctions (and connexin43) in rats and human during pregnancy","volume":"167","author":"T Tabb","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"ref125","doi-asserted-by":"crossref","first-page":"C168","DOI":"10.1152\/ajpcell.1978.235.5.C168","article-title":"Possible role of gap junctions in activation of myometrium during parturition","volume":"235","author":"R Garfield","year":"1978","journal-title":"Am J Physiol"},{"key":"ref126","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1540-8167.1995.tb00423.x","article-title":"The molecular basis of anisotropy: role of gap junctions","volume":"6","author":"J Saffitz","year":"1995","journal-title":"Electrophysiol"},{"key":"ref127","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00029.2009","article-title":"Molecular background of leak K<sup>+<\/sup> currents: two-pore domain potassium channels","volume":"90","author":"P Enyedi","year":"2010","journal-title":"Physiol Rev"},{"key":"ref128","doi-asserted-by":"crossref","first-page":"C50","DOI":"10.1152\/ajpcell.1977.232.1.C50","article-title":"Control of intracellular Ca<sup>2+<\/sup> activity in rat myometrium","volume":"232","author":"R Janis","year":"1977","journal-title":"Am J Physiol"},{"key":"ref129","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00029.2009","article-title":"Molecular background of leak K<sup>+<\/sup> currents: Two-pore domain potassium channels","volume":"90","author":"P Enyedi","year":"2010","journal-title":"Physiol Rev"},{"key":"ref130","doi-asserted-by":"crossref","first-page":"C278","DOI":"10.1152\/ajpcell.1982.242.5.C278","article-title":"Ca<sup>2+<\/sup>-dependence of calcium uptake by rat myometrium plasma membrane","volume":"242","author":"A Grover","year":"1982","journal-title":"Am J Physiol"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"331","DOI":"10.33549\/physiolres.930000.49.331","article-title":"Ca-ATPase of human myometrium plasma membranes","volume":"49","author":"F Carrera","year":"2000","journal-title":"Physiol Res"},{"key":"ref132","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s004410051050","article-title":"The significance of the isoforms of plasma membrane calcium ATPase","volume":"292","author":"D Guerini","year":"1998","journal-title":"Cell Tissue Res"},{"key":"ref133","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0143-4160(83)90001-5","article-title":"Calmodulin-dependent Ca<sup>2+<\/sup>-pump ATPase of human smooth muscle sarcolemma","volume":"4","author":"L Popescu","year":"1983","journal-title":"Cell Calcium"},{"key":"ref134","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1085\/jgp.56.3.360","article-title":"Characteristics of electrogenic sodium pumping in rat myometrium","volume":"56","author":"F Taylor","year":"1970","journal-title":"J Gen Physiol"},{"key":"ref135","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0002-9378(99)70390-X","article-title":"Contractile activity, membrane potential, and cytoplasmic calcium in human uterine smooth muscle in the their trimester of pregnancy and during labor","volume":"181","author":"H Parkington","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"ref136","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s004240050761","article-title":"Carboxyeosin decreases the rate of decay of the [Ca<sup>2+<\/sup>]<sub><italic>i<\/italic><\/sub> transient in uterine smooth muscle cells isolated from pregnant rats","volume":"437","author":"A Shmigol","year":"1998","journal-title":"Pfl\u00fcgers Arch"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"617","DOI":"10.4067\/S0716-97602004000400017","article-title":"Ca<sup>2+<\/sup> entry, efflux and release in smooth muscle","volume":"37","author":"A Matthew","year":"2004","journal-title":"Biol Res"}],"container-title":["PLOS Computational 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