{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:31:42Z","timestamp":1790760702439,"version":"4.1.0"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R015600\/1"],"award-info":[{"award-number":["MR\/R015600\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["213494\/Z\/18\/Z"],"award-info":[{"award-number":["213494\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["213494\/Z\/18\/Z"],"award-info":[{"award-number":["213494\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012331","name":"Agentschap Innoveren en Ondernemen","doi-asserted-by":"publisher","award":["HBC.2019.2906"],"award-info":[{"award-number":["HBC.2019.2906"]}],"id":[{"id":"10.13039\/100012331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Dengue virus (DENV) is a public health challenge across the tropics and subtropics. Currently, there is no licensed prophylactic or antiviral treatment for dengue. The novel DENV inhibitor JNJ-1802 can significantly reduce viral load in mice and non-human primates. Here, using a mechanistic viral kinetic model calibrated against viral RNA data from experimental\n                    <jats:italic>in-vitro<\/jats:italic>\n                    infection studies, we assess the\n                    <jats:italic>in-vitro<\/jats:italic>\n                    inhibitory effect of JNJ-1802 by characterising infection dynamics of two DENV-2 strains in the absence and presence of different JNJ-1802 concentrations. Viral RNA suppression to below the limit of detection was achieved at concentrations of &gt;1.6 nM, with a median concentration exhibiting 50% of maximal inhibitory effect (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of 1.23x10\n                    <jats:sup>-02<\/jats:sup>\n                    nM and 1.28x10\n                    <jats:sup>-02<\/jats:sup>\n                    nM for the DENV-2\/RL and DENV-2\/16681 strains, respectively. This work provides important insight into the\n                    <jats:italic>in-vitro<\/jats:italic>\n                    inhibitory effect of JNJ-1802 and presents a first step towards a modelling framework to support characterization of viral kinetics and drug effect across different host systems.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1011662","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T13:37:42Z","timestamp":1701869862000},"page":"e1011662","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics"],"prefix":"10.1371","volume":"19","author":[{"given":"Clare P.","family":"McCormack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Goethals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Goeyvaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier D.","family":"Woot de Trixhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Geluykens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doortje","family":"Borrenberghs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Ackaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-0706","authenticated-orcid":true,"given":"Ilaria","family":"Dorigatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"pcbi.1011662.ref001","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue.","volume":"393","author":"A Wilder-Smith","year":"2019","journal-title":"Lancet"},{"key":"pcbi.1011662.ref002","doi-asserted-by":"crossref","first-page":"e1760","DOI":"10.1371\/journal.pntd.0001760","article-title":"Refining the Global Spatial Limits of Dengue Virus Transmission by Evidence-Based Consensus.","volume":"6","author":"OJ Brady","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"pcbi.1011662.ref003","volume-title":"Global Strategy for Dengue Prevention and Control 2012\u20132020","author":"WHO","year":"2012"},{"key":"pcbi.1011662.ref004","first-page":"12","article-title":"Mapping global variation in dengue transmission intensity","author":"L Cattarino","year":"2020"},{"key":"pcbi.1011662.ref005","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"CP Simmons","year":"2012","journal-title":"N Engl J Med"},{"key":"pcbi.1011662.ref006","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.2149\/tmh.2011-S05","article-title":"Dengue, Urbanization and Globalization: The Unholy Trinity of the 21st","volume":"39","author":"DJ Gubler","year":"2011","journal-title":"Century. 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