{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:51:57Z","timestamp":1792788717307,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1014152","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000}}],"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\/05221-2020"],"award-info":[{"award-number":["RGPIN\/05221-2020"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-02949"],"award-info":[{"award-number":["RGPIN-2021-02949"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCalgary\u2019s VPR Postdoctoral Match-Funding Program"},{"name":"Alberta Graduate Excellence Scholarship"},{"name":"Alberta Innovates Graduate Student Scholarship","id":[{"id":"https:\/\/ror.org\/00ynafe15","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    A central question in neuroscience is how neural processing generates or encodes behavior.\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    is well suited to addressing this question, given its compact nervous system and near-complete structural connectome. Despite this, findings from previous studies remain inconclusive. While some have shown that the connectome can robustly encode specific behaviors such as locomotion, others report that functional connectivity can be reconfigured across behaviors. We aim to understand the relationship between structural connectivity, functional connectivity and biological behavior\n                    <jats:italic>in silico<\/jats:italic>\n                    by using an experimentally motivated computational model leveraging the structural connectome. Stimulation of specific neurons in the model induces oscillatory neural responses, enabling us to infer neuronal functional connectivity. Functional connectivity is found to be stronger among some neurons, allowing us to identify functional communities. We find that electrical synapses play a critical role in determining functional communities, and the resulting mesoscale functional architecture is predominantly gap junctionally assortative. Furthermore, comparison with behavioral circuits shows that locomotion circuits are largely segregated into distinct functional communities while other circuits are more distributed across multiple functional communities. We also observe that stimulation of neurons belonging to these distributed circuits elicits a more synchronized neuronal response compared to stimulation of neurons within the more segregated circuits. This is consistent with the presence of behavioral patterns that originate in one circuit and terminate in another (e.g., chemosensation leading to locomotion), such that stimulation of one circuit can activate the other and eventually result in a synchronized response. We also find a large repertoire of chimera-like synchronization patterns upon stimulation of certain sensory circuits (chemosensation, mechanosensation) indicating high dynamical flexibility. Overall, our results demonstrate that while certain behaviors are governed by functionally segregated circuits, others emerge from the synchronization of multiple functional communities, which are, to begin with, influenced by the underlying structural connectivity.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1014152","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:17:26Z","timestamp":1789496246000},"page":"e1014152","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronization properties in C. elegans: Relating behavioral circuits to structural and functional neuronal connectivity"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-4834","authenticated-orcid":true,"given":"Gourab Kumar","family":"Sar","sequence":"first","affiliation":[{"name":"University of Calgary","place":["Calgary, Alberta, Canada"],"department":["Complexity Science Group, Department of Physics and Astronomy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Patton","sequence":"additional","affiliation":[{"name":"University of Calgary","place":["Calgary, Alberta, Canada"],"department":["Complexity Science Group, Department of Physics and Astronomy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Towlson","sequence":"additional","affiliation":[{"name":"University of Calgary","place":["Calgary, Alberta, Canada"],"department":["Complexity Science Group, Department of Physics and Astronomy"]},{"name":"University of Calgary","place":["Calgary, Alberta, Canada"],"department":["Hotchkiss Brain Institute"]},{"name":"University of Calgary","place":["Calgary, Alberta, Canada"],"department":["Department of Computer Science"]},{"name":"University of Calgary","place":["Calgary, Alberta, Canada"],"department":["Alberta Children\u2019s Hospital Research Institute"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8103-4442","authenticated-orcid":true,"given":"J\u00f6rn","family":"Davidsen","sequence":"additional","affiliation":[{"name":"University of Calgary","place":["Calgary, Alberta, Canada"],"department":["Complexity Science Group, Department of Physics and Astronomy"]},{"name":"University of Calgary","place":["Calgary, Alberta, Canada"],"department":["Hotchkiss Brain Institute"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"1165","key":"pcbi.1014152.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rstb.1986.0056","article-title":"The structure of the nervous system of the nematode Caenorhabditis elegans","volume":"314","author":"JG White","year":"1986","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"2","key":"pcbi.1014152.ref002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1001066","article-title":"Structural properties of the Caenorhabditis elegans neuronal network","volume":"7","author":"LR Varshney","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"pcbi.1014152.ref003","unstructured":"Altun ZF, Herndon L, Wolkow C, Crocker C, Lints R, Hall D. 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