{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:40:12Z","timestamp":1791394812436,"version":"4.3.3"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1013561","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000}}],"reference-count":161,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Hereditary Hemorrhagic Telangiectasia (HHT) is a currently incurable genetic disorder caused by loss-of-function mutations in the ALK1-BMP9 pathway, leading to dysregulated angiogenesis and consequential vascular malformations. Recent experiments also implicate the mechanotransducers YAP\/TAZ in HHT pathology. However, how YAP\/TAZ stiffness sensitivity and signaling activity contribute to aberrant HHT angiogenesis remains poorly understood. Here, we extended our previous computational framework of stiffness-mediated YAP\/TAZ-VEGF-NOTCH crosstalk to account for ALK1 signalling and predict the resulting angiogenic temporal dynamics. Our simulations predicted that ALK1 knockout impairs NOTCH activation, slowing endothelial phenotypic selection and shuffling while enhancing filopodia activity, features corresponding with hypersprouting. These effects were most pronounced in low stiffness environments, consistent with the previously observed prevalence of HHT vascular malformations in low stiffness organs. Importantly, the temporal dynamics of endothelial phenotypic selection and shuffling, as well as key protein activity levels, were partially restored by direct or cytoskeleton-mediated inhibition of YAP\/TAZ resulting from increased NOTCH activation. These computational findings offer more mechanistic insight into the signalling pathways and temporal dynamics of endothelial phenotypic selection underlying HHT vascular anomalies, and suggest that targeting YAP\/TAZ and endothelial stiffness sensitivity may offer a promising therapeutic strategy to restore physiological angiogenesis.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1013561","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:44:58Z","timestamp":1784223898000},"page":"e1013561","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeting stiffness-dependent YAP\/TAZ restores angiogenesis dynamics impaired by ALK1 knockout in 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