{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:35:11Z","timestamp":1789504511718,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1014022","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000}}],"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Neural mass models (NMMs) aim to capture the principles underlying mesoscopic neural activity representing the average behavior of large neural populations in the brain. Recently, a biophysically grounded laminar NMM (LaNMM) has been proposed, capable of generating coupled slow and fast oscillations resulting from interactions between different cortical layers. This concurrent oscillatory activity provides a mechanistic framework for studying information processing mechanisms and various disease-related oscillatory dysfunctions. We show that this model can exhibit periodic, quasiperiodic, and chaotic oscillations. Additionally we demonstrate, through bifurcation analysis and numerical simulations, the emergence of rhythmic activity and various frequency couplings in the model, including delta-gamma, theta-gamma, and alpha-gamma couplings. We also examine how alterations linked with Alzheimer\u2019s disease impair the model\u2019s ability to display multifrequency activity. Furthermore, we show that the model remains robust when coupled to another neural mass. Together, our results offer a dynamical systems perspective of the laminar NMM model, thereby providing a foundation for future modeling studies and investigations into cognitive processes that depend on cross-frequency coupling.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1014022","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:37:37Z","timestamp":1775237857000},"page":"e1014022","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Emergence of multifrequency activity in a laminar neural mass model"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-2293","authenticated-orcid":true,"given":"Raul","family":"de Palma 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