{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:02:26Z","timestamp":1790704946156,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1010314","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000}}],"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"INRAE metaprogram GISA","award":["FORESEE project"],"award-info":[{"award-number":["FORESEE project"]}]},{"DOI":"10.13039\/501100022077","name":"INRAE","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022077","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013414","name":"Conseil R\u00e9gional des Pays de la Loire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013414","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007204","name":"CIRAD","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007204","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003246","name":"Dutch research council","doi-asserted-by":"crossref","award":["One Health PACT 109986"],"award-info":[{"award-number":["One Health PACT 109986"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Quantifying the variation of pathogens\u2019 life history traits in multiple host systems is crucial to understand their transmission dynamics. It is particularly important for arthropod-borne viruses (arboviruses), which are prone to infecting several species of vertebrate hosts. Here, we focus on how host-pathogen interactions determine the ability of host species to transmit a virus to susceptible vectors upon a potentially infectious contact. Rift Valley fever (RVF) is a viral, vector-borne, zoonotic disease, chosen as a case study. The relative contributions of livestock species to RVFV transmission has not been previously quantified. To estimate their potential to transmit the virus over the course of their infection, we 1) fitted a within-host model to viral RNA and infectious virus measures, obtained daily from infected lambs, calves, and young goats, 2) estimated the relationship between vertebrate host infectious titers and probability to infect mosquitoes, and 3) estimated the net infectiousness of each host species over the duration of their infectious periods, taking into account different survival outcomes for lambs. Our results indicate that the efficiency of viral replication, along with the lifespan of infectious particles, could be sources of heterogeneity between hosts. Given available data on RVFV competent vectors, we found that, for similar infectious titers, infection rates in the\n                    <jats:italic>Aedes<\/jats:italic>\n                    genus were on average higher than in the\n                    <jats:italic>Culex<\/jats:italic>\n                    genus. Consequently, for\n                    <jats:italic>Aedes<\/jats:italic>\n                    -mediated infections, we estimated the net infectiousness of lambs to be 2.93 (median) and 3.65 times higher than that of calves and goats, respectively. In lambs, we estimated the overall infectiousness to be 1.93 times higher in individuals which eventually died from the infection than in those recovering. Beyond infectiousness, the relative contributions of host species to transmission depend on local ecological factors, including relative abundances and vector host-feeding preferences. Quantifying these contributions will ultimately help design efficient, targeted, surveillance and vaccination strategies.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1010314","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T13:39:13Z","timestamp":1658497153000},"page":"e1010314","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Heterogeneity of Rift Valley fever virus transmission potential across livestock hosts, quantified through a model-based analysis of host viral load and vector infection"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5687-3570","authenticated-orcid":true,"given":"H\u00e9l\u00e8ne","family":"Cecilia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-427X","authenticated-orcid":true,"given":"Roosmarie","family":"Vriens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-2438","authenticated-orcid":true,"given":"Paul J.","family":"Wichgers Schreur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5758-636X","authenticated-orcid":true,"given":"Mariken M.","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-196X","authenticated-orcid":true,"given":"Rapha\u00eblle","family":"M\u00e9tras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0034-8950","authenticated-orcid":true,"given":"Pauline","family":"Ezanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-1406","authenticated-orcid":true,"given":"Quirine A.","family":"ten Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"issue":"1411","key":"pcbi.1010314.ref001","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1098\/rstb.2001.0888","article-title":"Risk factors for human disease emergence","volume":"356","author":"LH Taylor","year":"2001","journal-title":"Phil Trans R Soc Lond B"},{"issue":"1411","key":"pcbi.1010314.ref002","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1098\/rstb.2001.0889","article-title":"Diseases of humans and their domestic mammals: pathogen characteristics, host range and the risk of emergence","volume":"356","author":"S Cleaveland","year":"2001","journal-title":"Phil Trans R Soc Lond B"},{"key":"pcbi.1010314.ref003","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.epidem.2014.08.007","article-title":"Seven challenges for modelling indirect transmission: Vector-borne diseases, macroparasites and neglected tropical diseases","volume":"10","author":"TD Hollingsworth","year":"2015","journal-title":"Epidemics"},{"key":"pcbi.1010314.ref004","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.epidem.2014.10.001","article-title":"Eight challenges in modelling disease ecology in multi-host, multi-agent systems","volume":"10","author":"MG Buhnerkempe","year":"2015","journal-title":"Epidemics"},{"key":"pcbi.1010314.ref005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.epidem.2014.09.002","article-title":"Nine challenges in modelling the emergence of novel pathogens","volume":"10","author":"JO Lloyd-Smith","year":"2015","journal-title":"Epidemics"},{"issue":"1719","key":"pcbi.1010314.ref006","doi-asserted-by":"crossref","first-page":"20160091","DOI":"10.1098\/rstb.2016.0091","article-title":"Who acquires infection from whom and how? 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