{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:56:35Z","timestamp":1790726195631,"version":"4.1.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K01AI139284"],"award-info":[{"award-number":["K01AI139284"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI168291"],"award-info":[{"award-number":["R01AI168291"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["2T32AI070077"],"award-info":[{"award-number":["2T32AI070077"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:sec id=\"sec021\">\n<jats:title>Background<\/jats:title>\n<jats:p>From smallpox to poliomyelitis, halting contagion transmission through simultaneous mass vaccination is ubiquitous and often perceived as the only possible solution. But implementing mass vaccination campaigns in large populations within a short period poses many challenges. For example, in Arequipa, Peru, sweeping mass vaccination campaigns conducted yearly over a single weekend have failed to achieve the required \u2018herd immunity\u2019 to halt canine rabies transmission. Contrary to the global paradigm of a simultaneous campaign, the 2022 Arequipa rabies campaign was implemented at the sub-district level (patches), with dates of the campaign staggered across 6 months.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec022\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We constructed a stochastic, metapopulation model to examine how the timing of pulsed vaccination campaigns across patches can affect metapopulation dynamics. We explore general metapopulation dynamics for pulsed vaccinations as well as parameterizing the model for canine rabies in Arequipa, Peru. We simulated how the timing of the planned vaccination campaign, staggered over 6 months versus a single yearly pulse, affected the prospects for regional rabies elimination.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec023\">\n<jats:title>Results<\/jats:title>\n<jats:p>Metapopulation dynamics can affect the efficacy of pulsed vaccination campaigns. In the case of Arequipa, Peru, the planned staggered mass dog vaccination campaign has the potential for local elimination with the tradeoffs of increased time to elimination and increased outbreak size due to metapopulation dynamics.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec024\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Heterogeneities caused by control strategies enactment at sub-population scales should be accounted for when modeling transmission dynamics. In Arequipa, Peru, although metapopulation dynamics may allow for re-introduction of canine rabies in previously vaccinated patches when mass dog vaccination campaigns are staggered temporally over 6 months, continuous mass vaccination reaching recommended vaccination coverage levels is sufficient to eliminate canine rabies.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pcbi.1012780","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T18:37:17Z","timestamp":1738953437000},"page":"e1012780","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Challenging a paradigm: Staggered versus single-pulse mass dog vaccination strategy for rabies elimination"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5386-414X","authenticated-orcid":true,"given":"Brinkley Raynor","family":"Bellotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvis W.","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"De la Puente-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Rieders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio E.","family":"Recuenco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Z.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6629-2139","authenticated-orcid":true,"given":"Ricardo","family":"Castillo-Neyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"pcbi.1012780.ref001","author":"WHO, FAO, OIE","year":"2018"},{"issue":"3","key":"pcbi.1012780.ref002","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0264-410X(95)00197-9","article-title":"Immunization coverage required to prevent outbreaks of dog rabies","volume":"14","author":"PG Coleman","year":"1996","journal-title":"Vaccine"},{"key":"pcbi.1012780.ref003","unstructured":"Pan American Health Organization. Dog mediated human rabies in the Americas [Internet]. 2019 [cited 2022 Dec 5]. Available from: https:\/\/www.paho.org\/en\/documents\/dog-mediated-human-rabies-americas"},{"issue":"1623","key":"pcbi.1012780.ref004","doi-asserted-by":"crossref","first-page":"20120143","DOI":"10.1098\/rstb.2012.0143","article-title":"Progress towards eliminating canine rabies: policies and perspectives from Latin America and the Caribbean","volume":"368","author":"MAN Vigilato","year":"2013","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"pcbi.1012780.ref005","unstructured":"WHO. WHO expert consultation on rabies: third report [Internet]. 2018 [cited 2024 Oct 19]. Available from: https:\/\/www.who.int\/publications\/i\/item\/WHO-TRS-1012"},{"issue":"1","key":"pcbi.1012780.ref006","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0966-842X(97)81769-6","article-title":"Vaccination in pulses: a strategy for global eradication of measles and polio?","volume":"5","author":"DJ Nokes","year":"1997","journal-title":"Trends Microbiol"},{"issue":"Suppl 4","key":"pcbi.1012780.ref007","doi-asserted-by":"crossref","first-page":"S697","DOI":"10.1093\/clinids\/10.Supplement_4.S697","article-title":"Mass vaccination campaign against rabies: are dogs correctly protected? The Peruvian experience","volume":"10","author":"B Chomel","year":"1988","journal-title":"Rev Infect Dis"},{"issue":"3","key":"pcbi.1012780.ref008","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pbio.1000053","article-title":"Transmission dynamics and prospects for the elimination of canine rabies","volume":"7","author":"K Hampson","year":"2009","journal-title":"PLoS Biol"},{"key":"pcbi.1012780.ref009","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/B978-0-12-818705-0.00020-0","article-title":"Chapter 20 - Modeling canine rabies virus transmission dynamics.","volume-title":"Rabies","author":"M Rajeev","year":"2020"},{"issue":"8","key":"pcbi.1012780.ref010","doi-asserted-by":"crossref","first-page":"e2372","DOI":"10.1371\/journal.pntd.0002372","article-title":"Designing programs for eliminating canine rabies from islands: Bali, Indonesia as a case study","volume":"7","author":"SE Townsend","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"pcbi.1012780.ref011","first-page":"284","article-title":"Modeling transmission dynamics of rabies in Nepal","volume":"6","author":"B Pantha","year":"2021","journal-title":"Infect Dis Model"},{"key":"pcbi.1012780.ref012","unstructured":"Rajeev M. Data and modeling to inform canine rabies control and elimination. 