{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:04:23Z","timestamp":1787731463667,"version":"build-2784847793"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1012709","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000}}],"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Liaison Committee for Education, Research and Innovation in Central Norway"},{"name":"The K. G. Jebsen Foundation"},{"DOI":"10.13039\/100001201","name":"The Kavli Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100001201","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Civitan Norway"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Numerous studies of the human brain supported by experimental results from rodent and cell models point to a central role for intracellular amyloid beta (A\u03b2) in the onset of Alzheimer\u2019s disease (AD). In a rat model used to study AD, it was recently shown that in layer II neurons of the anteriolateral entorhinal cortex expressing high levels of the glycoprotein reelin (Re\n                    <jats:sup>+<\/jats:sup>\n                    alECLII neurons), reelin and A\u03b2 engage in a direct protein\u2013protein interaction. If reelin functions as a sink for intracellular A\u03b2 and if the binding to reelin makes A\u03b2 physiologically inert, it implies that reelin can prevent the neuron from being exposed to the harmful effects typically associated with increased levels of oligomeric A\u03b2. Considering that reelin expression is extraordinarily high in Re\n                    <jats:sup>+<\/jats:sup>\n                    alECLII neurons compared to most other cortical neurons, such a protective role appears to be very difficult to reconcile with the fact that this subset of ECLII neurons is clearly a major cradle for the onset of AD. Here, we show that this conundrum can be resolved if Re\n                    <jats:sup>+<\/jats:sup>\n                    alECLII neurons have a higher maximum production capacity of A\u03b2 than neurons expressing low levels of reelin, and we provide a rationale for why this difference has evolved.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1012709","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T13:46:07Z","timestamp":1736257567000},"page":"e1012709","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intraneuronal binding of amyloid beta with reelin\u2014Implications for the onset of Alzheimer\u2019s disease"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2379-2982","authenticated-orcid":true,"given":"Asgeir","family":"Kobro-Flatmoen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig W.","family":"Omholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,7]]},"reference":[{"key":"pcbi.1012709.ref001","doi-asserted-by":"crossref","first-page":"101307","DOI":"10.1016\/j.arr.2021.101307","article-title":"Re-Emphasizing Early Alzheimer\u2019s Disease Pathology Starting in Select Entorhinal Neurons, with a Special Focus on Mitophagy","volume":"67","author":"A Kobro-Flatmoen","year":"2021","journal-title":"Ageing Res Rev"},{"issue":"9","key":"pcbi.1012709.ref002","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1093\/brain\/awab114","article-title":"Early Stages of Tau Pathology and Its 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