2021 [cited 2024 Oct 19]. Available from: https:\/\/dataspace.princeton.edu\/handle\/88435\/dsp01vt150n33g"},{"issue":"5","key":"pcbi.1012780.ref013","doi-asserted-by":"crossref","first-page":"e0009414","DOI":"10.1371\/journal.pntd.0009414","article-title":"The impact of the COVID-19 pandemic on rabies reemergence in Latin America: the case of Arequipa, Peru","volume":"15","author":"B Raynor","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"pcbi.1012780.ref014","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mbs.2017.02.005","article-title":"Modeling the transmission dynamics and control of rabies in China","volume":"286","author":"S Ruan","year":"2017","journal-title":"Math Biosci"},{"issue":"35","key":"pcbi.1012780.ref015","doi-asserted-by":"crossref","first-page":"14996","DOI":"10.1073\/pnas.0904740106","article-title":"Transmission dynamics and economics of rabies control in dogs and humans in an African city","volume":"106","author":"J Zinsstag","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1012780.ref016","article-title":"Metapopulation network models for understanding, predicting, and managing the coronavirus disease COVID-19","volume":"8","author":"D Calvetti","year":"2020","journal-title":"Front Phys [Internet]"},{"issue":"5","key":"pcbi.1012780.ref017","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.2307\/2265556","article-title":"Disease in metapopulation models: implications for conservation","volume":"77","author":"G Hess","year":"1996","journal-title":"Ecology"},{"key":"pcbi.1012780.ref018","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1038\/srep05522","article-title":"Random and targeted interventions for epidemic control in metapopulation models","volume":"4","author":"G Tanaka","year":"2014","journal-title":"Sci Rep"},{"issue":"6","key":"pcbi.1012780.ref019","doi-asserted-by":"crossref","first-page":"e02711","DOI":"10.1002\/ecy.2711","article-title":"Integrating social and ecological data to model metapopulation dynamics in coupled human and natural systems","volume":"100","author":"ND Van Schmidt","year":"2019","journal-title":"Ecology"},{"key":"pcbi.1012780.ref020","volume-title":"Modeling infectious diseases in humans and animals [Internet]","author":"M Keeling","year":"2014"},{"issue":"2","key":"pcbi.1012780.ref021","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3934\/mbe.2010.7.455","article-title":"Pulse vaccination strategies in a metapopulation SIR model","volume":"7","author":"AJ Terry","year":"2010","journal-title":"Math Biosci Eng"},{"key":"pcbi.1012780.ref022","unstructured":"Red Arequipa Caylloma. Plan de accion de la campa\u00f1a de vacunacion antirabica canina 2019 [Internet]. 2019. Available from: https:\/\/redperifericaaqp.gob.pe\/wp-content\/uploads\/2019\/04\/accion-de-la-campana-atirabica-2019-comprimido.pdf"},{"key":"pcbi.1012780.ref023","author":"RK McCormack","year":"2006"},{"issue":"1","key":"pcbi.1012780.ref024","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/17513750601032711","article-title":"Multi-patch deterministic and stochastic models for wildlife diseases","volume":"1","author":"RK McCormack","year":"2007","journal-title":"J Biol Dyn"},{"key":"pcbi.1012780.ref025","author":"J Cheng","year":"2024"},{"key":"pcbi.1012780.ref026","unstructured":"CARTO Contributors. CartoDB. 2014. Available from: https:\/\/carto.com\/basemaps"},{"issue":"6592","key":"pcbi.1012780.ref027","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1126\/science.abn0713","article-title":"Rabies shows how scale of transmission can enable acute infections to persist at low prevalence","volume":"376","author":"R Mancy","year":"2022","journal-title":"Science"},{"key":"pcbi.1012780.ref028","unstructured":"PAHO. Manual de rabia [Internet]. Available from: https:\/\/www.paho.org\/arg\/publicaciones\/publicaciones%20virtuales\/cdmanualRabia\/index.html"},{"key":"pcbi.1012780.ref029","author":"R Core Team"},{"key":"pcbi.1012780.ref030","unstructured":"OpenStreetMap Contributors. OpenStreetMap [Internet]. 2015. Available from: https:\/\/www.openstreetmap.org\/."},{"issue":"3","key":"pcbi.1012780.ref031","doi-asserted-by":"crossref","first-page":"e0005460","DOI":"10.1371\/journal.pntd.0005460","article-title":"Barriers to dog rabies vaccination during an urban rabies outbreak: qualitative findings from Arequipa, Peru","volume":"11","author":"R Castillo-Neyra","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"pcbi.1012780.ref032","doi-asserted-by":"crossref","first-page":"e0007600","DOI":"10.1371\/journal.pntd.0007600","article-title":"Socio-spatial heterogeneity in participation in mass dog rabies vaccination campaigns, Arequipa, Peru","volume":"13","author":"R Castillo-Neyra","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"pcbi.1012780.ref033","author":"O Reyes"},{"key":"pcbi.1012780.ref034","doi-asserted-by":"crossref","first-page":"104978","DOI":"10.1016\/j.prevetmed.2020.104978","article-title":"Movement patterns of free-roaming dogs on heterogeneous urban 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